Insulin resistance is associated with DNA damage in peripheral blood cells in non-diabetic patients with genotype 1 chronic hepatitis C

2013 ◽  
Vol 47 (9) ◽  
pp. 750-756
Author(s):  
P. N. Sakae ◽  
S. S. M. Ihara ◽  
D. A. Ribeiro ◽  
L. de Carvalho ◽  
E. R. Parise
Keyword(s):  
Insulin Resistance ◽  
Dna Damage ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Diabetic Patients ◽  
Peripheral Blood Cells ◽  
Genotype 1

scholarly journals Insulin resistance in non-diabetic patients of chronic Hepatitis C

2012 ◽  
Vol 29 (1) ◽  
Author(s):  
Zareen Kiran ◽  
Bader Faiyaz Zuberi ◽  
Daniah Anis ◽  
Rashid Qadeer ◽  
Khalid Hasan ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Diabetic Patients

scholarly journals Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3

Gut ◽  
2011 ◽  
Vol 61 (1) ◽  
pp. 128-134 ◽  
Author(s):  
Alexander J Thompson ◽  
Keyur Patel ◽  
Wan-Long Chuang ◽  
Eric J Lawitz ◽  
Maribel Rodriguez-Torres ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Viral Clearance ◽  
Genotype 1 ◽  
Genotype 2

388 Race, insulin resistance, visceral adiposity and hepatic steatosis in genotype 1 patients with chronic hepatitis C

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 347-347 ◽  
Author(s):  
H CONJEEVARAM ◽  
D KLEINER ◽  
N AFDHAL ◽  
R BROWN ◽  
M FRIED ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Hepatic Steatosis ◽  
Chronic Hepatitis C ◽  
Visceral Adiposity ◽  
Genotype 1

scholarly journals Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?

2011 ◽  
Vol 55 (6) ◽  
pp. 412-418 ◽  
Author(s):  
Aécio Flávio Meirelles de Souza ◽  
Fábio Heleno de Lima Pace ◽  
Júlio Maria Fonseca Chebli ◽  
Lincoln Eduardo Villela Vieira de Castro Ferreira
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hepatic Fibrosis ◽  
Liver Steatosis ◽  
Diabetic Patients ◽  
Histological Findings ◽  
C Reactive Protein ◽  
Reactive Protein

OBJECTIVES: To determine the prevalence of insulin resistance (IR) in non-diabetic patients with chronic hepatitis C, and to assess the association between IR, laboratory parameters and histological findings. SUBJECTS AND METHODS: Eighty-two patients had their serum analyzed for glucose, lipid profile, C-reactive protein (CRP), ferritin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), HOMA-IR, viral load and HCV genotype. Patients with HOMA-IR levels > 2.5 were considered as carriers of insulin resistance. RESULTS: IR was observed in 27% of patients and was associated with age, waist circumference and body mass index. IR patients were more likely to have more advanced hepatic fibrosis and necroinflammatory activity, higher levels of aminotransferases and liver steatosis than patients without IR. CONCLUSIONS: Insulin resistance is often present in patients with chronic hepatitis C, and this parameter is associated with more advanced HCV-related hepatic fibrosis.

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