scholarly journals Molecular Noninvasive Diagnosis of Hepatocellular Carcinoma Using Microsatellite Instability

2021 ◽  
Vol 22 (10) ◽  
pp. 3337-3346
Author(s):  
Samah Mamdouh ◽  
Tarek Aboushousha ◽  
Amr Abdelraouf ◽  
Hussam Hamdy ◽  
Mohamed Seleem ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microsatellite Instability ◽  
Noninvasive Diagnosis

scholarly journals Noninvasive Diagnosis of Hepatocellular Carcinoma on Sonazoid-Enhanced US: Value of the Kupffer Phase

Diagnostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 141
Author(s):  
Hiroshi Takahashi ◽  
Katsutoshi Sugimoto ◽  
Naohisa Kamiyama ◽  
Kentaro Sakamaki ◽  
Tatsuya Kakegawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnostic Performance ◽  
Late Phase ◽  
Imaging Feature ◽  
Arterial Phase ◽  
Liver Imaging ◽  
Noninvasive Diagnosis ◽  
Contrast Enhanced ◽  
Treatment Naïve ◽  
Hepatic Lesions

The aim of this study was to compare the diagnostic performance of Contrast-Enhanced US Liver Imaging Reporting and Data System (CEUS LI-RADS) version 2017, which includes portal- and late-phase washout as a major imaging feature, with that of modified CEUS LI-RADS, which includes Kupffer-phase findings as a major imaging feature. Participants at risk of hepatocellular carcinoma (HCC) with treatment-naïve hepatic lesions (≥1 cm) were recruited and underwent Sonazoid-enhanced US. Arterial phase hyperenhancement (APHE), washout time, and echogenicity in the Kupffer phase were evaluated using both criteria. The diagnostic performance of both criteria was analyzed using the McNemar test. The evaluation was performed on 102 participants with 102 lesions (HCCs (n = 52), non-HCC malignancies (n = 36), and benign (n = 14)). Among 52 HCCs, non-rim APHE was observed in 92.3% (48 of 52). By 5 min, 73.1% (38 of 52) of HCCs showed mild washout, while by 10 min or in the Kupffer phase, 90.4% (47 of 52) of HCCs showed hypoenhancement. The sensitivity (67.3%; 35 of 52; 95% CI: 52.9%, 79.7%) of modified CEUS LI-RADS criteria was higher than that of CEUS LI-RADS criteria (51.9%; 27 of 52; 95% CI: 37.6%, 66.0%) (p = 0.0047). In conclusion, non-rim APHE with hypoenhancement in the Kupffer phase on Sonazoid-enhanced US is a feasible criterion for diagnosing HCC.

Incidence of microsatellite instability‐high hepatocellular carcinoma among Japanese patients and response to pembrolizumab

2020 ◽  
Vol 50 (7) ◽  
pp. 885-888 ◽  
Author(s):  
Tomokazu Kawaoka ◽  
Yuwa Ando ◽  
Masami Yamauchi ◽  
Yosuke Suehiro ◽  
Kenji Yamaoka ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microsatellite Instability ◽  
Japanese Patients

scholarly journals Loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in Taiwan

1999 ◽  
Vol 80 (3-4) ◽  
pp. 468-476 ◽  
Author(s):  
J-C Sheu ◽  
Y-W Lin ◽  
H-C Chou ◽  
G-T Huang ◽  
H-S Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Microsatellite Instability ◽  
Loss Of Heterozygosity

The Impact of Vascular and Nonvascular Findings on the Noninvasive Diagnosis of Small Hepatocellular Carcinoma Based on the EASL and AASLD Criteria

2010 ◽  
Vol 105 (3) ◽  
pp. 599-609 ◽  
Author(s):  
Simona Leoni ◽  
Fabio Piscaglia ◽  
Rita Golfieri ◽  
Valeria Camaggi ◽  
Gianpaolo Vidili ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Noninvasive Diagnosis ◽  
Small Hepatocellular Carcinoma ◽  
The Impact

scholarly journals Contrast-enhanced ultrasound algorithm (ACR CEUS LI-RADSv 2017)– a valuable tool for the noninvasive diagnosis of hepatocellular carcinoma in patients with chronic liver disease

2021 ◽  
Author(s):  
Ana Maria Ghiuchici ◽  
Mirela Dănilă ◽  
Alina Popescu ◽  
Roxana Șirli ◽  
Tudor Moga ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
High Risk ◽  
Predictive Value ◽  
Real Life ◽  
Reference Method ◽  
Focal Liver Lesions ◽  
Noninvasive Diagnosis ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Malignant Lesions

