A Single Cohort Study Collecting Interval Timed Incisional Epidermal and Dermal Tissue Samples During Surgical Procedures to Profile Temporal Response of Tissue After Noxious Stimuli

2020 ◽  
Author(s):  
Keyword(s):  
Cohort Study ◽  
Surgical Procedures ◽  
Temporal Response ◽  
Tissue Samples ◽  
Dermal Tissue ◽  
Noxious Stimuli ◽  
Single Cohort

scholarly journals Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study

2014 ◽  
Vol 132 (5) ◽  
pp. 290-296 ◽  
Author(s):  
Renan Oliveira Vaz-de-Melo ◽  
Luiz Tadeu Giollo-Júnior ◽  
Débora Dada Martinelli ◽  
Heitor Moreno-Júnior ◽  
Marco Antônio Mota-Gomes ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Antihypertensive Drugs ◽  
Augmentation Index ◽  
Stage I ◽  
Central Blood Pressure ◽  
Hypertensive Patients ◽  
Before And After ◽  
Β Blocker ◽  
Single Cohort

CONTEXT AND OBJECTIVES: Assessment of central blood pressure (BP) has grown substantially over recent years because evidence has shown that central BP is more relevant to cardiovascular outcomes than peripheral BP. Thus, different classes of antihypertensive drugs have different effects on central BP despite similar reductions in brachial BP. The aim of this study was to investigate the effect of nebivolol, a β-blocker with vasodilator properties, on the biochemical and hemodynamic parameters of hypertensive patients.DESIGN AND SETTING: Experimental single cohort study conducted in the outpatient clinic of a university hospital.METHODS: Twenty-six patients were recruited. All of them underwent biochemical and hemodynamic evaluation (BP, heart rate (HR), central BP and augmentation index) before and after 3 months of using nebivolol.RESULTS: 88.5% of the patients were male; their mean age was 49.7 ± 9.3 years and most of them were overweight (29.6 ± 3.1 kg/m2) with large abdominal waist (102.1 ± 7.2 cm). There were significant decreases in peripheral systolic BP (P = 0.0020), diastolic BP (P = 0.0049), HR (P < 0.0001) and central BP (129.9 ± 12.3 versus 122.3 ± 10.3 mmHg; P = 0.0083) after treatment, in comparison with the baseline values. There was no statistical difference in the augmentation index or in the biochemical parameters, from before to after the treatment.CONCLUSIONS: Nebivolol use seems to be associated with significant reduction of central BP in stage I hypertensive patients, in addition to reductions in brachial systolic and diastolic BP.

scholarly journals Effect of Contemporary Bariatric Surgical Procedures on Type 2 Diabetes Remission. A Population-Based Matched Cohort Study

2016 ◽  
Vol 26 (10) ◽  
pp. 2308-2315 ◽  
Author(s):  
Martin C. Gulliford ◽  
◽  
Helen Pascale Booth ◽  
Marcus Reddy ◽  
Judith Charlton ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Surgical Procedures ◽  
Population Based ◽  
Diabetes Remission ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Type 2 Diabetes Remission

Real time FTIR spectroscopy of tissue smears from gynecologic cancer tissues: A preliminary study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17089-e17089
Author(s):  
Ilan Bruchim ◽  
Dov Malonek ◽  
Ben Zion Dekel ◽  
Renat Reens Carmel ◽  
Gabi Groisman ◽  
...  
Keyword(s):  
Ftir Spectroscopy ◽  
Sensitivity And Specificity ◽  
Surgical Procedures ◽  
Gynecologic Cancer ◽  
Attenuated Total Reflection ◽  
Benign Tumors ◽  
Tissue Preparation ◽  
Tissue Samples ◽  
Absorbance Spectra

e17089 Background: Women with suspected Gynecologic cancer undergo surgical procedures during which tissue from suspected areas is excised. Fast histopathology analysis is performed intra-operatively using frozen section (FS) analysis, results of which are available within less than an hour. However, the accuracy of the FS test ranges between 75% and 100% when compared to final histopathology diagnoses. Fourier transform Infrared (FTIR) spectroscopy, utilized for classification of tissue samples into malignant and benign tumors, has shown comparable results to those of FS histopathology analysis. However, the sample preparation time and the effects of tissue preparation on the measured spectra have been a concern for the utilization of this technique in clinical practice. In this study we used attenuated total reflection (ATR) FTIR spectroscopy to examine fresh tissue impression smears as an alternative to the FS technique for rapid classification of tissue samples obtained during surgery. Methods: The study was approved by relevant ethics committees and was conducted in accordance with the Declaration of Helsinki. All patients provided written, informed consent. In total, 23 biopsies (ovarian and uterine) were extracted from suspected tumor sites during surgical procedures and sent to the histopathology laboratory for both pathological and FTIR analyses. Results of the histopathology analysis classified 15 samples as benign and 8 samples as malignant. Prior to the histopathologic analysis, tissue samples from these tumors were lightly pressed against the surface of an ATR crystal, leaving on its' surface impression smears. These smears were air dried for ~5 minutes. Mid-IR absorbance spectra were collected using an ATR-FTIR spectrometer. Machine learning techniques (PCA-LDA and SVM) were utilized to build discrimination models from the absorbance data of the measured smears. Sensitivity and specificity were calculated. Results: IR absorbance spectra of malignant smears were consistently higher from spectra of benign smears in the 850cm-1 to 1450 cm-1 range and they were consistently lower in the 3200cm-1 to 3600cm-1 range. The PCA-LDA discrimination model correctly classified the samples with a sensitivity and specificity of 100%, and the SVM showed a training accuracy of 100% and a cross validation accuracy of 91.3%. Conclusions: These preliminary results suggest that ATR-FTIR spectroscopy of tissue smears may have an important role in the development of next-generation techniques for intra-operative tumor classification.

scholarly journals Severity and workload related to adverse events in the ICU

2017 ◽  
Vol 70 (5) ◽  
pp. 942-948 ◽  
Author(s):  
Clarita Terra Rodrigues Serafim ◽  
Magda Cristina Queiroz Dell’Acqua ◽  
Meire Cristina Novelli e Castro ◽  
Wilza Carla Spiri ◽  
Hélio Rubens de Carvalho Nunes
Keyword(s):  
Intensive Care Unit ◽  
Patient Safety ◽  
Cohort Study ◽  
Intensive Care ◽  
Adverse Events ◽  
Direct Relationship ◽  
Daily Activities ◽  
Nursing Workload ◽  
Critical Patients ◽  
Single Cohort

ABSTRACT Objective: To analyze whether an increase in patient severity and nursing workload are correlated to a greater incidence of adverse events (AEs) in critical patients. Method: A prospective single cohort study was performed on a sample of 138 patients hospitalized in an intensive care unit (ICU). Results: A total of 166 AEs, occurred, affecting 50.7% of the patients. Increased patient severity presented a direct relationship to the probability of AEs occurring. However, nursing workload did not present a statistically significant relationship with the occurrence of AEs. Conclusion: The results cast light on the importance of using evaluation tools by the nursing personnel in order to optimize their daily activities and focus on patient safety.

Sign in / Sign up

Export Citation Format

Share Document