scholarly journals Significance of genotyping in the diagnosis of arthritis associated with C-viral hepatitis

2021 ◽  
pp. 146-151
Author(s):  
F. N. Shukurova ◽  
D. A. Parpiboeva ◽  
M. Sh. Karimov
Keyword(s):  
Hepatitis C ◽  
Viral Hepatitis ◽  
Clinical Manifestations ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Rheumatic Manifestations ◽  
The Republic ◽  
Relationship Of ◽  
The Relationship ◽  
Subtype 1B

To date, a number of studies have been conducted on the relationship of HCV genotypes with complications such as liver cirrhosis, hepatocellular carcinoma, but research on the correlation of the genotype with extrahepatic clinical manifestations associated with HCV, especially rheumatic manifestations, is insufficient. The purpose of the study is to analyze the most common genotypes of viral hepatitis C in the Republic of Uzbekistan and study their correlation with rheumatic manifestations of HCV. Methods: This study involved 88 patients with HCV infection who received inpatient and subsequent ambulatornoe treatment in Scientific Research Institute of Epidemiology, Microbiology and Infectious diseases of the Republic of Uzbekistan. Diagnostics procedures at the initial level included a set of studies, i. e. clinical, rheumatological and laboratory studies, ultrasound of the joint. In addition, 88 samples of RNA - positive serum from patients diagnosed with HCV were genotyped. Results: the Results showed that genotype 1 of HCV (subtype 1b) is the main genetic variant of HCV in Uzbekistan. Based on the results obtained, the genotypic features of viruses can be markers of the development of extrahepatic clinical manifestations. There is a reliable direct correlation between the incidence and severity of associated arthritis in patients with chronic viral hepatitis C with genotype 1b of the virus according to our research. Conclusions: The results of the study can be provided to help the doctor of the polyclinic service as recommendations that patients with the 1b genotype of the virus have a greater adherence to associated arthritis, and in this case, timely targeted consultation of a specialist is necessary.

scholarly journals Clinical-epidemiological and pathogenetic features of viral hepatitis C in the hemodialysis departments

2019 ◽  
Vol 11 (4) ◽  
pp. 282-289
Author(s):  
R. N. Akalaev ◽  
G. Z. Aripkhodzhaeva ◽  
S. A. Rashidova ◽  
A. N. Abdullaev ◽  
K. A. Khashimov
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Chronic Renal Disease ◽  
Chronic Viral Hepatitis ◽  
Adverse Outcomes ◽  
Viral Hepatitis C ◽  
Viral Hepatitis B ◽  
The Republic ◽  
Chronic Viral Hepatitis C

Background. Today, the programmed hemodialysis belongs to the clinical medicine area where patients are at a constant risk of viral hepatitis infection. This is associated with surgical interventions on the vessels, fairly frequent transfusions of blood components, and regular hemodialysis procedures. But in recent years, the ratio of reported cases of viral hepatitis B and C in patients on programmed hemodialysis has changed significantly. With an abrupt increase in the incidence of viral hepatitis C, there is a decrease in the number of registered viral hepatitis B cases.The aim. To study the clinical, epidemiological and pathogenetic features of viral hepatitis C in hemodialysis units.Material and methods. A multicenter study was conducted that enrolled the patients from the Programmed Hemodialysis Units in Tashkent and the regional departments of the Republic of Uzbekistan. The study involved 395 patients on programmed hemodialysis for 7.5 ± 0.7 years. The age of patients was 43.5 ± 0.91 years. The diagnosis of chronic viral hepatitis C was made on the basis of medical history, clinical and laboratory data, and detection of anti-HCV IgG and RNA-HCV in blood.Results. When analyzing the clinical examination and laboratory test results of 395 patients, the parenteral viral infection markers were detected in 181 patients (45.8%). The analysis of the overall incidence of viral hepatitis showed that chronic viral hepatitis C had the highest rates and was found in 125 patients (31.6%). The analysis of the chronic viral hepatitis C course in the presence of the end-stage chronic renal disease showed that in 11 (34%) of 32 patients of the Main group the disease proceeded as a fulminant form of chronic renal-hepatic failure with the development of adverse outcomes. Twenty seven patients (84%) in this group developed progressive anemia. In 16 patients (50%), persistent polyserositis developed in the form of hydrothorax, ascites, and pericarditis, which reflected the aggravating effect of chronic viral hepatitis C on the course of chronic renal disease.Conclusions. In Hemodialysis Units, both in the city of Tashkent, and in the regional departments of the Republic of Uzbekistan, the incidence of chronic viral hepatitis C prevails, having the form of a pathological process with a minimally low activity. Chronic viral hepatitis C has an aggravating effect on the course of the underlying disease with the development of adverse outcomes.

