Effect of bisphenol A on blood glucose, lipid profile and oxidative stress indices in adult male mice

2015 ◽  
Vol 25 (7) ◽  
pp. 507-513 ◽  
Author(s):  
Heshmat Sepehri Moghaddam ◽  
Saeed Samarghandian ◽  
Tahereh Farkhondeh
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Bisphenol A ◽  
Lipid Profile ◽  
Adult Male ◽  
Male Mice ◽  
Stress Indices ◽  
And Oxidative Stress

Alteration Effect of Exendin-4 on Oxidative Stress and Metabolic Disorders Induced by Bisphenol A in Adult Male Mice

2016 ◽  
Vol 7 (5) ◽  
Author(s):  
Akram Ahangarpour ◽  
Golshan Afshari ◽  
Seyyed Ali Mard ◽  
Ali Khodadadi ◽  
Mahmoud Hashemitabar
Keyword(s):  
Oxidative Stress ◽  
Bisphenol A ◽  
Adult Male ◽  
Metabolic Disorders ◽  
Male Mice

scholarly journals Effects of Carob Fruit Extract on Spermatogenesis, Antioxidant Status, and Apoptosis in Adult Male Mice

2019 ◽  
Vol 25 (3) ◽  
pp. 184-189
Author(s):  
Seyed Sadegh Sadat ◽  
Shabnam Mohammadi ◽  
Ghasem Sazegar ◽  
Alireza Fazel ◽  
Alireza Ebrahimzadeh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Statistical Analysis ◽  
Adult Male ◽  
Sham Group ◽  
Sperm Parameters ◽  
Male Mice ◽  
Fruit Extract ◽  
Significant Difference ◽  
The Mean ◽  
And Oxidative Stress

Background: Certain plants stimulate spermatogenesis and increase fertility; in contrast, some plants arrest the spermatogenesis cycle. Ceratonia siliqua is an herb plant with a strong antioxidant property. The aim of this study was to evaluate the effects of carob fruit extract on spermatogenesis, testicular apoptosis, and oxidative stress in adult male mice. Methods: Forty adult male mice were randomly divided into five groups: control, sham, and carob 1–3. The sham group was injected with normal saline and the carob 1–3 groups were injected with 200, 400, and 800 mg/kg of the carob fruit extract intraperitoneally for 14 days, respectively. At the end of the injection period, spermatogenesis, testicular apoptosis, and oxidative stress were examined. Results: The sperm parameters increased in the mice that received 200 mg/kg of carob compared to the sham group (p <0.05). There was a significant increase in the weight index of the epididymis in the carob 3 group in comparison to the sham group (p = 0.01). The number of positive tunnel cells was not statistically significant between different groups (p>0.05). The level of malondialdehyde decreased in the carob 1 and carob 3 groups, but this reduction was not statistically significant (p > 0.05). In addition, the statistical analysis showed a significant difference in the mean superoxide dismutase levels in the carob 2 and carob 3 groups in comparison to the sham group (p ≤ 0.001). The statistical analysis showed a significant increase in the mean level of the catalase enzyme in the carob 1 group in comparison to the sham (p = 0.02), and carob 2 groups (p = 0.008). Conclusion: The administration of 200 mg of the carob fruit extract for 14 days increased the testicular index as well as sperm parameters and decreased the level of oxidative stress in the testicular tissue of adult mice.

scholarly journals STATISTICAL DATA ANALYSIS WHICH RESULT FROM THE BIO-DIAGNOSIS AND BIO-TREATMENT OF INJURED RATS WITH THE HYPERLIPIDEMIA AND HYPERGLYCEMIA DISEASES

2016 ◽  
Vol 9 (9) ◽  
pp. 122
Author(s):  
Hanan Farouk Aly Abduallah ◽  
Howaida I Abdalla ◽  
Sanaa A Ali ◽  
Mohamed M Mamdooh ◽  
Reda Abo Alez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Liver Function ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Glucose Level ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Ipomoea Tricolor ◽  
And Oxidative Stress

