Experiences with a Combination of Group Therapy and Methadone Maintenance in the Treatment of Heroin Addiction

1974 ◽  
Vol 9 (4) ◽  
pp. 605-617 ◽  
Author(s):  
John C. Larosa ◽  
Stephen H. Lipsius ◽  
Judith H. Larosa
Keyword(s):  
Group Therapy ◽  
Methadone Maintenance ◽  
Heroin Addiction

Association study of genetic polymorphisms in GABRD with treatment response and dose in methadone maintenance treatment

2021 ◽  
Author(s):  
Xiaohu Xie ◽  
Jun Gu ◽  
Dingding Zhuang ◽  
Xiaoyu Chen ◽  
Yun Zhou ◽  
...  
Keyword(s):  
Treatment Response ◽  
Methadone Maintenance Treatment ◽  
Maintenance Treatment ◽  
Methadone Maintenance ◽  
Methadone Treatment ◽  
Heroin Addiction ◽  
High Dose ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Delta Subunit

Aim: This study determined if gene variants in the GABA receptor delta subunit ( GABRD) are associated with treatment response and dose in methadone maintenance treatment (MMT) for heroin addiction. Materials & methods: A total of 286 MMT patients were recruited and divided into response and nonresponse groups based on retention time in therapy. A total of 177 responders were classified into low dose and high dose subgroups according to the stabilized methadone dose. Four (single nucleotide polymorphisms) SNPs (rs13303344, rs4481796, rs2376805 and rs2229110) in GABRD were genotyped using the TaqMan SNP assay. Logistic regression was used to assess the genetic effects of the SNPs in MMT. Results: No significant associations were observed between the SNPs and treatment response or dose, except the frequency of haplotype ACGC at the four SNPs significantly differed between responders and nonresponders. Conclusion: The results indicated that GABRD variants may play a small role in modulating methadone treatment response.

METHADONE AND CHILDREN

PEDIATRICS ◽  
1971 ◽  
Vol 48 (2) ◽  
pp. 173-175
Author(s):  
Saul Blatman
Keyword(s):  
United States ◽  
Urban Areas ◽  
Methadone Maintenance ◽  
The United States ◽  
Heroin Addiction ◽  
Analgesic Drug ◽  
Heroin Addicts ◽  
Near Future

The increasing use of methadone maintenance (substitution) programs1-3 in the treatment of adult heroin addiction has created situations for children which require the attention of pediatricians. Methadone is an analgesic drug. In urban areas, thousands of heroin addicts are now receiving high dosage of methadone, usually 80 to 120 mg daily. This approach to heroin addiction has met with greater success than any other form of treatment. It is expected that increasing numbers of heroin addicts will be treated in the near future by this method throughout the United States and Canada.4 Pediatricians should focus on three aspects of the problem as follows:

scholarly journals Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence

2020 ◽  
Vol 21 (13) ◽  
pp. 903-917
Author(s):  
Matthew Randesi ◽  
Orna Levran ◽  
Wim van den Brink ◽  
Peter Blanken ◽  
Jan M van Ree ◽  
...  
Keyword(s):  
Interaction Effect ◽  
Opioid Dependence ◽  
Methadone Maintenance ◽  
Heroin Dependence ◽  
Heroin Addiction ◽  
Drug Induced ◽  
Stress Related Genes ◽  
Stress Influences

Aim: Heroin addiction is a chronic, relapsing disease that has genetic and environmental, including drug-induced, contributions. Stress influences the development of addictions. This study was conducted to determine if variants in stress-related genes are associated with opioid dependence (OD). Patients & methods: One hundred and twenty variants in 26 genes were analyzed in 597 Dutch subjects. Patients included 281 OD in methadone maintenance with or without heroin-assisted treatment and 316 controls. Results: Twelve SNPs in seven genes showed a nominally significant association with OD. Experiment-wise significant associations (p < 0.05) were found for three SNP pairs, through an interaction effect: NPY1R/ GAL rs4691910/rs1893679, NPY1R/ GAL rs4691910/rs3136541 and GALR1/GAL rs9807208/rs3136541. Conclusion: This study lends more evidence to previous reports of association of stress-related variants with heroin dependence.

Clinical Efficacy of Acupuncture as an Adjunct to Methadone Treatment Services for Heroin Addicts: A Randomized Controlled Trial

2014 ◽  
Vol 42 (03) ◽  
pp. 569-586 ◽  
Author(s):  
Yuan-Yu Chan ◽  
Wan-Yu Lo ◽  
Tsai-Chung Li ◽  
Lih-Jong Shen ◽  
Szu-Nian Yang ◽  
...  
Keyword(s):  
Methadone Maintenance ◽  
Short Form ◽  
Controlled Trial ◽  
Scientific Evidence ◽  
Methadone Treatment ◽  
Sham Acupuncture ◽  
Opiate Dependence ◽  
Heroin Addiction ◽  
Daily Consumption ◽  
Heroin Addicts

Scant scientific evidence supports the efficacy of acupuncture in the treatment of opiate dependence. The purpose of this study was to examine the effectiveness of acupuncture for heroin addicts on methadone maintenance by measuring the daily consumption of methadone, variations in the 36-item Short Form Health Survey-36 (SF-36) and Pittsburgh Sleep Quality Index (PSQI) scores, and heroin craving. Sixty heroin addicts were randomly assigned to true acupuncture (electroacupuncture at the Hegu [LI4] and Zusanli [ST36] acupoints, as well as acupuncture at the Ear Shenmen) or sham acupuncture (minimal acupuncture at the Hegu and Zusanli acupoints without electrical stimulation and superficial acupuncture at the Ear Shenmen), twice weekly for 4 weeks. From week 2 onwards, the daily dose of methadone was reduced by a significantly greater amount with true acupuncture compared with sham acupuncture. True acupuncture was also associated with a greater improvement in sleep latency at follow-up. All adverse events were mild in severity. Acupuncture appears to be a useful adjunct to methadone maintenance therapy (MMT) in heroin addiction.

