scholarly journals Unstimulated Saliva-Related Caries Risk Factors in Individuals with Cystic Fibrosis: A Cross-Sectional Analysis of Unstimulated Salivary Flow, pH, and Buffering Capacity

2016 ◽  
Vol 51 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Alaa A. Alkhateeb ◽  
Lloyd A. Mancl ◽  
Richard B. Presland ◽  
Marilynn L. Rothen ◽  
Donald L. Chi
Keyword(s):  
Risk Factors ◽  
Cystic Fibrosis ◽  
Dental Caries ◽  
Flow Rate ◽  
Salivary Flow ◽  
Buffering Capacity ◽  
Salivary Flow Rate ◽  
Caries Prevalence ◽  
Caries Risk ◽  
Salivary Ph

Salivary flow rate, pH, and buffering capacity are associated with dental caries, but studies from the cystic fibrosis (CF) literature are inconclusive regarding these salivary factors and caries. The aim of this study was to evaluate these factors and their associations with dental caries in individuals with CF. Unstimulated whole saliva was collected from individuals aged 6-20 years at Seattle Children's Hospital CF Clinic, USA (n = 83). Salivary flow rate was measured in milliliters per minute. Salivary pH was assessed using a laboratory pH meter. Buffering capacity was assessed by titration with HCl. The outcome measure was caries prevalence, defined as the number of decayed, missing, or filled primary and permanent tooth surfaces. Spearman's rank correlation coefficient and the t test were used to test for bivariate associations. Multiple variable linear regression models were used to (1) run confounder-adjusted analyses and (2) assess for potential interactions. There was no significant association between salivary flow rate or buffering capacity and caries prevalence. There was a significant negative association between salivary pH and caries prevalence, but this association was no longer significant after adjusting for age. There was no significant interaction between salivary flow rate and buffering capacity or between antibiotic use and the 3 salivary factors. Our results indicate that unstimulated salivary factors are not associated with dental caries prevalence in individuals with CF. Future studies should investigate other potential saliva-related caries risk factors in individuals with CF such as cariogenic bacteria levels, salivary host defense peptide levels, and medication use.

Children with a Higher Activity of Carbonic Anhydrase VI in Saliva Are More Likely to Develop Dental Caries

2017 ◽  
Vol 51 (4) ◽  
pp. 394-401 ◽  
Author(s):  
Daniele de Cassia Rodrigues Picco ◽  
Lenita Marangoni Lopes ◽  
Marcelo Rocha Marques ◽  
Sergio Roberto Peres Line ◽  
Thaís Manzano Parisotto ◽  
...  
Keyword(s):  
Dental Caries ◽  
Carbonic Anhydrase ◽  
Free Group ◽  
Flow Rate ◽  
Negative Correlation ◽  
School Children ◽  
Salivary Flow ◽  
Buffering Capacity ◽  
Salivary Flow Rate ◽  
Salivary Ph

Objective: This study aimed to analyze the concentration and activity of carbonic anhydrase (CA) VI in the saliva of school children. We investigated the relationship among caries, CA VI concentration/activity, flow rate, pH, and buffering capacity. Materials and Methods: Seventy-four school children were divided into a caries-free group and a caries group. Clinical examinations were conducted by one examiner according to World Health Organization criteria + early caries lesions. Salivary flow rate, pH, and buffering capacity were analyzed. Salivary CA VI concentration and activity were evaluated by ELISA and zymography, respectively. The data were analyzed using Student's t test and the Mann-Whitney test, and Pearson and Spearman correlation analyses were also done. In multivariate modeling, associations between variables were expressed as odds ratios. Results: The results showed that salivary flow rate, salivary pH, and BC were significantly higher in the saliva of caries-free children. Also, the salivary CA VI concentration was significantly higher in the saliva of caries-free children. The salivary CA VI activity was higher in children with caries. We found a negative correlation between BC and dental caries. Also, in the caries group we found a positive correlation between the concentration and the activity of CA VI and a negative correlation between BC and CA VI activity. A negative correlation between salivary pH and CA VI concentration was observed in the caries-free group. A high activity of CA and a low salivary flow rate were associated with dental caries. Conclusion: These results support the conclusion that dental caries is highly affected by the activity of CA VI in saliva as well as by the salivary flow rate.

Relation of Salivary Risk Factors to Dental Caries in Children with Cerebral Palsy

2010 ◽  
Vol 34 (4) ◽  
pp. 355-360 ◽  
Author(s):  
Priya Subramaniam ◽  
KL Girish Babu ◽  
Anil Rodriguez
Keyword(s):  
Risk Factors ◽  
Cerebral Palsy ◽  
Dental Caries ◽  
Flow Rate ◽  
Salivary Flow ◽  
Buffering Capacity ◽  
Ph Buffering ◽  
Salivary Ph ◽  
The Mean

One of the primary handicapping conditions of childhood is cerebral palsy (CP). Controversy exists about the incidence of dental caries and its associated salivary risk factors in cerebral palsied children. Thus the present study evaluated the correlation between dental caries and certain salivary risk factors in these children. One hundred non-institutionalized children in the age group of 5-12 years having cerebral palsy were selected. The W.H.O. criteria was used for diagnosis and recording of dental caries. Determination of the unstimulated salivary pH, buffering capacity and flow rate of stimulated saliva was carried out. The mean deft and DMFT values were 2.51 and 0.73, respectively. Salivary pH was 6.83, buffering capacity 10.84 and salivary flow rate 1.08ml/per min. A significant correlation was observed only between salivary pH and dental caries in the primary dentition of CP children.

