Cardano (Girolamo, Gerolamo, b. 1501–d. 1576) is an Italian polymath, one of the most prominent authors of the Renaissance. He was not only a physician, mathematician, and astrologer but also a philosopher and a curious researcher of nature, interested in all areas of human knowledge and experience. At the end of his life, he was brought to trial by the Catholic Inquisition, and all his works, except the medical ones, were condemned. Yet his writings in the philosophy of nature, especially the encyclopedic De subtilitate and De rerum varietate, were frequently read until the Enlightenment. For the general public, his name is renowned for some inventions and discoveries as the solution of cubic equations. What we call Cardan joint is named after him. His fascinating autobiography has been translated in many languages. Scholars read him as a radical thinker, crypto-Reformer critic of religions, and a forerunner of the new science still immersed in magic. A more complex image of Cardano has now been emerging, thanks to recent editions and translations of his works. Cardano sensed the crisis of the humanistic tradition in the age of the Counter-Reformation. As then, he still offers tools for understanding what is continuously transforming, and getting closer to the truth.