Study to Evaluate the Pharmacokinetics and Metabolism of [14C] CR845 (Difelikefalin) in Patients With End Stage Renal Disease on Hemodialysis and in Healthy Subjects

2019 ◽  
Author(s):  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Healthy Subjects ◽  
Stage Renal Disease ◽  
End Stage

Hyperleptinemia in Patients with End-Stage Renal Disease Undergoing Continuous Ambulatory Peritoneal Dialysis

1998 ◽  
Vol 18 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Samuel Dagogo-Jack ◽  
Fernando Ovalle ◽  
Michael Landt ◽  
Barbara Gearing ◽  
Daniel W. Coyne
Keyword(s):  
Peritoneal Dialysis ◽  
Renal Disease ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
End Stage Renal Disease ◽  
Healthy Subjects ◽  
Tertiary Care ◽  
Prospective Comparison ◽  
Stage Renal Disease ◽  
End Stage ◽  
Plasma Leptin

Objective To determine whether the increased plasma leptin levels reported in hemodialyzed patients is a feature of end-stage renal disease or an artifact of hemodialysis, we studied plasma levels in patients treated exclusively by continuous ambulatory peritoneal dialysis (CAPD). Design Prospective comparison of end points in CAPD patients and matched healthy subjects. Setting Tertiary care institutional dialysis center. Participants Fifty-six healthy subjects, age 50.8 ± 2.3 years, body mass index (BMI) 27.7 ± 1.3 kg/m2, recruited through public announcement, and 36 patients with end-stage renal disease, age 51.0 ± 2.4 yr, BM128.2 ± 1.3 kg/m2, enrolled in a CAPD treatment program. Intervention Four exchanges of CAPD per day, using 2.0, 2.5, or 3.0 L of dialysate over a period of 1 -96 months (median 22 mth). Main Outcome Measures The primary outcome measure was plasma leptin concentration. Secondary measures included plasma glucose, insulin, C-peptide, and cortisol concentrations; and residual renal function and dialysis adequacy (Kt/V). Results Plasma leptin levels in CAPD patients were 27.1 -490 ng/mL(women)and 1.3 -355 ng/mL(men); the levels in healthy subjects were 2.0 84.7 ng/mL (women) and 1.8 -55.4 ng/mL (men). The mean leptin levels were 5-fold higher among CAPD-treated men than control men (49.9 ± 18.4 vs 9.8 ± 2.5 ng/mL, p < 0.001) and 7.5-fold higher among CAPD-treated women than control women (220 ± 28.1 vs 29.3 ± 3.7 ng/mL, p < 0.0001). Female gender and BMI were the strongest predictors of hyperleptinemia in CAPD patients. Conclusion These results indicate that hyperleptinemia is a feature of terminal renal failure, not an artifact of hemodialysis.

scholarly journals Neutrophil to Lymphocyte Ratio in Patients with End Stage Renal Disease in Benue State University Teaching Hospital, Makurdi, Nigeria

2020 ◽  
Vol 3 (1) ◽  
pp. 250-255
Author(s):  
MO Ogiator ◽  
JE Ojobi ◽  
OO Ijachi
Keyword(s):  
Renal Disease ◽  
Systemic Inflammation ◽  
Teaching Hospital ◽  
End Stage Renal Disease ◽  
Healthy Subjects ◽  
University Teaching ◽  
State University ◽  
The Mean ◽  
Stage Renal Disease ◽  
End Stage

Chronic Kidney Disease (CKD) leads to end-stage renal disease (ESRD) and cardiovascular events. An important determinant of progression in CKD is chronic systemic inflammation which can be evaluated using the neutrophil to lymphocyte ratio (NLR). We aimed to investigate the value of NLR in patients with ESRD compared with healthy subjects. This was a retrospective study that analyzed data from patients with end-stage renal disease and equal number of age and sex matched control (healthy subjects) seen at Benue State University Teaching Hospital Makurdi from October 1st, 2012 to 31st December 2015. Out of the 118 patients studied 70(59.3) were males while 48 (40.7) were females. The mean age of the study population was 45.9 ± 16.4. The mean NLR for patients with ESRD was 3.55± 4.01 while that of healthy subjects was 1.29± 0.25. The mean NLR for patients was 3.47±4.01 for males and 3.68±4.06 for females while for the healthy subjects the mean NLR was 1.30±0.27 for males 1.27±0.22 for females. This study revealed elevated NLR in patients with ESRD. NLR reflects systemic inflammation. The availability of this ratio (NLR) can help improve outcome of patients with CKD.

