Impact of a Gluten-free Diet on Quality of Life in Patients With Axial Spondyloarthritis.

Abstract Background Coeliac disease (CD) is characterised by diverse clinical symptoms, which may cause diagnostic problems and reduce the patients’ quality of life. A study conducted in the United Kingdom (UK) revealed that the mean time between the onset of coeliac symptoms and being diagnosed was above 13 years. This study aimed to analyse the diagnostic process of CD in Poland and evaluate the quality of life of patients before and after CD diagnosis. In addition, results were compared to the results of the original study conducted in the UK. Methods The study included 2500 members of the Polish Coeliac Society. The patients were asked to complete a questionnaire containing questions on socio-demographic factors, clinical aspects and quality of life, using the EQ-5D questionnaire. Questionnaires received from 796 respondents were included in the final analysis. Results The most common symptoms reported by respondents were bloating (75%), abdominal pain (72%), chronic fatigue (63%) and anaemia (58%). Anaemia was the most persistent symptom, with mean duration prior to CD diagnosis of 9.2 years, whereas diarrhoea was observed for the shortest period (4.7 years). The mean duration of any symptom before CD diagnosis was 7.3 years, compared to 13.2 years in the UK. CD diagnosis and the introduction of a gluten-free diet substantially improved the quality of life in each of the five EQ-5D-5L health dimensions: pain and discomfort, anxiety and depression, usual activities, self-care and mobility (p < 0.001), the EQ-Index by 0.149 (SD 0.23) and the EQ-VAS by 30.4 (SD 28.3) points. Conclusions Duration of symptoms prior to the diagnosis of CD in Poland, although shorter than in the UK, was long with an average of 7.3 years from first CD symptoms. Faster CD diagnosis after the onset of symptoms in Polish respondents may be related to a higher percentage of children in the Polish sample. Introduction of a gluten-free diet improves coeliac patients’ quality of life. These results suggest that doctors should be made more aware of CD and its symptoms across all age groups.

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MyHealthyGut: Findings from a pilot randomized controlled trial on adherence to a gluten-free diet and quality of life among adults with celiac disease or gluten intolerance

Digital Health ◽

10.1177/2055207620903627 ◽

2020 ◽

Vol 6 ◽

pp. 205520762090362

Author(s):

A Justine Dowd ◽

Cassandra B Warbeck ◽

Karen TY Tang ◽

Tak Fung ◽

S Nicole Culos-Reed

Keyword(s):

Quality Of Life ◽

Randomized Controlled Trial ◽

Celiac Disease ◽

Controlled Trial ◽

Gluten Free Diet ◽

Gluten Free ◽

Gluten Intolerance ◽

Randomized Controlled ◽

Pilot Randomized Controlled Trial

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Adherence to Gluten-Free Diet in Coeliac Paediatric Patients Assessed through a Questionnaire Positively Influences Growth and Quality of Life

Nutrients ◽

10.3390/nu12123802 ◽

2020 ◽

Vol 12 (12) ◽

pp. 3802

Author(s):

Deianira Pedoto ◽

Riccardo Troncone ◽

Margherita Massitti ◽

Luigi Greco ◽

Renata Auricchio

Keyword(s):

Quality Of Life ◽

Influencing Factors ◽

Average Length ◽

Study Data ◽

Gluten Free Diet ◽

Gluten Free ◽

Diet Adherence ◽

School Career

Assessment of adherence to gluten-free diet (GFD) represents the cornerstone in the management of coeliac disease. The primary aim of this study was to assess diet adherence through a questionnaire adapted to children. The secondary aim was to identify influencing factors and outcomes related to diet adherence. In this study, data about diagnosis, education, quality of life (QoL) and anti-transglutaminase (anti-TG2) titers of 160 coeliac children were collected. For the assessment of diet adherence, all participants completed the questionnaire modified from Leffler et al. (2009), while a random sample of 37 also underwent an extensive dietary interview. According to the questionnaire, diet adherence was excellent in 95 (59.4%), fair in 46 (28.8%) and low in 19 (11.9%) patients. Children diagnosed with biopsy showed better adherence than those with a biopsy-sparing approach (p = 0.036). Adherence to GFD tended to worsen during the follow up, with the average length of follow up being associated with lower scores of diet adherence (p = 0.009). Moreover, adherence to GFD decreased throughout school career, dropping from elementary until high school (p = 0.037). A positive correlation was observed between adherence to GFD and growth percentiles, which increased when higher scores of adherence were achieved. Diet adherence positively correlated with QoL (p = 0.001). In conclusion, the questionnaire displayed good sensitivity in detecting problems in diet adherence, being useful as a screening tool. Better comprehension of influencing factors and outcomes may allow the development of new strategies to improve diet adherence.

