Feasibility and acceptability of cognitive bias modification for interpretation as an adjunctive treatment for OCD and related disorders: A pilot randomized controlled trial

2021 ◽  
Author(s):  
Martha J Falkenstein ◽  
Kara N. Kelley ◽  
Devin Dattolico ◽  
Jennie M Kuckertz ◽  
Andreas Bezahler ◽  
...  
Keyword(s):  
Cognitive Bias ◽  
Controlled Trial ◽  
Cognitive Bias Modification ◽  
Interpretation Bias ◽  
Feasibility Trial ◽  
Adjunctive Treatment ◽  
Obsessive Compulsive ◽  
Post Intervention ◽  
Adolescents And Adults ◽  
Bias Modification

Background: Cognitive models implicate interpretation bias in the development and maintenance of obsessive compulsive and related disorders (OCRDs), and research supports Cognitive Bias Modification for Interpretation (CBM-I) in targeting this mechanism. However, prior studies in OCRDs have been limited to nonclinical populations, adolescents, and adults in a laboratory setting. This study evaluated the feasibility and acceptability of CBM-I as an adjunctive intervention during intensive/residential treatment (IRT) for adults with OCRDs.Method: We modified a lab-based CBM-I training for adults seeking IRT for OCRDs, and conducted a feasibility trial (N = 4) and subsequent pilot RCT; participants (N = 31) were randomized to receive CBM-I or psychoeducation.Results: Benchmarks were met for feasibility, acceptability, and target engagement. From pre- to post-intervention, the CBM-I group showed a large effect for change in interpretation bias (d = .90), whereas this effect was trivial (d = .06) for psychoeducation.Conclusions: This was the first study to evaluate CBM-I in naturalistic treatment for OCRDs. Findings support the feasibility and acceptability of CBM-I in this novel sample and setting. A larger scale RCT is needed to determine whether CBM-I can enhance OCRD treatment response.

scholarly journals Online Cognitive Bias Modification of Interpretation for Children With Obsessive-Compulsive Disorder

2020 ◽  
Vol 8 (4) ◽  
pp. 325-334
Author(s):  
Saeed Nasiry ◽  
◽  
Zahra Ameli ◽  
Pegah Pezeshki ◽  
◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Cognitive Bias ◽  
Cognitive Bias Modification ◽  
Interpretation Bias ◽  
Control Group ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Study Results ◽  
Bias Modification

Objective: Numerous children with Obsessive-Compulsive Disorder (OCD) either have no access to its main treatment, i.e. Cognitive Behavioral Therapy (CBT), or fail to respond to it. Cognitive Bias Modification of Interpretation (CBMI) is a novel and promising intervention that targets the incorrect interpretation of intrusive thoughts and impulses, i.e. the characteristics of OCD. The present study aimed to determine the effects of CBMI in children with OCD for the first time. Besides, we evaluated the possibility of online implementation of this intervention. Methods: A sample of 35 children with OCD (aged 7-12 years) were randomly assigned to two study groups. The experimental group (n=18) received CBMI and the controls (n=17) received placebo treatment. Interpretation bias and OCD severity were assessed at pre-test, post-test, and 2-month follow-up stages, using the Obsessive Compulsive Inventory-Child Version (OCICV), Obsessive Beliefs Questionnaire-Child Version (OBQCV), and Ambiguous Scenarios Task (AST). The present study results were analyzed using two-way repeated-measures Analysis of Variance (ANOVA) and Paired Samples t-test. Results: The collected findings demonstrated that after receiving CBMI, children’s propensity to positively interpret ambiguous situations was increased, their tendency towards negative interpretation and OCD severity was also decreased. There was no such significant change in the control group. Furthermore, the effects of CBMI was sustained at the 2-month follow-up step. Conclusion: This study provided preliminary evidence that suggests CBMI is capable of modifying interpretation bias in children with OCD, can reduce the severity of their disorder, and works as an online intervention. This brief and inexpensive intervention could be considered as an auxiliary or standalone treatment for OCD in children.

scholarly journals Protocol for a randomised controlled trial of cognitive bias modification training during inpatient withdrawal from alcohol use disorder

Trials ◽  
2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Victoria Manning ◽  
Joshua B. B. Garfield ◽  
Samuel C. Campbell ◽  
John Reynolds ◽  
Petra K. Staiger ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Alcohol Use ◽  
Cognitive Bias ◽  
Alcohol Use Disorder ◽  
Controlled Trial ◽  
Cognitive Bias Modification ◽  
Randomised Controlled ◽  
Bias Modification

scholarly journals The ReThink study: a 3-arm parallel randomized trial of cognitive bias modification, with and without adherence promotion, for adolescent anxiety disorder: trial design and protocol

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shelley Reetz ◽  
Gregory Clarke ◽  
Robin Weersing ◽  
Nader Amir ◽  
John Dickerson ◽  
...  
Keyword(s):  
Cognitive Bias ◽  
Large Scale ◽  
Technical Assistance ◽  
Controlled Trial ◽  
Cost Effective ◽  
Cognitive Bias Modification ◽  
High Ratio ◽  
Will Self ◽  
Bias Modification ◽  
At Home

Abstract Background Anxiety disorders are the most common mental health problem among youth, contribute to reduced quality of daily life, and are associated with high rates of comorbidity. However, treatment rates for anxiety are very low, causing a sizeable treatment gap. There is an immediate need to identify treatment interventions that are effective, affordable, and can be delivered easily to the youth population. Cognitive Bias Modification (CBM) is one potentially effective intervention that could reach youth on a large scale, especially when self-administered at home. Thus, we aim to assess the benefit of CBM to treat youth anxiety. Further, we aim to test whether adding an adherence promotion (AP) component to the CBM intervention can improve outcomes, and whether CBM delivered both with and without the AP component is cost effective. Methods This is a 12-month randomized controlled trial (RCT) conducted within an existing healthcare system. Potentially eligible youth (ages 12 to 17) will be identified by reviewing the electronic health record (EHR) for clinical anxiety diagnoses, which are then confirmed via research interview. We aim to enroll 498 participants and randomize them 1:1:1 to one of three arms: Arm 1 is a Low-Ratio version of the CBM program (nearly identical to the other CBM versions, but minimally effective); Arm 2 is a High-Ratio “active” CBM program; and Arm 3 is the High-Ratio CBM program with an added AP component. Participants will complete assessments at baseline, 1-, 3-, 6- and 12-months post-baseline. Youth in all three arms will self-administer the CBM program at home and will be asked to complete twelve intervention sessions over a four-week period. Arm 3 participants (High-Ratio CBM + AP) will also receive up to four telephone calls from phone coaches during the intervention period to provide technical assistance, encouragement, and motivational enhancement to increase adherence. The primary clinical outcome will be anxiety remission at 6-month follow-up. Discussion This study protocol describes the method and design for an RCT to test whether self-administered CBM both with and without adherence promotion can be an effective at-home treatment for anxious youth. Trial registration ClinicalTrials.gov: NCT02156531, First Posted June 5, 2014.

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