scholarly journals Histomorphological Mimickers of benign prostatic lesions with prostatic adenocarcinoma

2021 ◽  
Vol 11 (1) ◽  
pp. 1859-1863
Author(s):  
Priyanka Sangappa Murgod ◽  
Preeti Rajeev Doshi ◽  
Amit Ravindra Nisal ◽  
Ravindra Chandrashekar Nimbargi
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Intraepithelial Neoplasia ◽  
Clinical History ◽  
Prostate Adenocarcinoma ◽  
Prostatic Adenocarcinoma ◽  
Cell Hyperplasia ◽  
Histopathological Features ◽  
Serum Prostate Specific Antigen ◽  
Prostatic Diseases

Background: The prostate is a walnut-sized organ that surrounds the urethra. More than 99% of prostate cancers are prostatic adenocarcinoma. It is the second most commonly occurring cancer in men and the fourth most commonly occurring cancer in India and all over the world. Numerous lesion of the prostate are very similar to prostate cancer, hence awareness is very important. This study aimed to determine the histopathological features of prostate adenocarcinoma and its common mimickers.Materials and Methods: A retrospective study of histopathological features of radical prostatectomy and transurethral resection of the prostate specimens, sent to the department of pathology for a period of one year. A brief clinical history and serum prostate-specific antigen levels were noted.Results: The surgical specimens of 303 cases of prostatic diseases were studied. Benign prostatic hyperplasia was the most frequent diagnosis in 192 patients followed by Prostate adenocarcinoma seen in 80 patients. Prostatic intraepithelial neoplasia formed the predominant mimicker (5.9%), followed by basal cell hyperplasia (3.0%). Serum prostate-specific antigen was seen in the range of 1.73 - 100 ng/ml in the cases of adenocarcinoma. In the mimics, prostate-specific antigen was in the range of 1.2- 18ng/ml.Conclusions: Biopsy remains a gold standard for the diagnosis of adenocarcinoma and its mimickers. The lesions in this study were diagnosed on hematoxylin and eosin staining.

Nuclear Deoxyribonucleic Acid Ploidy and Serum Prostate Specific Antigen in Operable Prostatic Adenocarcinoma

1990 ◽  
Vol 144 (2 Part 1) ◽  
pp. 303-306 ◽  
Author(s):  
Ofer Nativ ◽  
Robert P. Myers ◽  
George M. Farrow ◽  
Terry M. Therneau ◽  
Horst Zincke ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Deoxyribonucleic Acid ◽  
Specific Antigen ◽  
Prostatic Adenocarcinoma ◽  
Serum Prostate Specific Antigen ◽  
Nuclear Deoxyribonucleic Acid

scholarly journals Histopathological study of prostatic lesions in correlation with serum prostate specific antigen levels in elderly men

2020 ◽  
Vol 8 (9) ◽  
pp. 3304
Author(s):  
Nikhil S. Deshpande ◽  
Swati V. Dahe ◽  
Anil B. Munemane ◽  
Gajanan D. Dhokikar ◽  
Ravindra R. Karle
Keyword(s):  
Prostate Specific Antigen ◽  
Single Case ◽  
Transitional Cell ◽  
Specific Antigen ◽  
Intraepithelial Neoplasia ◽  
Significant Rise ◽  
Histopathological Study ◽  
Benign Lesions ◽  
Elderly Men ◽  
Cell Hyperplasia

Background: Prostatic lesions are common among elderly men with urinary complaints. Variety of prostatic lesions range from inflammatory, benign to malignant pathologies. The Prostate specific antigen (PSA) is secreted by glandular epithelium of prostate shows raised serum levels in these pathologies. Usually significant rise is commonly associated with Prostatic adenocarcinomas (PCa) with exceptions.Methods: In this retrospective study, total 63 diagnosed cases of prostatic lesions over a one-year period for which serum PSA levels were available, were selected. Cases without serum PSA levels & inadequate biopsies were excluded. Histological diagnosis of prostatic lesions reconfirmed and its correlation with serum PSA was done.Results: Study included patients with mean age 67.84 years (range: 48-60) at the time of diagnosis. Benign lesions were commonest prostatic lesions accounting for total 54 cases (85.71%) out of which 38 were of Benign prostatic hyperplasia (BPH), 14 cases of BPH with prostatitis while single case each for BPH with granulomatous prostatitis and basal cell hyperplasia. Mean PSA value for benign lesions was 6.57 ng/ml. Total 8 were malignant which included 7 (11.11%) PCa while single (1.59%) case of metastatic transitional cell carcinoma. Mean PSA for PCa were 35.05 ng/ml. Single case (1.59%) of high grade prostatic intraepithelial neoplasia also detected.Conclusion: Common age group at the time of presentation of prostatic pathologies is 60-70 years. The most common prostatic lesions are benign predominantly BPH. PCa are commonest malignancies. Elevated PSA levels >20 ng/ml are commonly observed in PCa. However lower or normal values don’t rule out PCa.

Prostate-Specific Antigen Expression and Lipochrome Pigment Granules in the Differential Diagnosis of Prostatic Adenocarcinoma Versus Seminal Vesicle–Ejaculatory Duct Epithelium

1999 ◽  
Vol 123 (11) ◽  
pp. 1093-1097 ◽  
Author(s):  
Vinod B. Shidham ◽  
Paul F. Lindholm ◽  
André Kajdacsy-Balla ◽  
Zainab Basir ◽  
Varghese George ◽  
...  
Keyword(s):  
Seminal Vesicle ◽  
Prostate Specific Antigen ◽  
Ejaculatory Duct ◽  
Specific Antigen ◽  
Intraepithelial Neoplasia ◽  
Antigen Expression ◽  
Prostatic Adenocarcinoma ◽  
Pigment Granules

Abstract Background.—Lipochrome pigment granules (LPGs) and prostate-specific antigen (PSA) localization have been cited as helpful adjuncts in differentiating atypical histologic patterns of seminal vesicle–ejaculatory duct (SVED) from prostatic adenocarcinoma. However, LPGs have been described in both benign and neoplastic prostatic acini, and PSA expression within the intraprostatic SVED has not been fully explored. Design.—Fifty radical prostatectomy specimens were studied for LPGs and 9 cases for PSA expression. Results.—Two morphologic types of LPGs (type 1 and type 2) were observed. The reproducibility in classifying LPGs was evaluated by κ statistics, which demonstrated a strong agreement between 4 observers. Type 1 was restricted to SVED in all 50 specimens. Type 2 was subclassified into 2A and 2B. Type 2 LPGs were observed in prostatic acini of different zones, high-grade prostatic intraepithelial neoplasia, prostatic adenocarcinoma, and occasionally with type 1 LPG in SVED. Focal reactivity for PSA in the distal portion of SVED near urethra was noted in 1 of 9 cases. Conclusion.—Awareness about morphologic differences between the 2 types of LPGs could help to avoid a potential diagnostic pitfall of misinterpreting SVED epithelium for adenocarcinoma. Caution is recommended in interpreting PSA expression, since rare focal PSA reactivity was observed in the distal SVED.

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