scholarly journals Evaluation of Breast Lump by Fine Needle Aspiration Cytology

2017 ◽  
Vol 9 (2) ◽  
pp. 38-42
Author(s):  
Suman Poudel ◽  
S Ranabhat ◽  
B Parajuli ◽  
G Pun
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
College Teaching ◽  
Needle Aspiration ◽  
Breast Lump ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Medical College ◽  
Significant Difference ◽  
Needle Aspiration Cytology

Introduction: Fine needle aspiration cytology (FNAC) is the important part of triple assessment in diagnosing the palpable breast lump. It categorizes the lesion into benign, malignant and its subtypes. It can also identify the residual diseases after treatment.Methods: It was a cross sectional descriptive study of cases of breast lump carried out during June 2015 to May 2016 in the Department of Pathology, Gandaki Medical College Teaching Hospital, Pokhara, Nepal. All the patients presenting in Pathology Department with history of breast lump were examined in detail. FNAC was done by standard procedure; smears were prepared and stained with Giemsa and pap for evaluation. Histopathology slides were stained with hematoxylin and eosin stain and evaluated by pathologists in Gandaki Medical College Teaching Hospital.Results: The study showed that, fibroadenoma of breast is the commonest benign lesion among the young populations. Only 13.11% of breast lump is malignant in the elderly population.Conclusion: FNAC is one of the safest and cheapest procedure that can be done in outpatient department for the diagnosis of breast lump. And there is no significant difference in diagnosis made by FNAC and histopatholgy examination. Journal of Gandaki Medical CollegeVolume, 09, Number 2, July December  2016, Page: 38-42

Role of fine needle aspiration cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm

2014 ◽  
Vol 19 (2) ◽  
pp. 110-118
Author(s):  
Mohammad Amzad Hossain ◽  
Md Zahedul Alam ◽  
Md Rojibul Haque ◽  
Md Nazmul Haque ◽  
KM Nurul Alam ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Medical College ◽  
Preoperative Diagnostic ◽  
Needle Aspiration Cytology

Objective: To evaluate the role of Fine Needle Aspiration Cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm. Methods: This cross sectional study on 50 cases was conducted in the Department of Otolaryngology and Head-Neck Surgery of Sir Salimullah Medical College Mitford Hospital and Dhaka Medical College Hospital from January’2009 to June 2010. Results: Fine needle aspiration cytology findings of our all 50 cases were compared with postoperative histopathological reports. Out of the 50 cases, in 36(72%) cases of benign neoplasm and 7(14%) cases of malignant neoplasm, pre-operative FNAC findings and post operative histopathological findings were same. In 7 cases, FNAC and post operative histopathological findings did not matched. These were 2 (4%) false positive and 5 (10%) false negative result.In our study sensitivity of FNAC for reporting malignancy was 58.33%, specificity to rule out malignancy was 94.73% and overall accuracy in detecting malignant tumour was 86%. Positive predictive value and negative value were 77.77% and 87.80% respectively. It can be concluded that fine needle aspiration cytology is a safe, cheap and useful preoperative diagnostic tool in the diagnosis of malignancy in parotid and submandibular gland, but as fine needle aspiration cytology partly depends on operator skill, it may give false negative and false positive result. Conclusion: FNAC is a useful preoperative diagnostic tool for malignant parotid and submandibular glands with high specificity and sensitivity. DOI: http://dx.doi.org/10.3329/bjo.v19i2.17634 Bangladesh J Otorhinolaryngol 2013; 19(2): 110-118

Cytopathological Evaluation of Thyroid Lesions Based on Bethesda System in Patients Attending Birat Medical College and Teaching Hospital

2020 ◽  
Vol 22 (4) ◽  
pp. 260-265
Author(s):  
Neeta Kafle ◽  
B Koirala ◽  
SU Kafle ◽  
M Singh ◽  
A Sinha
Keyword(s):  
Teaching Hospital ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Medical College ◽  
Bethesda System ◽  
Needle Aspiration Cytology ◽  
Thyroid Lesions

