Release of Interleukin-8 and Calprotectin During and after Paediatric Cardiopulmonary Bypass with and Without Ultrafiltration

1996 ◽  
Vol 30 (2) ◽  
pp. 53-59 ◽  
Author(s):  
Kjell Saatvedt ◽  
Harald Lindberg ◽  
Odd Ragnar Geiran ◽  
Svein Michelsen ◽  
Thore Pedersen ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Interleukin 8

Clinical application of a new ternary polymer, SEC-1 coat™, for pediatric cardiopulmonary bypass circuits: a prospective randomized pilot study

Perfusion ◽  
2020 ◽  
Vol 35 (8) ◽  
pp. 826-832
Author(s):  
Tomomi Hasegawa ◽  
Yoshihiro Oshima ◽  
Shinji Yokoyama ◽  
Asuka Akimoto ◽  
Yusuke Misaka ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Pilot Study ◽  
Interleukin 6 ◽  
Patient Characteristics ◽  
Serum Levels ◽  
Pediatric Cardiac Surgery ◽  
Interleukin 8 ◽  
Control Group ◽  
Platelet Counts

Objective: The use of biocompatible materials to reduce the systemic activation of inflammation and coagulation pathways is expanding rapidly. However, there have been few clinical studies of biocompatible circuits for pediatric cardiopulmonary bypass. This pilot study aimed to preliminarily evaluate the biocompatibility of SEC-1 coat™ (SEC) for cardiopulmonary bypass circuits in pediatric cardiac surgery. Methods: Twenty infants undergoing cardiac surgery for isolated ventricular septal defects at Kobe Children’s Hospital were assigned randomly to an SEC-coated (SEC group, n = 10) or heparin-coated (control group, n = 10) circuit. Perioperative data and the following markers were prospectively analyzed: platelet counts and interleukin-6, interleukin-8, C3a, β-thromboglobulin, and thrombin–antithrombin complex levels. Results: Neither patient characteristics nor postoperative clinical outcomes differed significantly between the SEC and control groups. Platelet counts markedly decreased during cardiopulmonary bypass in both groups, but were significantly better preserved in the SEC group. Fewer patients needed postoperative platelet transfusions in the SEC group. After cardiopulmonary bypass termination, serum levels of β-thromboglobulin and thrombin–antithrombin complex were significantly lower in the SEC than in the control group. Although the differences were not statistically significant, serum levels of interleukin-6, interleukin-8, and C3a had a tendency toward being lower in the SEC group, with good preservation of leukocyte counts, fibrinogen, and antithrombin III. Conclusion: SEC-1 coat™ for cardiopulmonary bypass circuits have good biocompatibility with regard to platelet preservation and in terms of attenuating inflammatory reaction or coagulation activation during pediatric cardiac surgery. It can be beneficial in pediatric as well as adult cardiac surgery.

Aprotinin Reduces Interleukin-8 Production and Lung Neutrophil Accumulation After Cardiopulmonary Bypass

1996 ◽  
Vol 83 (4) ◽  
pp. 696-700 ◽  
Author(s):  
Gary E. Hill ◽  
Roman Pohorecki ◽  
Anselmo Alonso ◽  
Stephen I. Rennard ◽  
Richard A. Robbins
Keyword(s):  
Cardiopulmonary Bypass ◽  
Interleukin 8 ◽  
Neutrophil Accumulation

Interleukin-8 mRNA expression in circulating leucocytes during cardiopulmonary bypass

Perfusion ◽  
1998 ◽  
Vol 13 (6) ◽  
pp. 409-417 ◽  
Author(s):  
Alison E John ◽  
Joseph Galea ◽  
Sheila E Francis ◽  
Cathy M Holt ◽  
Adam Finn
Keyword(s):  
Cardiopulmonary Bypass ◽  
Mrna Expression ◽  
Interleukin 8

Neutrophil Adhesion Molecule Expression and Serum Concentration of Soluble Adhesion Molecules during and after Pediatric Cardiovascular Surgery with or without Cardiopulmonary Bypass

2002 ◽  
Vol 96 (5) ◽  
pp. 1078-1085 ◽  
Author(s):  
Jörg Hambsch ◽  
Pavel Osmancik ◽  
József Bocsi ◽  
Peter Schneider ◽  
Attila Tárnok
Keyword(s):  
Cardiopulmonary Bypass ◽  
Serum Concentration ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Cardiovascular Surgery ◽  
Interleukin 8 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Serum Concentrations ◽  
Pediatric Cardiovascular Surgery

