Treatment With Specific Carbohydrate Diet in Children With Juvenile Idiopathic Arthritis

2019 ◽  
Author(s):  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Carbohydrate Diet ◽  
Specific Carbohydrate Diet

scholarly journals A pilot study of possible anti-inflammatory effects of the specific carbohydrate diet in children with juvenile idiopathic arthritis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Lillemor Berntson
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Health Assessment ◽  
Short Chain Fatty Acids ◽  
Carbohydrate Diet ◽  
Positive Effects ◽  
Link Type ◽  
Parents And Children ◽  
Inflammatory Proteins ◽  
Anti Inflammatory ◽  
Specific Carbohydrate Diet

Abstract Background To explore possible anti-inflammatory effects of the specific carbohydrate diet in children with juvenile idiopathic arthritis. This diet has shown anti-inflammatory effect in children with inflammatory bowel disease. Methods Twenty-two patients with juvenile idiopathic arthritis (age 6.3–17.3 years), with ≤2 inflamed joints and an erythrocyte sedimentation rate < 30 mm/h, were included in this explorative study. Fifteen children completing four weeks on the diet were evaluated. A dietician introduced parents and children to the diet, and two follow-ups were performed during the intervention. Conventional laboratory tests and multiplex analyses of 92 inflammatory proteins were used. Short-chain fatty acids in faecal samples were examined. Results The diet significantly decreased morning stiffness (p = 0.003) and pain (p = 0.048). Physical function, assessed through the child health assessment questionnaire, improved (p = 0.022). Arthritis improved in five of the seven children with arthritis; in those seven, multiplex analyses showed a significant decrease in nine inflammatory proteins, including TNF-alpha (p = 0.028), after four weeks. Faecal butyrate, analysed in all 15 participants, increased significantly (p = 0.020). Conclusion The specific carbohydrate diet may have significant positive effects on arthritis in children with juvenile idiopathic arthritis, but further studies are needed. Clinical trials identifier NCT04205500, 2019/12/17, retrospectively registered. URL: https://register.clinicaltrials.gov

scholarly journals Anti-inflammatory effect of the specific carbohydrate diet in children with juvenile idiopathic arthritis

2020 ◽  
Author(s):  
Lillemor Berntson
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Physical Function ◽  
Dietary Intervention ◽  
Morning Stiffness ◽  
Short Chain Fatty Acids ◽  
Carbohydrate Diet ◽  
Intestinal Immune System ◽  
Anti Inflammatory ◽  
Specific Carbohydrate Diet ◽  
Inflammatory Effect

Abstract Background Diet has an effect on the intestinal immune system, which may have consequences for inflammatory diseases. Specific carbohydrate diet (SCD) is an effective anti-inflammatory treatment for inflammatory bowel disease in children. We explored the anti-inflammatory effect of SCD in children with juvenile idiopathic arthritis (JIA). Methods Twenty-two patients with JIA (age 6.3–17.3 years), with stable, low-to-medium disease activity, were included in the study. Seven children dropped out within two weeks from the start of SCD, and fifteen patients, who completed four to five weeks of SCD, were evaluated in the final analyses. A dietician introduced parents and children to SCD with written and verbal instructions, and regular follow-ups were performed during the intervention period. Patients were studied with clinical and laboratory examinations before, during and after the intervention. In addition to conventional JIA laboratory tests, analyses were performed of short chain fatty acids in faecal samples at inclusion and after two and four weeks of SCD. Results SCD significantly decreased morning stiffness (p = 0.003) and pain (p = 0.048), and improved physical function assessed through the child health assessment questionnaire (p = 0.022). Arthritis improved in five of the seven children with arthritis at inclusion. Faecal butyrate increased significantly (p = 0.020). Conclusions SCD has significant positive effect on arthritis activity, morning stiffness, pain and physical function in children with JIA. Our results suggest that change in bacterial activity of the intestinal canal by dietary intervention may provide an effective and feasible complementary treatment for JIA.

scholarly journals Anti-inflammatory effect of the specific carbohydrate diet in children with juvenile idiopathic arthritis

2020 ◽  
Author(s):  
Lillemor Berntson
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Physical Function ◽  
Dietary Intervention ◽  
Morning Stiffness ◽  
Short Chain Fatty Acids ◽  
Carbohydrate Diet ◽  
Intestinal Immune System ◽  
Anti Inflammatory ◽  
Specific Carbohydrate Diet ◽  
Inflammatory Effect

