scholarly journals Peripheral Giant Cell Granuloma

2012 ◽  
Vol 5 (1) ◽  
pp. 46-48
Author(s):  
Neha Chopra ◽  
Sanjeev Puri ◽  
Hemant Chopra
Keyword(s):  
Giant Cell ◽  
Stromal Cells ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Cell Hyperplasia ◽  
Lower Jaw ◽  
Periodontal Membrane ◽  
Peripheral Giant Cell Granuloma ◽  
Chronic Trauma ◽  
Superficial Erosion

ABSTRACT The peripheral giant cell granuloma (PGCG), also known as osteoclastoma, giant cell reparative granuloma, giant cell epulis or giant cell hyperplasia, is a relatively frequent reactive benign exophytic lesion of the oral cavity originating from the periosteum or periodontal membrane following local irritation or chronic trauma. PGCG manifests as a red-purple nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells located in the region of the gums or edentulous alveolar margins, fundamentally in the lower jaw. The lesion can develop at any age, though it is more common between the fifth and sixth decades of life, and shows a slight female predilection. PGCG is a soft tissue lesion that very rarely affects the underlying bone, though the latter may suffer superficial erosion. Here, we present a case of PGCG who presented with the chief complaint of nasal blockade with a palatal mass. How to cite this article Chopra H, Puri S, Chopra N. Peripheral Giant Cell Granuloma. Clin Rhinol Int J 2012;5(1):46-48.

scholarly journals Peripheral giant cell granuloma: a case repo

2016 ◽  
Vol 4 (2) ◽  
pp. 44
Author(s):  
Saad Shahnawaz Ahmed ◽  
Hira Zaman ◽  
Fahad Bin Abrar ◽  
Sadia Khalid
Keyword(s):  
Giant Cell ◽  
Stromal Cells ◽  
Unknown Origin ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Cell Hyperplasia ◽  
Peripheral Giant Cell Granuloma ◽  
Good Healing ◽  
Chronic Trauma

Peripheral giant cell granuloma (PGCG) is a common benign gingival lesion in the oral cavity of unknown origin, believed to be stimulated by local irritation or chronic trauma. It is also known as giant cell epulis, giant cell reparative granuloma, or giant-cell hyperplasia, presenting as purplish-red soft tissue nodule clinically and histologically consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. This case report describes a 40 year old male previously reported with peripheral giant cell granuloma 2 years back which on excision reoccurred after 3-4 months and persistently growing since then. The gingival lesion between his maxillary central incisors was excised and the Biopsy specimen sent in 10% formalin to histopathological lab and was diagnosed as PGCG. There was good healing of tissue of the surgical site during the 9 months follow-up.

Aggressive behavior of peripheral giant cell granuloma: A case report

2021 ◽  
Vol 2 (4) ◽  
Author(s):  
Nadia Fathy Hassabou ◽  
◽  
Yasmine Alaa Eldin ◽  
Amina Fouad Farag ◽  
◽  
...  
Keyword(s):  
Giant Cell ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Periodontal Membrane ◽  
Neoplastic Lesion ◽  
Peripheral Giant Cell Granuloma ◽  
Chronic Trauma

Background: Peripheral Giant Cell Granuloma (PGCG) considered one of the commonest oral giant cell lesions and gingival epulis. It is probably a non neoplastic lesion but rather reactive in nature which originates from the periodontal membrane or the periosteum as a reaction to chronic trauma or local irritation. This article reports a case of PGCG in a 6 years old male patient complaining of massive gingival swelling associated with looseness of related teeth which is highly unlikely to occur with such lesions, that may lead to misdiagnosis. Material and method: Surgical excision followed by histopathological examination was performed and confirmed using CD34 and CD45 for detection and confirming the origin of multinucleated giant cells (MNGCs). Results: Immunopositivity for CD34 was demonstrated only as cytoplasmic reaction of endothelial cells lining blood vessels while negative reaction was observed in MNGCs or in stromal mononuclear cell. Moreover, cytoplasmic immunoreactivity for CD45 was revealed in MNGCs and few stromal cells. Conclusion: Correlating clinical, radiographic and histopathologic examination reaching definite and early diagnosis is mandatory for management of such lesions thus eliminating potential risk of damaging to adjacent hard tissue structures. Keywords: Peripheral giant cell granuloma; multinucleated giant cells; CD34; CD45.

