Acute Effects of Postpartal Subcutaneous Injection of Glucagon and/or Oral Administration of Glycerol on Blood Metabolites and Hormones and Liver Lipids and Glycogen of Holstein Dairy Cows Induced with Fatty Liver Disease

2007 ◽  
Author(s):  
Mohamed Osman ◽  
Portia Allen ◽  
Nimer Mehyar ◽  
Gerd Bobe ◽  
Johann Coetzee ◽  
...  
Keyword(s):  
Liver Disease ◽  
Oral Administration ◽  
Fatty Liver ◽  
Dairy Cows ◽  
Subcutaneous Injection ◽  
Fatty Liver Disease ◽  
Blood Metabolites ◽  
Acute Effects ◽  
Liver Lipids ◽  
Holstein Dairy Cows

scholarly journals Identification of Crucial Genetic Factors, Such as PPARγ, that Regulate the Pathogenesis of Fatty Liver Disease in Dairy Cows Is Imperative for the Sustainable Development of Dairy Industry

Animals ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 639 ◽  
Author(s):  
Kerong Shi ◽  
Ranran Li ◽  
Zhongjin Xu ◽  
Qin Zhang
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Dairy Cows ◽  
Fatty Liver Disease ◽  
Molecular Mechanisms ◽  
Economic Value ◽  
Perinatal Period ◽  
Alcoholic Fatty Liver ◽  
The Sustainable Development ◽  
Typical Type

Frequently occurring fatty liver disease in dairy cows during the perinatal period, a typical type of non-alcoholic fatty liver disease (NAFLD), results in worldwide high culling rates of dairy cows (averagely about 25%) after calving. This has been developing into a critical industrial problem throughout the world, because the metabolic disease severely affects the welfare and economic value of dairy cows. Findings about the molecular mechanisms how the fatty liver disease develops would help scientists to discover novel therapeutic targets for NAFLD. Studies have shown that PPARγ participates or regulates the fat deposition in liver by affecting the biological processes of hepatic lipid metabolism, insulin resistance, gluconeogenesis, oxidative stress, endoplasmic reticulum stress and inflammation, which all contribute to fatty liver. This review mainly focuses on crucial regulatory mechanisms of PPARγ regulating lipid deposition in the liver via direct and/or indirect pathways, suggesting that PPARγ might be a potential critical therapeutic target for fatty liver disease, however, it would be of our significant interest to reveal the pathology and pathogenesis of NAFLD by using dairy cows with fatty liver as an animal model. This review will provide a molecular mechanism basis for understanding the pathogenesis of NAFLD.

scholarly journals Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

2015 ◽  
Vol 468 (1) ◽  
pp. 125-132 ◽  
Author(s):  
Rebecca J. Ford ◽  
Morgan D. Fullerton ◽  
Stephen L. Pinkosky ◽  
Emily A. Day ◽  
John W. Scott ◽  
...  
Keyword(s):  
Liver Disease ◽  
Insulin Sensitivity ◽  
Fatty Liver ◽  
Type Ii Diabetes ◽  
Fatty Liver Disease ◽  
Type Ii ◽  
Improve Insulin Sensitivity ◽  
Liver Lipids ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Combining low, clinically relevant doses of metformin and salicylate synergistically activate AMPK, lower liver lipids and improve insulin sensitivity, and may be effective for treating non-alcoholic fatty liver disease and type II diabetes.

Altered plasma lipidome profile of dairy cows with fatty liver disease

2017 ◽  
Vol 110 ◽  
pp. 47-59 ◽  
Author(s):  
C. Gerspach ◽  
S. Imhasly ◽  
M. Gubler ◽  
H. Naegeli ◽  
M. Ruetten ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Dairy Cows ◽  
Fatty Liver Disease

scholarly journals Effect of l-ornithine-l-aspartate therapy on the hyperammonemia level and results of the number connection test of patients suffering from nonalcoholic fatty liver disease

2020 ◽  
pp. 80-84 ◽  
Author(s):  
E. A. Kizova ◽  
Yu. P. Potekhina
Keyword(s):  
Liver Disease ◽  
Oral Administration ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Blood Chemistry ◽  
Nonalcoholic Fatty Liver ◽  
Before And After ◽  
Number Connection Test

The aim was to study the hyperammonemia level and the duration of implementation of the number connection test (NCT) for patients with nonalcoholic fatty liver disease (NAFLD) in the pre-cirrhosis stage, including effect of the oral administration of L-ornithine-L-aspartate (LOLA) on these indices, and NCT correlation with body chemistry values. Material and methods: the research covered 103 patients with NAFLD to study the hyperammonemia level and other relevant blood chemistry values; we performed NCT before and after the LOLA treatment. The aim was to study the hyperammonemia level and the duration of implementation of the number connection test (NCT) for patients with nonalcoholic fatty liver disease (NAFLD) in the pre-cirrhosis stage, including effect of the oral administration of L-ornithine-L-aspartate (LOLA) on these indices, and NCT correlation with body chemistry values. Material and methods: the research covered 103 patients with NAFLD to study the hyperammonemia level and other relevant blood chemistry values; we performed NCT before and after the LOLA treatment.

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