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The Relationship Between Quality of Life and Coping Strategies of Adults With Celiac Disease Adhering to a Gluten-Free Diet

Gastroenterology Nursing ◽

10.1097/sga.0b013e318237d201 ◽

2011 ◽

Vol 34 (6) ◽

pp. 460-468 ◽

Cited By ~ 12

Author(s):

Melissa M. Smith ◽

Linda Goodfellow

Keyword(s):

Quality Of Life ◽

Celiac Disease ◽

Coping Strategies ◽

Gluten Free Diet ◽

Gluten Free ◽

And Coping ◽

The Relationship

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T02.02.9 QUALITY OF LIFE IN CELIAC PATIENTS ON A GLUTEN FREE DIET: A CROSS SECTIONAL EVALUATION

Digestive and Liver Disease ◽

10.1016/s1590-8658(20)30687-3 ◽

2020 ◽

Vol 52 ◽

pp. S87-S88

Author(s):

I. Marsilio ◽

C. Canova ◽

C. Marinelli ◽

B. Barberio ◽

A. D'Odorico ◽

...

Keyword(s):

Quality Of Life ◽

Gluten Free Diet ◽

Gluten Free ◽

Cross Sectional

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Coeliac disease and the gluten-free diet: a review of the burdens; factors associated with adherence and impact on health-related quality of life, with specific focus on adolescence

Journal of Human Nutrition and Dietetics ◽

10.1111/jhn.12375 ◽

2016 ◽

Vol 29 (5) ◽

pp. 593-606 ◽

Cited By ~ 51

Author(s):

L. E. White ◽

E. Bannerman ◽

P. M. Gillett

Keyword(s):

Quality Of Life ◽

Coeliac Disease ◽

Gluten Free Diet ◽

Gluten Free ◽

Health Related Quality ◽

Factors Associated ◽

Specific Focus ◽

Related Quality ◽

Health Related

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Clinical impact of a gluten-free diet on health-related quality of life in seven fibromyalgia syndrome patients with associated celiac disease

BMC Gastroenterology ◽

10.1186/1471-230x-13-157 ◽

2013 ◽

Vol 13 (1) ◽

Cited By ~ 20

Author(s):

Luis Rodrigo ◽

Ignacio Blanco ◽

Julio Bobes ◽

Frederick J de Serres

Keyword(s):

Quality Of Life ◽

Celiac Disease ◽

Fibromyalgia Syndrome ◽

Clinical Impact ◽

Gluten Free Diet ◽

Gluten Free ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Medical and Economic Impact of the Gluten-Free Diet on the Quality of Life and Social Adaptation in Patients with Gluten Enteropathy - а Ten-Year Clinical Experience

Izvestia Journal of the Union of Scientists - Varna. Economic Sciences Series ◽

10.36997/ijusv-ess/2019.8.3.163 ◽

2019 ◽

Vol 8 (3) ◽

pp. 163-170

Author(s):

Lili Grudeva ◽

Keyword(s):

Quality Of Life ◽

Economic Impact ◽

Clinical Experience ◽

Social Adaptation ◽

Gluten Free Diet ◽

Gluten Free ◽

Gluten Enteropathy

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Effectiveness of nutritional supplementation for children with coeliac disease who are on a gluten-free diet

Medical Council ◽

10.21518/2079-701x-2019-17-138-146 ◽

2019 ◽

pp. 138-146

Author(s):

V. A. Kur’yaninova ◽

M. V. Stoyan ◽

I. N. Zakharova ◽

L. Ya. Klimov ◽

V. S. Kashnikov ◽

...

Keyword(s):

Quality Of Life ◽

Coeliac Disease ◽

Physical Development ◽

Nutritional Supplementation ◽

Gluten Free Diet ◽

Gluten Free ◽

Nutrient Deficiencies ◽

Quality Of Life Indicators ◽

Enteric Nutrition

Patients on a gluten-free diet are at risk of developing polyhypoavitaminosis and deficiency states, which requires the supplementation of their diet to prevent nutrient deficiencies. The aim of the study: to analyze the dynamics of anthropometric and laboratory parameters, components of the quality of life in children with coeliac disease on the background of a month-long course of administration of hypercaloric mixture for enteric nutrition. Materials and methods: 45 children with coeliac disease aged 2-10 years (mean age 6.3 ± 0.3 years) on a strict gluten-free diet for more than one year. All patients received additional enteric nutrition with a hypercaloric mixture in the volume of 200 ml/day (300 kcal/day) for 1 month as a supplement to the main food ration. Two groups of patients receiving the supplement in 2012-2013 and 2017-2018 were identified. Physical development was assessed under the WHO AnthroPlus programme. The quality of life indicators were assessed using the PedQL 4.0 questionnaire. Results: the total frequency of protein-сalorie deficiency (PCD) before the course of nutritional supplementation was 13 (28.9%) cases, while acute PCD was diagnosed in 6 (13.3%) and chronic PCD in 7 (15.6%) patients. Against the background of the course of nutritious supplementation in children with coeliac disease, there was a significant reduction in weight, height and BMI in both groups. Patients in 2012-2013 initially had a greater gap in weight and height compared to children in 2017-2018. There was an improvement in the sum of the quality of life indicators by 6.3% for children in the first group and by 4.3% for children in the second group against the background of nutritional supplementation. Conclusions: Enrichment of children’s diets with a hypercaloric blend of dietary fiber helps to accelerate the pace of physical development, reduce the number of children with diabetes mellitus, improve hemogram rates and most components of quality of life.

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