More than 50% of the world’s population has at least a thyroid nodule. Detail clinical examination and radiology may help in diagnosing thyroid lesions but the management depends upon the cytopathological diagnosis. Optimum use of fine needle aspiration cytology (FNAC) and better understanding of cytomorphological characteristic of thyroid lesions by using Bethesda system, triaging of patients who are to be treated medically or surgically is more accurate. The objective of this present study is cytopathological evaluation of thyroid lesions based on Bethesda System in patients attending Birat Medical College and Teaching Hospital. The objective was also to correlate the cytological findings with histopathological findings where ever possible. A total of 104 patients with thyroid lesions underwent fine needle aspiration cytology in a period of a year (September 1, 2019 to August 31, 2020). Cytological features were evaluated and classified according to the Bethesda system. Histopathological features were evaluated and correlated wherever available. Among 104 patients with thyroid lesions 93 were female and 11 were male. Four cases turned out to be non diagnostic, 85 benign, three Atypia of undetermined significance, three Suspicious for follicular neoplasm and eight Suspicious of malignancy and one Malignant according to Bethesda system. Histopathology specimen was received in 31 patients out of whom 20 (64.5%) patients were reported as colloid nodule, two follicular adenoma, one Hurthle cell adenoma, six papillary carcinoma and two follicular carcinoma. Medullary carcinoma and anaplastic carcinoma were not seen in the patients evaluated. Specificity and sensitivity of fine needle aspiration cytology was 94.7% and 88.9% respectively. Thus reporting thyroid lesions FNAC with Bethesda system allow a more specific cytological diagnosis.

scholarly journals Cytopathological Evaluation of Thyroid by Fine Needle Aspiration Cytology and Correlation with T3 T4 and TSH Levels

2015 ◽  
Vol 3 (4) ◽  
pp. 37-41
Author(s):  
Suman Poudel ◽  
Sudeep Regmi ◽  
Anita Shahi ◽  
Ashok Samdurkar
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Thyroid Function Test ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Asymptomatic Patients ◽  
Significant Difference ◽  
Needle Aspiration Cytology ◽  
Thyroid Lesions

INTRODUCTION: Fine Needle Aspiration Cytology (FNAC) of the thyroid gland is now a well-established, first line diagnostic test for the evaluation of thyroid lesions. An FNA is performed along with Thyroid Function Test (TFT) profile to correlate cytology with hormonal function in symptomatic or asymptomatic patients. MATERIALAND METHODS: Total of 117 cases of FNAC of thyroid lesions were selected who had undergone TFT profile. The lesions were evaluated cytologically and categorized according to Bethesda System of classification and correlated with TFT profile. RESULTS: Out of 117 cases studied, the middle aged (20-49 years) females were most commonly affected by thyroid diseases. The predominant lesions cytologically were Benign Follicular Nodule (BFN) with frequency of 51.3%.With respect to hormonal status most of the lesions were Euthyroid (53.8%). The study showed no significant difference in mean of TFT profile with regard to various FNAC diagnoses. CONCLUSION: The study showed that FNAC and TFT profile both are essential for the proper management of thyroid lesions and, there is no significant difference between FNAC diagnosis and mean TFT profile.

scholarly journals Significance of Quadruple assessment of breast lump–A hospital based study

