Mucocutaneous involvement in behçet’s disease

2020 ◽  
Vol 5 (5) ◽  
pp. 01-03
Author(s):  
Z. alaya Alaya
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chronic Inflammatory Disease ◽  
Behcet's Disease ◽  
Male Predominance ◽  
Skin Ulcers ◽  
Systemic Manifestations ◽  
Inflammatory Drugs ◽  
Perianal Ulcers

Behçet's disease is a chronic inflammatory disease characterized by its clinical polymorphism associating mucocutaneous involvement to systemic manifestations. The mucocutaneous lesions are considered the hallmark of the disease, being the most common symptoms presenting at the onset of disease. Our objective was to determine the characteristics of this skin involvement during Behçet's disease. We conducted a descriptive study over a period of 30 years, having collected all patients with Behçet's disease. These were 98 patients. A male predominance was observed in our studied population with a Sex Ratio of 2.5. The mean age at diagnosis was 34 years. Mucocutaneous involvement was observed in all patients. Oral aphthosis was constant and genital ulcers, were observed in 81 cases. The other mucocutaneous manifestations were: pseudofolliculitis (61 cases), erythema nodosum (7 cases), skin ulcers (4 cases), acneiform lesions (2 cases), perianal ulcers (1 case), skin ulceration (1 case) and erythema multiforme. (1 case). All of our patients were treated with colchicine. Corticosteroids and non-steroidal anti-inflammatory drugs were each indicated in one case for resistant forms.

Mucocutaneous involvement in behçet’s disease

2020 ◽  
Vol 5 (5) ◽  
pp. 01-03
Author(s):  
Z. alaya ◽  
R amri ◽  
A. fraj ◽  
I. chaabane ◽  
W. Garbouj ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chronic Inflammatory Disease ◽  
Behcet's Disease ◽  
Male Predominance ◽  
Skin Ulcers ◽  
Systemic Manifestations ◽  
Inflammatory Drugs ◽  
Perianal Ulcers

Behçet's disease is a chronic inflammatory disease characterized by its clinical polymorphism associating mucocutaneous involvement to systemic manifestations. The mucocutaneous lesions are considered the hallmark of the disease, being the most common symptoms presenting at the onset of disease. Our objective was to determine the characteristics of this skin involvement during Behçet's disease. We conducted a descriptive study over a period of 30 years, having collected all patients with Behçet's disease. These were 98 patients. A male predominance was observed in our studied population with a Sex Ratio of 2.5. The mean age at diagnosis was 34 years. Mucocutaneous involvement was observed in all patients. Oral aphthosis was constant and genital ulcers, were observed in 81 cases. The other mucocutaneous manifestations were: pseudofolliculitis (61 cases), erythema nodosum (7 cases), skin ulcers (4 cases), acneiform lesions (2 cases), perianal ulcers (1 case), skin ulceration (1 case) and erythema multiforme. (1 case). All of our patients were treated with colchicine. Corticosteroids and non-steroidal anti-inflammatory drugs were each indicated in one case for resistant forms.

scholarly journals Successful Treatment of Intracardiac and Pulmonary Thrombi in Behçet’s Disease with Oral Anticoagulant and Immunosuppressive Therapy

2012 ◽  
Vol 55 (4) ◽  
pp. 186-188 ◽  
Author(s):  
Uğur Canpolat ◽  
Hikmet Yorgun ◽  
Ali Akdoğan ◽  
Kudret Aytemir
Keyword(s):  
Immunosuppressive Therapy ◽  
Behçet’S Disease ◽  
Oral Anticoagulant ◽  
Behcet’S Disease ◽  
Cardiac Involvement ◽  
Behçet's Disease ◽  
Chronic Inflammatory Disease ◽  
Vascular Involvement ◽  
Behcet's Disease ◽  
Ventricular Thrombus

Behçet’s disease is a multisystem chronic inflammatory disease generally presenting as recurrent oral-genital ulcers and uveitis. Vascular involvement is a common presentation. However, cardiac involvement is rare in this disorder. In this case report, we present a large right ventricular thrombus detected both in computed tomography and echocardiography in a 32 year-old male patient with complaints of fever, haemoptysis and weight loss. Intracardiac thrombus showed both clinical and radiological regression with oral anticoagulant and immunosuppressive therapy.

scholarly journals Behçet’s Disease and Tuberculosis: A Complex Relationship

2020 ◽  
Author(s):  
Sara Mendonça Freitas ◽  
Joana Silva Marques ◽  
Ana Grilo ◽  
Rodolfo Gomes ◽  
Fernando Martos Gonçalves
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Systemic Vasculitis ◽  
Gastrointestinal Involvement ◽  
Behcet's Disease ◽  
History Of ◽  
Systemic Manifestations ◽  
Work Up

