scholarly journals MORPHOLOGICAL CHANGES IN THE MUCOUS MEMBRANE OF THE STOMACH AND DUODENUM IN ACUTE EROSIVE - ULCERATIVE LESIONS OF VARIOUS ETIOLOGICAL ORIGIN.

2021 ◽  
Vol 3 (73) ◽  
pp. 9-11
Author(s):  
E. Pshukova ◽  
F. Gamaeva ◽  
A. Musukaeva
Keyword(s):  
Mucous Membrane ◽  
Morphological Changes ◽  
Duodenal Mucosa ◽  
Stress Ulcers ◽  
Ulcerative Lesions

The article considers morphological disorders of cellular renewal of the stomach and duodenal mucosa in acute erosive-ulcerative lesions of various etiological origins (stress ulcers)

scholarly journals DIAGNOSTIC VALUE OF MORPHOLOGICAL CHANGES IN GASTROESOPHAGEAL REFLUX DISEASE IN BIOPSY MATERIAL OF THE DISTAL ESOPHAGUS IN ADOLESCENTS SICKLY WITH ACUTE RESPIRATORY DISEASES

2019 ◽  
Vol 1 ◽  
pp. 15-23
Author(s):  
Olena Zhuravel ◽  
Tetyana Pochinok ◽  
Tamara Zadorozhna ◽  
Tetyana Archakova ◽  
Valentyna Zamula
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Mucous Membrane ◽  
Reflux Disease ◽  
Respiratory Diseases ◽  
Morphological Changes ◽  
Diagnostic Value ◽  
Distal Esophagus ◽  
Biopsy Material ◽  
Acute Respiratory Diseases

The article dedicated to the problem of the diagnostic value of morphological changes in gastroesophageal reflux disease in the biopsy of the distal esophagus in pubertal children of childbearing age. Aim of the research is to investigate the diagnostic value of morphological changes in gastroesophageal reflux disease in esophageal biopsy material in adolescents sickly with acute respiratory diseases. Methodology. The objective of the study was achieved through examination of 90 adolescents (10 to 16 years old, average age 13.1±3.54 years) kept under observation at the Children’s Clinical Hospital No. 9 of Kyiv and on the basis of the Department of Pediatrics No. 1 Center of Primary Health Care No. 4 of the Desnianskyi district of Kyiv. All adolescents belonged to the group of sickly with a number of respiratory diseases averaging 6-8 times a year, lasting from 8 to 18 days (on average 12.8±5.41 days). All children have undergone endoscopic examination of the esophagus, stomach and duodenum with the esophagus mucosa biopsy using the OLYMPUS GIF-P3 flexible fiberscope. Results. It was found that the least valuable diagnostic feature in the morphological examination of the mucous membrane of the distal esophagus in the pain-causing children with GERD was thickening of the epithelium with a sensitivity of 13,0 %, a specificity of 96.0 %, and total value of 65.0 %. It has been proved that hyperplasia of cells of the basal layer of the mucous membrane of the distal esophagus at the GERD in the infected children is 46.7 % (specificity – 93.3 %, the total value is 75.6 %). Increase in the number of papillae and their prolongation in 33.3 % cases (sensitivity – 33.3 %, specificity – 93.3 %, overall diagnostic value – 70.8 %). Conclusion. The peculiarity of the morphological manifestations of GERD in childbearing children is dystrophic changes in keratocytes in the superficial parts of the multilayer squamous epithelium, which are detected at 100.0 % of patients (specificity is 93.3 %, total value is 96.8 %), with parakeratosis centers at 13.3 % of cases. It has been shown that a frequent and diagnostically valuable indication is inflammatory infiltration of the esophageal mucosa, which are verified in all cases (100.0 %, with dilatation and hyperemia in 46.7 % of patients (specificity – 40.0 %, total value – 81.3 %).