Portal vein thrombosis as a complication of coronavirus infection against the background of chronic viral hepatitis

2021 ◽  
Vol 2 (88) ◽  
pp. 66-70
Author(s):  
A.V. Kuznetsova ◽  
◽  
A.V. Ivolgina ◽  
Ye.V. Dubotolkina ◽  
T.Ye. Makarova ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Portal Vein ◽  
Viral Hepatitis ◽  
Abdominal Ultrasound ◽  
Chronic Viral Hepatitis ◽  
Outpatient Basis ◽  
Vein Thrombosis ◽  
Viral Hepatitis C ◽  
Coronavirus Infection

The article presents an extract from an outpatient case history card of a 47-year-old patient observed at the Central Hospital for Chronic Hepatitis C. In 2017, he received a course of therapy for this disease (Pegasis in combination with ribavirin). A sustained virological response (SVR) has been achieved. According to elastometry data dated 12/13/2017 – the degree of fibrosis F4 Metavir, 13.1 KPa. In January 2021, he suffered a coronavirus infection (according to the CT scan of the lungs, the lesion was 20 %). The disease proceeded against the background of chronic viral hepatitis C complicated by liver cirrhosis. He was treated symptomatically on an outpatient basis. He did not receive anticoagulant therapy. In February 2021, abdominal ultrasound (ABP) revealed a thrombus in the portal vein. The presence of a thrombus in the portal vein contributes to the further progression of liver cirrhosis

scholarly journals Assessment of adherence to chronic viral hepatitis C treatment in Romania: an open, single center, prospective study

2016 ◽  
Vol 2 (2) ◽  
pp. 59-68
Author(s):  
Anca Streinu-Cercel ◽  
Maria-Magdalena Moțoi ◽  
Alina Cristina Neguț ◽  
Luminița Bradu ◽  
Daniela Manolache ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Prospective Study ◽  
Viral Hepatitis ◽  
Chronic Viral Hepatitis ◽  
Single Center ◽  
Hepatitis C Treatment ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C

Epidemiological, demographic and clinical data on chronic viral hepatitis C in Tuscany

2018 ◽  
Vol 35 (4) ◽  
pp. 661-666 ◽  
Author(s):  
Cristina Stasi ◽  
Caterina Silvestri ◽  
Roberto Berni ◽  
Maurizia Rossana Brunetto ◽  
Anna Linda Zignego ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Viral Hepatitis ◽  
Clinical Data ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C

Chronic viral hepatitis C. Approach to therapy

2021 ◽  
Vol 87 (1) ◽  
pp. 37-41
Author(s):  
T. Ye. Makarova ◽  
◽  
N.N. Dudareva ◽  
N.N. Poletaeva ◽  
E.A. Medvedeva ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
High Incidence ◽  
Chronic Viral Hepatitis C

The problem of chronic viral hepatitis C currently remains relevant due to the high incidence, frequent outcomes in liver cirrhosis, high disability of the population, and expensive treatment. The article discusses timely approaches to the treatment of chronic viral hepatitis C, using interferon-free therapy regimens.

Antiviral therapy of liver cirrhosis in the outcome of chronic viral hepatitis C

2021 ◽  
pp. 89-97
Author(s):  
ANARKAN SHABOLOTOVNA TASHPOLOTOVA ◽  
GULMIRA SAIBILDAEVNA SURANBAEVA ◽  
MYSKAL MAMAZIAEVNA ABDIKERIMOVA ◽  
ALTYNAI BORUBAEVNA MYRZAKULOVA ◽  
ANARA SHAMSHIDINOVNA DJUMAGULOVA ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Viral Hepatitis ◽  
Antiviral Therapy ◽  
Chronic Viral Hepatitis ◽  
Viral Hepatitis C ◽  
Chronic Viral Hepatitis C
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