scholarly journals Safranal Effect against Cyclophosphamide-Induced Liver Injury

2021 ◽  
Vol 30 (2) ◽  
pp. 208-213
Author(s):  
Munaf Hashim Zalzala ◽  
Victoria S. Kareem
Keyword(s):  
Group Treatment ◽  
Liver Toxicity ◽  
Free Radical Scavenger ◽  
Control Group ◽  
Radical Scavenger ◽  
Protective Effects ◽  
Treatment Groups ◽  
Radical Scavenger Activity ◽  
Scavenger Activity ◽  
Anti Oxidant

The liver is the primary organ for drug metabolism, elimination, Cyclophosphamid is the classical alkylating agent nitrogen mustard, its metabolism into two cytotoxic metabolites, and increase reactive oxygen species that is make liver toxicity. Safranal as the most abundant chemical in saffron essential oil, it have anti-oxidant, anti-inflammatory, antiapoptic and free radical scavenger activity. The aim of study is to assess the protective effects of safranal on the cyclophosphamide-induce liver toxicity in rat model. This occur by using five different groups of rats; control group, treatment group, cyclophosamide group (intraperitoneal i.p), cyclophosamide and (50mg and 100mg) oral safranal treatment groups. This study showed this protective by decreasing liver parameter enzyme (aminotransferase enzyme) and MDA level, increases glutathione and NRF2

Melatonin: a Potential Shield against Electromagnetic Waves

2021 ◽  
Vol 19 ◽  
Author(s):  
Maya Jammoul ◽  
Nada Lawand
Keyword(s):  
Oxidative Stress ◽  
Electromagnetic Waves ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Protective Effects ◽  
Electromagnetic Hypersensitivity ◽  
Oxidative Balance ◽  
Therapeutic Benefits ◽  
Radical Scavenger Activity ◽  
Scavenger Activity

: Melatonin, a vital hormone synthesized by the pineal gland, has been implicated in various physiological functions and in circadian rhythm regulation. Its role in the protection against the non-ionizing electromagnetic field (EMF), known to disrupt the body’s oxidative/anti-oxidative balance, has been called into question due to inconsistent results observed across studies. This review provides the current state of knowledge on the interwoven relationship between melatonin, EMF, and oxidative stress. Based on synthesized evidence, we present a model that best describes the mechanisms underlying the protective effects of melatonin against RF/ELF-EMF induced oxidative stress. We show that the free radical scavenger activity of melatonin is enabled through reduction of the radical pair singlet-triplet conversion rate and the concentration of the triplet products. Moreover, this review aims to highlight the potential therapeutic benefits of melatonin against the detrimental effects of EMF, in general, and electromagnetic hypersensitivity (EHS), in particular.

scholarly journals Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Luciane Angela Nottar Nesello ◽  
Maria Luisa Maes Lima Beleza ◽  
Marihá Mariot ◽  
Luísa Nathália Bolda Mariano ◽  
Priscila de Souza ◽  
...  
Keyword(s):  
Atpase Activity ◽  
Free Radical Scavenger ◽  
Total Phenolic ◽  
Radical Scavenger ◽  
Lipid Hydroperoxides ◽  
Ulcer Area ◽  
Morus Nigra ◽  
Radical Scavenger Activity ◽  
Scavenger Activity

This study evaluated the gastroprotective value of the methanol extracts from fruits of Morus nigra L. (black mulberry (MEMN)) and Rubus niveus Thunb (raspberry (MERN)). The total phenolic compounds and flavonoids were measured, as well as the in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenger activity. The gastroprotective effects of the extracts against 60% ethanol/0.3 M HCl were evaluated in mice. After that, the lipid hydroperoxides and reduced glutathione levels at ulcerated tissue were determined. The effects of extracts on H+/K+-ATPase activity were also verified. The extracts exhibited high contents of polyphenols; however, MERN presented 1.5-fold higher levels. The presence of flavonoids also was confirmed. In addition, MEMN (IC50 = 13.74 μg/mL) and MERN (IC50 = 14.97 μg/mL) scavenged DPPH radical. The MEMN reduced the ulcer area only at 300 mg/kg (p.o.) by 64.06%. Interestingly, MERN decreased the ulcer area in a superior potency (ED50 = 20.88 mg/kg), reducing the ulcer area by 81.86% at 300 mg/kg, and increased the gastric mucin levels. The antioxidant effects of extracts were evidenced by reduced lipoperoxides and increased reduction of glutathione amount in the gastric mucosa. However, MEMN or MERN did not change the H+/K+-ATPase activity. These results confirm that M. nigra and R. niveus are berries with a gastroprotective value by strengthening of gastric protective factors.

