scholarly journals Immobilization of Analgetic AB-101 into Calcium Alginate Gels

2017 ◽  
Vol 4 (4) ◽  
pp. 293 ◽  
Author(s):  
R.M. Iskakov ◽  
E.O. Batyrbekov ◽  
B.A. Zhubanov ◽  
Y.Y. Fomicheva ◽  
V. K. Yu ◽  
...  
Keyword(s):  
Average Diameter ◽  
Lag Time ◽  
Fickian Diffusion ◽  
Burst Release ◽  
Sodium Ions ◽  
Alginate Gel ◽  
Gel Beads ◽  
Alginate Gels ◽  
Calcium Alginate Gels ◽  
G Ratio

<p>A new analgetic drug AB-101 has been immobilized into Ca<sup>2+</sup>-alginate gel beads with average diameter of 1 mm. A series of the alginate gel contains with various mannuronic/guluronic (M/G) ratios has been chosen to control the diffusion of the drug. Release of the drug from the alginate gel beads into physiological solutions consisting of sodium ions has been examined. A discontinuous time of the Fickian diffusion of the drug depending on M/G ratio was followed by a burst release of the remaining drugs. The burst release was due to a swift disintegration of Ca<sup>2+</sup>-alginate with exchange on sodium ions. The preceding discontinuous lag time promotes a free dissociate exchange of sodium-calcium ions in M units, while the burst disintegration leads to fast dissociation of G units. The lag time can be control by M/G ratio of Ca<sup>2+</sup>-alginate gels. The lag time increases if a content of the M units decreases. The increase of M units was led to more extensive swelling of the gel beads. Such way could be promising for a controlled drug delivery or the use in implants with controlled drug effect.</p>

On the design of Ag–morin nanocomposite to modify calcium alginate gel: framing out a novel sodium ion trap

RSC Advances ◽  
2015 ◽  
Vol 5 (70) ◽  
pp. 57223-57230 ◽  
Author(s):  
Kangkana Sarkar ◽  
Kamalika Sen
Keyword(s):  
Calcium Alginate ◽  
Ion Trap ◽  
Unique Property ◽  
Sodium Ion ◽  
Sodium Ions ◽  
Alginate Gel ◽  
Calcium Alginate Gel ◽  
Calcium Alginate Gels ◽  
Uptake And Release ◽  
Subsequent Incorporation

The present work describes the design of a Ag–morin nanocomposite and its subsequent incorporation in calcium alginate gels which have the unique property to uptake and release sodium ions.

scholarly journals Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3326
Author(s):  
Estefanía Tiburcio ◽  
Eduardo García-Junceda ◽  
Leoncio Garrido ◽  
Alfonso Fernández-Mayoralas ◽  
Julia Revuelta ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Bacterial Resistance ◽  
Diffusion Mechanism ◽  
In Vitro Release ◽  
Antibacterial Properties ◽  
Fickian Diffusion ◽  
Burst Release ◽  
E Coli ◽  
Gel Beads

Although aminoglycosides are one of the common classes of antibiotics that have been widely used for treating infections caused by pathogenic bacteria, the evolution of bacterial resistance mechanisms and their inherent toxicity have diminished their applicability. Biocompatible carrier systems can help sustain and control the delivery of antibacterial compounds while reducing the chances of antibacterial resistance or accumulation in unwanted tissues. In this study, novel chitosan gel beads were synthesized by a double ionic co-crosslinking mechanism. Tripolyphosphate and alginate, a polysaccharide obtained from marine brown algae, were employed as ionic cross-linkers to prepare the chitosan-based networks of gel beads. The in vitro release of streptomycin and kanamycin A was bimodal; an initial burst release was observed followed by a diffusion mediated sustained release, based on a Fickian diffusion mechanism. Finally, in terms of antibacterial properties, the particles resulted in growth inhibition of Gram-negative (E. coli) bacteria.

The fixation of a water-soluble drug in calcium-induced alginate gel beads and the release profiles from the vehicle.

1997 ◽  
Vol 12 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Yoshifumi Murata ◽  
Norie Katayana ◽  
Takashi Kajita ◽  
Etsuko Miyamoto ◽  
Susumu Kawashima
Keyword(s):  
Water Soluble ◽  
Alginate Gel ◽  
Gel Beads ◽  
Water Soluble Drug ◽  
Release Profiles

Nitrification and Autotrophic Denitrification in Calcium Alginate Beads

1987 ◽  
Vol 19 (1-2) ◽  
pp. 175-182 ◽  
Author(s):  
Z. Lewandowski ◽  
R. Bakke ◽  
W. G. Characklis
Keyword(s):  
Calcium Carbonate ◽  
Calcium Ions ◽  
Continuous Flow ◽  
Calcium Alginate ◽  
Microbial Respiration ◽  
Flow System ◽  
Alginate Beads ◽  
Alginate Gel ◽  
Gel Beads ◽  
Calcium Alginate Gel

Immobilization of nitrifiers and autotrophic denitrifiers (Thiobacillus denitrificans) within calcium alginate gel was demonstrated. Calcium carbonate reagent was immobilized along with bacteria as the stabilizing agent. Protons released as a result of microbial respiration reacted with calcium carbonate producing calcium ions which internally stabilized the calcium alginate gel. The microbially active gel beads were mechanically stable and active for three months in a continuous flow system without addition of calcium.