scholarly journals Peripheral giant cell granuloma: a case report

2015 ◽  
Vol 3 (1) ◽  
pp. 606
Author(s):  
Kasim Kota ◽  
Ram Kodanda ◽  
V P Jaisekharan
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
The Other ◽  
Giant Cell Granuloma ◽  
Local Irritation ◽  
Periodontal Membrane ◽  
Peripheral Giant Cell Granuloma ◽  
Normal Occlusion ◽  
Chronic Trauma

Peripheral giant cell granuloma (PGCG) is a non neoplastic reactive lesion of the gingiva, originating from the periosteum or periodontal membrane following local irritation or chronic trauma. PGCG manifests as a red-purple growth located in the gingiva or edentulous alveolar margins. The lesion can develop at any age, shows a slight female predilection. Usually, they cause one or the other problem in eruption or alignment of teeth, but may also present without disturbing the normal occlusion or eruption pattern. Management of these teeth depends on the symptoms. Presented here is a case of PGCG in relation to the lower right  first premolar in a 10 year old child.

scholarly journals Peripheral Gingiva Giant Cell Granuloma: A Differential Diagnosis Approach among Gingival Overgrowths: A Case Report and a Brief Review of the Literature

2015 ◽  
Vol 19 (3) ◽  
pp. 141-144
Author(s):  
Theodoros Dervisoglou ◽  
Apostolos Matiakis ◽  
Thomas Zaraboukas
Keyword(s):  
Giant Cell ◽  
Accurate Diagnosis ◽  
Giant Cell Granuloma ◽  
Review Of The Literature ◽  
Soft Or ◽  
Giant Cell Lesion ◽  
Periodontal Membrane ◽  
Peripheral Giant Cell Granuloma ◽  
Chronic Trauma ◽  
Diagnosis Approach

SummaryPeripheral giant cell granuloma is the most common jaw located giant cell lesion. It originates from periosteum or from periodontal membrane as a response to local irritation or chronic trauma. It appears as a firm, soft or elastic nodule, sessile or pedunculated. Early and accurate diagnosis leads to sufficient management, minimizing possible damage of the adjacent tissues.This article reports the management of a peripheral giant cell granuloma in a 40-year-old male patient.

scholarly journals Management of recurrent peripheral giant cell granuloma -a case report

2016 ◽  
Vol 4 (2) ◽  
pp. 138
Author(s):  
Santha Kumari Prathypaty ◽  
Santhi Priya Potharaju ◽  
Ravi Kanth Chintala ◽  
Satheesh Kumar Guvvala ◽  
Jai Krishna Srikanth Kolliboyana
Keyword(s):  
Case Report ◽  
Giant Cell ◽  
Chronic Infection ◽  
Tooth Extraction ◽  
Benign Tumor ◽  
Surgical Excision ◽  
Giant Cell Granuloma ◽  
Complete Excision ◽  
Periodontal Membrane ◽  
Peripheral Giant Cell Granuloma

Peripheral giant cell granuloma (PGCG) which is also called as Giant cell Epulis is one of the most common reactive hyperplastic lesions of the oral cavity. There are various etiologies relating PGCG which include local irritation, trauma, tooth extraction, irregular restorations, plaque, calculus, chronic infection & impacted food. One important other etiology of this benign tumor is its origin from periosteum or periodontal membrane. Excision of the lesion completely along with extraction of involved tooth is the option of treatment to prevent recurrence of the lesion in some cases. This case report describes the recurrence of the Peripheral giant cell granuloma even after complete excision in 3 months.Management of recurrent Peripheral giant cell granuloma by surgical excision of the lesion was carried out along with extraction of the associated tooth and curettage of the bone walls. Profuse bleeding after tooth extraction was managed by gel-spun. Periodic recalls doesn’t show any recurrence until one month.

