scholarly journals Estimation of salivary pH, buffering capacity, flow rate, caries prevalence and oral manifestation in chronic renal failure patients undergoing dialysis

2020 ◽  
Vol 10 (2) ◽  
pp. 19-24
Author(s):  
Bidhata Ojha ◽  
Radha Baral ◽  
Dipshikha Bajracharya

Background: Renal failure is a process that expresses a loss of functional capacity of the nephrons, independently of its etiology. Although acute renal failure is reversible in the majority of cases, chronic renal failure presents a progressive course towards terminal renal failure. Hemodialysis is the most widely used technique leading to systemic alterations, oral complications and variations in the flow and composition of the saliva. The purpose of this study was to estimate salivary pH, buffering capacity, flow rate in chronic renal failure patients undergoing hemodialysis with its oral manifestation and caries prevalence. Methods: Saliva samples were collected from 40 patients with chronic renal failure undergoing dialysis and 40 healthy subjects after taking the informed consent. Saliva samples were then taken to the lab for processing. Salivary pH, buffering capacity and flow rate was estimated. DMFT was calculated. The statistical analysis was done using SPSS version 23. Results: A statistically significant rise in salivary pH, buffering capacity with decrease in flow rate was noted in chronic renal failure patients undergoing dialysis compared to controls. Furthermore, decrease in DMFT value was noted in CRF group despite of poor oral hygiene of the patient. We could also observe different oral manifestations in CRF group among which uremic fetor being the commonest. Conclusions: Our report suggest that saliva is noninvasive tool which act as an adjunct in diagnos­ing oral lesions and manifestations in CRF patients whose oral hygiene is often neglected with their reluctance in long term dental appointment in the middle of regular hemodialysis schedule.

2018 ◽  
Vol 63 (01) ◽  
pp. 63-68
Author(s):  
Efka Zabokova Bilbilova ◽  
Ana Sotirovska Ivkovska ◽  
Olivera Sarakinova ◽  
Olga Kokoceva Ivanovska ◽  
Natasha Stavreva

The aim of this study was to determine salivary pH, buffering capacity and calcium levels in caries-free and caries-active children. We examined 80 children of both genders, 15 years of age. Subjects were divided into four groups as follows: caries-free females, caries-active females, caries-free males, caries-active males; each group consisted of 20 subjects. The unstimulated saliva sample was collected by the spitting method and then pH, buffering capacity and calcium in saliva was measured. The results showed that mean level of buffering capacity of saliva was decreased significantly in the caries-active group as compared to caries-free group. The obtained data showed that the mean levels of pH and calcium were decreased in the caries-active group as compared to the caries-free group, but the difference was not statistically significant. The saliva with its constituents plays an important role in maintaining oral and especially dental health. Salivary pH values were found to be higher in the caries-free group. In our study, there was no significant correlation of pH values and caries activity with gender. Buffer capacity values were significantly lower in the caries-active group than in the caries-free group. There were significant differences when the groups were compared in the caries-active group where buffer capacity values were higher in boys than in girls. Calcium content of saliva was higher in the caries-free group. The results obtained in this study related to the values of the pH, buffering capacity and calcium in saliva, may serve as parameters for determining the caries risk patients, and accordingly to plan and carry appropriate caries preventive measures. Keywords: saliva, dental caries, pH, buffer capacity, calcium


2018 ◽  
Vol 42 (6) ◽  
pp. 445-449 ◽  
Author(s):  
Sudharani A Pyati ◽  
R Naveen Kumar ◽  
Vinod Kumar ◽  
N H Praveen Kumar ◽  
K M Parveen Reddy

Objectives: To measure and compare the levels of salivary flow rate, pH, buffering capacity, total protein, malondialdehyde (MDA) and total antioxidant capacity (TAC) between caries active and caries free children and to study the correlation between the DMFS/dfs score and above salivary parameters in caries active children. Study design: 50 caries active (DMFS/dfs ≥ 5) and 50 caries free (DMFS/dfs = 0) children aged between 6 to 12 years were included in the study. From all the children, unstimulated, mid-morning saliva samples were collected and salivary flow rate was calculated. Salivary pH, buffering capacity, total protein, MDA and TAC were measured. Results: The mean levels of salivary flow rate, pH, buffering capacity were significantly decreased (p < 0.05) and total protein, MDA and TAC were significantly increased (p < 0.05) in caries active children when compared to caries free controls. There was a proportionate decrease (p < 0.05) in salivary flow rate, pH and buffering capacity and proportionate increase (p > 0.05) in salivary total protein, MDA and TAC as DMFS/dfs score increased in caries active children. Conclusions: Significant alteration in the levels of salivary flow rate, pH, total proteins, MDA and TAC and their correlation with DMFS/dfs score in caries active children suggest, the levels of these physico-chemical properties of saliva can act as strong indicators of caries status in children.


2016 ◽  
Vol 51 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Alaa A. Alkhateeb ◽  
Lloyd A. Mancl ◽  
Richard B. Presland ◽  
Marilynn L. Rothen ◽  
Donald L. Chi

Salivary flow rate, pH, and buffering capacity are associated with dental caries, but studies from the cystic fibrosis (CF) literature are inconclusive regarding these salivary factors and caries. The aim of this study was to evaluate these factors and their associations with dental caries in individuals with CF. Unstimulated whole saliva was collected from individuals aged 6-20 years at Seattle Children's Hospital CF Clinic, USA (n = 83). Salivary flow rate was measured in milliliters per minute. Salivary pH was assessed using a laboratory pH meter. Buffering capacity was assessed by titration with HCl. The outcome measure was caries prevalence, defined as the number of decayed, missing, or filled primary and permanent tooth surfaces. Spearman's rank correlation coefficient and the t test were used to test for bivariate associations. Multiple variable linear regression models were used to (1) run confounder-adjusted analyses and (2) assess for potential interactions. There was no significant association between salivary flow rate or buffering capacity and caries prevalence. There was a significant negative association between salivary pH and caries prevalence, but this association was no longer significant after adjusting for age. There was no significant interaction between salivary flow rate and buffering capacity or between antibiotic use and the 3 salivary factors. Our results indicate that unstimulated salivary factors are not associated with dental caries prevalence in individuals with CF. Future studies should investigate other potential saliva-related caries risk factors in individuals with CF such as cariogenic bacteria levels, salivary host defense peptide levels, and medication use.


2014 ◽  
Vol 5 (3) ◽  
pp. 324 ◽  
Author(s):  
Dwitha Animireddy ◽  
VenkataThimma Reddy Bekkem ◽  
Pranitha Vallala ◽  
SunilBabu Kotha ◽  
Swetha Ankireddy ◽  
...  

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