Peripheral Giant Cell Granuloma: A Case Report

Peripheral giant cell granuloma is a benign reactive lesion of gingiva. It manifests as a firm, soft, bright nodule, sessile or pedunculate mass. It is an infrequent exophytic lesion of the oral cavity, also known as giant cell epulis, osteoclastoma, giant cell reparative granuloma, or giant-cell hyperplasia. The aim in publishing this report is to present the clinical, histopathological features and treatment of a peripheral giant cell granuloma case, which was seen in gingiva of a 10 year old male child, with history of disturbed chewing functions due to its large size. Intraoral examination revealed a raised, round, sessile, smooth-edged mass of size 2x 1 cm2 and was located on the canine, deciduous first molar region. After initial periodontal treatment, excisional biopsy was performed under local anesthesia. The lesion was diagnosed as Peripheral Giant Cell Granuloma after clinical and pathological examination. DOI: http://dx.doi.org/10.3126/jcmc.v3i3.8635 Journal of Chitwan Medical College 2013; 3(3): 28-30

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Clinical Management of a Peri-Implant Giant Cell Granuloma

Case Reports in Dentistry ◽

10.1155/2015/976756 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7

Author(s):

A. Pacifici ◽

D. Carbone ◽

R. Marini ◽

G. L. Sfasciotti ◽

L. Pacifici

Keyword(s):

Giant Cell ◽

Dental Implant ◽

Correct Diagnosis ◽

Excisional Biopsy ◽

Giant Cell Granuloma ◽

Peripheral Giant Cell Granuloma ◽

Natural Teeth ◽

Implant Therapy

Purpose. Implant therapy plays an important role in contemporary dentistry with high rates of long-term success. However, in recent years, the incidence of peri-implantitis and implant failures has significantly increased. The peripheral giant cell granuloma (PGCG) rarely occurs in peri-implant tissues and it is clinically comparable to the lesions associated with natural teeth. Therefore, the study of possible diseases associated with dental implants plays an important role in order to be able to diagnose and treat these conditions.Materials and Methods. This report described a 60-year-old Caucasian male who presented a reddish-purple pedunculated mass, of about 2 cm in diameter, associated with a dental implant and the adjacent natural tooth.Results. An excisional biopsy was performed and the dental implant was not removed. Histological examination provided the diagnosis of PGCG. After 19-month follow-up, there were no signs of recurrence of peri-implantitis around the implant.Conclusion. The correct diagnosis and appropriate surgical treatment of peri-implant giant cell granuloma are very important for a proper management of the lesion in order to preserve the implant prosthetic rehabilitation and prevent recurrences.

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Peripheral Giant Cell Granuloma: A Case Report with Review on Its Histogenesis and Recurrence

Dental Journal of Advance Studies ◽

10.1055/s-0039-1688548 ◽

2019 ◽

Vol 07 (02) ◽

pp. 095-098

Author(s):

Deepti Garg Jindal ◽

Sandhya Singh Kushwaha ◽

Sonia Joshi ◽

Namita Sepolia ◽

Varun Jindal ◽

...

Keyword(s):

Case Report ◽

Oral Cavity ◽

Giant Cell ◽

Growth Potential ◽

Biological Behavior ◽

Ossifying Fibroma ◽

Giant Cell Granuloma ◽

Cell Hyperplasia ◽

High Tendency ◽

Peripheral Giant Cell Granuloma

AbstractGiant cell granulomas (GCGs) of the jaws are non-neoplastic lesions that arise either peripherally in periodontal ligament, mucoperiosteum, or centrally in the bone. Histologically, both peripheral and central giant cell granuloma are characterized by the presence of numerous multinucleated giant cells in a prominent fibrous stroma. Peripheral giant cell granuloma is an infrequent reactive, exophytic lesion of the oral cavity, also known as giant-cell epulis, osteoclastoma, giant cell reparative granuloma, or giant cell hyperplasia. It is the most common giant cell lesion of the jaws and originates from the connective tissue of the periosteum or from the periodontal membrane, in response to local irritation or chronic trauma. The lesion develops mostly in adults, commonly in the lower jaw, with slight female predilection although is uncommon in children. Clinically, it shows resemblance to pyogenic granuloma, peripheral ossifying fibroma, and many other peripheral lesions seen in the oral cavity, but in our case it resembled a squamous cell carcinoma, thereby histopathology is mandatory for the diagnosis of this lesion. The lesion although being relatively common, still has a lot of ambiguity. The ambiguity is in terms of its etiology, growth potential, biological behavior (recurrence), histogenesis of its cells, and its treatment. The entity further holds significance because of its notorious behavior and high tendency to recur. This is a case report of a 30-year-old female patient with history of swelling in the lower anterior region of jaw since 1 year. After complete excision of lesion, lesion reoccurred after few months.