scholarly journals A rare coexistence of central giant cell granuloma and parathyroid adenoma: Case report

2021 ◽  
Vol 6 (2) ◽  
pp. 155-158
Author(s):  
Rohini Sebastian ◽  
Meethu Rappai
Keyword(s):  
Case Report ◽  
Connective Tissue ◽  
Parathyroid Adenoma ◽  
Giant Cell ◽  
Stromal Cells ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Bony Lesion

Central giant cell granuloma is a reparative bony lesion characterised by abundant multinucleated giant cells within a sea of spindle shaped mesenchymal stromal cells. Giant cells are scattered throughout the fibrovascular connective tissue stroma containing hemorrhage. Its coexistence with parathyroid adenoma is very rare. Brown tumour is a close differential in this scenario. Herein we present the case of a central giant cell granuloma of maxilla and parathyroid adenoma diagnosed almost during the same time in a 58 years old male.

scholarly journals Peripheral giant cell granuloma – case report

2016 ◽  
Vol 63 (3) ◽  
pp. 139-144
Author(s):  
Slavoljub Tomić ◽  
Bojana Davidović
Keyword(s):  
Giant Cell ◽  
Soft Tissue Tumor ◽  
Oral Lesion ◽  
Giant Cells ◽  
Vertical Position ◽  
Dental Arch ◽  
Giant Cell Granuloma ◽  
Maxillary Canine ◽  
Large Lesion ◽  
Peripheral Giant Cell Granuloma

Abstract Peripheral giant cell granuloma (PGCG) or “Epulis gigantocelularis” is the most common oral lesion that originates from giant cells. It typically manifests in the form of soft tissue tumor purple-red or red-watery color consisting of multinuclear giant cells in the mononuclear stroma and extravascular erythrocytes. This lesion is not considered true neoplasm, rather reactive lesion stimulated by local irritation and trauma. However, the cause is not known with certainty. This paper presents a 13-year-old boy with a large lesion in the region of right maxillary canine that was retained in jaw despite favorable vertical position and available space to accommodate in the dental arch. The lesion was completely removed under local anesthesia and histopathological findings confirmed the diagnosis of PGCG. Postoperative period went without complications. After four months additional surgical procedure was needed due to the recurrence, which after tooth naturally erupted and positioned in the dental arch.

scholarly journals Peripheral Giant Cell Granuloma: A Case Report with Review on Its Histogenesis and Recurrence

2019 ◽  
Vol 07 (02) ◽  
pp. 095-098
Author(s):  
Deepti Garg Jindal ◽  
Sandhya Singh Kushwaha ◽  
Sonia Joshi ◽  
Namita Sepolia ◽  
Varun Jindal ◽  
...  
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Giant Cell ◽  
Growth Potential ◽  
Biological Behavior ◽  
Ossifying Fibroma ◽  
Giant Cell Granuloma ◽  
Cell Hyperplasia ◽  
High Tendency ◽  
Peripheral Giant Cell Granuloma

