BackgroundWork-related exposure to silica is a health hazard worldwide causing i.e. silicosis. Inflammation is known to be a cause of cardiovascular diseases and some studies have presented elevated cardiovascular disease mortality in relation to silica exposure. The aim of this study was to investigate the relationship between inhalation of exposure to silica in Swedish iron foundries and markers of inflammation and coagulation in blood.MethodsPersonal sampling of respirable dust and silica was performed for 85 subjects in three Swedish iron foundries. Stationary measurements were used to study concentrations of respirable dust and silica, inhalable and total dust, PM10 and PM2.5, the particle surface area and the particle number concentrations. The markers of inflammation analyzed were, interleukins (IL-1β, IL-6, IL-8, IL-10 and IL-12), C-reactive protein, serum amyloid A (SAA), and markers of coagulation fibrinogen, factor VIII (FVIII), von Willebrand factor, and d-dimer were measured in plasma or serum. The sampling was performed on the second or third day of a working week following a work free weekend, and additional sampling on the fourth or fifth day.The personal and stationary measurement data were categorized into three classes to introduce high contrast with a minimum of 10 workers in each group. A mixed model analysis adjusted for sex, age, smoking, infections, blood group, sampling day and BMI was used.ResultsFor personal sampling the average 8 hour time-weighted average air concentration of respirable dust were 0.85 mg/m3 and respirable silica 0.052 mg/m3. For the high exposure group, statistically significant increased levels of SAA, fibrinogen and FVIII were determined for some exposure measures.ConclusionsThis study may indicate an increased risk of cardiovascular disease when observing relations between particle exposure and inflammatory markers.
O3C.1 Silica exposure in swedish iron foundries and biological markers of inflammation and coagulation in blood
