Background: Coronary Artery Calcifications (CACs) are associated with coronary atherosclerosis
and Cardiovascular (CV) events. In “non-cardiovascular” settings, CACs can be easily detected
on chest Multi-Detector Computed Tomography (MDCT). Their evaluation may help to better
stratify CV risk in the general population, especially for primary prevention.
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Aims: We retrospectively evaluated the relationship between CAC distribution and CV risk, determined
by Framingham Risk Score (FRS), in a cohort of patients who underwent chest MDCT performed for
several clinical indications.
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Method: We retrospectively recruited 305 patients (194 men, 111 women; mean age 70.5 years) from 3
different Italian centres. Patients with coronary stent, pacemaker and/or CV devices were excluded from
the study. Circumflex Artery (LCX), Left Main Coronary Artery (LMCA), left Anterior Descending
artery (LAD) and right coronary artery (RCA) were analysed.
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Results: From a total population of 305 patients, 119 (39%) had low FRS (<10%), 115 (38%) had intermediate
FRS (10-20%), and 71 (23%) had high FRS (>20%). The study identified 842 CACs located
in decreasing order as follows: RCA (34.5%), LAD (32.3%), LCX (28%) and LMCA (13%). Statistical
two-step analysis subdivided patients into two clusters according to FRS (risk threshold = 12.38%):
cluster I (mean 9.34) and cluster II (mean 15.09). A significant association between CAC distribution
and cluster II was demonstrated. CACs were mostly detected in patients with intermediate FRS. All
patients (100%) with the highest CV risk showed intermediate RCA and LMCA involvement.
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Conclusion: Radiologists can note the distribution of CACs on a chest MDCT and should mandatorily
record them in their reports. Depending on CAC presence and location, these findings may have important
clinical implications, mostly in asymptomatic patients with intermediate FRS. This information may
reclassify a patients’ CV risk and improve clinical management.