The Correlation Between Fine Needle Aspiration Cytology and Histopathology of Head and Neck Lesions in Kathmandu University Hospital

Background Fine needle aspiration cytology (FNAC) with it’s minimally invasiveness has been a well accepted procedure in the initial diagnosis of various swellings. With time and experience high sensitivity and specificity of FNAC over conventional open biopsy has lead to the wide acceptance of this procedure.Objective To evaluate the utility of aspiration cytology as a first-line diagnostic tool in palpable head and neck masses and correlate with histologic results for evaluating diagnostic accuracy.Methods A hospital based prospective, comparative study was conducted among patients with various swellings at Head and Neck regions in the Department of Pathology, Dhulikhel Hospital between July 2011 to June 2012. FNAC were done from the palpable masses of head and neck regions and were compared with biopsy findings of the same lesions. Data entry and analysis performed using SPSS version 16. The sensitivity, specificity and accuracy rates were calculated.Results A total 64 patients were subjected to both FNAC and histopathological examination (HPE). Total 39 (61 %) were females and 25 (39 %) were males with M: F ratio of 1:1.6. The age group ranged from 9 to 80 years. Twenty five percent of patients were in the age group below 20 years. The highest number of cases included lymph nodes 29 (45%) followed by thyroid 24(37.5 %), salivary glands 10(16%) and 1 case (1.6%) was a soft tissue swelling over the occipital region. Highest sensitivity, specificity and accuracy rate for diagnosis by FNAC were observed in thyroid. The overall sensitivity and specificity of FNAC were 86% and 97% respectively in determining the various pathologies. The overall accuracy of FNAC in present study was 87.4%.Conclusion FNAC is a minimally invasive first line investigation with a high sensitivity and specificity for the diagnosis of various head and neck lesionsKathmandu Univ Med J 2013; 11(4): 296-299

Download Full-text

Role of fine needle aspiration cytology (FNAC) in head and neck neoplasms with histopathological correlation

National Journal of Clinical Anatomy ◽

10.1055/s-0039-3401554 ◽

2015 ◽

Vol 04 (02) ◽

pp. 80-85

Author(s):

Junu Devi ◽

Kunja Lal Talukdar

Keyword(s):

Lymph Node ◽

Head And Neck ◽

Fine Needle Aspiration ◽

Head And Neck Neoplasms ◽

Fine Needle Aspiration Cytology ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Needle Aspiration Cytology ◽

Sensitivity Specificity

Abstract Background : Fine needle aspiration cytology is a simple, quick,inexpensive and minimally invasive technique used to diagnose head and neck neoplasms commonly originated from cervical lymph node, thyroid, parotid and other salivary glands. In this study a correlation was done between cytology and histopathology whenever surgical specimens were available. Aim : To assess the frequency of various benign and malignant neoplasms in different age groups and to evaluate the sensitivity, specificity of fine needle aspiration cytology(FNAC) in head and neck neoplasms. Materials and method : The study was conducted between September 2011 to August 2013 and total 249 cases of head and neck neoplasms were analysed. Patients between 1 to 80 years were included in the study. Fine needle aspiration cytology (FNAC) diagnosis was correlated with histopathology whenever possible. Results: Out of 249 head and neck neoplasms 55.42% were from lymph node, 19.28% were from salivary gland, 14.86% were from thyroid gland, 1.20% were nasal mass, 9.24% from other sites (skin and soft tissue). M:F was 1.4:1. Most commonly affected age group was 51-60 years. Metastatic squamous cell carcinoma was most commonly encountered neoplastic lesion. Overall sensitivity, specificity oflme needle aspiration cytology(FNAC) were 97.92% and 91.67% respectively. Conclusion : Fine needle aspiration cytology is a highly sensitive, specific and has a definite role in diagnosing most of the head and neck neoplasms.

Download Full-text

Accuracy of fine needle aspiration cytology in diagnosis of thyroid swelling

Journal of Pathology of Nepal ◽

10.3126/jpn.v3i6.8988 ◽

2013 ◽

Vol 3 (6) ◽

pp. 433-436 ◽

Cited By ~ 1

Author(s):

S Hirachand ◽

M Maharjan ◽

M Lakhey ◽

R Thapa ◽

S Kafle

Keyword(s):

