scholarly journals Citrulline increases cholesterol efflux from macrophages in vitro and ex vivo via ATP-binding cassette transporters

2014 ◽  
Vol 55 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Harumi Uto-Kondo ◽  
Makoto Ayaori ◽  
Kazuhiro Nakaya ◽  
Shunichi Takiguchi ◽  
Emi Yakushiji ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Ex Vivo ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Atp Binding Cassette

scholarly journals Endocrine Disruptors Differentially Target ATP-Binding Cassette Transporters in the Blood-Testis Barrier and Affect Leydig Cell Testosterone Secretion In Vitro

2013 ◽  
Vol 136 (2) ◽  
pp. 382-391 ◽  
Author(s):  
Anita C. A. Dankers ◽  
Maarke J. E. Roelofs ◽  
Aldert H. Piersma ◽  
Fred C. G. J. Sweep ◽  
Frans G. M. Russel ◽  
...  
Keyword(s):  
Endocrine Disruptors ◽  
Leydig Cell ◽  
Atp Binding ◽  
Testosterone Secretion ◽  
Atp Binding Cassette Transporters ◽  
Blood Testis Barrier ◽  
Atp Binding Cassette

Regulation of Hematopoiesis by Cholesterol

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. SCI-53-SCI-53 ◽  
Author(s):  
Alan R. Tall
Keyword(s):  
Growth Factor ◽  
Cell Surface ◽  
Cholesterol Efflux ◽  
Surface Expression ◽  
Membrane Lipid ◽  
Cell Surface Expression ◽  
Atp Binding ◽  
Gm Csf ◽  
Atp Binding Cassette Transporters ◽  
Atp Binding Cassette

Abstract Leukocytosis is a risk factor for athero-thrombotic disease in humans, and develops in animal models of atherosclerosis in response to feeding high-fat, high-cholesterol diets. The ATP binding cassette transporters ABCA1 and ABCG1 promote cholesterol efflux to apoA-1 and high density lipoprotein (HDL), respectively and are targets of liver X receptor (LXR) transcription factors. Mice lacking ABCA1/G1 develop a dramatic myeloproliferative phenotype with monocytosis and neutrophilia, associated with expansion and proliferation of hematopoietic stem and myeloid progenitor populations (HSPCs). The transporters are highly expressed in HSPCs where they act to control proliferative responses to growth factors (IL-3, GM-CSF) by regulating plasma membrane lipid rafts and cell surface expression of the common β subunit of the IL-3/GM-CSF receptor. ABCG4 is closely related to ABCG1 but is expressed primarily in the megakaryocyte progenitor (MkP) population of the bone marrow. ABCG4-deficient mice have MkP proliferation and expansion, thrombocytosis, increased platelet/leukocyte aggregates and accelerated atherosclerosis. ABCG4 promotes cholesterol efflux onto HDL, and thereby reduces the cell surface expression of the thrombopoietin (TPO) receptor. This appears to involve membrane cholesterol enrichment and interruption of a negative feedback loop involving the TPO receptor and mediated by Lyn Kinase and c-CBL which mediate ubiquitination and internalization/degradation of the receptor. Overall results suggest that ATP binding cassette transporters promote cholesterol efflux, decrease membrane lipid raft formation and enhance the feedback downregulation of growth factor receptors in response to growth factor binding, with anti-proliferative responses that may be beneficial in atherosclerosis and myeloproliferative neoplasms. Disclosures No relevant conflicts of interest to declare.

scholarly journals Linoleic Acid Suppresses Cholesterol Efflux and ATP-Binding Cassette Transporters in Murine Bone Marrow-Derived Macrophages

Lipids ◽  
2014 ◽  
Vol 49 (5) ◽  
pp. 415-422 ◽  
Author(s):  
Nicole L. Spartano ◽  
Stefania Lamon-Fava ◽  
Nirupa R. Matthan ◽  
Martin S. Obin ◽  
Andrew S. Greenberg ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Linoleic Acid ◽  
Cholesterol Efflux ◽  
Atp Binding ◽  
Murine Bone Marrow ◽  
Atp Binding Cassette Transporters ◽  
Atp Binding Cassette

[14] IN VITRO AND EX VIVO FUNCTIONAL CHARACTERIZATION ON NEWLY IDENTIFIED ATP BINDING CASSETTE A1 MUTATIONS

2009 ◽  
Vol 19 ◽  
pp. S4
Author(s):  
C. Candini ◽  
R. Franssen ◽  
A.W. Schimmel ◽  
J. Peter ◽  
G.M. Dallinga-Thie ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Functional Characterization ◽  
Atp Binding ◽  
Atp Binding Cassette

scholarly journals The Capacity of APOB-Depleted Plasma in Inducing ATP-Binding Cassette A1/G1-Mediated Macrophage Cholesterol Efflux—But Not Gut Microbial-Derived Metabolites—Is Independently Associated with Mortality in Patients with ST-Segment Elevation Myocardial Infarction

