scholarly journals Association of Plasma and Aqueous Humor Ascorbic Acid Level with Morphology Pattern of Age-Related Cataract

2020 ◽  
Vol 9 (1) ◽  
pp. 36-40
Author(s):  
Shailesh Mani Pokharel ◽  
Poonam Lavaju ◽  
Bhuwan Govinda Shrestha ◽  
Seraj Ahmed Khan ◽  
Sangeeta Shah

Background: Age-related cataract is one of the most important causes of preventable blindness among elderly population in the world. Among various causes of cataract, the level of ascorbic acid in the plasma and aqueous humor is an important parameter that can prevent cataract formation. The level of ascorbic acid in the plasma and aqueous humor is also an indicator of various morphological pattern of cataract. Materials and Methods: A hospital-based cross-sectional study was conducted among 136 patients with immature age-related cataract (≥50 years) who underwent Manual Small Incision Cataract Surgery in the Ophthalmology Department of BPKIHS for the duration of 1 year. Plasma and aqueous humor ascorbic acid levels were determined by standard competitive ELISA test. Results: Ascorbic acid concentrations in aqueous humor as well as plasma were statistically significant with the nuclear type of cataract (p<0.001). There was a positive correlation between plasma and aqueous ascorbic acid level with r = 0.532 and p<0.001. Conclusion: The finding of the study concludes that nuclear type of cataract has a strong association with both aqueous humor and plasma ascorbic acid level.

1998 ◽  
Vol 8 (6) ◽  
pp. 378-383 ◽  
Author(s):  
Shoichiro Tsugane ◽  
Michael T. Fahey ◽  
Minatsu Kobayashi ◽  
Satoshi Sasaki ◽  
Yoshitaka Tsubono ◽  
...  

1940 ◽  
Vol 44 (2) ◽  
pp. 495-499 ◽  
Author(s):  
C. J. Farmer ◽  
A. F. Abt ◽  
H. C. S. Aron

Author(s):  
Hakan Ozan ◽  
Ahmet Esmer ◽  
Nedret Kolsal ◽  
Ömer Utku Çopur ◽  
Bülent Ediz

1979 ◽  
Vol 41 (3) ◽  
pp. 409-411 ◽  
Author(s):  
S. Vallance

1. During the course of a nutritional survey on an Antarctic base, leucocyte ascorbic acid estimations (Denson & Bowers, 1961) were found to be significantly affected (P < 0.0001) by the leucocyte count measured during analysis.2. The effect was significantly less (P < 0.05) when leucocyte levels were at or near saturation than when subsaturated.3. This suggests that leucocytes share available ascorbic acid, especially in subsaturated subjects, and that assessment of nutritional status from the leucocyte ascorbic acid level should take account of the leucocyte count and the plasma ascorbic acid titre.


Blood ◽  
1983 ◽  
Vol 62 (3) ◽  
pp. 532-537
Author(s):  
L Toy ◽  
EA Young ◽  
JB Longenecker

Blood levels of ascorbic acid, vitamin A, folic acid, and amino acids were studied in patients at the South Texas Comprehensive Hemophilia Center, San Antonio, TX. The mean plasma ascorbic acid level in hemophiliacs was significantly lower than controls (p less than 0.0001). This was observed despite a dietary ascorbic acid intake in excess of 66% of the Recommended Dietary Allowances (RDA). However, those subjects receiving specific factor replacement therapy at home and consuming at least 66% RDA of ascorbic acid maintained a mean plasma ascorbic acid level not significantly less than controls. Hemophilic subjects not on home therapy, on the other hand, had a mean plasma ascorbic acid level significantly below that of controls while receiving optimal dietary ascorbic acid. With prompt adequate medical care of bleeding episodes and with optimal nutrition, the demand for ascorbic acid needed for tissue repair in hemophilic patients may be lessened. Hemophiliacs had mean serum vitamin A, mean serum folate, and mean red cell folate levels that were not significantly different from controls. Significantly higher mean plasma arginine and lower, but not significantly lower, mean plasma ornithine levels were found in hemophilic subjects, suggesting altered arginase activity.


Blood ◽  
1983 ◽  
Vol 62 (3) ◽  
pp. 532-537 ◽  
Author(s):  
L Toy ◽  
EA Young ◽  
JB Longenecker

Abstract Blood levels of ascorbic acid, vitamin A, folic acid, and amino acids were studied in patients at the South Texas Comprehensive Hemophilia Center, San Antonio, TX. The mean plasma ascorbic acid level in hemophiliacs was significantly lower than controls (p less than 0.0001). This was observed despite a dietary ascorbic acid intake in excess of 66% of the Recommended Dietary Allowances (RDA). However, those subjects receiving specific factor replacement therapy at home and consuming at least 66% RDA of ascorbic acid maintained a mean plasma ascorbic acid level not significantly less than controls. Hemophilic subjects not on home therapy, on the other hand, had a mean plasma ascorbic acid level significantly below that of controls while receiving optimal dietary ascorbic acid. With prompt adequate medical care of bleeding episodes and with optimal nutrition, the demand for ascorbic acid needed for tissue repair in hemophilic patients may be lessened. Hemophiliacs had mean serum vitamin A, mean serum folate, and mean red cell folate levels that were not significantly different from controls. Significantly higher mean plasma arginine and lower, but not significantly lower, mean plasma ornithine levels were found in hemophilic subjects, suggesting altered arginase activity.


1999 ◽  
Vol 54 (9-10) ◽  
pp. 830-833 ◽  
Author(s):  
Akira Wadano ◽  
Mitsuharu Azeta ◽  
Shin-ichi Itotani ◽  
Ai Kanda ◽  
Toshio Iwaki ◽  
...  

Grafting is an easy way to produce a new seedling, which can tolerate against various stresses. During the acclimation after grafting, however, the seedlings still suffer a severe water stress. It is well known that water stress produces active oxygen to oxidize ascorbic acid. The concentration of ascorbic acid in the leaves was analyzed by HPLC equipped with an electrochemical detector. The column used was SP-120-5-ODS-BP (DAISO, JAPAN) and elution was performed with 0.1 ᴍ phosphate buffer, pH 3.0. After grafting the seedlings were acclimated under a 6-hr light/dark regimen. The content of ascorbic acid increased gradually during 2 days compared with control. The ascorbate peroxidase showed about constant activity, so the increase of ascorbic acid may be due to its requirement to cure the grafting


2013 ◽  
pp. 7-14
Author(s):  
Khursheed Jahan ◽  
Maksuda Parvin ◽  
Abdullah Ibn Mafiz

Background: Nutritional status in relation to selected biochemical parameters and also nutrient intakes in the pre-eclampsia and eclampsia was assessed in 52 patients and compared with that of 52 normal pregnant (NP) women. Serum calcium, ascorbic acid and blood Hb levels in the pre-eclamptic and eclamptic patients were significantly lower than the values of NP women. By unpaired t-test demonstrated in our study, the serum calcium, ascorbic acid and blood Haemoglobin (Hb) level were highly significantly different but not correlated with each other when compared among these groups. However, total statistical analysis revealed that among all the factors studied serum calcium level, ascorbic acid level and blood Hb level have effect on nutritional status of pre-eclampsia and eclampsia.DOI: http://dx.doi.org/10.3329/bjnut.v24i0.14032 Bangladesh J. Nutr. Vol. 24-25 Dec 2011-2012 pp.7-14


1983 ◽  
Vol 38 (1) ◽  
pp. 26-30 ◽  
Author(s):  
R. Sasaki ◽  
T. Kurokawa ◽  
S. Tero-kubota

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