Thyroid Gland ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

High Sensitivity ◽

Needle Aspiration ◽

Histopathological Diagnosis ◽

Aspiration Cytology ◽

Fine Needle ◽

Needle Aspiration Cytology ◽

Sensitivity Specificity

Background: Fine needle aspiration cytology has been shown to be simple, safe, cost effective and quick to perform procedure with excellent patient compliance. It is a well established technique for preoperative investigation of thyroid gland swellings with high sensitivity, specificity and accuracy. The aim of this study was to determine the accuracy of fine needle aspiration cytology of thyroid swellings performed at our institution. Materials and Methods: This study was carried out at Kathmandu Medical College and Teaching hospital, department of Pathology over a period of 3 years (January 2010 to December 2012). Two hundred and seventy three patients of all age groups and both sexes who underwent fine needle aspiration cytology for thyroid swelling were evaluated. Out of 273 patients, histopathological diagnosis was available in 45 patients. Results: Fine needle aspiration cytology result revealed 245 cases (89.7%) as non-neoplastic, 21 cases (7.7%) as neoplastic and 7 cases (2.6%) inadequate due to lack of cellularity. The commonest lesion in the thyroid gland was colloid goiter. Among the malignant neoplasms the commonest was papillary carcinoma. Out of 273 patients, histopathological diagnosis was available in 45 patients. Statistical analysis of our data shows the diagnostic accuracy of fine needle aspiration cytology to be 95.7%. Fine needle aspiration cytology showed a sensitivity of 96.4% and a specificity of 94.4%. Conclusion: Fine needle aspiration cytology is a well established technique for pre operative investigation of thyroid gland swellings with high sensitivity, specificity and accuracy. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8988Journal of Pathology of Nepal (2013) Vol. 3, 433-436

Download Full-text

FINE NEEDLE ASPIRATION CYTOLOGY

The Professional Medical Journal ◽

10.29309/tpmj/2011.18.03.2320 ◽

2011 ◽

Vol 18 (03) ◽

pp. 386-389

Author(s):

SHER UZ ZAMAN BHATTI ◽

SAIF UL MALOOK ◽

M TARIQ ◽

Ali Zulqurnain

Keyword(s):

Sensitivity And Specificity ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Thyroid Nodules ◽

High Sensitivity ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Cross Sectional ◽

Fine Needle ◽

Needle Aspiration Cytology

Introduction: Goiter is a common problem in southern Punjab and thyroid surgery is frequently performed in surgical units of BVH Bahawalpur. Fine Needle Aspiration Cytology is the investigation of choice in detection of carcinoma thyroid. It is simple and quick to perform and can be readily repeated. Objectives: The aim of the study was to find out the diagnostic accuracy of FNAC in thyroid nodules. Study Design: Cross sectional study. Period: June 2009 to November 2009. Setting: Department of Surgery, BVH Bahawalpur. Methods: Fifty patients of goiter of age ranging from 16to60 years, irrespective of gender, presenting with a thyroid nodule and undergoing surgery were included in the study at Department of Surgery, BVH Bahawalpur. Information of each patient was collected on a structural Performa and then analyzed on SPSS to assess the sensitivity and specificity of the FNAC. Results: the sensitivity and specificity of FNAC was 72.2% and 97.8% respectively. Conclusions: FNAC should be performed in all cases of thyroid nodules because of its high sensitivity and specificity to diagnose the benign as well as the malignant lesions of thyroid.

Download Full-text

A study of correlation of pre-operative fine needle aspiration cytology and ultrasonography with post-operative histopathology in thyroid swellings

International Surgery Journal ◽

10.18203/2349-2902.isj20201851 ◽

2020 ◽

Vol 7 (5) ◽

pp. 1456

Author(s):

Rajkumar Parameshwar Narayanakar ◽

Darshan Saligrama Govinda Shetty

Keyword(s):

Sensitivity And Specificity ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Histopathological Examination ◽

High Sensitivity ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Malignant Lesions ◽

