Fine Needle Aspiration Cytology of Thyroid: Role as a first line investigation in children and young adults-A 5-year experience at a Medical College Teaching Hospital

Introduction: Fine needle aspiration cytology (FNAC) is the important part of triple assessment in diagnosing the palpable breast lump. It categorizes the lesion into benign, malignant and its subtypes. It can also identify the residual diseases after treatment.Methods: It was a cross sectional descriptive study of cases of breast lump carried out during June 2015 to May 2016 in the Department of Pathology, Gandaki Medical College Teaching Hospital, Pokhara, Nepal. All the patients presenting in Pathology Department with history of breast lump were examined in detail. FNAC was done by standard procedure; smears were prepared and stained with Giemsa and pap for evaluation. Histopathology slides were stained with hematoxylin and eosin stain and evaluated by pathologists in Gandaki Medical College Teaching Hospital.Results: The study showed that, fibroadenoma of breast is the commonest benign lesion among the young populations. Only 13.11% of breast lump is malignant in the elderly population.Conclusion: FNAC is one of the safest and cheapest procedure that can be done in outpatient department for the diagnosis of breast lump. And there is no significant difference in diagnosis made by FNAC and histopatholgy examination. Journal of Gandaki Medical CollegeVolume, 09, Number 2, July December 2016, Page: 38-42

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Role of fine needle aspiration cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm

Bangladesh Journal of Otorhinolaryngology ◽

10.3329/bjo.v19i2.17634 ◽

2014 ◽

Vol 19 (2) ◽

pp. 110-118

Author(s):

Mohammad Amzad Hossain ◽

Md Zahedul Alam ◽

Md Rojibul Haque ◽

Md Nazmul Haque ◽

KM Nurul Alam ◽

...

Keyword(s):

Submandibular Gland ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

False Negative ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Medical College ◽

Preoperative Diagnostic ◽

Needle Aspiration Cytology

Objective: To evaluate the role of Fine Needle Aspiration Cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm. Methods: This cross sectional study on 50 cases was conducted in the Department of Otolaryngology and Head-Neck Surgery of Sir Salimullah Medical College Mitford Hospital and Dhaka Medical College Hospital from January2009 to June 2010. Results: Fine needle aspiration cytology findings of our all 50 cases were compared with postoperative histopathological reports. Out of the 50 cases, in 36(72%) cases of benign neoplasm and 7(14%) cases of malignant neoplasm, pre-operative FNAC findings and post operative histopathological findings were same. In 7 cases, FNAC and post operative histopathological findings did not matched. These were 2 (4%) false positive and 5 (10%) false negative result.In our study sensitivity of FNAC for reporting malignancy was 58.33%, specificity to rule out malignancy was 94.73% and overall accuracy in detecting malignant tumour was 86%. Positive predictive value and negative value were 77.77% and 87.80% respectively. It can be concluded that fine needle aspiration cytology is a safe, cheap and useful preoperative diagnostic tool in the diagnosis of malignancy in parotid and submandibular gland, but as fine needle aspiration cytology partly depends on operator skill, it may give false negative and false positive result. Conclusion: FNAC is a useful preoperative diagnostic tool for malignant parotid and submandibular glands with high specificity and sensitivity. DOI: http://dx.doi.org/10.3329/bjo.v19i2.17634 Bangladesh J Otorhinolaryngol 2013; 19(2): 110-118

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Cytopathological Evaluation of Thyroid Lesions Based on Bethesda System in Patients Attending Birat Medical College and Teaching Hospital

Nepal Medical College Journal ◽

10.3126/nmcj.v22i4.34194 ◽

2020 ◽

Vol 22 (4) ◽

pp. 260-265

Author(s):

Neeta Kafle ◽

B Koirala ◽

SU Kafle ◽

M Singh ◽

A Sinha

Keyword(s):

Teaching Hospital ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Medical College ◽

Bethesda System ◽

Needle Aspiration Cytology ◽

Thyroid Lesions

More than 50% of the world’s population has at least a thyroid nodule. Detail clinical examination and radiology may help in diagnosing thyroid lesions but the management depends upon the cytopathological diagnosis. Optimum use of fine needle aspiration cytology (FNAC) and better understanding of cytomorphological characteristic of thyroid lesions by using Bethesda system, triaging of patients who are to be treated medically or surgically is more accurate. The objective of this present study is cytopathological evaluation of thyroid lesions based on Bethesda System in patients attending Birat Medical College and Teaching Hospital. The objective was also to correlate the cytological findings with histopathological findings where ever possible. A total of 104 patients with thyroid lesions underwent fine needle aspiration cytology in a period of a year (September 1, 2019 to August 31, 2020). Cytological features were evaluated and classified according to the Bethesda system. Histopathological features were evaluated and correlated wherever available. Among 104 patients with thyroid lesions 93 were female and 11 were male. Four cases turned out to be non diagnostic, 85 benign, three Atypia of undetermined significance, three Suspicious for follicular neoplasm and eight Suspicious of malignancy and one Malignant according to Bethesda system. Histopathology specimen was received in 31 patients out of whom 20 (64.5%) patients were reported as colloid nodule, two follicular adenoma, one Hurthle cell adenoma, six papillary carcinoma and two follicular carcinoma. Medullary carcinoma and anaplastic carcinoma were not seen in the patients evaluated. Specificity and sensitivity of fine needle aspiration cytology was 94.7% and 88.9% respectively. Thus reporting thyroid lesions FNAC with Bethesda system allow a more specific cytological diagnosis.

