Effect of induced bilateral cryptorchidism on the carbohydrate metabolism of reproductive tissues in albino rats

1983 ◽  
Vol 91 (5) ◽  
pp. 405-410 ◽  
Author(s):  
K. Venkatarami Reddy ◽  
N. Geethanjali ◽  
Y. Dhananjaya Reddy ◽  
P. Reddanna ◽  
S. Govindappa
Keyword(s):  
Carbohydrate Metabolism ◽  
Albino Rats ◽  
Reproductive Tissues ◽  
Bilateral Cryptorchidism

scholarly journals Alterations in carbohydrate metabolism under cryptorchid condition in albino rats

2009 ◽  
Vol 1 (1) ◽  
pp. 62-65
Author(s):  
K. Narasimha Varma ◽  
E. Madhuri ◽  
S. Sadak Basha ◽  
YR. Radha Madhavi ◽  
M Guru Sekhar ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Prostate Gland ◽  
The Body ◽  
Albino Rats ◽  
Phosphorylase Activity ◽  
Glucose Content ◽  
Reproductive Tissues ◽  
Wistar Strain ◽  
Bilateral Cryptorchidism ◽  
Free Glucose

Bilateral cryptorchidism was induced surgically in adult wistar strain albino rats and the carbohydrate metabolic pathway has been studied in testis, and sex accessory organs of both control and cryptorchid animals by estimating the marker enzymes and the substrates of the metabolism. In cryptorchid animal tissues, accumulation of lactic acid and glycogen was observed with inhibited phosphorylase activity in comparison to the controls. The reproductive tissues like testis, epididymis, prostate gland and seminal vesicles had shown remarkable elevation in the glycogen content, which can be attributed to decreased phosphorylase activity. In view of androgen dependent nature of phosphorylase its inhibition can be correlated to decreased testosterone circulation in the body. Consequently the free glucose content of the tissues was markedly decreased suggesting a decrease in the mobilization of the carbohydrates into energy metabolism. All the reproductive tissues had shown significant accumulation of lactic acid with inhibited oxidative enzyme activities. Thus the reproductive tissue oxidative metabolism had been suppressed during cryptorchidism leading to a shift towards glycolysis and creating a situation of functional suppression.

Attenuation of Helicteres isora L. bark extracts on streptozotocin-induced alterations in glycogen and carbohydrate metabolism in albino rats

2009 ◽  
Vol 28 (11) ◽  
pp. 689-696 ◽  
Author(s):  
G. Kumar ◽  
G. Sharmila Banu ◽  
AG Murugesan
Keyword(s):  
Skeletal Muscle ◽  
Carbohydrate Metabolism ◽  
Glycogen Content ◽  
Bark Extract ◽  
Albino Rats ◽  
Glucose Levels ◽  
Helicteres Isora ◽  
Insulin Dependent ◽  
Hypoglycemic Drug ◽  
Normal Controls

The present study was undertaken to assess the effect of Helicteres isora L. on four important enzymes of carbohydrate metabolism (glucokinase [GK], hexokinase [HK] phosphofructokinase [PFK] and fructose-1, 6-bisphosphatase [FBP]) along with glycogen content of insulin-dependent (skeletal muscle and liver) and insulin-independent tissues (kidneys and brain) in streptozotocin (STZ; 60 mg/kg)-induced model of diabetes for 30 days. Administration of bark extracts (100, 200 mg/kg) for 30 days led to decrease in plasma glucose levels by approximately 9.60% and 22.04% and 19.18% and 33.93% on 15th and 30th day, respectively, of the experiment. Liver and two-kidney weight expressed as percentage of body weight significantly increased in diabetics (P < 0.05) versus normal controls. Renal glycogen content increased by 10 folds while hepatic and skeletal muscle glycogen content decreased by 75% and 68% in diabetic controls versus controls. H. isora did not affect glycogen content in any tissue. The decreased activities of PFK, GK, FBP and HK in diabetic controls were 40%, 50%, 50% and 60% and bark extract of H. isora partially corrected this alteration. The efficacy of the bark extract was comparable with Tolbutamide, a well-known hypoglycemic drug.

