scholarly journals The effect of cassia seed extract on the regulation of the LKB1–AMPK–GLUT4 signaling pathway in the skeletal muscle of diabetic rats to improve the insulin sensitivity of the skeletal muscle

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Qiu-Ying Wang ◽  
Ai-Hua Tong ◽  
Ying-Ying Pan ◽  
Xian-Dang Zhang ◽  
Wen-Yu Ding ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Blood Glucose ◽  
Lipid Level ◽  
Blood Lipid ◽  
Seed Extract ◽  
Blood Lipid Level ◽  
Stress Indices ◽  
Insulin Tolerance ◽  
And Oxidative Stress

Abstract Background This study aimed to observe the hypoglycemic effect of cassia seed extract in rats with type-2 diabetes mellitus and its effect on reducing insulin resistance in the skeletal muscle. Methods 50 rats were randomly divided into the normal, model, high-dose, middle-dose, and low-dose groups of cassia seed extract (n = 10 each). A high-fat diet combined with streptozotocin administration was adopted to build type 2 diabetes models. The cassia seed extract groups were fed different concentrations cassia seed extract while the normal and model groups were fed the same volume of normal saline. The weight, FINS, GIR, insulin tolerance, blood glucose and blood lipid level, oxidative stress indices and expressions related to the LKB1–AMPK–GLUT4 pathway were detected and compared between the two groups. Results Compared with the normal group, the model group showed lower weight, glucose infusion rate and expressions related to LKB1–AMPK–GLUT4 pathway and higher FINS, insulin tolerance, blood glucose and blood lipid level and oxidative stress indices (all P < 0.05). Compared with the model group, higher weight, glucose infusion rate and expressions related to LKB1–AMPK–GLUT4 pathway and lower FINS, insulin tolerance, blood glucose and blood lipid level and oxidative stress indices were observed in all groups that were administered cassia see extract (all P < 0.05). Conclusion Cassia seed extract could noticeably improve the insulin resistance of diabetic rats and enhance the insulin sensitivity of their skeletal muscles. Its mechanism may be related to damage repair of the LKB1–AMPK–GLUT4 signaling pathway and oxidative stress in the skeletal muscle.

scholarly journals Antioxidant Activity of β-Glucan

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Kyoko Kofuji ◽  
Ayumi Aoki ◽  
Kazufumi Tsubaki ◽  
Masanori Konishi ◽  
Takashi Isobe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Extraction Method ◽  
Lipid Level ◽  
Food Additives ◽  
Molecular Size ◽  
Blood Lipid ◽  
Food Additive ◽  
Blood Lipid Level ◽  
Causal Factors

β-Glucans extracted from barley, which mainly contains β-(1,3-1,4)-D-glucan, are used extensively as supplements and food additives due to their wide biologic activities, including a reduction in blood lipid level. In this study, the antioxidant activity of β-glucan was examined to assess potential new benefits associated with β-glucan, because oxidative stress is considered one of the primary causal factors for various diseases and aging. β-Glucan extracted from barley was found to possess significant antioxidant activity. The amount of antioxidant activity was influenced by different physiologic properties (e.g., structure and molecular size) of β-glucan, which varied depending on the source and extraction method used. The antioxidant activity of β-glucan was significantly higher than that of various polymers that are used as food additives. These results indicate that β-glucan has promise as a polymeric excipient for supplement and food additive with antioxidant and other benefits, which may contribute to enhancing health and beauty.

scholarly journals Effects of avocado seed extract in different trisextenders on sperm and oxidative stress indices of vitrified goat spermatozoa

2016 ◽  
Vol 61 (4) ◽  
pp. 359-374
Author(s):  
Daramola Olamitibo ◽  
Onanuga Dayo ◽  
Abioja Oladimeji ◽  
Adeleke Mathew ◽  
Olowofeso Olajide ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Citric Acid ◽  
Sodium Phosphate ◽  
Sodium Citrate ◽  
Seed Extract ◽  
West African ◽  
Stress Indices ◽  
Live Sperm ◽  
And Oxidative Stress ◽  
Avocado Seed

Effects of avocado seed extract (ASE) in different tris-extenders on sperm and seminal oxidative stress indices of vitrified spermatozoa of West African Dwarf (WAD) goats during vitrification were assessed. Semen samples were diluted with varying levels (0, 5, 10, 15 and 20 mL/100 mL of diluent) of ASE in tris citric acid (TCA), tris sodium phosphate (TSP) and tris sodium citrate (TSC) extenders while a tris-extender without citric acid, sodium phosphate and sodium citrate served as control. Diluted semen samples were vitrified and preserved. The results revealed higher (P<0.05) progressive sperm motility in TCA extenders at 10%, 15% and 20%, and TSP extender at 20% ASE. Acrosome integrities were higher (P<0.05) in the different tris-extenders at 15% and 20% ASE. TCA, TSP and TSC extenders had higher (P<0.05) membrane integrities at 10%, 15% and 20% ASE. TSP extenders had higher (P<0.05) live sperm at 20% ASE. TCA extenders had higher acrosome reaction while TSP at 20% ASE and TSC at 15% and 20% of ASE had higher sperm capacitation. TCA extender at 20% ASE had reduced malondialdehyde (MDA) concentrations while higher acrosin activities were observed at 20% ASE in TCA extender (P<0.05). The findings indicated that 20% ASE in the tris-extenders improved sperm and oxidative stress indices and the tris-extenders were ranked best in this order: TCA > TSP > TSC.