THE STATE AND ROLE OF ESOPHAGUS, STOMACH, INTESTINAL MICROBIOTA IN PATIENTS WITH ULCER DISEASE, CHRONIC GASTRITIS, ESOPHAGITIS

2020 ◽  
Vol 65 (1) ◽  
pp. 42-49
Author(s):  
V. M. Chervinets ◽  
A. Yu. Mironov ◽  
Yu. V. Chervinets ◽  
S. N. Bazlov
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Mucous Membrane ◽  
Chronic Gastritis ◽  
Low Frequency ◽  
Duodenal Mucosa ◽  
Pathological Process ◽  
Quantitative Composition ◽  
Ulcer Disease ◽  
Opportunistic Bacteria

The microflora of 64 biopsies taken during fibrogastroduodenoscopy of the mucous membrane of the esophagus, stomach and duodenum in healthy volunteers and 1120 samples obtained from the same parts of the digestive tract in patients with esophagitis, chronic gastritis and peptic ulcer disease were studied. The patients ranged in age from 18 to 62 years. Traditional bacteriological method was used to isolate and identify microorganisms. Staphylococcus spp., Streptococcus spp., Lactobacillus spp., Bacteroides spp., Stomatococcus spp., Enterobacteriaceae, Corynebacterium spp., Micrococcus spp., Neisseria spp., Veilonella spp. were isolated from biopsies of healthy respondents in an average amount from 3.2 to 4.68 lg CFU/g. H.pylori was found in 60% (5.66 lg CFU/g) in the esophagus, in 33.3% of cases (5.12 lg CFU/g) from the fundal part of the stomach, in 44.4% (5.25 lg CFU/g) from the antral part of the stomach, in 5.5% (4.2 lg CFU/g) in the duodenal mucosa. In samples obtained from the inflamed and eroded mucous membrane of the esophagus, stomach and duodenum, opportunistic bacteria of the genera Klebsiella, Enterobacter, Proteus, Pseudomonas, Peptococcus, Actinomyces, yeast fungi of the genus Candida etc. were detected in an amount exceeding 4 lg CFU/g. H. pylori isolated in 6.3-16.7% of patients (4.25-4.6 lg CFU/g) and did not dominate in relation to other microorganisms, and in most cases had a low frequency of its occurrence. In patients with the recurrence of peptic ulcer disease, exacerbation of chronic gastritis and esophagitis, dysbiosis was developed, characterized by an increase in the species and quantitative composition of opportunistic microflora, an increase in its enzymatic and cytotoxic activity, which can contribute to the maintenance of inflammatory and necrotic processes and inhibit the elimination of the pathological process.

Morphological changes of the gastric and duodenal mucosa in adolescents with chronic gastroduodenitis and their serum vitamin D levels

2017 ◽  
Vol 15 (2) ◽  
pp. 37-41
Author(s):  
V.P. Novikova ◽  
◽  
I.Yu. Mel’nikova ◽  
O.V. Guzeeva ◽  
A.N. Petrovskiy ◽  
...  
Keyword(s):  
Vitamin D ◽  
Morphological Changes ◽  
Serum Vitamin ◽  
Duodenal Mucosa ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Comparative Anatomic Description of the Mucosal Folds of the Duodendrum in Newborns and Adults

2018 ◽  
pp. 42-47
Author(s):  
V. V. Kovalenko ◽  
E. K. Shesterina ◽  
A. I. Balako
Keyword(s):  
Mucous Membrane ◽  
Duodenal Mucosa ◽  
Morphometric Study ◽  
Distinctive Features ◽  
Qualitative And Quantitative ◽  
General Plan ◽  
Quantitative Characteristics ◽  
General Signs ◽  
Mucosal Folds ◽  
Qualitative And Quantitative Characteristics

Objective : to reveal distinctive features of the structure of the mucosal folds of each part of the duodenum in newborns and adults. Material and methods . We have performed a comparative anatomic and morphometric study of the folds of the duodenal mucosa of 40 newborns and 93 adults aged 31-75. Results . We have obtained new data on general signs and distinctive features of the structure of the folds of the duodenal mucosa in newborns and adults. Conclusion . Complicated relief of the mucous membrane in each part of the duodenum expressed in changes of qualitative and quantitative characteristics of its folds should be considered as a morphological manifestation of adaptation to the type of food having changed in the conditions of extrauterine life. General signs of the macroscopical structure of the folds of the duodenal mucosa of newborns and adults are reflexion of the general plan of the structure of the relief of the human duodenal mucosa.

scholarly journals MORPHOLOGICAL CHANGES IN THE SMALL INTESTINE OF RATS WITH ACUTE GENERALIZED PERITONITIS

2019 ◽  
pp. 110-113
Author(s):  
I. Ya. Dzyubanovsky ◽  
B. M. Vervega ◽  
S. R. Pіdruchna ◽  
N. A. Melnyk
Keyword(s):  
Endothelial Cells ◽  
Small Intestine ◽  
Mucous Membrane ◽  
Morphological Changes ◽  
Histological Study ◽  
Abdominal Cavity ◽  
Inflammatory Infiltration ◽  
Generalized Peritonitis ◽  
White Rats ◽  
Fecal Suspension

