scholarly journals A Case Report on Scalp edema in a case of HSP in a young adult

2019 ◽  
Vol 8 (2) ◽  
pp. 35-37 ◽  
Author(s):  
S. Thapaliya ◽  
M. Nepal ◽  
B. Nepal ◽  
R. Pathak
Keyword(s):  
Case Report ◽  
Young Adult ◽  
Early Recognition ◽  
Renal Involvement ◽  
Organ Damage ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Age Group ◽  
Palpable Purpura ◽  
Schonlein Purpura

Henoch Schonlein Purpura (HSP) is a systemic small vessel vasculitis which most commonly affects children. HSP is characterized by non-thrombocytopenic palpable purpura, arthritis or arthalgia, gastrointestinal and renal involvement. Scalp edema is uncommon in children over 3 years. Early recognition, especially outside of the typical age group, with appropriate management can reduce morbidity and organ damage. We present a case of a young adult with HSP who

scholarly journals Henoch-Schonlein Purpura—A Case Report and Review of the Literature

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Amit B. Sohagia ◽  
Srinivas Guptha Gunturu ◽  
Tommy R. Tong ◽  
Hilary I. Hertan
Keyword(s):  
Early Recognition ◽  
Leukocytoclastic Vasculitis ◽  
Systemic Disease ◽  
Renal Involvement ◽  
Symptomatic Treatment ◽  
Adolescent Male ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointestinal tract. Steroid therapy led to complete resolution of the symptoms. HSP is the most common childhood vasculitis, and is characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthritis or arthralgias, gastrointestinal and renal involvement. It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. Mild disease resolves spontaneously, and symptomatic treatment alone is sufficient. Systemic steroids are recommended for moderate to severe HSP. The prognosis depends upon the extent of renal involvement, which requires close followup. Early recognition of multiorgan involvement, especially outside of the typical age group, as in our adolescent patient, and appropriate intervention can mitigate the disease and limit organ damage.

scholarly journals Henoch-Scholein Purpura (HSP): A Clinico-etiological Study

2016 ◽  
Vol 12 (1) ◽  
pp. 38-33
Author(s):  
SN Kareem ◽  
N Riyaz
Keyword(s):  
Age Of Onset ◽  
Renal Involvement ◽  
Gastrointestinal Symptoms ◽  
Occult Blood ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Joint Involvement ◽  
Upper Respiratory Tract ◽  
Palpable Purpura ◽  
American College Of Rheumatology

Background: Henoch–Schönlein (HSP) is a small vessel vasculitis affecting skin and internal organs.  Objectives: To determine the age group affected, etiological factors, clinical features, complications and association with other diseases. Methods: The study included 50 patients over a period of 3 years selected on the modified criteria by American College of Rheumatology. Clinical assessment was done and investigated for any focus of hidden infections especially Dental and ENT by respective departments. Associated conditions, complications and recurrence were also observed. Results: All patients had palpable purpura (pruritic in 58% and with hemorrhagic bullae in 6%) with upper respiratory tract prodrome (44%), joint involvement (94%) and gastrointestinal symptoms (90%). Precipitating factors were sore throat (74%), caries tooth (44%), drugs (30%) and food (16%) in varying combinations. On investigation 56% had raised ESR and 22% were with abnormal peripheral smears. All biopsies showed leucocytoclastic vasculitis. Occult blood in stool was detected in 10% and 2% showed Streptococci in throat swab culture. Renal involvement was 54% (RBC and albumin-42%, RBC alone-12%). One patient had intestinal perforation. Bleeding time, Clotting time, Platelet count, Cryoglobulin, ANA, Rheumatoid factor, HBs Ag, VDRL and X-ray chest were within normal limits. LE cell test was negative. Follow up study showed recurrence in 98%. Conclusion: HSP is a small vessel vasculitis in response to any unknown foreign or endogenous antigen. The age of onset varied from below 7 to 58 years, with most of them below 20. The most important clinical presentation was palpable purpura in lower extremities. GIT and joint involvement were more. Renal involvement found to be the most common complication. DOI: http://dx.doi.org/10.3126/njdvl.v12i1.10593 Nepal Journal of Dermatology, Venereology & Leprology Vol.12(1) 2014 pp.28-33 

