scholarly journals Endocrine Disruptors Differentially Target ATP-Binding Cassette Transporters in the Blood-Testis Barrier and Affect Leydig Cell Testosterone Secretion In Vitro

2013 ◽  
Vol 136 (2) ◽  
pp. 382-391 ◽  
Author(s):  
Anita C. A. Dankers ◽  
Maarke J. E. Roelofs ◽  
Aldert H. Piersma ◽  
Fred C. G. J. Sweep ◽  
Frans G. M. Russel ◽  
...  
Keyword(s):  
Endocrine Disruptors ◽  
Leydig Cell ◽  
Atp Binding ◽  
Testosterone Secretion ◽  
Atp Binding Cassette Transporters ◽  
Blood Testis Barrier ◽  
Atp Binding Cassette

Endocrine disruptors target ATP binding cassette transporters in the blood--testis barrier and impair Leydig cell steroidogenesis

2013 ◽  
Author(s):  
Maarke J E Roelofs ◽  
Anita C A Dankers ◽  
Aldert H Piersma ◽  
Frans G M Russel ◽  
den Berg Martin van ◽  
...  
Keyword(s):  
Endocrine Disruptors ◽  
Leydig Cell ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Blood Testis Barrier ◽  
Atp Binding Cassette

scholarly journals Citrulline increases cholesterol efflux from macrophages in vitro and ex vivo via ATP-binding cassette transporters

2014 ◽  
Vol 55 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Harumi Uto-Kondo ◽  
Makoto Ayaori ◽  
Kazuhiro Nakaya ◽  
Shunichi Takiguchi ◽  
Emi Yakushiji ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Ex Vivo ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Atp Binding Cassette

scholarly journals Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8

2003 ◽  
Vol 278 (18) ◽  
pp. 15565-15570 ◽  
Author(s):  
Liqing Yu ◽  
Jennifer York ◽  
Klaus von Bergmann ◽  
Dieter Lutjohann ◽  
Jonathan C. Cohen ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Liver X Receptor ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Cholesterol Excretion ◽  
Liver X Receptor Agonist ◽  
Stimulation Of ◽  
Atp Binding Cassette

scholarly journals The capacity of Listeria monocytogenes mutants with in-frame deletions in putative ATP-binding cassette transporters to form biofilms and comparison with the wild type

2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Marina Ceruso ◽  
Pina Fratamico ◽  
Claudia Chirollo ◽  
Rosanna Taglialatela ◽  
Maria Luisa Cortesi ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Atp Binding ◽  
Wild Type ◽  
Atp Binding Cassette Transporters ◽  
Atp Binding Cassette

scholarly journals A Selective ATP-Binding Cassette Subfamily G Member 2 Efflux Inhibitor Revealed via High-Throughput Flow Cytometry

2012 ◽  
Vol 18 (1) ◽  
pp. 26-38 ◽  
Author(s):  
J. Jacob Strouse ◽  
Irena Ivnitski-Steele ◽  
Hadya M. Khawaja ◽  
Dominique Perez ◽  
Jerec Ricci ◽  
...  
Keyword(s):  
Molecular Probes ◽  
Atp Binding ◽  
Specific Substrate ◽  
Tumor Resistance ◽  
Drug Concentrations ◽  
Efflux Inhibition ◽  
Substrate Inhibitor ◽  
Atp Binding Cassette

Chemotherapeutics tumor resistance is a principal reason for treatment failure, and clinical and experimental data indicate that multidrug transporters such as ATP-binding cassette (ABC) B1 and ABCG2 play a leading role by preventing cytotoxic intracellular drug concentrations. Functional efflux inhibition of existing chemotherapeutics by these pumps continues to present a promising approach for treatment. A contributing factor to the failure of existing inhibitors in clinical applications is limited understanding of specific substrate/inhibitor/pump interactions. We have identified selective efflux inhibitors by profiling multiple ABC transporters against a library of small molecules to find molecular probes to further explore such interactions. In our primary screening protocol using JC-1 as a dual-pump fluorescent reporter substrate, we identified a piperazine-substituted pyrazolo[1,5-a]pyrimidine substructure with promise for selective efflux inhibition. As a result of a focused structure-activity relationship (SAR)–driven chemistry effort, we describe compound 1 (CID44640177), an efflux inhibitor with selectivity toward ABCG2 over ABCB1. Compound 1 is also shown to potentiate the activity of mitoxantrone in vitro as well as preliminarily in vivo in an ABCG2-overexpressing tumor model. At least two analogues significantly reduce tumor size in combination with the chemotherapeutic topotecan. To our knowledge, low nanomolar chemoreversal activity coupled with direct evidence of efflux inhibition for ABCG2 is unprecedented.

scholarly journals Expression profiling of ATP-binding cassette transporters in childhood T-cell acute lymphoblastic leukemia

2006 ◽  
Vol 5 (8) ◽  
pp. 1986-1994 ◽  
Author(s):  
Thomas Efferth ◽  
Jean-Pierre Gillet ◽  
Axel Sauerbrey ◽  
Felix Zintl ◽  
Vincent Bertholet ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Expression Profiling ◽  
Lymphoblastic Leukemia ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Atp Binding Cassette

scholarly journals Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters

FEBS Letters ◽  
2001 ◽  
Vol 492 (1-2) ◽  
pp. 66-72 ◽  
Author(s):  
Peter Roerig ◽  
Peter Mayerhofer ◽  
Andreas Holzinger ◽  
Jutta Gärtner
Keyword(s):  
Functional Analysis ◽  
Nucleotide Binding ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Atp Binding Cassette
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