In vitro maturation and surrogacy in patients with vascular-type Ehlers–Danlos syndrome – A safe assisted reproductive technology approach

2014 ◽  
Vol 17 (2) ◽  
pp. 141-144 ◽  
Author(s):  
Marie-Eve Bergeron ◽  
Tim Child ◽  
Muhammad Fatum
Keyword(s):  
Assisted Reproductive Technology ◽  
In Vitro Maturation ◽  
Reproductive Technology ◽  
Ehlers Danlos Syndrome ◽  
Vascular Type ◽  
Danlos Syndrome

scholarly journals The Place of In Vitro Maturation in Assisted Reproductive Technology

2019 ◽  
Vol 01 (01) ◽  
pp. 11-15 ◽  
Author(s):  
Lan N. Vuong ◽  
Tuong M. Ho ◽  
Robert B. Gilchrist ◽  
Johan Smitz
Keyword(s):  
Assisted Reproductive Technology ◽  
Ovarian Stimulation ◽  
In Vitro Maturation ◽  
Polycystic Ovary ◽  
Reproductive Technology ◽  
Vitro Fertilization ◽  
Medication Costs ◽  
Main Barrier ◽  
Patient Burden

In vitro maturation (IVM) is an assisted reproductive technology (ART) whereby immature cumulus-oocyte complexes are collected and matured in vitro, without need for controlled ovarian stimulation and ovulation triggering. Advantages of IVM over in vitro fertilization (IVF) include mild or no stimulation, lower medication costs and less patient burden. However, early clinical outcomes with IVM were suboptimal. More recently, clinical studies reported live birth rates after IVM of about 40%. New IVM culture systems are being used to improve the efficacy of IVM. These have been in widespread use for animals for many years and are now showing promise in the clinical setting. Patients more likely to benefit from IVM over IVF include those at risk of OHSS (e.g. women with polycystic ovary syndrome), when the time for ovarian stimulation is limited, or where sustained elevations of estradiol are contraindicated (e.g. oncofertility indications). The main barrier to use of IVM to date was its relative efficacy compared with IVF, and there have also been concerns over the health of infants born following IVM. However, no differences in congenital abnormalities between IVM and other ARTs have been identified. In addition, there is a lack of both experience and standardized protocols. Strategies to overcome barriers to the use of IVM include better training for clinicians, more and better funded research in the field, and improved recognition of IVM by fertility specialists. Overall, IVM offers a valuable alternative for ART in select patient populations. New approaches to IVM appear to have the potential to achieve pregnancy outcomes equivalent to those after IVF. Increasing the use of IVM in the future can be achieved with improved training and education for fertility specialists, and increased funding for IVM research, with the ultimate goal of improving fertility outcomes.

scholarly journals Suplementasi Antioksidan pada Maturasi In Vitro Menurunkan Kadar ROS: A Literature Review

2019 ◽  
Vol 11 (1) ◽  
pp. 23
Author(s):  
Amalia Ratna Kusumaningrum
Keyword(s):  
Reactive Oxygen Species ◽  
Literature Review ◽  
Assisted Reproductive Technology ◽  
In Vitro Maturation ◽  
Reactive Oxygen ◽  
Reproductive Technology ◽  
Fertility Treatment ◽  
Oxygen Species ◽  
Survival And Development

One of the reproductive health problems is infertility. In vitro maturation (IVM) is emerging as a popular technology at the forefront of fertility treatment. IVM conditions inducing a series of events related to reactive oxygen species (ROS), which have been implicated as one of the major causes for reduced embryonic development. Therefore, the supplementation of IVM media with antioxidants could improve the survival and development of the oocytes. The method of searching conducted online database such as Science Direct, Sage, Pubmed, Springer, and Oxford. The keywords that used were “antioxidant”, “reactive oxygen species”, “in vitro maturation”, “infertility” and “assisted reproductive technology”. The literatures restricted in 2008 year until 2019 in English. The results of the study show that there were 3 main themes, types, dosages, antioxidant benefits for reduced ROS levels during IVM. The drawback that might arise in this study is that there are still possibilities of not getting some related articles. The literature review is expected to be a basis for research assisted reproductive technology. Keywords: antioxidant; in vitro maturation; infertility; Reactive oxygen species (ROS)

scholarly journals In Vitro Maturation (IVM) of Human Oocytes: Promising Potential, Challenges and Chances for Improvement

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Roza Silvia
Keyword(s):  
In Vitro Fertilization ◽  
Assisted Reproductive Technology ◽  
In Vitro Maturation ◽  
Reproductive Technology ◽  
Human Oocyte ◽  
Routine Practice ◽  
Vitro Fertilization ◽  
Human Oocytes ◽  
Maturation In Vitro