scholarly journals Clinical characteristics and outcome of vasculitides

2016 ◽  
Vol 3 (2) ◽  
pp. 3-9
Author(s):  
Buddhi Prasad Paudyal ◽  
Anjana Education Rajbhandari
Keyword(s):  
Medical Records ◽  
Clinical Characteristics ◽  
Cross Sectional Study ◽  
Health Sciences ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Cross Sectional ◽  
The Mean ◽  
Schonlein Purpura ◽  
Overall Mortality

 Introductions: Vasculitides can cause significant morbidity and mortality if not treated on time. There is lack of data locally. This study aims to define the pattern, clinical characteristics, and outcome of vasculitides.Methods: This was a cross sectional study between January 2011 and December 2015 at Patan Hospital, Patan Academy of Health Sciences, Lalitpur, Nepal. The medical records of patients diagnosed with vasculitides in adults rheumatology service of the hospital were reviewed.Results: Ninety six patients were diagnosed with vasculitides during the study period. The mean age was 42.2 years. Sixty nine (71.8%) patient had small vessel, 20 (20.8%) large vessel and five (5.2%) had variable vessel vasculitides. Seventy five patients (78.1%) had primary and 21 (21.8%) secondary vasculitides. Cutaneous leucocytoclasticangitis was seen in 27 (28.1%), Takayasu arteritis in 17 (17.7), Henoch-Schonlein purpura in 11 (11.4%) and Rheumatoid arthritis associated vasculitis in nine patients. Purpura was present in all 96 (100%). The overall mortality was 9 (9.3%).Conclusions: Primary vasculitides were more common than secondary forms. Small vessel vasculitis was the most common. Cutaneous symptoms were predominant features. The mortality was attributed to active disease, sepsis, and complications of the primary disease. Journal of Patan Academy of Health  Sciences. 2016 Dec;3(2):3-9

scholarly journals Koebner phenomenon in leukocytoclastic vasculitis: A case report and an updated review of the literature

2019 ◽  
Vol 7 ◽  
pp. 2050313X1985035
Author(s):  
Farah Kassam ◽  
Sabrina Nurmohamed ◽  
Richard M Haber
Keyword(s):  
Case Report ◽  
Leukocytoclastic Vasculitis ◽  
Immunoglobulin A ◽  
Small Vessel Vasculitis ◽  
Review Of The Literature ◽  
Henoch Schonlein Purpura ◽  
Koebner Phenomenon ◽  
Vessel Injury ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Leukocytoclastic vasculitis is the most common form of cutaneous vasculitis. It is a neutrophilic small vessel vasculitis resulting from the deposition of circulating immune complexes. Henoch-Schonlein purpura is a systemic type of leukocytoclastic vasculitis, characterized by immunoglobulin A-mediated blood vessel injury. We present a case of Henoch-Schonlein purpura in an adult female manifesting with a vasculitic rash with Koebner phenomenon.

scholarly journals MULTIPLE MYELOMA PRESENTING AS SMALL VESSEL VASCULITIS IN A PATIENT WITH NO CRYOGLOBULINEMIA: CASE REPORT

2021 ◽  
Author(s):  
Túlio Silva Freire ◽  
Villane Matheus Fernandes Silva ◽  
Raquel Anne Bacurau Monteiro ◽  
Hugo Deleon de Lima ◽  
Guilherme Augusto Silva ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Small Vessel ◽  
Small Vessel Vasculitis

scholarly journals Acute appendicitis as the first manifestation of HenochSchönlein purpura