The main cause of mortality in acute generalized peritonitis (AGP) is the development of multiple organ insufficiency. The intestine is the organ where the first changes develop in this pathology. The aim of the study – to research and evaluate the morphological changes in the small intestine wall of animals with experimental AGP. Materials and Methods. 32 white rats were used in this study. Acute peritonitis was modeled by introduction of 10 % fecal suspension in the dosage of 0.5 ml per 100 g of the animal's weight into the abdominal cavity of rats by puncture. The terms of observation: the 1st, 3rd and the 7th days from the beginning of the peritonitis modeling. For histological study the intestinal tissue was taken. The resulting pieces of the organ were fixed in a 10 % neutral formalin solution, which were then stained with hematoxylin and eosin. Results and Discussion. On the 3rd day of the experiment in animals with a modeled AGP, vascular changes were manifested first of all by the rounding (retraction) of endothelial cells or their desquamation and the appearance of defects, that allow plasma proteins and the formed elements of blood to leave circulation boundaries of the vascular bed. On the 7 th day in animals with a modeled AGP increased vascular permeability of the mucous membrane of the small intestine was accompanied by a significant edema of the stroma of the villi and by focal hemorrhages. Conclusion. Consequently, the distinct inflammatory changes in all terms of the injury were seen in the wall of the small intestine at the simulated AGP. The significant expansion of the capillaries and venules against the background of inflammatory infiltration in the stroma of the glandular component of the small intestine was noted on the 1st day from the beginning of the experiment. An increase in the height of intestinal villus and a crypt with retraction and desquamation of endothelial cells in the wall of vessels, which caused platelet adhesion in the areas of destruction was observed on the 3rd day. The areas of focal necrosis of the superficial epithelium, which were accompanied by multiple hemorrhages per diapedesis in the perivascular space of the mucous membrane, were seen in the wall of the small intestine of animals with a simulated AGP on the 7th day.

scholarly journals The morphological changes relationship in the small intestine mucous membrane with the dynamics of the enterocyte’s membranes polypeptide composition in cattle during the fetal period of their ontogenesis

2021 ◽  
Vol 9 (1) ◽  
pp. 52-56
Author(s):  
D. M. Masiuk
Keyword(s):  
Molecular Weight ◽  
Mucous Membrane ◽  
Apical Membrane ◽  
Morphological Changes ◽  
Basolateral Membrane ◽  
Intestinal Wall ◽  
Current Data ◽  
Polypeptide Composition ◽  
Fetal Period ◽  
Molecular Weights

The article presents current data on the relationship of morphological changes in the jejenum intestine mucous membrane with the dynamics of the polypeptide composition in the cattle enterocytes membranes during the fetal period of ontogenesis. The study was carried out on 80 fetuses of Holstein cattle, aged 2–9 months, with a body weight of 0.6–39 kg. It was found that during the fetal period of ontogenesis, structural transformations took place in the jejunal mucous membrane of cattle, characterized by intense morphofunctional changes in its structural components. The polypeptide composition of the jejunal enterocytes plasma membrane in cattle during the fetal period of ontogenesis was determined, in particular, in the apical and basolateral membranes, respectively, 27 and 25 protein fractions with a molecular weight of 9.6–14.2 kDa to 300 kDa were found, respectively. With the help of the correlation analysis for the received data, reliable interconnections of morphological changes in the jejunal mucous layer with the dynamics of the polypeptide composition of the cattle enterocyte’s membranes during the fetal period of ontogenesis were obtained. It has been proven that the thickness of the intestinal wall with villi and the mucous membrane with villi is directly related to the content of proteins with a molecular weight of 250 kDa and 155 kDa on the apical domain of enterocytes (P ≤ 0.01–0.001). The height of the villi is associated only with the content of polypeptides with a molecular weight of 250 kDa and 155 kDa (P ≤ 0.05–001) in the apical membrane and is inversely related to the content of polypeptides with a molecular weight of 9.6–14.2 kDa, 21 kDa, 22.5 kDa, 26 kDa, 33 kDa, 35 kDa, 170–185 kDa (P ≤ 0.01–0.001). The width of the villi is related to the content on the apical membrane of proteins with a molecular weight of 170–185 kDa and 21 kDa (P ≤ 0.05–0.01). The thickness of the intestinal wall with villi and mucous membrane with villi is associated with the content of proteins with molecular weights 155 kDa, 100 kDa, 87 kDa, 66 kDa, 52 kDa) and 43 kDa (P ≤ 0.05–0.001) on the basolateral domain of enterocytes and inversely dependent on the content of polypeptides with molecular weights of 19 kDa, 21 kDa and 31 kDa (P ≤ 0.05). The height of enterocyte villi is directly related to the content of polypeptides with a molecular weight of 155 kDa and 52 kDa (P ≤ 0,05–0,01) in the basolateral membrane and is inversely dependent on the content of polypeptides with a molecular weight of 24 kDa, 22.5 kDa and 17 kDa (P ≤ 0.05–0.001). The width of the villi of enterocytes is reliably inversely related only to the content of proteins with a molecular weight of 155 kDa on the basolateral membrane (P ≤ 0.05).