Needle Aspiration Cytology

Background:Diseases of the thyroid gland can be due to inflammatory and neoplastic causes. Many diagnostic tests like ultrasound, thyroid nuclear scan and fine needle aspiration cytology (FNAC) are available for their evaluation. Histopathologically, they can be adenomas, colloid nodules, cysts, infectious nodules, lymphocytic or granulomatous nodules, congenital abnormalities or hyperplasia, or various types of malignancy. It is therefore crucial to have a clear diagnostic approach to ensure patients are managed appropriately and are not over or under-treated. Present study was done to evaluate FNAC and ultrasonography (USG) as a diagnostic method in thyroid swellings and to plan surgery accordingly.Methods: A prospective observational study was conducted among 60 adult patients undergoing thyroid surgery at Victoria and Bowring and Lady Curzon Hospital. They were investigated with FNAC and USG of thyroid, and were subjected to surgery and subsequent histopathological examination. The histopathological examination reports were correlated with the findings of FNAC and USG in order to evaluate their findings by statistical methods.Results:The sensitivity and specificity of FNAC was 87.5% and 98% respectively. All malignant lesions on FNAC were confirmed by histopathology indicating its excellence. Therefore FNAC helps in planning the correct management and avoids second surgery. And the sensitivity and specificity of USG was 75% and 86% respectively. Therefore combination of both FNAC and ultrasonography will improve the diagnostic accuracy to higher level and helps in better management. Conclusions:FNAC has high sensitivity and specificity, so it is closest to ideal test. However, a combination of both FNAC and ultrasound will give desirable results and so that we can avoid mismanagement.

Download Full-text

Clinical and laboratory evaluation of lymphadenopathy in particular with fine needle aspiration cytology

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20193152 ◽

2019 ◽

Vol 6 (5) ◽

pp. 1850

Author(s):

Nageshwara Rao K. ◽

Harisha Gopal ◽

Gautham M.

Keyword(s):

Simple Procedure ◽

Needle Aspiration ◽

Laboratory Evaluation ◽

Age Group ◽

First Line ◽

Peripheral Smear ◽

Aspiration Cytology ◽

Fine Needle ◽

Male Preponderance ◽

Needle Aspiration Cytology

Background: To know the various causes of lymphadenopathy in children and to know the usefulness of FNAC in diagnosis of various causes of lymphadenopathy.Methods: Children less than 12 years with significant lymphadenopathy (lymphadenopathy of >1 cm in cervical, axillary and >1.5 cm in inguinal region) were included.Results: A total of 50 children were enrolled in the study. The incidence of lymphadenopathy was more common in the age group of 4-8 year during the lymphoid phase with male preponderance of all the causes infections especially tuberculosis was the major cause of lymphadenopathy which is totally preventable by giving BCG vaccination. The sensitivity of FNAC in the present study was 71.3%. In 3 cases FNAC 69 was not done because peripheral smear examination revealed that the patients are suffering from acute lymphoblastic leukemia.Conclusions: FNAC is a simple bed side investigation though traumatic is of immense value for diagnosing various cases. Even though it may not be a replacement for lymphnode biopsy, it is preferred as a first line investigation because of its simple procedure.

Download Full-text

Fine-Needle Aspiration in the Diagnosis of Thyroid Diseases: An Appraisal in Our Institution

ISRN Pathology ◽

10.5402/2012/912728 ◽

2012 ◽

Vol 2012 ◽

pp. 1-4 ◽

Cited By ~ 6

Author(s):

Heydar Ali Esmaili ◽

Hassan Taghipour

Keyword(s):

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

High Sensitivity ◽

Cost Effective ◽

Needle Aspiration ◽

Thyroid Disorders ◽

Aspiration Cytology ◽

Fine Needle ◽

Needle Aspiration Cytology ◽

Sensitivity Specificity

Objective and Aims. In the last two decades, fine-needle aspiration cytology (FNAC) of thyroid has been introduced as the most reliable and cost-effective method for diagnosing of clinically important thyroid disorders. The aim of our study was to determine the accuracy and reliability of FNAC in our center. Materials and Methods. Thyroid fine-needle aspiration cytology (FNAC) of 1639 patients from October 2007 to September 2011 was evaluated in our center. Only patients which had a solitary or multiple thyroid nodules were selected for FNA. The FNAC results are classified as benign, malignant, suspicious, and unsatisfactory. From above patients, 192 (11.7%) cases underwent surgery, and histopathologic examination was performed. By comparing the FNAC reports with the corresponding histopathologic results, the accuracy of thyroid FNAC was determined. Results. According to FNAC diagnostic criteria, there were 1054 (64.3%) benign cases, 128 (7.8%) malignant, 306 (18.66%) suspicious and 151 (9.2%) inadequate for diagnosis. In 192 cases, which underwent surgery, FNAC reports were compared with histopathologic results and statistical indices were calculated. The sensitivity, specificity, and accuracy were 91.6%, 100%, and 97%, respectively. These findings strongly support that FNAC as a useful technic for preoperative diagnosis of thyroid lesions. Conclusion. This technique is easy to perform, cost effective, minimally invasive with few complications. FNAC has high sensitivity in diagnosis of thyroid malignancy and also has high diagnostic accuracy in the evaluation of thyroid disorders.

Download Full-text