Change in Mean Arterial Pressure Following Isometric Exercise in Normotensive and Hypertensive Pregnancy: Validation of a Continuous Blood Pressure Monitor

1996 ◽  
Vol 15 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Michael S. Rogers ◽  
Cathy Hung
2000 ◽  
Vol 14 (3) ◽  
pp. 165-172 ◽  
Author(s):  
Jules P. Harrell ◽  
Leah J. Floyd

Abstract Hierarchical linear regression (HLR) can be used to quantify the relative contribution specific cardiovascular (CV) mechanisms make to blood-pressure responses. The impact particular mechanisms exert varies depending on the nature of situational demands and the length of time these demands have been imposed. Theoretically, the determinants of blood-pressure changes may exercise their influence independently as simple effects, or they might evidence a relationship that is correlated or shared with other mechanisms. Following a procedure Lindenberger and Potter (1998) outlined, we used HLR and computations of shared versus simple effect ratios to quantify the portions of variance several cardiovascular parameters accounted for independently in mean arterial pressure (MAP) reactivity during isometric handgrip and mirror tracing. The predictor variables included heart rate (HR), total peripheral resistance (TPR), and cardiac output (CO). CV activity of 50 college-aged males was measured during adjacent 30-s periods using impedance cardiography and a Dinamap blood pressure monitor. HR reactivity predicted MAP changes during all measurement periods. However, for mirror tracing, a substantial portion of the variance in MAP accounted for by HR was shared with CO reactivity (39% for period 1; 13% for period 2). For handgrip, 5% and 20% of variance HR accounted for in MAP during periods 1 and 2, respectively, were shared with changes in TPR. CO shared trivial amounts of variance in MAP changes with HR during handgrip. Finally, CO changes were correlated with TPR changes and uncorrelated with MAP reactivity when handgrip was performed. However, adding CO to the equation improved TPR's predictive utility, suggesting that suppressor effects were present.


1988 ◽  
Vol 1 (3 Pt 3) ◽  
pp. 161S-167S ◽  
Author(s):  
T. A. Manolio ◽  
S. C. Fishel ◽  
C. Beattie ◽  
J. Torres ◽  
R. Christopherson ◽  
...  

2019 ◽  
Vol 105 (4) ◽  
pp. 390-394
Author(s):  
Katherine Kirupakaran ◽  
Paula de Sousa ◽  
Celine Le Roux ◽  
Lauren Redwood ◽  
Heike Rabe ◽  
...  

ObjectiveTo evaluate whether changing dopamine infusions every 12 hours and preparing these infusions 30 min before administration reduces blood pressure fluctuations in preterm and term neonates.DesignThis was a retrospective study using data from live patients on the neonatal unit and prospective study exploring stability of infusions in a laboratory-based neonatal ward simulation.SettingSingle-centre study in a tertiary neonatal surgical unit in a university teaching hospital.PatientsNeonates who received more than one subsequent dopamine infusion and had invasive arterial blood pressure monitoring, during their admission in the neonatal unit, were included.InterventionsAs part of the Quality Improvement project, the standard operating procedure (SOP) was changed, and dopamine infusions were prepared by nursing staff and left to rest for 30 min before administering to the neonate. Additionally, infusions were replaced every 12 hours.Main outcome measuresThe percentage change in mean arterial pressure (MAP) and the percentage loss in the drug concentration during infusion during changeover.ResultsOur findings indicate that up to 15% of the initial dopamine concentration is lost after 24 hours. This results in a sharp variation in the dopamine concentration during infusion changeover that correlates with observed rapid fluctuations in MAP. In changing the SOP, no significant difference in the concentration of dopamine and MAP were observed over 12 hours.ConclusionsDelaying administration of dopamine infusions by 30 min after preparation combined with changing infusions 12 hourly has reduced MAP fluctuations. Therefore, the risks associated with MAP fluctuations, including intraventricular haemorrhages, are reduced.


2015 ◽  
Vol 20 (5) ◽  
pp. 291-294 ◽  
Author(s):  
Grzegorz Bilo ◽  
Cristina Zorzi ◽  
Juan E. Ochoa Munera ◽  
Camilla Torlasco ◽  
Valentina Giuli ◽  
...  

2008 ◽  
Vol 99 (6) ◽  
pp. 1284-1292 ◽  
Author(s):  
Alessandro Braschi ◽  
Donald J. Naismith

Blood pressure (BP) shows a continuous relationship with the risk of CVD. There is substantial evidence that dietary potassium exerts an anti-pressor effect. Most clinical trials have used KCl. However, the chloride ion may have a pressor effect and in foods potassium is associated with organic anions. In a double-blind randomized placebo-controlled trial we explored the effect on BP of two salts of potassium, KCl and potassium citrate (K-cit), in predominantly young healthy normotensive volunteers. The primary outcome was the change in mean arterial pressure as measured in a clinic setting. After 6 weeks of supplementation, compared with the placebo group (n31), 30 mmol K-cit/d (n28) changed mean arterial pressure by − 5·22 mmHg (95 % CI − 8·85, − 4·53) which did not differ significantly from that induced by KCl (n26), − 4·70 mmHg ( − 6·56, − 2·84). The changes in systolic and diastolic BP were − 6·69 (95 % CI − 8·85, − 4·43) and − 4·26 (95 % CI − 6·31, − 2·21) mmHg with K-cit and − 5·24 (95 % CI − 7·43, − 3·06) and − 4·30 (95 % CI − 6·39, − 2·20) mmHg with KCl, and did not differ significantly between the two treatments. Changes in BP were not related to baseline urinary electrolytes. A greater treatment-related effect was observed in those with higher systolic BP. Increasing dietary potassium could therefore have a significant impact on the progressive rise in BP in the entire population.


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