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Evaluation of fine needle aspiration cytology (FNAC) in diagnosis of papulo-nodular skin lesion

Northern International Medical College Journal ◽

10.3329/nimcj.v5i2.23133 ◽

2015 ◽

Vol 5 (2) ◽

pp. 342-344

Author(s):

Ayesha Siddiqua ◽

Nargis Akhtar ◽

Lubna Khondaker ◽

Md Aminul Islam ◽

Md Mahabubur Rahaman ◽

...

Keyword(s):

Skin Lesion ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Good Alternative ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Medical College ◽

Needle Aspiration Cytology ◽

Medical University

Objective : The objective of this study was to evaluate the accuracy of Fine Needle Aspiration Cytology (FNAC) in diagnosis of Papulonodular skin disease.Methodology : This prospective study was carried out in Bangabandhu Sheik Mujib Medical University (BSMMU) in the department of Dermatology and Veneral disease and department of Pathology. Study period was March 2012 to August 2012 (six months). Thirty (30) patients with papulonodular skin lesion for more than 6 weeks were enrolled. Data were collected and analysis was done by using SPSS.Results : Among 30 patients, 14 cases which were histopathologically diagnosed as epidermal inclusion cyst, pilar cyst, lipoma were also diagnosed positive by FNAC and accuracy were 100%. Rest 16 cases which were histopathologically positive as lupus vulgaris, prurigo nodularies,post kala-a zar dermal leishmaniasis, erythema nodosum, mycosis fungoides were diagnosed negative by FNAC . Overall accuracy of FNAC was only 46.7%.Conclusions : FNAC has significant limitation for diagnosis of papulonodular skin disease and not a good alternative to histopathology in diagnosis of papulonodular skin disease.Northern International Medical College Journal Vol.5(2) 2014: 342-344

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Fine needle aspiration cytology - a powerful tool in the diagnosis of space occupying and mass lesions: a review

Journal of Chittagong Medical College Teachers Association ◽

10.3329/jcmcta.v19i2.3873 ◽

1970 ◽

Vol 19 (2) ◽

pp. 54-56

Author(s):

Babul Osman Chowdhury ◽

Md Shahab Uddin Ahamad ◽

Mohammad Zobair

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

College Teachers ◽

Aspiration Cytology ◽

Fine Needle ◽

Medical College ◽

Needle Aspiration Cytology ◽

Mass Lesions

doi: 10.3329/jcmcta.v19i2.3873Journal of Chittagong Medical College Teachers' Association 2008: 19(2):54-56

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Fine needle aspiration cytology of the testis as the first-line diagnostic modality in azoospermia: a comparative study of cytology and histology

Cytopathology ◽

10.1111/j.1365-2303.2007.00485.x ◽

2008 ◽

Vol 19 (6) ◽

pp. 363-368 ◽

Cited By ~ 12

Author(s):

R. Mehrotra ◽

D. Chaurasia

Keyword(s):

Comparative Study ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

First Line ◽

Aspiration Cytology ◽

Diagnostic Modality ◽

Fine Needle ◽

Needle Aspiration Cytology

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Comparison between histopathology and fine needle aspiration cytology in the case of breast lumps

International Surgery Journal ◽

10.18203/2349-2902.isj20195129 ◽

2019 ◽

Vol 6 (11) ◽

pp. 4095

Author(s):

Vishnu V. K. ◽

Ashwini R. K. ◽

S. Rajagopalan

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Diagnostic Method ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Medical College ◽

Needle Aspiration Cytology ◽

Breast Lumps ◽

A Prospective Study

Background: Breast lump is one of the common pathologies seen in surgical practice. Hence it is of importance to have a reliable diagnostic method to distinguish between benign and malignant lumps. Aim of this study was to bring out fine needle aspiration cytology (FNAC) as a rapid, inexpensive, accurate and least invasive diagnostic method for this purpose.Methods: A prospective study conducted between December 2017 to November 2018 on all 30 patients admitted at Rajarajeswari Medical College and Hospital with breast lumps. Patients were subjected to clinical examination FNAC and Histopathology.Results: Clinically 64% were categorized as benign lumps and 36% malignant. On FNAC 64% were fibroadenoma, 30% suggestive of malignancy and 6% suspicious of malignancy. On Histopathology 60% were fibroadenoma, 33% turned out to be carcinoma and 7% benign phyllodes. 4% of benign lesions on FNAC turned out malignant on histopathology.Conclusions: Although son mammography is the conventional approach with a sensitivity of 76.5% and specificity of 90.48%, in this study FNAC was found to have sensitivity of 96.6% and specificity of 100% and can be a reliable tool for early diagnosis in the case of breast lumps.