Sesquiterpene lactones fromLychnophora pohlii: neutrophil chemiluminescence inhibition and free radical scavenger activity

2006 ◽  
Vol 58 (6) ◽  
pp. 853-858 ◽  
Author(s):  
Alexandre Kanashiro ◽  
Luciana M. Kabeya ◽  
Cristiane F. F. Grael ◽  
Christiane O. Jordão ◽  
Ana Elisa C.S. Azzolini ◽  
...  
Keyword(s):  
Free Radical ◽  
Sesquiterpene Lactones ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Radical Scavenger Activity ◽  
Scavenger Activity

Nutritive composition and free radical scavenger activity of honey enriched with of Rosa spp.

LWT ◽  
2014 ◽  
Vol 55 (1) ◽  
pp. 408-413 ◽  
Author(s):  
D. Štajner ◽  
B.M. Popović ◽  
J. Čanadanović-Brunet ◽  
S. Đilas ◽  
G. Ćetković
Keyword(s):  
Free Radical ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Radical Scavenger Activity ◽  
Scavenger Activity ◽  
Nutritive Composition

S109 – N-2 MPG in Groin Flaps Subjected to Vein Occlusion

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P113-P114
Author(s):  
Benoit J Gosselin ◽  
Louise Davies
Keyword(s):  
Free Radical ◽  
Sham Group ◽  
Venous Occlusion ◽  
Free Radical Scavenger ◽  
Control Group ◽  
Radical Scavenger ◽  
Flap Survival ◽  
Vein Occlusion ◽  
Scavenger Activity ◽  
The Mean

Objectives In a prior communication, we showed that ischemic rat groin flaps exposed to the free radical scavenger N-2 mercaptopropionylglycine (MPG) at the time of arterial and venous occlusion had a higher rate of survival than untreated flaps. In this study, the objective is to test the efficacy and timing of administration of MPG in salvaging rat groin flaps subjected to venous occlusion alone. Methods Randomized controlled trial. Main outcome is mean percentage of flap survival at 7 days. 30 mature Sprague-Dawley rats were randomized to 3 groups based on timing of treatment with MPG: 1- flap raised, no MPG, no venous occlusion (sham group); 2- flap raised, no MPG, 10-hour period of venous occlusion (control group); 3- flap raised, MPG after 10 hours venous occlusion (post-reperfusion group). Results There was no statistical difference noted in mean survival of venous occluded flaps when comparing the control and post-reperfusion groups, after 7 days. Specifically, the mean flap survival in the control group at 7 days was 10.9% (median 0%, range 0–100%). The mean flap survival in the post-reperfusion group was 14.6% (median 0%, range 0–100%). The mean flap survival in the sham group was 90.0% (median 100%, range 0–100%). Conclusions Post-reperfusion MPG administration is not helpful for flaps subjected to venous occlusion alone. The free-radical scavenger activity of MPG is potentiated within the tissues prior to vein occlusion. Potential applications for free flap salvage would need further study.

Thymus zygis Oil: Its Effects on CCI4-Induced Hepatotoxicity and Free Radical Scavenger Activity

1993 ◽  
Vol 5 (2) ◽  
pp. 153-158 ◽  
Author(s):  
J. Jiménez ◽  
M. C. Navarro ◽  
M. P. Montilla ◽  
A. Martin ◽  
A. Martinez
Keyword(s):  
Free Radical ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Thymus Zygis ◽  
Radical Scavenger Activity ◽  
Scavenger Activity

scholarly journals DPPH FREE RADICAL SCAVENGER ACTIVITY OF FLAVONOID FROM THE LEAVES OF FERN Chingia sakayensis (Zeiller) Holtt

2010 ◽  
Vol 5 (2) ◽  
pp. 173-176
Author(s):  
Suyatno Suyatno ◽  
Noor Cholies Zaini ◽  
Motoo Tori
Keyword(s):  
Ascorbic Acid ◽  
Free Radical ◽  
Vitamin E ◽  
Methanol Extract ◽  
Ethyl Acetate Fraction ◽  
Free Radical Scavenger ◽  
Flavonoid Compound ◽  
Radical Scavenger ◽  
Radical Scavenger Activity ◽  
Scavenger Activity

A flavonoid compound in flavonol type namely kaemferol was isolated from the ethyl acetate fraction of the methanol extract of the fern Chingia sakayensis (Zeiller) Holtt's leaves. The DPPH free radical scavenger activity of kaemferol was stronger than buthyl hyroxy toluene (BHT) but it was weaker than ascorbic acid (vitamin C) and -tocopherol (vitamin E).   Keywords: Chingia sakayensis, kaemferol, DPPH free radical scavenger activity  

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