2020 ◽  
Vol 0 ◽  
pp. 1-3
Author(s):  
Pedro Nogarotto Cembraneli ◽  
Julia Brasileiro de Faria Cavalcante ◽  
Renata Brasileiro de Faria Cavalcante ◽  
José Edison da Silva Cavalcante
Keyword(s):  
Abdominal Pain ◽  
Acute Appendicitis ◽  
Acute Abdomen ◽  
Joint Pain ◽  
Systemic Vasculitis ◽  
Symptom Control ◽  
Small Vessel ◽  
Palpable Purpura ◽  
Gangrenous Appendicitis ◽  
Schonlein Purpura

Henoch-Schönlein purpura (HSP) is a small vessel systemic vasculitis. Typical symptoms include palpable purpura, joint pain, and abdominal pain. Most cases improve after a few weeks, not requiring any treatments other than symptom control. Acute abdomen resulting from vasculitis is very rare and should be treated as a surgical emergency. We report the case of a 9-year-old boy with acute gangrenous appendicitis as the first manifestation of HSP.

scholarly journals Assessment of the correlation of commonly used laboratory tests with clinical activity, renal involvement and treatment of systemic small-vessel vasculitis with the presence of ANCA antibodies

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Magdalena Mosakowska ◽  
Dorota Brodowska Kania ◽  
Katarzyna Szamotulska ◽  
Aleksandra Rymarz ◽  
Stanisław Niemczyk
Keyword(s):  
Peripheral Blood ◽  
Laboratory Tests ◽  
Renal Involvement ◽  
Infectious Complications ◽  
Microscopic Hematuria ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Clinical Activity ◽  
Kidney Involvement ◽  
D Dimer

Abstract Background The aim of the study was to assess the correlation of commonly used laboratory tests with clinical activity, degree of kidney involvement and treatment of systemic small-vessel vasculitis with the presence of ANCA antibodies. Methods The study included 28 patients with active AAV (BVAS ≥ 3). The following tests were performed: MPO-ANCA, PR3-ANCA, peripheral blood count, ESR, CRP, procalcitonin, creatinine, GFR, urea, albumin, fibrinogen, d-dimer, components of the C3 and C4 complement systems, urinalysis with sediment evaluation and diurnal proteinuria. The assessments were conducted twice: at study entry (A0) and after 6 months (A6) (BVAS = 0). Results At the time of inclusion in the study, the mean creatinine concentration was 3.39 mg/dl (GFR 33.17 ml/min/1.73 m²), after achieving remission in 11 patients (39.3 %) GFR remained below 30 ml/min/1.73 m², 4 patients (14.3 %) continued renal replacement therapy, and 3 patients (10.7 %) with advanced renal failure died. Microscopic hematuria occurred in 80.9 % of the studied population, withdrew in most patients, strongly correlated with renal involvement p < 0.001 and was not related to disease severity p = 0.147. CRP, ESR, fibrinogen, d-dimer, albumin and hemoglobin in the peripheral blood showed a strong correlation with the clinical activity of AAV and well identified severe patients. High procalcitonin concentrations correlated with a severe form of the disease, pulmonary involvement with respiratory failure and alveolar hemorrhage (mean 3.41 ng/ml, median 0.91 ng/ml, SD 7.62, p = 0.000), and were associated with the occurrence of infectious complications and the need to administer antibiotic therapy. ANCA antibodies were useful in the evaluation of patients with AAV, the amount of antibodies did not correlate with the severity of vasculitis (p = 0.685) and the results in many patients did not match the expected assumptions. Conclusions CRP, ESR, fibrinogen, d-dimers, albumin and hemoglobin in the peripheral blood correlate well with the activity of vasculitis and identify severe patients. The resolution of microscopic hematuria suggests remission of the disease in the renal area. Procalcitonin may be slightly increased in patients with active AAV without infection, high concentrations are strongly associated with infectious complications. ANCA antibodies should always be interpreted in the context of the observed clinical symptoms.

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