scholarly journals Current State and Understanding of Methamphetamine-associated Pulmonary Arterial Hypertension

2021 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Current State ◽  
Pulmonary Arterial

scholarly journals Exploring Functional Differences between the Right and Left Ventricles to Better Understand Right Ventricular Dysfunction

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Judith Bernal-Ramirez ◽  
Magda C. Díaz-Vesga ◽  
Matias Talamilla ◽  
Andrea Méndez ◽  
Clara Quiroga ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Right Ventricle ◽  
Arterial Hypertension ◽  
Right Ventricular Dysfunction ◽  
Current State ◽  
Functional Differences ◽  
Potential Benefits ◽  
Pulmonary Arterial ◽  
The Right ◽  
Effective Use

The right and left ventricles have traditionally been studied as individual entities. Furthermore, modifications found in diseased left ventricles are assumed to influence on right ventricle alterations, but the connection is poorly understood. In this review, we describe the differences between ventricles under physiological and pathological conditions. Understanding the mechanisms that differentiate both ventricles would facilitate a more effective use of therapeutics and broaden our knowledge of right ventricle (RV) dysfunction. RV failure is the strongest predictor of mortality in pulmonary arterial hypertension, but at present, there are no definitive therapies directly targeting RV failure. We further explore the current state of drugs and molecules that improve RV failure in experimental therapeutics and clinical trials to treat pulmonary arterial hypertension and provide evidence of their potential benefits in heart failure.

scholarly journals EXPRESS: Recent Advancements in Pulmonary Arterial Hypertension and Right Heart Failure Research: Overview of Selected Abstracts from ATS2020 and Emerging COVID-19 Research

2021 ◽  
pp. 204589402110372
Author(s):  
Francois Potus ◽  
Andrea Frump ◽  
Soban Umar ◽  
Rebecca Vanderpool ◽  
Imad Al Ghouleh ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
State Of The Art ◽  
Right Heart Failure ◽  
The Novel ◽  
Preclinical Research ◽  
Right Heart ◽  
Current State ◽  
Pulmonary Arterial ◽  
Rv Function

Each year the American Thoracic Society (ATS) Conference brings together scientists who conduct basic, translational and clinical research to present on the recent advances in the field of respirology. Due to the Coronavirus Disease of 2019 (COVID-19) pandemic, the ATS2020 Conference was held online in a series of virtual meetings. In this review, we focus on the breakthroughs in pulmonary hypertension (PH) research. We have selected ten of the best basic science abstracts which were presented at the ATS2020 Assembly on Pulmonary Circulation mini-symposium “What’s new in Pulmonary Arterial Hypertension (PAH) and Right Ventricular (RV) Signaling: Lessons from the Best Abstracts”, reflecting the current state-of-the-art and associated challenges in PH. Particular emphasis is placed on understanding the mechanisms underlying RV failure, the regulation of inflammation, and the novel therapeutic targets that emerged from preclinical research. The pathologic interactions between PH, RV function and COVID-19 are also discussed.

scholarly journals Genetic Counseling and Testing in Pulmonary Arterial Hypertension

2021 ◽  
Vol 17 (2) ◽  
pp. 101-105
Author(s):  
C Gregory Elliott
Keyword(s):  
Genetic Counseling ◽  
Genetic Testing ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Family Members ◽  
Gene Mutations ◽  
Current State ◽  
Counseling And Testing ◽  
Pulmonary Arterial ◽  
Pathogenic Gene

A subgroup of patients diagnosed with pulmonary arterial hypertension (PAH) carry transmissible pathogenic gene mutations. For many of these patients, the heritable nature of their disease can only be uncovered by genetic testing. Because identification of PAH patients who carry pathogenic gene mutations has important implications for other family members, genetic counseling and testing should be offered to patients diagnosed with idiopathic or familial PAH. This review describes the current state of genetic counseling and testing for patients diagnosed with PAH.

scholarly journals Current state of medicine usage and the predictor of mortality in pulmonary arterial hypertension in Japan

Life Sciences ◽  
2013 ◽  
Vol 93 (25-26) ◽  
pp. e46-e47
Author(s):  
Shiro Adachi ◽  
Akihiro Hirashiki ◽  
Syuzo Shimazu ◽  
Yoshihisa Nakano ◽  
Toyoaki Murohara ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Current State ◽  
Pulmonary Arterial
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