Dental Caries and Salivary Alterations in Type I Diabetes

2011 ◽  
Vol 36 (2) ◽  
pp. 181-184 ◽  
Author(s):  
Kavita Rai ◽  
Amitha Hegde ◽  
Ananth Kamath ◽  
Suchetha Shetty
Keyword(s):  
Dental Caries ◽  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Control Group ◽  
Diabetic Patients ◽  
Type I ◽  
Healthy Children ◽  
Salivary Ph ◽  
Anti Oxidant

Insulin dependent diabetes mellitus is a severe disease that raises blood glucose levels because of hyperglycemia and insulinopenia. Fluctuations in water and electrolyte levels may result in xerostomia and other changes in the salivary composition. Since diabetes has an influence on oral health, it is important for the dentist to be aware of newer advances in the field of diabetes and to recognize specific oral problems related to diabetes. Thus, the dentist becomes an important part of the health care team for the patients with diabetes. Aim: The present study correlated salivary flow rate, salivary pH and total salivary antioxidant levels and dental caries in type I diabetic patients. Method: A total of 200 children that included 100 known diabetic children (study group) and 100 healthy children (controls) of both the sexes and from similar socioeconomic backgrounds formed the part of this study. Dental caries was assessed using DMFT index. The salivary total anti-oxidant level was estimated using phospho molybdic acid using spectrophotometric method. The salivary flow rate was recorded using the Zunt method and the salivary pH using the pH indicating paper. The results were statistically analyzed using t-test. Conclusions: The analyzed parameters showed increase in salivary anti-oxidant levels, reduced salivary flow rate, increase incidence of dental caries, salivary pH was decreased when compared to the control group.

Evaluation of Oral Hygiene Status, Salivary Characteristics and Dental Caries Experience in Acute Lymphoblastic Leukemic (ALL) Children

2011 ◽  
Vol 35 (3) ◽  
pp. 319-323 ◽  
Author(s):  
AM Hegde ◽  
S Joshi ◽  
K Rai ◽  
S Shetty
Keyword(s):  
Health Status ◽  
Oral Health ◽  
Dental Caries ◽  
Flow Rate ◽  
Salivary Flow ◽  
Oral Health Status ◽  
Salivary Flow Rate ◽  
Caries Experience ◽  
Control Group ◽  
Salivary Ph

Leukemia constitutes approximately 30% of all childhood cancers and Acute Lymphoblastic Leukemia(ALL) is the most common type of malignancy. Oral dryness, ulceration, increased dental decay seen is due to altered salivary flow rate and buffering capacity in these children. Oxidative stress may play an important role in the malignancies resulting in onset of inflammatory oral pathologies. Saliva constitutes first line of defense against free radical-mediated oxidative stress. The present study attempted to relate the oral health status, salivary flow rate, salivary pH, gingival health status, dental caries experience and total salivary antioxidant levels in ALL children. A total of 120 children aged 4-10 years (90 leukemic children, study group and 30 normal healthy siblings, control group) were divided into 4 groups of 30 each. Oral health status, gingival status and dental caries experience was recorded followed by un-stimulated saliva collection. Total antioxidant capacity of un-stimulated saliva was evaluated. The results depicted deterioration in oral health status, gingival status and increased dental caries experience in leukemic children. Salivary flow rate, salivary pH and total salivary antioxidant levels were lowered in leukemic children when compared with control group.

scholarly journals The Relationship of Salivary Flow Rate and Salivary pH on Dental Caries in Children

2015 ◽  
Vol 2 (2) ◽  
pp. 87-91
Author(s):  
Gülser Kılınç ◽  
Müjdet Çetin ◽  
Hülya Ellidokuz
Keyword(s):  
Dental Caries ◽  
Flow Rate ◽  
Salivary Flow ◽  
Salivary Flow Rate ◽  
Salivary Ph ◽  
Relationship Of ◽  
The Relationship

scholarly journals Effects of the salivary flow rate, pH, viscosity and buffering capacity on dental caries experience in government school children in Bangalore city

2020 ◽  
Vol 7 (12) ◽  
pp. 4865
Author(s):  
Annapoorna H. B. ◽  
Dipayan Datta
Keyword(s):  
Dental Caries ◽  
Flow Rate ◽  
School Children ◽  
Salivary Flow ◽  
Buffering Capacity ◽  
Salivary Flow Rate ◽  
Caries Experience ◽  
Control Group ◽  
Government School ◽  
Bangalore City

Background: The present study was undertaken to evaluate effect of the salivary flow rate, pH, viscosity and buffering capacity on caries experience in government school children.Methods: This case-control study was conducted amongst the Government school children of Bangalore city aged 6-14 years. A total of 180 school children were selected out of what 90 were selected for the test group based on the presence of one or more active dental caries and another 90 were selected for the control group who were free of dental caries at the time of examination. Saliva samples were collected from all subjects and were estimated for flow rate, pH, viscosity and buffering capacity.Results: Mean salivary flow rate, pH and buffer capacity have been found to be significantly lower and mean salivary viscosity has been found to be significantly higher among children with dental caries.Conclusions: The physical and biochemical properties of saliva, such as salivary flow rate, pH, buffering capacity and viscosity are significantly related with the caries experience in children.

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