Background Increased neutrophil activation by cardiopulmonary bypass (CPB) during cardiovascular surgery is thought to be responsible for postoperative complications. In children, the contribution of cardiovascular surgery alone to this response is not well-characterized. Methods Children undergoing surgery with CPB (CPB group, n = 35) and without CPB (control, n = 22) were studied (age, 3-17 yr). Blood was drawn 24 h preoperatively before medication, after anesthesia, after connection to CPB, at reperfusion, 4 h to 2 days after surgery, at discharge, and months after surgery. Neutrophil antigen expression and serum concentration of adhesion molecules, interleukin 8, and C5a (fragment of C5 complement) were analyzed by flow cytometry and enzyme-linked immunosorbent assay, respectively. Results With and without CPB, anesthesia and surgery induced decreased LFA-1 (CD11a-CD18), Mac-1 (CD11b-CD18), CD45, and CD54 (intercellular adhesion molecule 1) surface expression and sICAM-1 serum concentrations (all P < 0.001). sL-selectin serum concentration decreased with CPB (P < 0.001) but was not significantly altered in the control. In contrast, CD62L expression increased during CPB (P < 0.001). The time course of all analyzed markers was not significantly different between CPB and control, with the exception of sL-selectin (P = 0.017). One-day preoperative baseline values were reached days to months after surgery. Interleukin 8 and C5a serum concentrations increased after surgery in both the CPB group and the control group. Conclusions Pediatric cardiovascular surgery leads to reduced adhesiveness and activity of circulating neutrophils. This reduction is more pronounced and sustained with CPB. These data may be useful in the assessment of novel therapeutic strategies.

Changes in neutrophil CD11b/CD18 andl-selectin expression and release of interleukin 8 and elastase in paediatric cardiopulmonary bypass

1993 ◽  
Vol 38 (S2) ◽  
pp. C44-C46 ◽  
Author(s):  
Adam Finn ◽  
Neil Moat ◽  
Naomi Rebuck ◽  
Nigel Klein ◽  
Stephan Strobel ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Interleukin 8

scholarly journals Investigation of interleukin-8 serum concentration in patients undergoing different types of open heart surgical procedures with the extracorporeal circulation

2003 ◽  
Vol 50 (2) ◽  
pp. 30-35
Author(s):  
Svetlana Tadic ◽  
Miljko Ristic ◽  
Bela Balint ◽  
Natasa Milic
Keyword(s):  
Cardiopulmonary Bypass ◽  
Serum Concentration ◽  
Surgical Procedures ◽  
Extracorporeal Circulation ◽  
Proinflammatory Cytokine ◽  
Interleukin 8 ◽  
Open Heart ◽  
Serum Concentrations ◽  
Aortic Valves ◽  
Different Types

Serum concentrations of proinflammatory cytokine interleukin-8 (IL-8) in 15 patients with surgically revascularized myocardium by triple venous cardiopulmonary bypass (CPB x 3) and in 10 patients with implanted artificial aortic valves (AV) were measured. Average IL-8 concentrations in ?CPB x 3? patients and in those with artficial aortic valve were 7,3 +/- 11,6 pg/mL 24 hours before surgery, i.e. 3,3 +/- 3,4 pg/mL; six hours after surgical procedure 32,7 +/- 71,4 pg/mL, i.e. 8,9 +/- 9,9 pg/mL; and 24 hours after surgery 10,9+/-9,7pg/mL, i.e. 8,3 +/- 4,6 pg/mL. Extracorporeal circulation (ECC) caused significant increase of IL-8 serum concentration in both investigated groups six hours after surgery. Comparing preoperative values of the both groups, as well as those of 6 and 24 hours after surgery, no significant values of IL-8 were found. Various types of open heart surgical procedures had no influence on the extent of the production and secretion of proinflammatory IL-8 cytokine measured in patients during 24 hours after surgery.

Interleukin-8 secretion following cardiopulmonary bypass in children as a marker of early postoperative morbidity

2002 ◽  
Vol 12 (2) ◽  
pp. 156-161 ◽  
Author(s):  
Ron Ben-Abraham ◽  
Avi A. Weinbroum ◽  
Danny Lotan ◽  
Ovdi Dagan ◽  
Rivka Schreriber-Scheffer ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Postoperative Morbidity ◽  
Interleukin 8
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