Aims: to evaluate the accuracy of LR-5 category from the latest Contrast-Enhanced Ultrasound algorithm (ACR CEUS LI-RADSv 2017) for the noninvasive diagnosis of hepatocellular carcinoma (HCC), in a real-life cohort of high-risk patients. Material and methods: We retrospectively re-analysed the CEUS studies of 464 focal liver lesions (FLL) in 382 patients at high-risk for HCC (liver cirrhosis of any aetiology, chronic B or C hepatitis with severe fibrosis) using the ACR CEUS LI-RADSv 2017 algorithm. CEUS LI-RADS categories used for the diagnosis of HCC were: CEUS LR-5 (definitely HCC) and CEUS LR-TIV (HCC with macrovascular invasion). Contrast-enhanced CT, contrast-enhanced MRI, or histology were used as diagnostic reference methods to evaluate the CEUS LI-RADS classification of the 464 lesions. Results: According to the reference method, the 464 lesions were classified as follows: 359 HCCs, 68 non-HCC-non-malignant lesions and 37 non-HCC malignant lesions. The diagnostic accuracy of LR-5 category for the diagnosis of hepatocellular carcinoma was 76.9%. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 71.9%, 94.3 %, 97.7% and 49.5%, respectively. Conclusions: LR-5 category from ACR CEUS LI-RADSv 2017 algorithm, has good sensitivity, excellent specificity, and PPV for the diagnosis of HCC. The HCC rate increases from LR-3 to LR-5.

scholarly journals Comparison of LI-RADS 2018 and KLCA-NCC 2018 for noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging

2020 ◽  
Vol 26 (3) ◽  
pp. 340-351 ◽  
Author(s):  
Sunyoung Lee ◽  
Seung-seob Kim ◽  
Dong ryul Chang ◽  
Hyerim Kim ◽  
Myeong-Jin Kim
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hepatocellular Carcinoma ◽  
High Risk ◽  
Magnetic Resonance ◽  
Statistical Significance ◽  
Liver Imaging ◽  
Noninvasive Diagnosis ◽  
Resonance Imaging ◽  
Extracellular Contrast Agent ◽  
Significant Difference

Background/Aims: This study aimed to compare the diagnostic performances of Liver Imaging Reporting and Data System (LI-RADS) 2018 and Korean Liver Cancer Association-National Cancer Center (KLCA-NCC) 2018 criteria on magnetic resonance imaging (MRI) for the noninvasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients.Methods: This retrospective study included 273 treatment-naïve patients (71 patients with extracellular contrast agent [ECA]-MRI and 202 patients with hepatobiliary agent [HBA]-MRI; 352 lesions including 263 HCCs) with high risk of HCC who underwent contrast-enhanced MRI between 2016 and 2017. Two readers evaluated all lesions according to the criteria of LI-RADS 2018 and KLCA-NCC 2018. The per-lesion diagnostic performances were compared using the generalized estimating equation method.Results: On ECA-MRI, the sensitivity and specificity of LI-RADS 2018 and KLCA-NCC 2018 were not significantly different (LR-5 vs. definite HCC: 75.8% vs. 69.4%, <i>P</i>=0.095 and 95.8% vs. 95.8%, <i>P</i>>0.999; LR-5/4 vs. definite/probable HCC: 87.1% vs.83.9%, P=0.313 and 87.5% vs. 91.7%, <i>P</i>=0.307). On HBA-MRI, definite HCC of KLCA-NCC 2018 showed significantly higher sensitivity (79.1% vs. 68.2%, <i>P</i><0.001) than LR-5 of LI-RADS 2018 without a significant difference in specificity (93.9% vs. 95.4%, <i>P</i>=0.314). Definite/probable HCC of KLCA-NCC 2018 had higher specificity (92.3% vs. 80.0%, <i>P</i>=0.003) than LR-5/4 of LI-RADS 2018. The sensitivity was lower for definite/probable HCC than for LR-5/4 without statistical significance (85.6% vs. 88.1%, <i>P</i>=0.057).Conclusions: On ECA-MRI, LI-RADS 2018 and KLCA-NCC 2018 showed comparable diagnostic performances. On HBA-MRI, definite HCC of KLCA-NCC 2018 provided better sensitivity than LR-5 category of LI-RADS 2018 without compromising the specificity, while definite/probable HCC of KLCA-NCC 2018 revealed higher specificity than LR-5/4 of LI-RADS 2018 for diagnosing HCC.

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