Studies on Diffusion in Alginate Gels. II. Effect of Acid and Subsequent Re-exposure to Calcium on the Diffusion of Caffeine and Theophylline in Alginate Gel Films

1997 ◽  
Vol 2 (3) ◽  
pp. 285-292 ◽  
Author(s):  
Eng Beng Lim ◽  
Ross A. Kennedy
Keyword(s):  
Alginate Gel ◽  
Alginate Gels

Subtle influence on alginate gel properties through host–guest interactions between covalently appended cyclodextrin and adamantane units

2021 ◽  
Author(s):  
Gabriela Ionita ◽  
Elena Irina Popescu ◽  
Ludmila Aricov ◽  
Sorin Mocanu ◽  
Iulia Matei ◽  
...  
Keyword(s):  
Daily Life ◽  
Structural Features ◽  
Gel Properties ◽  
Alginate Gel ◽  
Alginate Gels

Alginate gels have been explored in relevant domains for daily life such as pharmaceutics and environmental. The structural features of alginate allow functionalization which, in extension, can modify the gel...

Modified Microparticles of Calcium Alginate Gel for Controlled Release of Anesthetics

2007 ◽  
Vol 1060 ◽  
Author(s):  
Erkesh E. Batyrbekov ◽  
Turar N. Akylbekova ◽  
Rinat M. Iskakov
Keyword(s):  
Local Anesthetics ◽  
Calcium Alginate ◽  
Polymer Coating ◽  
Polymer Concentration ◽  
Alginate Beads ◽  
Physiological Solution ◽  
Polymeric Coating ◽  
Tail Flick ◽  
Alginate Gel ◽  
Alginate Gels

ABSTRACTThe aim of this work is the development of controlled delivery system immobilized by local anesthetics on the basis of modified microparticles of calcium alginate gels. The kazkain, rikhlokain, lidokain and novokain were used as local anesthetics. Modified microparticles were obtained by syringed dropwise a solution of ansthetics in sodium alginate into solution of polymers such as chitosan or polyethyleneimine in calcium chloride. The obtained modified alginate microparticles were contained immobilized anesthetics in core of particles and a surface layer of polymer. Effects of polymer concentration and exposure duration on the thickness of polymer coating were determined. The release of anesthetics from the modified alginate gel particles into a physiological solution with different thickness of coating were studied. All the release data show the typical pattern for a matrix controlled mechanism. The cumulative amount of drug released from alginate gels was linearly related to the square root of the time and the release rate decreased this time. The process is controlled by the diffusion of anesthetics through the polymeric coating. The data shown a possibility of the regulation of the rate of anesthetics release from the modified alginate particles by way of alternation of thickness of the polymer coating. The anesthetic effect of the alginate microparticles containing drugs was tested on rats by method “tail flick” according two criteria: full analgesia – the absence of reaction on pain and sufficient analgesia – exceeding of pain threshold sensibility two and more times. Medical-biological tests show that the duration of anesthetic activity for the drug-containing alginate beads increases at 5-8 times in comparison of free drugs.

scholarly journals Immobilization of Analgetic AB-101 into Calcium Alginate Gels

2017 ◽  
Vol 4 (4) ◽  
pp. 293 ◽  
Author(s):  
R.M. Iskakov ◽  
E.O. Batyrbekov ◽  
B.A. Zhubanov ◽  
Y.Y. Fomicheva ◽  
V. K. Yu ◽  
...  
Keyword(s):  
Average Diameter ◽  
Lag Time ◽  
Fickian Diffusion ◽  
Burst Release ◽  
Sodium Ions ◽  
Alginate Gel ◽  
Gel Beads ◽  
Alginate Gels ◽  
Calcium Alginate Gels ◽  
G Ratio

<p>A new analgetic drug AB-101 has been immobilized into Ca<sup>2+</sup>-alginate gel beads with average diameter of 1 mm. A series of the alginate gel contains with various mannuronic/guluronic (M/G) ratios has been chosen to control the diffusion of the drug. Release of the drug from the alginate gel beads into physiological solutions consisting of sodium ions has been examined. A discontinuous time of the Fickian diffusion of the drug depending on M/G ratio was followed by a burst release of the remaining drugs. The burst release was due to a swift disintegration of Ca<sup>2+</sup>-alginate with exchange on sodium ions. The preceding discontinuous lag time promotes a free dissociate exchange of sodium-calcium ions in M units, while the burst disintegration leads to fast dissociation of G units. The lag time can be control by M/G ratio of Ca<sup>2+</sup>-alginate gels. The lag time increases if a content of the M units decreases. The increase of M units was led to more extensive swelling of the gel beads. Such way could be promising for a controlled drug delivery or the use in implants with controlled drug effect.</p>

The fixation of a water-soluble drug in calcium-induced alginate gel beads and the release profiles from the vehicle.