Abstract Background Diet has an effect on the intestinal immune system, which may have consequences for inflammatory diseases. Specific carbohydrate diet (SCD) is an effective anti-inflammatory treatment for inflammatory bowel disease in children. We explored the anti-inflammatory effect of SCD in children with juvenile idiopathic arthritis (JIA). Methods Twenty-two patients with JIA (age 6.3–17.3 years), with stable, low-to-medium disease activity, were included in the study. Seven children dropped out within two weeks from the start of SCD, and fifteen patients, who completed four to five weeks of SCD, were evaluated in the final analyses. A dietician introduced parents and children to SCD with written and verbal instructions, and regular follow-ups were performed during the intervention period. Patients were studied with clinical and laboratory examinations before, during and after the intervention. In addition to conventional JIA laboratory tests, analyses were performed of short chain fatty acids in faecal samples at inclusion and after two and four weeks of SCD. Results SCD significantly decreased morning stiffness (p = 0.003) and pain (p = 0.048), and improved physical function assessed through the child health assessment questionnaire (p = 0.022). Arthritis improved in five of the seven children with arthritis at inclusion. Faecal butyrate increased significantly (p = 0.020). Conclusions SCD has significant positive effect on arthritis activity, morning stiffness, pain and physical function in children with JIA. Our results suggest that change in bacterial activity of the intestinal canal by dietary intervention may provide an effective and feasible complementary treatment for JIA.

scholarly journals A Pilot Study of Possible Anti-Inflammatory Effects of The Specific Carbohydrate Diet in Children with Juvenile Idiopathic Arthritis

2021 ◽  
Author(s):  
Lillemor Berntson
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Health Assessment ◽  
Short Chain Fatty Acids ◽  
Carbohydrate Diet ◽  
Positive Effects ◽  
Parents And Children ◽  
Inflammatory Proteins ◽  
Anti Inflammatory ◽  
Child Health Assessment Questionnaire ◽  
Specific Carbohydrate Diet

Abstract Background: To explore possible anti-inflammatory effects of the specific carbohydrate diet in children with juvenile idiopathic arthritis. This diet has shown anti-inflammatory effect in children with inflammatory bowel disease.Methods: Twenty-two patients with juvenile idiopathic arthritis (age 6.3–17.3 years), with ≤ 2 inflamed joints and an erythrocyte sedimentation rate < 30 mm/h, were included in this explorative study. Fifteen children completing four weeks on the diet were evaluated. A dietician introduced parents and children to the diet, and two follow-ups were performed during the intervention. Conventional laboratory tests and multiplex analyses of 92 inflammatory proteins were used. Short-chain fatty acids in faecal samples were examined.Results: The diet significantly decreased morning stiffness (p = 0.003) and pain (p = 0.048). Physical function, assessed through the child health assessment questionnaire, improved (p = 0.022). Arthritis improved in five of the seven children with arthritis; in those seven, multiplex analyses showed a significant decrease in nine inflammatory proteins, including TNF-alpha (p = 0.028), after four weeks. Faecal butyrate, analysed in all 15 participants, increased significantly (p = 0.020).Conclusion: The specific carbohydrate diet may have significant positive effects on arthritis in children with juvenile idiopathic arthritis, but further studies are needed.Clinical Trials Identifier: NCT04205500, 2019/12/17, retrospectively registered. URL:https://register.clinicaltrials.gov.

scholarly journals The Specific Carbohydrate Diet and Diet Modification as Induction Therapy for Pediatric Crohn’s Disease: A Randomized Diet Controlled Trial

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3749
Author(s):  
David L. Suskind ◽  
Dale Lee ◽  
Young-Mo Kim ◽  
Ghassan Wahbeh ◽  
Namita Singh ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Therapeutic Potential ◽  
Controlled Trial ◽  
Intestinal Microbiome ◽  
Patient Specific ◽  
Carbohydrate Diet ◽  
Microbiome Composition ◽  
The Impact ◽  
Specific Carbohydrate Diet

Background: Crohn’s disease (CD) is a chronic inflammatory intestinal disorder associated with intestinal dysbiosis. Diet modulates the intestinal microbiome and therefore has a therapeutic potential. The aim of this study is to determine the potential efficacy of three versions of the specific carbohydrate diet (SCD) in active Crohn’s Disease. Methods: 18 patients with mild/moderate CD (PCDAI 15–45) aged 7 to 18 years were enrolled. Patients were randomized to either SCD, modified SCD(MSCD) or whole foods (WF) diet. Patients were evaluated at baseline, 2, 4, 8 and 12 weeks. PCDAI, inflammatory labs and multi-omics evaluations were assessed. Results: Mean age was 14.3 ± 2.9 years. At week 12, all participants (n = 10) who completed the study achieved clinical remission. The C-reactive protein decreased from 1.3 ± 0.7 at enrollment to 0.9 ± 0.5 at 12 weeks in the SCD group. In the MSCD group, the CRP decreased from 1.6 ± 1.1 at enrollment to 0.7 ± 0.1 at 12 weeks. In the WF group, the CRP decreased from 3.9 ± 4.3 at enrollment to 1.6 ± 1.3 at 12 weeks. In addition, the microbiome composition shifted in all patients across the study period. While the nature of the changes was largely patient specific, the predicted metabolic mode of the organisms increasing and decreasing in activity was consistent across patients. Conclusions: This study emphasizes the impact of diet in CD. Each diet had a positive effect on symptoms and inflammatory burden; the more exclusionary diets were associated with a better resolution of inflammation.

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