CARI ONE Induces Anagen Phase of Telogenic Hair Follicles Through Regulation of β-Catenin, Stimulation of Dermal Papilla Cell Proliferation, and Melanogenesis

2014 ◽  
Vol 11 (4) ◽  
pp. 320-333 ◽  
Author(s):  
Hye-Jin Park
Keyword(s):  
Cell Proliferation ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Dermal Papilla Cell ◽  
Anagen Phase ◽  
Stimulation Of

scholarly journals Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles

2015 ◽  
Vol 27 (6) ◽  
pp. 667 ◽  
Author(s):  
Hosein Rastegar ◽  
Hamidreza Ahmadi Ashtiani ◽  
Mahmoud Aghaei ◽  
Behrooz Barikbin ◽  
Amirohushang Ehsani
Keyword(s):  
Cell Proliferation ◽  
Human Hair ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Herbal Extracts ◽  
Dermal Papilla Cell

scholarly journals Aqueous Extract of Red Deer Antler Promotes Hair Growth by Regulating the Hair Cycle and Cell Proliferation in Hair Follicles

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jing-jie Li ◽  
Zheng Li ◽  
Li-juan Gu ◽  
Yun-bo Wang ◽  
Mi-ra Lee ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Aqueous Extract ◽  
Hair Growth ◽  
Red Deer ◽  
Growth Parameters ◽  
Hair Follicles ◽  
Control Group ◽  
Deer Antler ◽  
Vehicle Control Group ◽  
Anagen Phase

Deer antlers are the only mammalian appendage capable of regeneration. We aimed to investigate the effect of red deer antler extract in regulating hair growth, using a mouse model. The backs of male mice were shaved at eight weeks of age. Crude aqueous extracts of deer antler were prepared at either 4°C or 100°C and injected subcutaneously to two separate groups of mice (n=9) at 1 mL/day for 10 consecutive days, with water as a vehicle control group. The mice skin quantitative hair growth parameters were measured and 5-bromo-2-deoxyuridine was used to identify label-retaining cells. We found that, in both the 4°C and the 100°C deer antler aqueous extract-injection groups, the anagen phase was extended, while the number of BrdU-incorporated cells was dramatically increased. These results indicate that deer antler aqueous extract promotes hair growth by extending the anagen phase and regulating cell proliferation in the hair follicle region.

scholarly journals Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

2020 ◽  
Vol 6 (30) ◽  
pp. eaba1685 ◽  
Author(s):  
Shiqi Hu ◽  
Zhenhua Li ◽  
Halle Lutz ◽  
Ke Huang ◽  
Teng Su ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Hair Cycle ◽  
Paracrine Signaling ◽  
Hair Regrowth ◽  
Study Results ◽  
Anagen Phase ◽  
Hair Follicle Cycle

The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid–derived exosomes up-regulated β-catenin, promoting the development of hair follicles.

scholarly journals Establishment of Rat Dermal Papilla Cell Lines that Sustain the Potency to Induce Hair Follicles from Afollicular Skin

1998 ◽  
Vol 111 (5) ◽  
pp. 767-775 ◽  
Author(s):  
Mutsumi Inamatsu ◽  
Takashi Matsuzaki ◽  
Hiroko Iwanari ◽  
Katsutoshi Yoshizato
Keyword(s):  
Cell Lines ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Dermal Papilla Cell

Triterpenes in the Ethanol Extract of Poria cocos Induce Dermal Papilla Cell Proliferation

2019 ◽  
Vol 16 (1) ◽  
pp. 1-9
Author(s):  
Chun-Chieh Wang ◽  
Lu-Kai Wang ◽  
Mao-Liang Chen ◽  
Chan-Yen Kuo ◽  
Fu-Ming Tsai ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Ethanol Extract ◽  
Dermal Papilla ◽  
Poria Cocos ◽  
Dermal Papilla Cell
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