AgAnt: A computational tool to assess Agonist/Antagonist mode of interaction

Activity modulation of proteins is an essential biochemical process in cell. The interplay of the protein, as receptor, and it's corresponding ligand dictates the functional effect. It is imperative to decipher the receptor-ligand functional effect for understanding native biochemical processes as well as for drug discovery. Experimental activity determination is a time extensive process and computational solution towards prediction of activity specific to the receptor-ligand interaction would be of wide interest. We train machine learning models to differentiate between agonist and antagonist protein-ligand pairs and deploy a pairwise approach to utilize the properties of both the receptor and the ligand.

Review on Indirect Dark Matter Searches with Neutrino Telescopes

The search for dark matter is one of the hottest topics in Physics today. The fact that about 80% of the matter of the Universe is of unknown nature has triggered an intense experimental activity to detect this kind of matter and a no less intense effort on the theory side to explain it. Given the fact that we do not know the properties of dark matter well, searches from different fronts are mandatory. Neutrino telescopes are part of this experimental quest and offer specific advantages. Among the targets to look for dark matter, the Sun and the Galactic Center are the most promising ones. Considering models of dark matter densities in the Sun, neutrino telescopes have put the best limits on spin-dependent cross section of proton-WIMP scattering. Moreover, they are competitive in the constraints on the thermally averaged annihilation cross-section for high WIMP masses when looking at the Galactic Centre. Other results are also reviewed.

Review on Dark Matter Searches with Neutrino Telescopes

The search for dark matter is one the hottest topics in Physics today. The fact that about 80% of the matter of the Universe is of unknown nature has triggered an intense experimental activity to detect such kind of matter and a no less intense effort on the theory side to explain it. Given the fact that we do not know well the properties of dark matter, searches from different fronts are mandatory. Neutrino telescopes are part of this experimental quest and offer specific advantages. Among the targets to look for dark matter, the Sun and the Galactic Center are the most promising ones. Neutrino telescopes have put the best limits on spin-dependent cross section of proton-WIMP scattering. Moreover, they are competitive in the constraints on the thermally averaged annihilation cross-section for high WIMP masses when looking at the Galactic Centre. Other results are also reviewed.

I-DLV-sr: A Stream Reasoning System based on I-DLV

We introduce a novel logic-based system for reasoning over data streams, which relies on a framework enabling a tight, fine-tuned interaction between Apache Flink and the $${{\mathcal I}^2}$$ -DLV system. The architecture allows to take advantage from both the powerful distributed stream processing capabilities of Flink and the incremental reasoning capabilities of $${{\mathcal I}^2}$$ -DLV, based on overgrounding techniques. Besides the system architecture, we illustrate the supported input language and its modeling capabilities, and discuss the results of an experimental activity aimed at assessing the viability of the approach.

Atividade experimental investigativa e e-book no ensino de ciências do ensino fundamental: uma experiência de estágio supervisionado

Resumo: Este artigo apresenta uma proposta didática pautada numa Sequência de Ensino Investigativa (SEI) em Ciências Físicas, com atividades experimentais investigativas e e-book. A intervenção foi realizada em oito encontros no Estágio Supervisionado II, na busca pela aprendizagem significativa dos discentes e dos problemas enfrentados pelos docentes ao usarem novas estratégias de ensino nas aulas de Ciências. Questionários foram usados como instrumentos de coleta de dados, em 84 discentes do 8º e 9º ano do Ensino Fundamental e 2 professores de Ciências de uma escola pública de Portel-PA. O processo de análise dos resultados foi mediado por um desenho de pesquisa quali-quantitativo. Os resultados mostraram que as atividades de ensino por investigação são raramente utilizadas pelos docentes entrevistados, embora eles reconheçam a importância de diferentes estratégias de ensino para a aprendizagem significativa dos discentes. Além disso, os discentes entrevistados referiram abertura para experimentar diferentes metodologias de ensino no âmbito escolar.Palavras-chave: Atividades experimentais; E-book; Ensino por investigação; Estágio supervisionado. Investigative experimental activity and e-book in science teaching to elementary school: a supervised internship experienceAbstract: This work presents a didactic proposal based on an Investigative Teaching Sequence (ITS) in Physical Sciences, with experimental investigative activities and e-book. The intervention was carried out in eight meetings in Supervised Internship II, in the search for meaningful learning of students and the problems faced by teachers when using new teaching strategies in Science classes. Questionnaires were used as data collection instruments in 84 students from the 8th and 9th grades of elementary school and 2 science teachers at the school in Portel-PA. The process of analyzing was mediated by a quali-quantitative research design. The results showed that research teaching activities are used by the interviewed teachers. But they recognize the importance of different teaching strategies as well as from TSI and TIS for meaningful learning by students. In addition, the interviewed students reported opening to experiment different methodologies in school scope.Keywords: Experimental activities; E-book; Teaching by investigation; Supervised internship.

A Novel Hybrid Seal: Design and Experimental Validation on a High Pressure Rotordynamic Test Rig

The design and experimental activity presented in this paper is related to a novel hybrid seal which is intended to work as a balance piston seal in an AMBs levitated high-pressure (about 300 bar delivery pressure) motor-compressor. The typical solution adopted for balance piston application is a damper seal (e.g. honeycomb seal), as the rotordynamic stability is a primary focus. However, due to interactions between the AMB controller and seal high stiffness level, the aforementioned selection is not so straightforward. After a review of the state of the art it was found that a combination of some conventional geometries (e.g. labyrinth and honeycomb) can be adopted to achieve the desired target. The design was done using a novel tool combining the validated bulk flow codes for each geometry. Moreover, a CFD analysis, based on some literature references, was carried out as a final verification of the design. The experimental activity was then performed at the Authors’ internal seal test rig. As in typical rotordynamic seal testing activity, the operating parameters leveraged to explore performance sensitivity are rotational speed, inlet pressure, pressure ratio and inlet swirl level. The outcome was satisfactory both in terms of leakage and rotordynamic coefficients.