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Peripheral giant cell granuloma associated with a dental implant

BMC Oral Health ◽

10.1186/s12903-019-0983-2 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Rafaela Carriço Porto Baesso ◽

Maria Carolina de Lima Jacy Monteiro Barki ◽

Rebeca de Souza Azevedo ◽

Karla Bianca Fernandes da Costa Fontes ◽

Débora Lima Pereira ◽

...

Keyword(s):

Giant Cell ◽

Histological Examination ◽

Dental Implant ◽

Excisional Biopsy ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Case Presentation ◽

Peripheral Giant Cell Granuloma ◽

Left Mandible

Abstract Background Peripheral giant cell granuloma (PGCG) is an uncommon pathology that affects gingival or alveolar mucosa. Although PGCG can be associated with dental implants, little is known about this lesion and implant osseointegration as well as its etiopathogenesis and the treatments available. This study sought to report a rare case of PGCG associated with dental implant, emphasizing its clinical and histopathological aspects. Case presentation A 53-year-old man had an exophytic, reddish lesion, around a crown attached to a dental implant located in the left mandible. Radiographically, there was bone loss around the implant. After excisional biopsy, histological examination revealed a submucosal proliferation of multinucleated giant cells rendering the diagnosis of peripheral giant cell granuloma. Patient has been under follow-up for 6 months with no recurrence. Conclusions Peri-implant lesions must be completely removed to prevent recurrence of PGCG and implant failure, even in cases suspected to be reactive. Besides, histological examination must be performed on all peri-implant reactions to achieve the appropriate diagnosis and, consequently, the best treatment and follow up.

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Peripheral Giant Cell Granuloma

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1119 ◽

2012 ◽

Vol 5 (1) ◽

pp. 46-48

Author(s):

Neha Chopra ◽

Sanjeev Puri ◽

Hemant Chopra

Keyword(s):

Giant Cell ◽

Stromal Cells ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Cell Hyperplasia ◽

Lower Jaw ◽

Periodontal Membrane ◽

Peripheral Giant Cell Granuloma ◽

Chronic Trauma ◽

Superficial Erosion

ABSTRACT The peripheral giant cell granuloma (PGCG), also known as osteoclastoma, giant cell reparative granuloma, giant cell epulis or giant cell hyperplasia, is a relatively frequent reactive benign exophytic lesion of the oral cavity originating from the periosteum or periodontal membrane following local irritation or chronic trauma. PGCG manifests as a red-purple nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells located in the region of the gums or edentulous alveolar margins, fundamentally in the lower jaw. The lesion can develop at any age, though it is more common between the fifth and sixth decades of life, and shows a slight female predilection. PGCG is a soft tissue lesion that very rarely affects the underlying bone, though the latter may suffer superficial erosion. Here, we present a case of PGCG who presented with the chief complaint of nasal blockade with a palatal mass. How to cite this article Chopra H, Puri S, Chopra N. Peripheral Giant Cell Granuloma. Clin Rhinol Int J 2012;5(1):46-48.

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A Review and Report of Peripheral Giant Cell Granuloma in a 4-Year-Old Child

Case Reports in Dentistry ◽

10.1155/2016/7536304 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Afsaneh Nekouei ◽

Alireza Eshghi ◽

Parisa Jafarnejadi ◽

Zahra Enshaei

Keyword(s):

Giant Cell ◽

Soft Tissue Mass ◽

Excisional Biopsy ◽

Definitive Diagnosis ◽

Giant Cell Granuloma ◽

Tissue Mass ◽

Anterior Maxilla ◽

Distinctive Features ◽

Hyperplastic Nodule ◽

Peripheral Giant Cell Granuloma

Peripheral giant cell granuloma is a common benign and reactive gingival epulis in oral cavity. It is often difficult to make a clinical diagnosis; thereby definitive diagnosis depends on histopathologic features. We report a case of a 4-year-old Caucasian boy presenting with a five-month history a 20 × 15 × 12 mm pedunculated, lobular soft tissue mass of the left anterior maxilla gingiva which was misdiagnosed and maltreated before his referral. An excisional biopsy of the lesion followed by histopathologic examination of the biopsy specimen revealed distinctive features of peripheral giant cell granuloma. Early detection and excision of this hyperplastic nodule especially in children are important to minimize potential dentoalveolar complications.