Behçet’s disease (BD) is a systemic vasculitis characterized by recurrent orogenital ulceration and several systemic manifestations (such as gastrointestinal involvement, vascular disease or arthritis). The pathogenesis is still unknown but the trigger role of certain pathogens such as Mycobacterium tuberculosis is well documented. Furthermore, patients with BD are more susceptible to tuberculosis due to immunity defects. Here, we describe the case of a 70-year-old woman with a history of recurrent oral aphthae and inflammatory arthritis presenting with extensive thrombosis of left upper limb major veins, a positive HLA B51 genotype and colon ulceration; hence, BD diagnosis was made after excluding other causes. Simultaneously, the patient had cutaneous abscesses not associated with immunosuppressive therapy with continuous development, and after recurrent negative tuberculosis work-up, M. tuberculosis was isolated in an abscess culture.

Behçet's Disease from Rheumatology and Neurology Perspectives with Special Reference to Children

2019 ◽  
Vol 18 (04) ◽  
pp. 175-181
Author(s):  
Yaşar B. Turgut ◽  
Ayşe F. Tosun ◽  
Beste K. Yüzbaşı ◽  
Hasan Tunca
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
International Study ◽  
Skin Lesions ◽  
Disease Classification ◽  
Behcet's Disease ◽  
Male Predominance ◽  
Pediatric Age Group ◽  
Pathergy Test

AbstractBehçet's disease (BD) is an idiopathic chronic relapsing multisystemic vascular inflammatory disease. Although it is generally seen in young adults with male predominance, the onset age of the disease is the pediatric age group in only 4 to 26% of all cases of BD. According to the International Study Group for Behçet's Disease Classification Criteria, a diagnosis of BD requires recurrent oral aphthous ulcerations with two of the following: genital ulcerations, skin lesions, eye lesions, or a positive pathergy test. In this article, we extensively reviewed the current literature with respect to the rheumatological and neurological findings of BD in childhood.

scholarly journals Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-αProduction in PBMC of Patients with Behçet’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sevgi Irtegun ◽  
Gulsum Pektanc ◽  
Zeynep M. Akkurt ◽  
Mehtap Bozkurt ◽  
Fatih M. Turkcu ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Proinflammatory Cytokines ◽  
Behcet’S Disease ◽  
Mononuclear Cells ◽  
Behçet's Disease ◽  
Skin Lesions ◽  
Chronic Inflammatory Disease ◽  
Src Family Kinases ◽  
Peripheral Blood Mononuclear ◽  
Behcet's Disease

Behçet’s disease (BD) is a multisystemic chronic inflammatory disease characterized by relapsing oral and genital ulcers, uveitis, and skin lesions. The pathogenesis of BD is still unknown. Aberrant production of some cytokines/chemokines plays an important role in the pathogenesis of various inflammatory diseases. Revealing a key signaling regulatory mechanism involved in proinflammatory cytokines/chemokines production is critical for understanding of the pathogenesis of BD. The aim of this study was to determine the role of Src family kinases (SFKs) in production of some LPS-induced proinflammatory cytokines/chemokines in peripheral blood mononuclear cells (PBMC) of active BD patients. Chemical inhibition of SFKs activity impaired LPS-induced TNF-αproduction in PBMC of active BD patients, suggesting that modulating SFKs activity may be a potential target for BD treatment.

scholarly journals Behçet’s Disease as a Model of Venous Thrombosis

2010 ◽  
Vol 4 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Micaela La Regina ◽  
Armen Yuri Gasparyan ◽  
Francesco Orlandini ◽  
Domenico Prisco
Keyword(s):  
Venous Thrombosis ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Skin Lesions ◽  
Chronic Inflammatory Disease ◽  
Vascular Lesions ◽  
Behcet's Disease ◽  
Therapeutic Measures ◽  
Arterial Aneurysms

Behçet’s disease (BD) is a chronic inflammatory disease of unknown aetiology characterized by recurrent oral, genital aphthous ulcerations, uveitis, skin lesions and other multisystem affections associated with vasculitis. Different types of vessels, predominantly veins, can be affected in BD. The frequency of vascular lesions in BD, such as superficial and deep venous thromboses, arterial aneurysms and occlusions, ranges between 7-29%. In this review, various factors of thrombogenesis in BD, particularly pro- and antithrombotic endothelial and non-endothelial factors, factors of coagulation, platelet activation and rheological changes are presented and discussed from positions of Virchow’s triad of venous thrombosis. Despite advances in understanding of thrombogenesis in BD, still many issues of diagnosis and targeted preventive and therapeutic measures remain unresolved. Further studies are needed to clarify the pathobiology of BD-related thrombosis and to provide the clinicians with recommendations over the utility, safety and effectiveness of the antithrombotic therapy in BD.