AbstractIn Vitro Maturation (IVM) of human oocytes is an innovation in Assisted Reproductive Technology (ART). It is believed more patient-friendly than conventional In Vitro Fertilization (IVF) method. It is a simple protocol that needs only less injection of ovarian stimulation for the patients and fewer blood sample and ultrasound scans, so this technique may become more favorable. Patients are also prevented from higher cost treatments and quite long control in the hospital. However, there are some problems to be addressed, such as how to improve the success rate, how to assure the safety and to avoid the health risk for the offsprings. Modification in IVM medium and optimizing the IVM protocols have increased the results in some studies. However, further investigation related to all aspects influencing the human oocyte maturation in vitro is still needed to make it enable to be a routine practice in ART centers for a defined group.Kata kunci: in vitro maturation, human oocyte, in vitro fertilization, assisted reproductive technology AbstrakMaturasi oosit in vitro atau In Vitro Maturation (IVM) terhadap oosit manusia merupakan suatu inovasi dalam Teknologi Reproduksi Berbantu (TRB). Teknik ini dianggap lebih nyaman bagi pasien dibandingkan dengan metode Fertilisasi In Vitro (FIV) konvensional. Metode IVM ini sederhana dan hanya membutuhkan lebih sedikit penyuntikan obat stimulasi ovarium ke pasien serta lebih sedikit pemeriksaan darah dan ultrasonografi, sehingga memungkinkan untuk menjadi suatu pilihan yang disukai oleh pasien. Pasien juga bisa terhindar dari biaya terapi yang lebih mahal serta waktu kontrol yang lama di rumah sakit. Namun demikian, terdapat beberapa masalah yang perlu ditangani terkait metode ini, seperti bagaimana meningkatkan angka keberhasilan serta memastikan keamanan dan mencegah resiko kesehatan pada anak yang akan dilahirkan. Modifikasi pada medium IVM serta pengoptimalan protokol IVM telah meningkatkan hasil pada beberapa penelitian. Penelitian yang lebih mendalam terkait semua aspek yang mempengaruhi maturasi in vitro oosit manusia masih diperlukan menuju penerapan rutin prosedur IVM untuk kelompok pasien tertentu di pusat-pusat pelayanan TRB.Keywords: maturasi in vitro, oosit manusia, fertilisasi in vitro, teknologi reproduksi berbantu

In Vitro Maturation and Its Role in Clinical Assisted Reproductive Technology

2015 ◽  
Vol 70 (1) ◽  
pp. 45-57 ◽  
Author(s):  
May-Tal Sauerbrun-Cutler ◽  
Mario Vega ◽  
Martin Keltz ◽  
Peter G. McGovern
Keyword(s):  
Assisted Reproductive Technology ◽  
In Vitro Maturation ◽  
Reproductive Technology

scholarly journals Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology

2020 ◽  
Vol 6 (3) ◽  
pp. 110-120
Author(s):  
Christie L Sun ◽  
Sally L Catt ◽  
Kiri Beilby ◽  
Mulyoto Pangestu
Keyword(s):  
Assisted Reproductive Technology ◽  
Natriuretic Peptide ◽  
In Vitro Maturation ◽  
Reproductive Technology ◽  
Developmental Competence ◽  
Nuclear Maturation ◽  
Oocyte Developmental Competence ◽  
Cytoplasmic Maturation ◽  
Camp Levels

In vitro maturation (IVM) is a promising assisted reproductive technology (ART) for human infertility treatment. However, when cumulus oocyte complexes (COCs) are removed from their follicular environment when manipulated in vitro, it can lead to a decrease of intra-oocyte cyclic adenosine 3’, 5’-monophosphare (cAMP) causing spontaneous nuclear maturation and an asynchrony with the oocytes’ cytoplasmic maturation, resulting in poor embryo developmental outcomes. Nuclear and cytoplasmic synchrony is important during oocyte maturation within antral follicles.It is maintained partially by the actions of c-type natriuretic peptide (CNP) binding with natriuretic peptide receptor 2 (NPR2), supporting high cAMP levels thus holding the oocyte in meiotic arrest. Addition of CNP to pre-IVM media has the capacity of maintaining cAMP levels and thus improve synchrony. Moreover, in women with advanced maternal age, successful IVM of aging oocytes faces significant challenges due to the morphological and cellular changes.  Inhibiting initiation of nuclear maturation by cAMP modulator, CNP during pre-IVM period and thus improve oocyte developmental competence regardless of oocyte age.

Follicular fluid and assisted reproductive technology programs outcomes (literature review)

GYNECOLOGY ◽  
2020 ◽  
Vol 21 (6) ◽  
pp. 36-40
Author(s):  
Anna G. Burduli ◽  
Natalia A. Kitsilovskaya ◽  
Yuliya V. Sukhova ◽  
Irina A. Vedikhina ◽  
Tatiana Y. Ivanets ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Assisted Reproductive Technology ◽  
Follicular Fluid ◽  
Economic Cost ◽  
Reproductive Technology ◽  
Art Programs ◽  
Vitro Fertilization ◽  
Non Invasive ◽  
Established Fact

The review presents data on metabolites in the follicular fluid (FF) from the perspective of reproductive medicine and their use in order to predict outcomes of assisted reproductive technology (ART) programs. It considers various components of this biological medium (hormones, lipids, melatonin, etc.) with an assessment of their predictive value in prognosis of the effectiveness of in vitro fertilization (IVF) programs. The data on experimental directions in this field and the prospects for their use in clinical practice are presented. The article emphasizes that the growing clinical need and the unsolved problem of increasing the effectiveness of ART programs determine the need for further studies of the FF composition. Materials and methods. The review includes data related to this topic from foreign and Russian articles found in PubMed which were published in recent years. Results. Given the established fact of a direct effect of FF composition on growth and maturation of oocytes, and further, on the fertilization process, various FF metabolites are actively investigated as non-invasive markers of quality of oocytes/embryos. The article provides data on the experimental directions in this field and the prospects for their use in clinical practice. However, clinical studies of a relation between various FF metabolites levels and outcomes of IVF programs are contradictory. Conclusion. Owing large economic cost for treatment of infertility with IVF, there is need for expansion and intensification of studies to identify and use reliable predictors in prognosis of ART programs outcomes.

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