Subtle influence on alginate gel properties through host–guest interactions between covalently appended cyclodextrin and adamantane units

2021 ◽  
Author(s):  
Gabriela Ionita ◽  
Elena Irina Popescu ◽  
Ludmila Aricov ◽  
Sorin Mocanu ◽  
Iulia Matei ◽  
...  
Keyword(s):  
Daily Life ◽  
Structural Features ◽  
Gel Properties ◽  
Alginate Gel ◽  
Alginate Gels

Alginate gels have been explored in relevant domains for daily life such as pharmaceutics and environmental. The structural features of alginate allow functionalization which, in extension, can modify the gel...

scholarly journals Formulation and optimization of gastroretentive bilayer tablets of calcium carbonate using D-optimal mixture design

e-Polymers ◽  
2021 ◽  
Vol 21 (1) ◽  
pp. 057-071
Author(s):  
Manasa Moganti ◽  
Shivakumar H. Nanjappa
Keyword(s):  
Calcium Carbonate ◽  
Optimization Technique ◽  
Lag Time ◽  
Mixture Design ◽  
Burst Release ◽  
Bilayer Tablets ◽  
Absorption Window ◽  
Upper Gastrointestinal ◽  
Gastric Retention Time

Abstract Gastroretentive bilayer tablets of calcium carbonate (CC) were developed using D-optimal mixture design. The effect of formulation factors such as levels of HPMC K100 M (X1), sodium bicarbonate (X2), and HPMC E15 LV (X3) on responses like floating lag time (R1) and release of CC at 1 h (R2) and 6 h (R3) was elucidated. The optimized formulations developed by numerical optimization technique were found to have short floating lag time (2.85 ± 0.98 min), minimum burst release (27.02 ± 1.18%), and controlled yet near complete release (88.98 ± 2.75%) at 6 h. In vivo radiographic studies in rabbits indicated that optimized batch displayed a mean gastric retention time (GRT) of 5.5 ± 1 h which was significantly prolonged (P < 0.05) compared to the conventional tablets that displayed a GRT of less than 1 h. The studies proved that the gastroretentive tablets can be a promising platform to improve bioavailability of nutrients having absorption window in upper gastrointestinal tract.

scholarly journals Applicability of Gum Karaya in the Preparation and in Vitro Evaluation of Losartan Potassium as Chronotherapeutic Drug Delivery System

2015 ◽  
Vol 7 (1-2) ◽  
pp. 65-74
Author(s):  
K. Latha ◽  
V. V. Srikanth ◽  
S. A. Sunil ◽  
N. R. Srinivasa ◽  
M. U. Uhumwangho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tensile Strength ◽  
Drug Delivery System ◽  
Delivery System ◽  
Lag Time ◽  
Losartan Potassium ◽  
In Vitro Dissolution ◽  
Burst Release ◽  
Gum Karaya

The objective of this investigation is to study the applicability of gum karaya, the natural gum for the preparation and in vitro evaluation of losartan potassium, as Chronotherapeutic Drug Delivery System (ChDDS). The compression-coated timed-release tablets (CCT) containing losartan potassium in the core tablet were prepared by dry coating technique with different ratios of gum karaya as the outer coat. The parameters investigated were tensile strength, friability, in vitro dissolution studies and drug concentration. The optimized formulation was further characterized by powder XRD and FTIR to investigate interactions and no interactions observed. The tensile strength and friability of all the CCT were between 1.06-1.23 MN/m2 and < 0.3% respectively.  All the CCT showed a clear lag time before a burst release of drug. However, the lag time of drug release increased as the amount of gum karaya in the outer layer increased. For instance, the lag time of LGK1, LGK2, LGK3, LGK4, LGK5, LGK6 and LGK7 were 16, 10.5, 5.5, 3, 2, 1.5 and 0.5 hrs respectively.  The drug content of all the CCT was >98%. Formulation LGK3 was taken as an optimized formulation which can be exploited to achieve ChDDS of losartan potassium for the treatment of hypertension. 

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