Conceptual model for NAb mRNA and PAC-MAN in-vivo delivery through rSARS-CoV-2 vector via ACE-2 receptors binding mechanism: Deep amalgamation approach to COVID-19 vaccine

The paper presents a conceptual model for the development of recombinant SARS-CoV-2 as a vector for in-vivo delivery of viral neutralizing antibodies gene and PAC-MAN into human respiratory epithelial cells. The theoretical proposal suggests the sequence length, potential antibody candidates (as reported in the recent literature) and brief protocol which can be applied to produce rSARS-CoV-2 in the laboratory to test its effectiveness against most of the SARS-CoV-2 strains. Finally, a method for release of such functional vector is been discussed.