ABSTRACTObjective: This study in bioinformatics aims to investigate the potential effect of Ipomoea tricolor and Sophora tomentosa on liver function enzymesactivity, serum lipid profile, oxidative stress biomarkers, and on blood glucose in high fat diet-induced hypercholesterolemia (HC) and STZ-inducedhyperglycemia (HG) in rats.Methods: Blood glucose level, liver function enzymes, alanine aminotransferases and aspartate aminotransferases, alkaline phosphatase, and lactatedehydrogenase (LDH) were determined. Besides, lipid profile including total cholesterol (TC), triacylglycerol (TG), total lipid, and high-densitylipoprotein-cholesterol was investigated. Moreover, oxidative stress biomarkers, lipid peroxide, and nitric oxide as well as non-enzymatic antioxidant,glutathione (GSH) were also examined in different therapeutic groups.Results: A significant increase in blood glucose level, liver function enzyme activities, LDH, lipid profile and oxidative stress markers, while significantdecrease in LDH-C and GSH level in HC-HG induced rats compared to control one. A marked amelioration in all biochemical parameters underinvestigation on treatment of HC-HG rats with I. tricolor and S. tomentosa with different fluctuating percentages of improvement. Histopathologicalexamination of liver and pancreas was also performed and declared HC-HG showed congestion in portal vessels and sinusoids with mild centrilobularhepatocyte degeneration, marked hepatocyte ballooning and hydropic degeneration, while HC-HG treated rats with I. tricolor and S. tomentosa showednormal lobular hepatic architecture with mild sinusoidal dilatation and congestion. On the other hand, a histological organization of pancreas of HC-HGrats showing disarrangement changes in pancreatic blood vessels and interlobular duct as well as disordered in acini. The treatment of HC-HG rats withI. tricolor and S. tomentosa showed enhancement in Langerhans cells and restore of most pancreatic tissue in comparison with standard drugs.Conclusion: The statistical results showed that each extract ameliorated high blood glucose level liver injury, HC and oxidative stress indicatingrelieving of oxidative damage associated with the complexity of HG and HC. These results demonstrated that these two plants extracts may be acandidate intelligent antioxidant, hypolipidemic, hypoglycemic, and hepatoprotective nutraceuticals which need further clinical investigation to beapplied effectively to reduce perturbation in HC associated diabetes.Keywords: Ipomoea tricolor, Sophora tomentosa, Lipid profile and liver function enzymes, Endothelial dysfunction markers, Statistics and imagerecognition, Histopathological analysis.

scholarly journals Effects of Bauhinia forficata on glycaemia, lipid profile, hepatic glycogen content and oxidative stress in rats exposed to Bisphenol A

2019 ◽  
Vol 6 ◽  
pp. 244-252 ◽  
Author(s):  
Mariane S. Pinafo ◽  
Philippe R. Benedetti ◽  
Letícia B. Gaiotte ◽  
Fabiano G. Costa ◽  
João Paulo F. Schoffen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bisphenol A ◽  
Lipid Profile ◽  
Glycogen Content ◽  
Hepatic Glycogen ◽  
Bauhinia Forficata ◽  
And Oxidative Stress

scholarly journals The effect of cassia seed extract on the regulation of the LKB1–AMPK–GLUT4 signaling pathway in the skeletal muscle of diabetic rats to improve the insulin sensitivity of the skeletal muscle

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Qiu-Ying Wang ◽  
Ai-Hua Tong ◽  
Ying-Ying Pan ◽  
Xian-Dang Zhang ◽  
Wen-Yu Ding ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Blood Glucose ◽  
Lipid Level ◽  
Blood Lipid ◽  
Seed Extract ◽  
Blood Lipid Level ◽  
Stress Indices ◽  
Insulin Tolerance ◽  
And Oxidative Stress

Abstract Background This study aimed to observe the hypoglycemic effect of cassia seed extract in rats with type-2 diabetes mellitus and its effect on reducing insulin resistance in the skeletal muscle. Methods 50 rats were randomly divided into the normal, model, high-dose, middle-dose, and low-dose groups of cassia seed extract (n = 10 each). A high-fat diet combined with streptozotocin administration was adopted to build type 2 diabetes models. The cassia seed extract groups were fed different concentrations cassia seed extract while the normal and model groups were fed the same volume of normal saline. The weight, FINS, GIR, insulin tolerance, blood glucose and blood lipid level, oxidative stress indices and expressions related to the LKB1–AMPK–GLUT4 pathway were detected and compared between the two groups. Results Compared with the normal group, the model group showed lower weight, glucose infusion rate and expressions related to LKB1–AMPK–GLUT4 pathway and higher FINS, insulin tolerance, blood glucose and blood lipid level and oxidative stress indices (all P < 0.05). Compared with the model group, higher weight, glucose infusion rate and expressions related to LKB1–AMPK–GLUT4 pathway and lower FINS, insulin tolerance, blood glucose and blood lipid level and oxidative stress indices were observed in all groups that were administered cassia see extract (all P < 0.05). Conclusion Cassia seed extract could noticeably improve the insulin resistance of diabetic rats and enhance the insulin sensitivity of their skeletal muscles. Its mechanism may be related to damage repair of the LKB1–AMPK–GLUT4 signaling pathway and oxidative stress in the skeletal muscle.

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