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Evaluation of fine needle aspiration cytology of lymph nodes in Kathmandu Medical College, Teaching hospital

Kathmandu University Medical Journal ◽

10.3126/kumj.v7i2.2707 ◽

1970 ◽

Vol 7 (2) ◽

pp. 139-142 ◽

Cited By ~ 10

Author(s):

S Hirachand ◽

M Lakhey ◽

J Akhter ◽

B Thapa

Keyword(s):

Lymph Nodes ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

College Teaching ◽

Needle Aspiration ◽

Metastatic Carcinoma ◽

Aspiration Cytology ◽

Fine Needle ◽

Needle Aspiration Cytology ◽

Tubercular Lymphadenitis

Background: Fine Needle Aspiration Cytology (FNAC) is a simple and rapid diagnostic technique. Because of early availability of results, simplicity, minimal trauma and complications, the aspiration cytology is now considered a valuable diagnostic aid and is part and parcel of a pathologist's repertoire. Objectives: The aim of the study was to evaluate the results of fine needle aspiration cytology (FNAC) of lymph nodes in our institution in comparison to result of histopathology. Materials and methods: The present study on 130 patients of lymphadenopathy was conducted in the Department of Pathology Kathmandu Medical College Teaching hospital, Kathmandu from June 2006 to May 2008 (2 years). Results: In this series of FNAC cervical lymph nodes were 66 (50.76%), and axillary lymph nodes were 20 (15.38%). Male to female ratio of the patients was 1: 0.9. Th age of patients ranged from 3 to 85 years. FNAC diagnosis was found to be as follows : reactive hyperplasia 54( 41.55%), tubercular lymphadenitis 36 (28 %), metastatic carcinoma 16 (12.3%), granulomatous lymphadenitis 12 ( 9.2 % ), lymphoma 8 (6%) and suppurative lymphadenitis 4(3%). Out of 28 cases of FNAC 26 (92.85%) were consistent with histopathological diagnosis of tubercular lymphadenitis. In metastatic carcinoma to lymph nodes sensitivity and specificity of FNAC were 100% each. Conclusion: FNAC is useful and reliable in diagnosing neoplastic and non- neoplastic lesions of lymph nodes. It helps in planning surgery for malignant cases, where definitive operative intervention can be performed in one session. Key words: FNAC; lymphadenopathy. DOI: 10.3126/kumj.v7i2.2707 Kathmandu University Medical Journal (2009) Vol.7, No.2 Issue 26,139-142

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Fine needle aspiration cytology as a first line investigation in cervical swellings of 470 cases

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20184051 ◽

2018 ◽

Vol 6 (10) ◽

pp. 3385

Author(s):

Bhavna G. Gamit ◽

Mubin I. Patel ◽

Mandakini M. Patel ◽

Sharmistha M. Patel

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Invasive Technique ◽

First Line ◽

Aspiration Cytology ◽

Fine Needle ◽

Granulomatous Lymphadenitis ◽

Needle Aspiration Cytology ◽

Reactive Hyperplasia

Background: Fine needle aspiration cytology (FNAC) is a first line investigation in cervical swellings. The etiology varies from an inflammatory process to a malignant condition.Methods: The study was carried out in department of Pathology, Government Medical College, affiliated with government hospital in Gujarat. There were 470 patients with cervical swelling in a period from January 2017 to December 2017. Patients with thyroid swelling (swelling moves with deglutition) were excluded from the study. FNAC procedure was performed, smears prepared, stained with haematoxylin and eosin (H and E), May Grunwald Giemsa (MGG) and Pap stain. Zeihl Neelsen stain was carried out when required. Patient history, local examination findings and microscopic findings were recorded.Results: Total 470 patients, age ranged from 2 months to 90 years were studied. There were 286 males and 184 females. There were 449 cases in which conclusive opinion given. 111 cases were neoplastic and 338 cases were non-neoplastic. Various cytological diagnosis were; 207 cases of granulomatous lymphadenitis (tuberculosis), 1 case of filarial lymphadenitis, 72 cases of chronic reactive hyperplasia, 25 cases of acute suppurative inflammation, 1 case of sialadenitis, 10 cases of keratinous cyst, 6 cases of benign cystic lesion, 12 cases of lipoma, 4 cases of lymphoproliferative lesion, 1 cases of benign appendage tumor, 2 cases of mucoepidermoid carcinoma, 103 cases of metastasis and 5 cases of non Hodgkin lymphoma.Conclusions: FNAC is a simple, quick, inexpensive and minimally invasive technique to diagnose cervical swellings. It can differentiate the infective process from neoplastic one and avoids unnecessary surgeries.

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