AbstractGiant cell granulomas (GCGs) of the jaws are non-neoplastic lesions that arise either peripherally in periodontal ligament, mucoperiosteum, or centrally in the bone. Histologically, both peripheral and central giant cell granuloma are characterized by the presence of numerous multinucleated giant cells in a prominent fibrous stroma. Peripheral giant cell granuloma is an infrequent reactive, exophytic lesion of the oral cavity, also known as giant-cell epulis, osteoclastoma, giant cell reparative granuloma, or giant cell hyperplasia. It is the most common giant cell lesion of the jaws and originates from the connective tissue of the periosteum or from the periodontal membrane, in response to local irritation or chronic trauma. The lesion develops mostly in adults, commonly in the lower jaw, with slight female predilection although is uncommon in children. Clinically, it shows resemblance to pyogenic granuloma, peripheral ossifying fibroma, and many other peripheral lesions seen in the oral cavity, but in our case it resembled a squamous cell carcinoma, thereby histopathology is mandatory for the diagnosis of this lesion. The lesion although being relatively common, still has a lot of ambiguity. The ambiguity is in terms of its etiology, growth potential, biological behavior (recurrence), histogenesis of its cells, and its treatment. The entity further holds significance because of its notorious behavior and high tendency to recur. This is a case report of a 30-year-old female patient with history of swelling in the lower anterior region of jaw since 1 year. After complete excision of lesion, lesion reoccurred after few months.

scholarly journals Peripheral giant cell granuloma associated with a dental implant

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Rafaela Carriço Porto Baesso ◽  
Maria Carolina de Lima Jacy Monteiro Barki ◽  
Rebeca de Souza Azevedo ◽  
Karla Bianca Fernandes da Costa Fontes ◽  
Débora Lima Pereira ◽  
...  
Keyword(s):  
Giant Cell ◽  
Histological Examination ◽  
Dental Implant ◽  
Excisional Biopsy ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Case Presentation ◽  
Peripheral Giant Cell Granuloma ◽  
Left Mandible

Abstract Background Peripheral giant cell granuloma (PGCG) is an uncommon pathology that affects gingival or alveolar mucosa. Although PGCG can be associated with dental implants, little is known about this lesion and implant osseointegration as well as its etiopathogenesis and the treatments available. This study sought to report a rare case of PGCG associated with dental implant, emphasizing its clinical and histopathological aspects. Case presentation A 53-year-old man had an exophytic, reddish lesion, around a crown attached to a dental implant located in the left mandible. Radiographically, there was bone loss around the implant. After excisional biopsy, histological examination revealed a submucosal proliferation of multinucleated giant cells rendering the diagnosis of peripheral giant cell granuloma. Patient has been under follow-up for 6 months with no recurrence. Conclusions Peri-implant lesions must be completely removed to prevent recurrence of PGCG and implant failure, even in cases suspected to be reactive. Besides, histological examination must be performed on all peri-implant reactions to achieve the appropriate diagnosis and, consequently, the best treatment and follow up.

scholarly journals Peripheral Giant Cell Granuloma: A Case Report

2013 ◽  
Vol 3 (3) ◽  
pp. 31-32
Author(s):  
N Ghimire ◽  
P Nepal ◽  
N Ghimire
Keyword(s):  
Giant Cell ◽  
Excisional Biopsy ◽  
Pathological Examination ◽  
Giant Cell Granuloma ◽  
Cell Hyperplasia ◽  
Medical College ◽  
Large Size ◽  
Peripheral Giant Cell Granuloma ◽  
History Of ◽  
Molar Region

Peripheral giant cell granuloma is a benign reactive lesion of gingiva. It manifests as a firm, soft, bright nodule, sessile or pedunculate mass. It is an infrequent exophytic lesion of the oral cavity, also known as giant cell epulis, osteoclastoma, giant cell reparative granuloma, or giant-cell hyperplasia. The aim in publishing this report is to present the clinical, histo­pathological features and treatment of a peripheral giant cell granuloma case, which was seen in gingiva of a 10 year old male child, with history of disturbed chewing functions due to its large size. Intraoral examination revealed a raised, round, sessile, smooth-edged mass of size 2x 1 cm2 and was located on the canine, deciduous first molar region. After initial peri­odontal treatment, excisional biopsy was performed under local anesthesia. The lesion was diagnosed as Peripheral Giant Cell Granuloma after clinical and pathological examination. DOI: http://dx.doi.org/10.3126/jcmc.v3i3.8635 Journal of Chitwan Medical College 2013; 3(3): 28-30

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