2014 ◽  
Vol 4 (8) ◽  
pp. 630-634
Author(s):  
MK Shrestha ◽  
D Ghartimagar ◽  
A Ghosh ◽  
E Shrestha ◽  
P Bolar
Keyword(s):  
Breast Cancer ◽  
Sensitivity And Specificity ◽  
Fine Needle Aspiration ◽  
Gold Standard ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lump ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Background: Approximately 10% of breast masses are breast cancer. It is important for women with a breast lump to receive appropriate evaluation. Mammography has been the “gold standard” in breast cancer detection for >40 years. Ultrasonography is non-invasive easily available, cheaper and accurate tool while Fine needle aspiration cytology has a high diagnostic accuracy rate in hands of experienced cytopathologist. Materials and methods: This was a retrospective and prospective study of 173 women attending radiology department in Manipal Teaching Hospital, Pokhara for mammography during a period of 18 months from January 2011 to June 2012.The age ranged from 20yrs to 75yrs. BIRADS score was given for both mammography and sonomammography. All malignant and suspicious cases had undergone fine needle aspiration cytology. Cytology reports were correlated with imaging study. Results: The most common age group for the breast lump was 40-49 years showing 65(37.57%) cases. Most lumps were seen on the left side 54.3% (94/ 173) cases and were seen in upper outer quadrant of the breast (74 cases). 11 cases each were given the BIRADS score of 4 in both mammography and sonomammography. Sensitivity and specificity of mammography and sonomammography were compared to cytologyreports. The sensitivity for mammogram was 73.7% while specificity was 96.3%. The sensitivity and specificity for sonomammogram was 78.9% and 95% respectively. Conclusion: Quadruple assessment i.e. clinical assessment, mammography, sonomammography and cytological study are the new “gold standard” in the investigation of breast disease. DOI: http://dx.doi.org/10.3126/jpn.v4i8.11499 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 630-634

scholarly journals Fine Needle Aspiration Cytology of Palpable Breast Lumps - Their Cytological Spectrum and Histopathological Correlation

KYAMC Journal ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 780-786
Author(s):  
Shaheen Akter ◽  
Md Jahidul Islam ◽  
Md Shariful Haque
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Breast Lump ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Histopathological Correlation ◽  
Palpable Breast ◽  
Needle Aspiration Cytology ◽  
Breast Lumps

Background: With the advent of fine needle aspiration cytology (FNAC), the approach to diagnosis and management of breast lumps has been revolutionized and it has high sensitivity and specificity.Aim: In this study we analyze the spectrum of FNAC diagnoses in breast lumps and compare the diagnostic accuracy of fine FNAC in differentiating the benign and malignant lesions of breast lumps with histopathological correlation.Materials & Methods: Two years prospective study was conducted in our institution and in that 490 aspirations, including 6 bilateral were performed. Suppurative and inflammatory lesions were excluded from the total aspirates. The cytological diagnosis was classified into 3 groups benign, suspicious and malignant. After this reporting all the available 94 cases were later subjected to mastectomy or open/excision biopsy and followed-up by histopathological confirmation. Later diagnostic accuracy of cytology reporting was compared with that of histopathology.Results: A total of 490 FNAC cases were reported including 373 as benign, 4 as suspicious for carcinoma and 113 as carcinoma. Majorities were premenopausal females and commonest age group was 31-40 years. Among them only 94 cases were followed-up by histopathologic confirmation. In histopathological correlation study, we had accuracy rate of 100% for benign lesion and 92.10% for malignant lesion with false negative rate of 7.90% and false positive rate of zero with fine needle aspiration cytology in the diagnosis of palpable breast lump. The overall sensitivity of fine needle aspiration in diagnosing the palpable breast lump is 92.10%, specificity is 100%, positive predictive value is 100% and negative predictive value is 94.91%.Conclusion: FNAC in experienced hands is a very useful tool with very high specificity and rare false positive result. Sensitivity can be further improved with clinical and imaging correlation.KYAMC Journal Vol. 7, No.-2, Jan 2017, Page 780-786

scholarly journals Evaluation of fine needle aspiration cytology (FNAC) in diagnosis of papulo-nodular skin lesion

2015 ◽  
Vol 5 (2) ◽  
pp. 342-344
Author(s):  
Ayesha Siddiqua ◽  
Nargis Akhtar ◽  
Lubna Khondaker ◽  
Md Aminul Islam ◽  
Md Mahabubur Rahaman ◽  
...  
Keyword(s):  
Skin Lesion ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Good Alternative ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Medical College ◽  
Needle Aspiration Cytology ◽  
Medical University