scholarly journals A comparative study of red cell folate and serum folate levels in patients on regular Hemodialysis

2016 ◽  
Vol 10 (4) ◽  
Author(s):  
Ikram Din Ujjan ◽  
Muhammad Tayyib ◽  
Tahira Tasneem ◽  
Muhammad Farooq ◽  
Muhammad Azhar Mughal ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Healthy Subjects ◽  
Serum Folate ◽  
Red Cell ◽  
Group A ◽  
Level Of Significance ◽  
Group B ◽  
Stage Renal Disease ◽  
End Stage

Sixty subjects were selected and were divided into two groups. Group A included 30 patients of end stage renal disease on regular dialysis and group B included 30 normal healthy subjects as control. Absolute values and Hb were done by hematology auto analyzer and serum and red cell folate were done by commercially available kits. Results were analyzed by using Student`s `t` test and level of significance was done. A significant decreased in serum and red cell folate in end stage renal disease patients with regular dialysis as compared to control.

scholarly journals Neutrophil to Lymphocyte Ratio in Patients with End Stage Renal Disease in Benue State University Teaching Hospital, Makurdi, Nigeria

2020 ◽  
Vol 3 (1) ◽  
pp. 250-255
Author(s):  
MO Ogiator ◽  
JE Ojobi ◽  
OO Ijachi
Keyword(s):  
Renal Disease ◽  
Systemic Inflammation ◽  
Teaching Hospital ◽  
End Stage Renal Disease ◽  
Healthy Subjects ◽  
University Teaching ◽  
State University ◽  
The Mean ◽  
Stage Renal Disease ◽  
End Stage

Chronic Kidney Disease (CKD) leads to end-stage renal disease (ESRD) and cardiovascular events. An important determinant of progression in CKD is chronic systemic inflammation which can be evaluated using the neutrophil to lymphocyte ratio (NLR). We aimed to investigate the value of NLR in patients with ESRD compared with healthy subjects. This was a retrospective study that analyzed data from patients with end-stage renal disease and equal number of age and sex matched control (healthy subjects) seen at Benue State University Teaching Hospital Makurdi from October 1st, 2012 to 31st December 2015. Out of the 118 patients studied 70(59.3) were males while 48 (40.7) were females. The mean age of the study population was 45.9 ± 16.4. The mean NLR for patients with ESRD was 3.55± 4.01 while that of healthy subjects was 1.29± 0.25. The mean NLR for patients was 3.47±4.01 for males and 3.68±4.06 for females while for the healthy subjects the mean NLR was 1.30±0.27 for males 1.27±0.22 for females. This study revealed elevated NLR in patients with ESRD. NLR reflects systemic inflammation. The availability of this ratio (NLR) can help improve outcome of patients with CKD.

scholarly journals Serum Endocannabinoid Levels in Patients With End-Stage Renal Disease

2019 ◽  
Vol 3 (10) ◽  
pp. 1869-1880
Author(s):  
Hamid Moradi ◽  
Christina Park ◽  
Miki Igarashi ◽  
Elani Streja ◽  
Donovan A Argueta ◽  
...  
Keyword(s):  
Renal Disease ◽  
Body Mass ◽  
End Stage Renal Disease ◽  
Healthy Subjects ◽  
Density Lipoprotein ◽  
Maintenance Hemodialysis ◽  
Anthropometric Measures ◽  
Serum Triglycerides ◽  
Stage Renal Disease ◽  
End Stage

Abstract Context Previous studies have shown that the endocannabinoid system plays a major role in energy metabolism through the actions of its main mediators, 2-arachidonoyl-sn-glycerol (2-AG) and anandamide (AEA). Objective We examined serum levels of major endocannabinoid mediators and their association with clinical parameters in patients with end-stage renal disease (ESRD). Design and Setting Serum concentrations of 2-AG and AEA were measured in patients on maintenance hemodialysis (MHD) and controls, and correlations with various clinical and laboratory indices were examined. 2-AG was also measured in age and sex-matched healthy subjects for comparison of levels in patients undergoing MHD. Main Outcome Measure Serum 2-AG. Results Serum 2-AG levels were significantly elevated in patients with ESRD compared with healthy controls. Higher levels of 2-AG were found in patients on MHD compared to healthy subjects, and similar findings were seen in a second set of subjects in independent analyses. Among 96 patients on MHD, 2-AG levels correlated significantly and positively with serum triglycerides (ρ = 0.43; P < 0.0001), body mass index (ρ = 0.40; P < 0.0001), and body anthropometric measures and negatively with serum high-density lipoprotein cholesterol (ρ = −0.33; P = 0.001) following adjustment for demographic and clinical variables. Conclusions In patients on MHD, levels of serum 2-AG, a major endocannabinoid mediator, were increased. In addition, increasing serum 2-AG levels correlated with increased serum triglycerides and markers of body mass. Future studies will need to evaluate the potential mechanisms responsible for these findings.