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Peripheral Giant Cell Granuloma Associated with a Dental Implant: A Case Report and Review of the Literature

Case Reports in Dentistry ◽

10.1155/2015/697673 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 9

Author(s):

Amy Louise Brown ◽

Paulo Camargo de Moraes ◽

Marcelo Sperandio ◽

Andresa Borges Soares ◽

Vera Cavalcanti Araújo ◽

...

Keyword(s):

Giant Cell ◽

Dental Implant ◽

Excisional Biopsy ◽

Giant Cells ◽

Infectious Agents ◽

Giant Cell Granuloma ◽

Review Of The Literature ◽

Peripheral Giant Cell Granuloma ◽

Foreign Body Reactions

The peripheral giant cell granuloma (PGCG) is a nonneoplastic lesion commonly caused by local irritation. This report describes a 46-year-old Caucasian male who presented with a PGCG associated with a dental implant. The dental implant was originally placed in August 2012. Ten months later, the patient presented with a well-circumscribed lesion associated with and covering the implant, at which time the lesion was excised. Four months later, due to recurrence of the lesion, a deeper and wider excisional biopsy with curettage of the adjacent bone was performed. No evidence of recurrence has been reported after 12 months of follow-up. Immunohistochemistry, using the antibody CD68, was performed to investigate the origin of the multinucleated giant cells, with their immunophenotype being similar to those of other giant cell lesions, including central giant cell granuloma, foreign-body reactions, and granulomatous reactions to infectious agents.

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Peripheral giant cell granuloma: a case repo

International Journal of Dental Research ◽

10.14419/ijdr.v4i2.6359 ◽

2016 ◽

Vol 4 (2) ◽

pp. 44

Author(s):

Saad Shahnawaz Ahmed ◽

Hira Zaman ◽

Fahad Bin Abrar ◽

Sadia Khalid

Keyword(s):

Giant Cell ◽

Stromal Cells ◽

Unknown Origin ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Cell Hyperplasia ◽

Peripheral Giant Cell Granuloma ◽

Good Healing ◽

Chronic Trauma

Peripheral giant cell granuloma (PGCG) is a common benign gingival lesion in the oral cavity of unknown origin, believed to be stimulated by local irritation or chronic trauma. It is also known as giant cell epulis, giant cell reparative granuloma, or giant-cell hyperplasia, presenting as purplish-red soft tissue nodule clinically and histologically consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. This case report describes a 40 year old male previously reported with peripheral giant cell granuloma 2 years back which on excision reoccurred after 3-4 months and persistently growing since then. The gingival lesion between his maxillary central incisors was excised and the Biopsy specimen sent in 10% formalin to histopathological lab and was diagnosed as PGCG. There was good healing of tissue of the surgical site during the 9 months follow-up.

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Peripheral Giant Cell Granuloma in a Child Associated with Ectopic Eruption and Traumatic Habit with Control of Four Years

Case Reports in Dentistry ◽

10.1155/2016/6725913 ◽

2016 ◽

Vol 2016 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Luiz Evaristo Ricci Volpato ◽

Cristhiane Almeida Leite ◽

Brunna Haddad Anhesini ◽

Jéssica Marques Gomes da Silva Aguilera ◽

Álvaro Henrique Borges

Keyword(s):

Giant Cell ◽

Tissue Injury ◽

Soft Tissue Injury ◽

Excisional Biopsy ◽

Oral Lesion ◽

Conservative Surgery ◽

Histopathological Analysis ◽

Giant Cell Granuloma ◽

Peripheral Giant Cell Granuloma ◽

Attached Gingiva

Peripheral giant cell granuloma (PGCG) is a nonneoplastic lesion that may affect any region of the gingiva or alveolar mucosa of edentulous and toothed areas, preferentially in the mandible and rarely occurring in children. This report describes the clinical and histopathological findings of a PGCG diagnosed in the maxilla of a 9-year-old boy associated with a tooth erupting improperly and a traumatic habit. The patient did not present anything noteworthy on extraoral physical examination or medical history, but the habit of picking his teeth and “poking” the gingiva. The oral lesion consisted of an asymptomatic, rounded, pink colored, smooth surface, soft tissue injury with fibrous consistency and approximated size of 1.5 cm located in the attached gingiva between the upper left permanent lateral incisor and the primary canine of the same side. Excisional biopsy was performed through curettage and removal of the periosteum, periodontal ligament, and curettage of the involved teeth with vestibular access. The histopathological analysis led to the diagnosis of PGCG. The prompt diagnosis and treatment of the PGCG resulted in a more conservative surgery and a reduced risk for tooth and bone loss and recurrence of the lesion. After four years of control, patient had no relapse of the lesion and good gingival and osseous health.

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