In Vitro Permeation Study of a Mucoadhesive Drug Delivery System for Controlled Delivery of Nonoxynol-9

1996 ◽  
Vol 1 (2) ◽  
pp. 135-145 ◽  
Author(s):  
Chi-Hyun Lee ◽  
Yie W. Chien
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Delivery ◽  
Permeation Study ◽  
In Vitro Permeation

scholarly journals In vitro evaluation of Transdermal Patch of Palonosetron for Antiemetic Therapy

2018 ◽  
Vol 9 (4) ◽  
pp. 119 ◽  
Author(s):  
Atul Tripathi ◽  
Piyush Tyagi ◽  
Amber Vyas ◽  
Beena Gidwani ◽  
Amol Chandekar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Antiemetic Therapy ◽  
Transdermal Patch ◽  
Barrier Membrane ◽  
Permeation Study ◽  
In Vitro Permeation

<p>Skin is one of the routes for systemic delivery of drugs through various drug delivery system. A transdermal Drug Delivery System (TDDS) is one of the most reliable and useful system to deliver drug systemically through skin. Generally medicated patch is placed on skin for delivery of medication through it into the blood stream. The aim of present study was to formulate and evaluate Palonosetron transdermal patch in vitro that could be used for antiemetic therapy. The incorporation ofPalonosetron a serotonin 5-HT<sub>3</sub> antagonist drug was envisaged. The TDDS was prepared by solvent evaporation technique and was evaluated for organoleptic characteristics and other physicochemical properties Thickness, Weight variation, Drug content uniformity, Tensile strength, % Elongation, Folding endurance &amp; Moisture content. The in vitro permeation study of the patch was carried out through KesaryChein diffusion cell as barrier membrane. Phosphate buffer pH 7.4 was used as dissolution medium and the temperature was maintained at 37 ± 1<sup>0</sup>C. The in vitro permeation study of the prepared patch indicated a time dependent increase in drug release throughout the study. The percentage of cumulative drug release was found to be 76.25% in 24 hours.The study shows a new approach to work in with Palonosetron.<strong></strong></p>

scholarly journals Effect of Formulation Components on the In Vitro Permeation of Microemulsion Drug Delivery System of Fluconazole

2009 ◽  
Vol 10 (3) ◽  
Author(s):  
Mrunali R. Patel ◽  
Rashmin B. Patel ◽  
Jolly R. Parikh ◽  
Ajay B. Solanki ◽  
Bharat G. Patel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Permeation

scholarly journals ZIF-8 as a promising drug delivery system for benznidazole: development, characterization, in vitro dialysis release and cytotoxicity

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Leslie Raphael de Moura Ferraz ◽  
Alinne Élida Gonçalves Alves Tabosa ◽  
Débora Dolores Souza da Silva Nascimento ◽  
Aline Silva Ferreira ◽  
Victor de Albuquerque Wanderley Sales ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Viability ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mtt Assay ◽  
Controlled Delivery ◽  
Zeolitic Imidazolate Framework ◽  
Potential Applications ◽  
Release Method

Abstract Chagas disease (CD), caused by the flagellate protozoan Trypanosoma cruzi, is one of the major public health problems in developing countries. Benznidazole (BNZ) is the only drug available for CD treatment in most countries, however, it presents high toxicity and low bioavailability. To address these problems this study used Zeolitic Imidazolate Framework-8 (ZIF-8), which has garnered considerable attention due to its potential applications, enabling the controlled delivery of drugs. The present work developed and characterized a BNZ@ZIF-8 system, and the modulation of BNZ release from the ZIF-8 framework was evaluated through the in vitro dialysis release method under sink conditions at different pH values. Moreover, the in vitro evaluation of cell viability and cytotoxicity by MTT assay were also performed. The dissolution studies corroborated that a pH sensitive Drug Delivery System capable of vectorizing the release of BNZ was developed, may leading to the improvement in the bioavailability of BNZ. The MTT assay showed that no statistically significant toxic effects occurred in the developed system, nor significant effects on cell viability.

scholarly journals Applicability of Gum Karaya in the Preparation and in Vitro Evaluation of Losartan Potassium as Chronotherapeutic Drug Delivery System

2015 ◽  
Vol 7 (1-2) ◽  
pp. 65-74
Author(s):  
K. Latha ◽  
V. V. Srikanth ◽  
S. A. Sunil ◽  
N. R. Srinivasa ◽  
M. U. Uhumwangho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tensile Strength ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lag Time ◽  
Losartan Potassium ◽  
In Vitro Dissolution ◽  
Burst Release ◽  
Gum Karaya

The objective of this investigation is to study the applicability of gum karaya, the natural gum for the preparation and in vitro evaluation of losartan potassium, as Chronotherapeutic Drug Delivery System (ChDDS). The compression-coated timed-release tablets (CCT) containing losartan potassium in the core tablet were prepared by dry coating technique with different ratios of gum karaya as the outer coat. The parameters investigated were tensile strength, friability, in vitro dissolution studies and drug concentration. The optimized formulation was further characterized by powder XRD and FTIR to investigate interactions and no interactions observed. The tensile strength and friability of all the CCT were between 1.06-1.23 MN/m2 and < 0.3% respectively.  All the CCT showed a clear lag time before a burst release of drug. However, the lag time of drug release increased as the amount of gum karaya in the outer layer increased. For instance, the lag time of LGK1, LGK2, LGK3, LGK4, LGK5, LGK6 and LGK7 were 16, 10.5, 5.5, 3, 2, 1.5 and 0.5 hrs respectively.  The drug content of all the CCT was >98%. Formulation LGK3 was taken as an optimized formulation which can be exploited to achieve ChDDS of losartan potassium for the treatment of hypertension. 

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