1997 ◽  
Vol 12 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Yoshifumi Murata ◽  
Norie Katayana ◽  
Takashi Kajita ◽  
Etsuko Miyamoto ◽  
Susumu Kawashima
Keyword(s):  
Water Soluble ◽  
Alginate Gel ◽  
Gel Beads ◽  
Water Soluble Drug ◽  
Release Profiles

Nitrification and Autotrophic Denitrification in Calcium Alginate Beads

1987 ◽  
Vol 19 (1-2) ◽  
pp. 175-182 ◽  
Author(s):  
Z. Lewandowski ◽  
R. Bakke ◽  
W. G. Characklis
Keyword(s):  
Calcium Carbonate ◽  
Calcium Ions ◽  
Continuous Flow ◽  
Calcium Alginate ◽  
Microbial Respiration ◽  
Flow System ◽  
Alginate Beads ◽  
Alginate Gel ◽  
Gel Beads ◽  
Calcium Alginate Gel

Immobilization of nitrifiers and autotrophic denitrifiers (Thiobacillus denitrificans) within calcium alginate gel was demonstrated. Calcium carbonate reagent was immobilized along with bacteria as the stabilizing agent. Protons released as a result of microbial respiration reacted with calcium carbonate producing calcium ions which internally stabilized the calcium alginate gel. The microbially active gel beads were mechanically stable and active for three months in a continuous flow system without addition of calcium.

Uptake and Recovery of Ruthenium by Alginate Gel Polymers

2002 ◽  
Vol 39 (6) ◽  
pp. 655-660 ◽  
Author(s):  
Hitoshi MIMURA ◽  
Hiroshi OHTA ◽  
Kenichi AKIBA ◽  
Yoshio ONODERA
Keyword(s):  
Alginate Gel ◽  
Gel Polymers

scholarly journals Antimicrobial Activity of Roselle-capped​ Silver​ Nanochip on Aggregatibacter actinomycetemcomitans

2021 ◽  
Author(s):  
Sirorat Wacharanad ◽  
Puncharee Thatree ◽  
Punchaya Yiemwattana ◽  
Penpitcha Paoprajak ◽  
Pimchanok Ngamsangiam ◽  
...  
Keyword(s):  
Nitrate Solution ◽  
Synthesis Method ◽  
Antimicrobial Effect ◽  
Silver Nitrate Solution ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Microwave Assisted Synthesis ◽  
Alginate Gel ◽  
Diffusion Technique ◽  
Inhibition Zones ◽  
Time Kill

Abstract Objectives This article aimed to study the effects of the​ roselle-capped​ silver​ nanochip​ ​(SNP-Ro​ chip)​ against Aggregatibacter actinomycetemcomitans, and the toxicity of this film on fibroblast cells to develop this SNP-Ro chip into a local chemical for the treatment of periodontitis in the future. Materials and Methods Using a microwave-assisted synthesis method, silver​ nanoparticles (SNPs) were prepared from a silver nitrate solution and roselle extract as a reducing and capping agent. Then, SNP-Ro chips were fabricated by mixing a solution of SNP-Ro with alginate gel. The antimicrobial effect of the synthesized SNP-Ro chips was performed by the disc diffusion technique and time kill assay. The cytotoxic effect was also determined by the MTS assay. Statistical Analysis One-way analysis of variance (ANOVA) and Scheffe’s method were used to analyze the data for this experiment. Results All three ratios of the SNP-Ro chip produced inhibition zones ranging between 18.75 ± 2.08 and 19.03 ± 2.25 mm. In studying the killing time, the three groups of the SNP-Ro chips completely eradicated A. actinomycetemcomitans within 180 minutes. The percentage of the viable SNP-Ro chip-treated human gingival fibroblasts (HGFs) were significantly increased when compared with the alginate chip-treated cells (p < 0.05). Conclusion This study developed a new method for the deposition of SNPs in alginate gel to make a thin small chip for the sustained release of the SNPs in a periodontal lesion. Therefore, the SNP-Ro chip has the potential to be developed as an adjunctive locally delivered antimicrobial agent in periodontal therapy.

Immobilization of glucose oxidase within calcium alginate gel capsules

2001 ◽  
Vol 36 (7) ◽  
pp. 601-606 ◽  
Author(s):  
A Blandino ◽  
M Macı́as ◽  
D Cantero
Keyword(s):  
Glucose Oxidase ◽  
Calcium Alginate ◽  
Alginate Gel ◽  
Calcium Alginate Gel

Porous bioceramic bead prepared by calcium phosphate with sodium alginate gel and PE powder

2008 ◽  
Vol 28 (7) ◽  
pp. 1149-1158 ◽  
Author(s):  
Y.C. Fu ◽  
M.L. Ho ◽  
S.C. Wu ◽  
H.S. Hsieh ◽  
C.K. Wang
Keyword(s):  
Calcium Phosphate ◽  
Sodium Alginate ◽  
Alginate Gel ◽  
Porous Bioceramic
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