Touch imprint cytology: a rapid diagnostic tool for oral squamous cell carcinoma

2015 ◽  
Vol 90 (5) ◽  
pp. 348-352 ◽  
Author(s):  
L Geetha ◽  
M Astekar ◽  
Kn Ashok ◽  
Gv Sowmya
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Diagnostic Tool ◽  
Imprint Cytology ◽  
Touch Imprint Cytology

Touch Imprint Cytology: A Rapid and Accurate Method for Diagnosis of Oral Cancer

2019 ◽  
Vol 63 (5) ◽  
pp. 411-416
Author(s):  
Amit Kumar Adhya ◽  
Madhabananda Kar ◽  
Ranjan Mohanty
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Cost Effective ◽  
Accurate Method ◽  
Imprint Cytology ◽  
Cytologic Examination ◽  
Touch Imprint Cytology

Objectives: Touch imprint cytology (TIC) is a rapid and cheap method and can be used as an adjunct to biopsy for the evaluation of suspected malignancy. We evaluated the advantages and limitations of TIC for the preoperative diagnosis of oral squamous cell carcinoma. Study Design: We used 280 incisional biopsies of clinically suspected oral squamous cell carcinoma and compared TIC diagnosis to histopathological sections. The sensitivity, specificity, and diagnostic accuracy of TIC were evaluated. Results: A total of 201 (82.5%) cases were diagnosed as malignant, 22 (7.9%) cases were diagnosed as suspicious of malignancy, and 54 (19.3%) cases as benign/negative on TIC. The overall sensitivity of TIC was 98.2%, specificity was 89.3%, the positive-predictive value 97.3%, and the negative-predictive value was 92.6%. The accuracy of the test was 96.4%. Conclusions: TIC is an accurate, simple, rapid, and cost-effective method that aids the diagnosis of oral squamous cell carcinoma but does not replace incisional biopsy. The cytologic examination of imprints of biopsies also helps determine the adequacy of the specimen for histologic examination.

Saliva as a Diagnostic Tool in Oral Squamous Cell Carcinoma – a Systematic Review with Meta Analysis

2019 ◽  
Vol 25 (2) ◽  
pp. 447-453 ◽  
Author(s):  
K. Hema Shree ◽  
Pratibha Ramani ◽  
Herald Sherlin ◽  
Gheena Sukumaran ◽  
Gifrrina Jeyaraj ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Diagnostic Tool ◽  
Meta Analysis

scholarly journals The Utility of Beta 2 Microglobulin (B2M) as an Initial Diagnostic Tool for Oral Squamous Cell Carcinoma (OSCC): Evidence from a Malaysian Scenario

2019 ◽  
Vol 18 (4) ◽  
pp. 729-735
Author(s):  
Maithrea Suresh Narayanan ◽  
Nur Karyatee Kassim ◽  
Tang Liszen ◽  
Baharuddin Abdullah ◽  
Julia Omar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Diagnostic Tool ◽  
High Risk Patient ◽  
Tumour Marker ◽  
Beta 2 ◽  
Beta 2 Microglobulin ◽  
Serum Tumour

Background: The delay in diagnosis of oral squamous cell carcinoma (OSCC) is a factor in rendering the poor prognosis, and recent research has explored the use of serum tumour markers such Beta 2 Microglobulin (B2M), to aid early diagnosis. However, despite a high incidence of OSCC in Southeast Asia, no studies on the clinical use of B2M in the region were found. Objectives: To determine if serum B2M level can serve as an initial diagnostic tool to indicate if a biopsy is warranted, and if so, to propose a local B2M serum reference value to identify OSSC patients. Methodology: Twenty-one patients were seen at Hospital Universiti Sains Malaysia (HUSM) for a one-year period, between June 2016 and June 2017, and equal number of healthy controls participated in the study. Apart from patient history, venous blood of approximately 5ml volume was collected from each subject at the pre-treatment stage and analysed by an Abbot ARCHITECT c8000 analyser using the immunoturbidimetry method. The results were analysed using ROC analysis and the Mann Whitney test. Results: Serum B2M levels showed a statistically significant increase (p<0.001) in patients compared to controls. The test was shown to have 90.5% sensitivity and 90.5% specificity. It was found to be a sensitive and specific serum tumour marker at a cut off value of 1.57mg/l to differentiate cases from controls. Conclusion: B2M is a sensitive and specific tumour marker to differentiate OSCC cases from controls. It is cost effective and minimally invasive, making it a potentially useful adjunct diagnostic tool in a high-risk patient pool. Bangladesh Journal of Medical Science Vol.18(4) 2019 p.729-735

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