scholarly journals Decaffeinated Coffee Consumption and Renal Function Impairment in Health and Diabetes: A Paradigm-Shift

2020 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Renal Function ◽  
Carbohydrate Metabolism ◽  
Coffee Consumption ◽  
Serum Glucose ◽  
Caffeine Intake ◽  
Albino Rats ◽  
Bioactive Constituents ◽  
Male And Female ◽  
Decaffeinated Coffee ◽  
Group 2

Aim: The belief that decaffeinated coffee (DCAF) does not contain a physiologically relevant concentration of caffeine and therefore has no significant adverse effect on renal endpoints makes patients who are vulnerable to renal dysfunction, renal compromised state, medical conditions that contraindicate caffeine intake or those already on prescription medications known to adversely affect the kidney to sometimes substitute DCAF for caffeinated coffee even as the credibility of this paradigm remains disputable. Therefore, the present study aimed to assess the effect of DCAF consumption on markers of renal function and carbohydrate metabolism in health and diabetes. Materials and Methods: Sixty Wistar Albino rats were divided into 12 groups (6pairs) (n=5per group) for male and female animals. Animals in group 1 served as normal control (NCTRL) and were given standard feed and water only. Animals in group 2 received standard feed plus DCAF. Group 3 was the diabetic (DIA) only group while groups 4, 5, and 6 were DIA plus DCAF treatment groups. After 4weeks of treatment, animals were sacrificed and blood obtained and analyzed for the biochemical indices of renal function and carbohydrate metabolism using standard methods. Results: Serum creatinine (SCr) levels increased significantly in all DCAF treated groups compared with the NCTRL group in male and female animals. Serum electrolytes did not show any significant change across groups. Serum Urea (SUr) increased and decreased in DIA alone group and DIA plus DCAF groups respectively. Serum glucose, insulin, and HOMA-IR increased and decreased significantly in DIA alone group and DIA plus DCAF treated groups respectively compared with NCTRL and DCAF control groups. Conclusion: The consumption of DCAF may adversely affect renal endpoints in health and diabetes but improves markers of carbohydrate metabolism in diabetes likely due to the re-enforcement effect of its caffeine and other bioactive constituents.

scholarly journals Pattern of lipid fractions in plasma and cardiovascular tissues under Cryptorchidism in albino rat

2010 ◽  
Vol 2 (1) ◽  
pp. 1-4
Author(s):  
K. Narasimha Varma ◽  
E. Madhuri ◽  
M. Bhaskar
Keyword(s):  
Fatty Acids ◽  
Dorsal Aorta ◽  
Albino Rats ◽  
Significant Elevation ◽  
Albino Rat ◽  
Cardiovascular Tissues ◽  
Wistar Strain ◽  
Bilateral Cryptorchidism ◽  
Lipid Fractions ◽  
Cardio Vascular

Bilateral cryptorchidism was induced surgically in adult wistar strain male albino rats and lipid fractions such as total lipids, total cholesterol, Free cholesterol, Esterified cholesterol, phospholipids, Triglycerides and free fatty acids were analysed in the plasma, heart and dorsal aorta. The lipid fractions such as triglycerides (56.63%), free (20.82%) and esterified (61.25%) cholesterol as well as fatty acids in glycerol (64.42%) had significant elevation in the plasma of cryptorchid animals. Similarly LDL lipid fractions (64.99%) were also elevated markedly undercryptorchid conditions which are the markers of the obesity and atherosclerosis. The lipid fractions such as triglycerides (50.47%, 48.17%), cholesterol (74.64%, 67.7%) and phospholipids (42.04%, 68.88%) showed significant elevations in the heart and dorsal aorta of the cryptorchid animals over the control. The heart, dorsal aorta and plasma had significant accumulation of triglycerides and cholesterol fractions, suggesting the possible deposition of lipid fractions in the tissues, which can be attributed to the possible suppression in the mobilization of lipid fractions into energy metabolism. Such an accumulation of lipid fractions under cryptorchid condition can be considered as the development of risk factor for the cardio-vascular disorders.

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