scholarly journals Morphological changes of the mucous membrane in children with chronic gastroduodenal pathology and infection with cytotoxic strains of Helicobacter pylori

2018 ◽  
Vol 14 (3) ◽  
pp. 314-318
Author(s):  
Gennady Mukolayovich Rudenko ◽  
◽  
Kateryna Vadimovna Khromykh ◽  
Marina Olexandrovna Shalamai ◽  
Irina Valerianovna Storozhuk ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Mucous Membrane ◽  
Morphological Changes

scholarly journals FINE STRUCTURE OF CELL SURFACE SPECIALIZATIONS IN THE MATURING DUODENAL MUCOSA OF THE CHICK

1964 ◽  
Vol 21 (1) ◽  
pp. 75-85 ◽  
Author(s):  
Jane Overton ◽  
Jane Shoup
Keyword(s):  
Cell Surface ◽  
Morphological Changes ◽  
Duodenal Mucosa ◽  
Developmental Changes ◽  
Regular Pattern ◽  
Cell Surfaces ◽  
Trypsin Treatment ◽  
Structure Changes ◽  
Junctional Complexes ◽  
Mitotic Figures

Cell surfaces in the duodenal mucosa have been studied in maturing tissue of the chick from incubation until hatching. Changes in the distribution of mitoses in this tissue give an indication of its rate of maturation. This rate is paralleled in developmental changes in microvilli and junctional complexes. Concentration of mitotic figures towards the base of villous folds is gradual from day 9 to day 16, then rapid to day 19, after which the mature pattern is acquired. By day 11, microvilli appear in a regular pattern which does not alter through hatching. Their height remains the same to day 16 when it increases gradually to day 19, then very sharply. The angle formed between the microvilli and the cell surface increases gradually to day 16, giving evidence of advancing internal structure. Changes in cell adhesion also occur at day 16. Thereafter, following trypsin treatment cells are held together in patches by the tight junctions of the terminal bar, although the desmosomes are separated. The timing of these morphological changes is compared with that of alkaline phosphatase accumulation in this tissue as reported by Moog (13). Increase in the surface area of the microvilli parallels the increase in the activity of the enzyme.

scholarly journals Morphological changes of mucous membrane of maxillary sinus at odontogenic perforative sinusitis

2010 ◽  
Vol 9 (6) ◽  
pp. 5-11
Author(s):  
O. D. Baydik ◽  
S. V. Logvinov ◽  
S. G. Zubarev ◽  
P. G. Sysolyatin ◽  
A. A. Gurin
Keyword(s):  
Maxillary Sinus ◽  
Mucous Membrane ◽  
Specific Volume ◽  
Structural Changes ◽  
Morphological Changes ◽  
Cellular Infiltration ◽  
Cd4 Cells ◽  
Electronic Microscopy ◽  
Single Row ◽  
Ciliated Epithelial Cells

Methods of light, electronic microscopy and immunohystochemistry lead research of structural changes of a mucous membrane maxillary sinus at 43 patients with odontogenic perforative sinusitis. The material is broken into 4 groups depending on a limitation period of punching. Degenerate changes ciliated epithelial cells came to light already on early terms after perforations of sinusitis and were shown by reduction of specific volume of mitochondrias, the GER, increase NCR. In globlet exocrine cells reduction NCR is connected to infringement of evacuation of a secret. In terms more than 3 months occured metaplasia of epithelium in single-row cubic and multilayered flat with keratosis, increased cellular infiltration own plate of a mucous membrane maxillary sinus. The contents of CD4 + cells in a mucous membrane of sine gradually increased, and on late terms of occurrence of perforations decreased. The contents of CD8+ and СD20+ cells in a mucous membrane with perforations of sinusitis were raised.

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