scholarly journals Association between Mean Heart Rate and Recurrence Quantification Analysis of Heart Rate Variability in End-Stage Renal Disease

Entropy ◽  
2020 ◽  
Vol 22 (1) ◽  
pp. 114 ◽  
Author(s):  
Martín Calderón-Juárez ◽  
Gertrudis Hortensia González-Gómez ◽  
Juan C. Echeverría ◽  
Héctor Pérez-Grovas ◽  
Claudia Lerma
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Healthy Subjects ◽  
The Mean ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients ◽  
Mean Heart Rate

Linear heart rate variability (HRV) indices are dependent on the mean heart rate, which has been demonstrated in different models (from sinoatrial cells to humans). The association between nonlinear HRV indices, including those provided by recurrence plot quantitative analysis (RQA), and the mean heart rate (or the mean cardiac period, also called meanNN) has been scarcely studied. For this purpose, we analyzed RQA indices of five minute-long HRV time series obtained in the supine position and during active standing from 30 healthy subjects and 29 end-stage renal disease (ESRD) patients (before and after hemodialysis). In the supine position, ESRD patients showed shorter meanNN (i.e., faster heart rate) and decreased variability compared to healthy subjects. The healthy subjects responded to active standing by shortening the meanNN and decreasing HRV indices to reach similar values of ESRD patients. Bivariate correlations between all RQA indices and meanNN were significant in healthy subjects and ESRD after hemodialysis and for most RQA indices in ESRD patients before hemodialysis. Multiple linear regression analyses showed that RQA indices were also dependent on the position and the ESRD condition. Then, future studies should consider the association among RQA indices, meanNN, and these other factors for a correct interpretation of HRV.

scholarly journals Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease

2003 ◽  
Vol 64 (3) ◽  
pp. 978-991 ◽  
Author(s):  
Jonathan Himmelfarb ◽  
Jane Kane ◽  
Ellen Mcmonagle ◽  
Eric Zaltas ◽  
Steve Bobzin ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Healthy Subjects ◽  
Gamma Tocopherol ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Neutrophil to Lymphocyte Ratio in Patients with End Stage Renal Disease in Benue State University Teaching Hospital, Makurdi, Nigeria

2020 ◽  
Vol 3 (1) ◽  
pp. 250-255
Author(s):  
MO Ogiator ◽  
JE Ojobi ◽  
OO Ijachi
Keyword(s):  
Renal Disease ◽  
Systemic Inflammation ◽  
Teaching Hospital ◽  
End Stage Renal Disease ◽  
Healthy Subjects ◽  
University Teaching ◽  
State University ◽  
The Mean ◽  
Stage Renal Disease ◽  
End Stage

Chronic Kidney Disease (CKD) leads to end-stage renal disease (ESRD) and cardiovascular events. An important determinant of progression in CKD is chronic systemic inflammation which can be evaluated using the neutrophil to lymphocyte ratio (NLR). We aimed to investigate the value of NLR in patients with ESRD compared with healthy subjects. This was a retrospective study that analyzed data from patients with end-stage renal disease and equal number of age and sex matched control (healthy subjects) seen at Benue State University Teaching Hospital Makurdi from October 1st, 2012 to 31st December 2015. Out of the 118 patients studied 70(59.3) were males while 48 (40.7) were females. The mean age of the study population was 45.9 ± 16.4. The mean NLR for patients with ESRD was 3.55± 4.01 while that of healthy subjects was 1.29± 0.25. The mean NLR for patients was 3.47±4.01 for males and 3.68±4.06 for females while for the healthy subjects the mean NLR was 1.30±0.27 for males 1.27±0.22 for females. This study revealed elevated NLR in patients with ESRD. NLR reflects systemic inflammation. The availability of this ratio (NLR) can help improve outcome of patients with CKD.

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