scholarly journals Behcet's Disease and Endocrine System

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Onur Ozhan ◽  
Kerem Sezer
Keyword(s):  
Insulin Resistance ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Systemic Vasculitis ◽  
Endocrine System ◽  
The Body ◽  
Behcet's Disease ◽  
Systemic Manifestations ◽  
Anterior Hypophysis

Behcet's disease (BD) is a chronic disease which is characterized by recurrent oral apthous ulcerations, recurrent genital ulcerations, skin eruptions, ocular involvements and other various systemic manifestations as well as systemic vasculitis. Endocrine involvement in BD regarding various systems can be seen. Hypophysis is one of the best and dense vascularized organs of the body, thus it is likely that it can be affected by BD. Not only anterior hypophysis functions, but posterior hypophysis functions as well can be affected. As BD is a disease of autoimmune process, it may be possible that adrenal insufficiency or alterations in the cortisol levels could be expected. Another concern is whether or not there is insulin resistance in patients with BD. The avaliable data suggests that there is an increased susceptibility to insulin resistance in patients with BD.

scholarly journals Molecular Analysis of Single-Nucleotide Polymorphisms of TRAF5 Gene in Patients with Behçet's Disease from the Azeri Population of Northwest Iran

2021 ◽  
Vol 8 (2) ◽  
pp. 01-07
Author(s):  
Mohammad Khalaj-Kondori ◽  
Reza Hosseinzadeh ◽  
Leila Saremi ◽  
Mohammad Ebrahim Ghaffari ◽  
Sepideh Babaniamansour
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Tumor Necrosis Factor Receptor ◽  
Chronic Inflammatory Disease ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Behcet's Disease ◽  
Significant Difference

Background: Behçet's disease (BD) is a chronic inflammatory disease with unknown causes. The geographical distribution is mostly consistent with the historic Silk Road. The role of tumor necrosis factor receptor-associated factor 5 (TRAF5) gene in the inflammation signaling pathway leads more attention to the potency of different polymorphisms of the TRAF5 gene, in the development of BD. Methods: This was a case-control study conducted among the Azeri Turk ethnic group (50 BD patients and 50 persons with no history of autoimmune disease), Tabriz, Iran. Four different TRAF5 gene polymorphisms were assessed via the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique. Data were analyzed by SPSS Version 20. Results: Genotypic distributions of four studied Single nucleotide polymorphisms (SNPs) had no significant difference between case and control groups (rs6540679 (p=0.50), rs12569232 (p=0.86), rs10863888 (p=0.14), and rs7514863 (p=0.24). There were also found no significant differences in SNP allelic frequencies between cases and controls

scholarly journals AB0723 JUVENILE BEHCET’S DISEASE: WHICH PARTICULARITIES?

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1393.1-1393
Author(s):  
O. Jomaa ◽  
O. Berriche ◽  
S. Arfa ◽  
A. Fraj ◽  
W. Romdhane ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Systemic Vasculitis ◽  
Joint Damage ◽  
Platelet Aggregation Inhibitors ◽  
Neurological Damage ◽  
Poor Prognostic Factor ◽  
Behcet's Disease ◽  
Male Predominance

Background:Behcet’s disease (BD) is a systemic vasculitis that affects young adults aged between 20 and 30 years old. It is rare in childhood.Objectives:This work aims to analyze the clinical features of this form by comparing it with adult BD.Methods:Through a retrospective study including 192 cases with BD seen in The Internal Medicine Department at Tahar Sfar Hospital Mahdia TUNISA, we report 8 cases of juvenile BD (4.2%) that occurred under the age of 16 years.Results:There were 8 male. The average age of BD onset was 14 years [11, 16 years]. Genital aphthosis was noted in 5 patients. Ophthalmologic damage was observed in 4 patients, dominated by uveitis (75% of cases). No cases of blindness were observed. Joint damage was seen in 5 patients and vascular and neurological damage in 2 patients respectively. All patients received colchicine in addition to a platelet aggregation inhibitors at the moment of BD diagnosis. When comparing juvenile BD group with that of adults, we have noticied, the frequency of cutaneo-mucous and articular manifestations, the rarity of neurological damage and the absence of cardiac and digestive damage in the juvenile BD group.Conclusion:Juvenile BD is a rare form, with a male predominance. The younger age is not a poor prognostic factor. Early diagnosis and treatment can reduce the disease’s complications.References:[1]doi: 10.1007/s00296-018-4208-9Disclosure of Interests:None declared

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