scholarly journals Differential expression of transforming growth factor beta receptor 2 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Differential Expression ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Primary Tumors ◽  
Beta Receptor ◽  
Growth Factor Beta

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding transforming growth factor beta receptor 2, TGFBR2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TGFBR2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TGFBR2 in primary tumors of the breast was correlated with recurrence-free survival in patients with HER2+ subtype cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. TGFBR2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of fibroblast growth factor 2 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Differential Expression ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding fibroblast growth factor 2, FGF2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. FGF2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of FGF2 in primary tumors of the breast was correlated with overall survival in patients with luminal A cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. FGF2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of the epidermal growth factor receptor in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Differential Expression ◽  
Growth Factor Receptor ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Primary Tumors ◽  
Epidermal Growth

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the epidermal growth factor receptor, EGFR, when comparing primary tumors of the breast to the tissue of origin, the normal breast. EGFR mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of EGFR in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. EGFR may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of c-fos induced growth factor in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Differential Expression ◽  
Survival Data ◽  
Molecular Subtype ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding c-fos induced growth factor, FIGF, when comparing primary tumors of the breast to the tissue of origin, the normal breast. FIGF was also differentially expressed in the tumor cells of patients with triple negative breast cancer. FIGF mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of FIGF in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. FIGF may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of TGFBR3 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Transforming Growth Factor ◽  
Molecular Subtype ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the transforming growth factor beta receptor 3, TGFBR3, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TGFBR3 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TGFBR3 in primary tumors of the breast was correlated with overall survival in patients with luminal A and luminal B cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. TGFBR3 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of platelet-derived growth factor D in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Differential Expression ◽  
Survival Data ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Platelet Derived Growth Factor ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding platelet-derived growth factor D, PDGFD, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PDGFD was also differentially expressed in the tumor cells of patients with triple negative breast cancer. PDGFD mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PDGFD in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. PDGFD may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of the alpha subunit of the receptor for the platelet-derived growth factor in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Differential Expression ◽  
Survival Data ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Platelet Derived Growth Factor ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding platelet-derived growth factor receptor alpha, PDGFRA, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PDGFRA mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PDGFRA in primary tumors of the breast was correlated with overall survival in patients with luminal A cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. PDGFRA may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of insulin-like growth factor binding protein 6 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Differential Expression ◽  
Binding Protein ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Insulin Like Growth Factor ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Factor Binding

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding insulin-like growth factor binding protein 6, IGFBP6, when comparing primary tumors of the breast to the tissue of origin, the normal breast. IGFBP6 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of IGFBP6 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancers in a contrary manner, demonstrating a complex relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. IGFBP6 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

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