Fenugreek seed extract ameliorates cognitive deficits in streptozotocin-induced diabetic rats

2019 ◽  
Vol 30 (4) ◽  
Author(s):  
Praveen K. Kodumuri ◽  
Christofer Thomas ◽  
Raghu Jetti ◽  
Anil Kumar Pandey
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Cognitive Dysfunction ◽  
Memory Impairment ◽  
Neuronal Loss ◽  
Diabetic Rats ◽  
Seed Extract ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
And Oxidative Stress

Abstract Background Natural medicinal plants have been the focus of current research for developing neuroprotective agents to be used in the diabetes-linked cognitive dysfunction. Trigonella foenum-graecum seeds (known as fenugreek, methi in Hindi), is a well-known traditional medicinal herb and possesses anti-diabetic, anti-oxidant, and anti-inflammatory properties. Purpose This study was undertaken to explore the ameliorative effects of T. foenum-graecum seed extract on diabetes-induced cognitive dysfunction. Methods Experimental diabetes was induced by administering a single dose of streptozotocin (60 mg/kg) through intraperitoneal dose. Cognitive function was assessed using a T-maze and the Morris water maze. Lipid peroxidation levels and oxidative stress in the hippocampus was measured. Quantification of hippocampal CA1 and CA3 regions was done using cresyl violet stain. Results Diabetic rats demonstrated learning and memory impairment, which was evident from poor performance in behavioral tasks, i.e. T-maze and Morris water maze tasks. Learning and memory impairment in diabetic animals is associated with increased blood glucose levels, increased oxidative stress in the hippocampus and decreased number of neurons in the CA1 and CA3 regions of the hippocampus. The diabetic rats administered with T. foenum-graecum showed improved performance in behavioral tasks, and these changes were associated with decreased blood glucose levels, decreased oxidative stress in the hippocampus, and decreased neuronal loss from the CA1 and CA3 regions of the hippocampus. Conclusion In conclusion, administration of T. foenum-graecum seed extract ameliorates diabetes-linked cognitive dysfunction in rats by decreasing blood glucose levels, reducing lipid peroxidation and oxidative stress in the hippocampus, and preventing neuronal loss from the hippocampus.

scholarly journals Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Olubanke O. Ogunlana ◽  
Babatunde O. Adetuyi ◽  
Miracle Rotimi ◽  
lohor Esalomi ◽  
Alaba Adeyemi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Seed Extract ◽  
The Body ◽  
High Concentration ◽  
Group 5

Abstract Background Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characterized by persistent hyperglycemic properties. This global disorder harms organs of the body such as the liver, kidney and spleen. Medicinal plants such as Hunteria umbellate have been shown to possess hypoglycemic, antioxidative and anti-diabetic properties owing to the high concentration of active phytochemical constituents like flavonoids and alkaloids. The present study seeks to evaluate the hypoglycemic activities of ethanolic seed extract of Hunteria umbellate on streptozotocin-induced diabetes rats. Methods Thirty (30) female experimental rats were randomly divided into five groups with six rats per group and were administered streptozotocin (STZ) and Hunteria umbellate as follows. Group 1 served as control and was given only distilled water, group 2 rats were administered 60 mg/kg STZ; Group 3 was administered 60 mg/kg STZ and 100 mg/kg metformin; group 4 rats were administered 60 mg/kg STZ and 800 mg/kg Hunteria umbellate, group 5 rats 60 mg/kg STZ and 400 mg/kg Hunteria umbellate. The fasting blood glucose level of each rat was measured before sacrifice. Rats were then sacrificed 24 h after the last dose of treatment. Results The results showed that Hunteria umbellate significantly reversed STZ-induced increase in fasting blood glucose and increase in body and organs weight of rats. Hunteria umbellate significantly reversed STZ-induced decrease in antioxidant enzyme in liver, kidney and spleen of rats. Hunteria umbellate significantly reversed STZ-induced increase in oxidative stress markers in liver, kidney and spleen of rats. Conclusion Collectively, our results provide convincing information that inhibition of oxidative stress and regulation of blood glucose level are major mechanisms through which Hunteria umbellate protects against streptozotocin-induced diabketes rats.

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