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1336
Author(s):  
Marina Canyelles ◽  
Álvaro García-Osuna ◽  
Alexandra Junza ◽  
Oscar Yanes ◽  
Núria Puig ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cholesterol Efflux ◽  
Cardiovascular Death ◽  
Atp Binding ◽  
St Segment Elevation ◽  
Statistical Adjustment ◽  
Macrophage Cholesterol Efflux ◽  
Atp Binding Cassette

Impaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality. The TMAO precursors, γ-butyrobetaine (γBB) and Trimethyllysine (TML), have also been recently associated with cardiovascular death, but their interactions with HDL-mediated cholesterol efflux remain unclear. We aimed to determine the associations between APOB depleted plasma-mediated macrophage cholesterol efflux and plasma TMAO, γBB, and TML concentrations and explore their association with two-year follow-up mortality in patients with acute ST-elevation myocardial infarction (STEMI) and unstable angina (UA). Baseline and ATP-binding cassette transporter ABCA1 and ABCG1 (ABCA1/G1)-mediated macrophage cholesterol efflux to APOB-depleted plasma was decreased in patients with STEMI, and the latter was further impaired in those who died during follow-up. Moreover, the circulating concentrations of TMAO, γBB, and TML were higher in the deceased STEMI patients when compared with the STEMI survivors or UA patients. However, after statistical adjustment, only ABCA1/G1-mediated macrophage cholesterol efflux remained significantly associated with mortality. Furthermore, neither the TMAO, γBB, nor TML levels altered the HDL-mediated macrophage cholesterol efflux in vitro. We conclude that impaired ABCA1/G1-mediated macrophage cholesterol efflux is independently associated with mortality at follow-up in STEMI patients.

ATP-Binding Cassette Transporters A1 and G1, HDL Metabolism, Cholesterol Efflux, and Inflammation: Important Targets for the Treatment of Atherosclerosis

2011 ◽  
Vol 12 (5) ◽  
pp. 647-660 ◽  
Author(s):  
Dan Ye ◽  
Bart Lammers ◽  
Ying Zhao ◽  
Illiana Meurs ◽  
Theo J.C. Van Berkel ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Hdl Metabolism ◽  
Atp Binding Cassette

Study of ATP-binding Cassette Transporter A1 (ABCA1)-mediated Cellular Cholesterol Efflux in Diabetic Golden Hamsters

2007 ◽  
Vol 35 (4) ◽  
pp. 508-516 ◽  
Author(s):  
Y Zhu ◽  
H-J Wang ◽  
L-F Chen ◽  
Q Fang ◽  
X-W Yan
Keyword(s):  
Cholesterol Efflux ◽  
Adenosine Monophosphate ◽  
Peritoneal Macrophages ◽  
Atp Binding ◽  
Cellular Cholesterol ◽  
Golden Hamsters ◽  
Atp Binding Cassette Transporter ◽  
Cellular Cholesterol Efflux ◽  
Atp Binding Cassette

The effects of cyclic adenosine monophosphate (cAMP) and atorvastatin on macrophage adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux were investigated in a diabetic animal model. Golden hamsters were fed a high-fat diet which resulted in insulin resistance. Diabetes was induced by a single intraperitoneal injection of streptozotocin (30 mg/kg). Normal golden hamsters were used as controls. Peritoneal macrophages were incubated with apolipoprotein A-1 (apoA-1), 8-bromoadenosine-3′,5′-cyclic monophosphate (8-br-cAMP), and atorvastatin in vitro Intracellular cholesterol accumulation was greater in the diabetic animals than in the insulin-resistant animals. Expression of ABCA1 mRNA in macrophages from diabetic animals was upregulated by 8-br-cAMP and atorvastatin. ApoA-1 caused a time-dependent cellular cholesterol efflux. Both atorvastatin and 8-br-cAMP significantly facilitated ABCA1-mediated cellular cholesterol efflux, with the maximal cholesterol efflux rate observed in the macrophages from diabetic animals. Accumulation of cholesterol in the macrophages of diabetic animals can be significantly alleviated by atorvastatin or 8-br-cAMP through improving ABCA1-mediated cellular cholesterol efflux.

scholarly journals Neratinib Reverses ATP-Binding Cassette B1-Mediated Chemotherapeutic Drug Resistance In Vitro, In Vivo, and Ex Vivo

2012 ◽  
Vol 82 (1) ◽  
pp. 47-58 ◽  
Author(s):  
Xiao-qin Zhao ◽  
Jing-dun Xie ◽  
Xing-gui Chen ◽  
Hong May Sim ◽  
Xu Zhang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Ex Vivo ◽  
Atp Binding ◽  
Chemotherapeutic Drug ◽  
Atp Binding Cassette
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