Objective : The objective of this study was to evaluate the accuracy of Fine Needle Aspiration Cytology (FNAC) in diagnosis of Papulonodular skin disease.Methodology : This prospective study was carried out in Bangabandhu Sheik Mujib Medical University (BSMMU) in the department of Dermatology and Veneral disease and department of Pathology. Study period was March 2012 to August 2012 (six months). Thirty (30) patients with papulonodular skin lesion for more than 6 weeks were enrolled. Data were collected and analysis was done by using SPSS.Results : Among 30 patients, 14 cases which were histopathologically diagnosed as epidermal inclusion cyst, pilar cyst, lipoma were also diagnosed positive by FNAC and accuracy were 100%. Rest 16 cases which were histopathologically positive as lupus vulgaris, prurigo nodularies,post –kala-a –zar dermal leishmaniasis, erythema nodosum, mycosis fungoides were diagnosed negative by FNAC . Overall accuracy of FNAC was only 46.7%.Conclusions : FNAC has significant limitation for diagnosis of papulonodular skin disease and not a good alternative to histopathology in diagnosis of papulonodular skin disease.Northern International Medical College Journal Vol.5(2) 2014: 342-344

scholarly journals Fine needle aspiration cytology - a powerful tool in the diagnosis of space occupying and mass lesions: a review

1970 ◽  
Vol 19 (2) ◽  
pp. 54-56
Author(s):  
Babul Osman Chowdhury ◽  
Md Shahab Uddin Ahamad ◽  
Mohammad Zobair
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
College Teachers ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Medical College ◽  
Needle Aspiration Cytology ◽  
Mass Lesions

doi: 10.3329/jcmcta.v19i2.3873Journal of Chittagong Medical College Teachers' Association 2008: 19(2):54-56

scholarly journals Diagnostic Utility of Cell Block Technique as an Adjunct Technique to Cytological Smears in Evaluation of Thyroid Aspirates on Fine Needle Aspiration Cytology

1969 ◽  
Vol 11 (4) ◽  
pp. 217-222
Author(s):  
Amreek Lal ◽  
Siyab Ahmad ◽  
Waseem Khan ◽  
Liaqat Ali ◽  
Mian Anwar Zeb ◽  
...  
Keyword(s):  
Informed Consent ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Diagnostic Utility ◽  
Cell Block ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Significant Difference ◽  
Needle Aspiration Cytology

Background: Fine needle aspiration cytology is a standard screening technique for the diagnosis and assessment of thyroidnodules. However, this approach has some drawbacks, such as false negative or positive outcomes and high rates ofunsatisfactory results.Objective: To describe the utility of cell block technique as an adjunct to conventional smear in the cytodiagnosis of thyroidepithelial lesions.Material and Methods: This Descriptive Cross-sectional study was done at the Pathology department of Saidu Group of TeachingHospital Saidu Sharif Swat from 1st November 2017 to 31st April 2018. Fine needle aspirates for both the direct smear and cell blockwere collected simultaneously from 60 patients, through non- probability convenient sampling. All patients having clinicallyenlarged thyroid, solitary or dominant thyroid nodule were included in the study.All patients below 22 years old and patients who didnot give informed consent were excluded. Ethical clearance was obtained from the ethical research committee before carrying outthe study. Written informed consent was taken from all the participating patients.Cellularity, obscuring background material, morphological and architectural preservation as well as cytodiagnosis on direct smearand cell block technique were compared. Data were analyzed using SPSS software version 21. McNemar's chi-square test wasapplied for significant difference. P-value of = 0.05 was considered significant.Results: Male to Female ratio was 1:7.5, (13%: 87%). The age ranged from 22 to 81 years with a mean age of 44.9 and standarddeviation of ±14.5 years. The study showed that the cell block technique has high cellularity, minimal obscuring background, betterarchitectural preservation and poor morphological preservation on cell block in comparison to direct smear. The majority of thecases were benign on both techniques. The unsatisfactory rate was reduced in cell block technique and showed additionalinformation in 13 % cases.Conclusion: The study demonstrated no significant difference in the diagnostic utility of both techniques.Keywords: Cell Block Cytopathology, FNAC, Mair et al criteria

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