Linkage to methadone treatment from acute opiate detoxification treatment

2006 ◽  
Vol 2 (6) ◽  
pp. 341 ◽  
Author(s):  
Nickolas D. Zaller, PhD ◽  
Portia Thurmond, MPH ◽  
Jon Brett, PhD ◽  
James C. Carleton, MS ◽  
Josiah D. Rich, MD, MPH
Keyword(s):  
Mental Health Treatment ◽  
Injection Drug Users ◽  
Drug Users ◽  
Methadone Maintenance ◽  
Methadone Treatment ◽  
Pilot Project ◽  
The State ◽  
Heroin Addiction ◽  
Treatment Services ◽  
Abuse Treatment

Methadone maintenance treatment (MMT) is a safe pharmacological treatment strategy for addiction to heroin and other opiates; however, linking individuals to MMT is often challenging. We present results from a pilot project (Project VISTA) funded by the Center for Substance Abuse Treatment that helps heroin-dependent injection drug users (IDUs) transition from acute heroin detoxification to MMT. Participants are referred to Project VISTA by the state detoxification center, and Project VISTA facilitates entry into an MMT program, providing full financial support for up to 24 weeks. In addition, Project VISTA provides case management and referral to ancillary services such as housing, other medical care, and mental health treatment. From May 2005 to May 2006, 60 individuals were enrolled in Project VISTA. A total of 41 participants (69.5 percent) remained in treatment for at least 24 weeks, with a mean number of weeks in treatment of 31. A Kaplan-Meier analysis was performed on all participants, and the incidence of individuals being discharged from treatment was 2 percent per week. Project VISTA, in cooperation with the state detoxification center and a Providence-based MMT program, has created a model that provides continuity of treatment services to high-risk, HIV-negative IDUs. Our model demonstrates that through facilitating the transition from an opiate detoxification program into an MMT program, individuals with chronic heroin addiction can successfully access and engage in treatment.

Methadone Maintenance in the Treatment of Narcotics Addiction

1991 ◽  
Vol 4 (6) ◽  
pp. 357-361
Author(s):  
Anthony C. Tommasello
Keyword(s):  
Drug Use ◽  
Methadone Maintenance ◽  
Treatment Approach ◽  
Risky Behaviors ◽  
Heroin Addiction ◽  
Admission Criteria ◽  
Narcotics Anonymous ◽  
Needle Sharing ◽  
Heroin Addicts ◽  
Degree Of Stability

Despite numerous studies documenting its success, methadone maintenance is an often misunderstood and frequently maligned treatment approach for heroin addiction. By taking 40 to 60 mg of methadone orally every day, heroin addicts are able to achieve a degree of stability in their lives allowing them to pursue productive goals while decreasing risky behaviors such as needle sharing and street drug use. Strict admission criteria for methadone maintenance are spelled out in Food and Drug Administration regulations, and those ineligible for methadone maintenance must avail themselves of other forms of treatment. The emergence of Narcotics Anonymous is an encouraging development for heroin addicts who achieve abstinence through a variety of new pharmacotherapeutic options.

scholarly journals Methadone Maintenance Therapy in Vietnam: An Overview and Scaling-Up Plan

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Tam T. M. Nguyen ◽  
Long T. Nguyen ◽  
Manh D. Pham ◽  
Hoang H. Vu ◽  
Kevin P. Mulvey
Keyword(s):  
Drug Users ◽  
Hiv Transmission ◽  
Methadone Maintenance ◽  
Methadone Treatment ◽  
Scaling Up ◽  
Injecting Drug Users ◽  
Heroin Addiction ◽  
Rehabilitation Centers ◽  
Positive Treatment ◽  
The Government

Vietnam is among the countries with the highest rate of HIV transmission through injecting drug users. HIV prevalence among injecting drug users is 20% and up to 50% in many provinces. An estimated number of drug users in the country by the end of 2011 were 171,000 in which the most common is heroin (85%). Detoxification at home, community, and in rehabilitation centers have been the main modalities for managing heroin addiction until Methadone Maintenance Treatment (MMT) was piloted in 2008. Recent reports have demonstrated positive treatment outcomes. Incidence of HIV was found remarkably low among patients on MMT. Treatment has significantly improved the quality of life as well as stability for society. The government has granted the Ministry of Health (MoH) to expand Methadone treatment to at least 30 provinces to provide treatment for more than 80,000 drug users by 2015. The Vietnam Administration for HIV/AIDS Control (VAAC) and MOH have outlined the role and responsibility of key departments at the central and local levels in implementing and maintaining MMT treatment. This paper will describe the achievements of the MMT pilot program and the scaling-up plan as well as strategies to ensure quality and sustainability and to overcome the challenges in the coming years.

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