scholarly journals Arterial stiffness during hyperglycemia in older adults with high physical activity vs low physical activity

2019 ◽  
Vol 65 (2) ◽  
pp. 146-152 ◽  
Author(s):  
Ryota Kobayashi ◽  
Kaori Sato ◽  
Toshihiko Takahashi ◽  
Kenji Asaki ◽  
Soichiro Iwanuma ◽  
...  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Adrián Noriega de la Colina ◽  
Atef Badji ◽  
Maxime Lamarre-Cliche ◽  
Louis Bherer ◽  
Hélène Girouard ◽  
...  

Hypertension ◽  
2010 ◽  
Vol 56 (3) ◽  
pp. 540-546 ◽  
Author(s):  
Yuko Gando ◽  
Kenta Yamamoto ◽  
Haruka Murakami ◽  
Yumi Ohmori ◽  
Ryoko Kawakami ◽  
...  

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
A Noriega De La Colina ◽  
A Badji ◽  
M Lamarre-Cliche ◽  
L Bherer ◽  
H Girouard ◽  
...  

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Merck Sharp & Dohme Corp Program of the Faculty of Medicine of the Université de Montréal The Canadian Institutes of Health Research (CIHR) Background The growing concern on the impact of higher arterial stiffness on cognitive decline in older adults, leads to the question of whether non-pharmacological interventions like physical activity should be introduced to correct or diminish the progression of arterial stiffness. Purpose The goal of this study is to elaborate a model for arterial stiffness as a moderator for the physical activity and global cognition relationship in function of age.  Methods One hundred ten healthy older adults aged 60 to 75 years old (46 men and 64 women) were examined for arterial stiffness (carotid-femoral Pulse Wave Velocity (cf-PWV)), global cognition (Montreal Cognitive Assessment and Mini Mental State Examination) and self-reported physical activity (PACED diary). The double moderation analysis used PROCESS macro for SPSS, where physical activity was included as the independent variable (X), global cognition as the dependent variable (Y), arterial stiffness as moderator 1 (W), and age moderator 2 (Z). This study used a cf-PWV cutoff of 8.5 m/s to identify micro-structural damage in the brain related to arterial stiffness. Results Results found that the arterial stiffness x age interaction moderated the effect of physical activity on global cognition (β = -.89, SE = .42, p = .037) (Model: R2 = .15, p = .018). Physical activity had a positive effect on cognition in younger-older adults (aged 60 to 68.5 years) with high arterial stiffness i.e. cf-PWV > 8.5 m/s (β = .57, SE = .222, p = .011, 95% CI .133 to 1.014), and in older-older adults (aged 68.6 to 75 years) with low arterial stiffness i.e. cf-PWV < 8.5 m/s (β = .49, SE = .190, p = .010, 95% CI = .116 to .869).  Conclusions These results support targeted physical activity interventions based on age and degree of arterial stiffness, furthering the notion that even daily life physical activity could play an important role in older adults’ cognitive performances. Physical activity on global cognition Conditional effects of physical activity on global cognition Moderators cf-PWV Age Effect SE p CI < 8.5 m/s < 68.5 years .171 .245 .487 -.315 to .657 < 8.5 m/s > = 68.5 years .574 .222 .011* .133 to 1.014 > = 8.5 m/s < 68.5 years .492 .190 .010* .116 to .868 > = 8.5 m/s > = 68.5 years .002 .180 .990 -.355 to .359 Physical activity conditional effects on global cognition at determined values of arterial stiffness and age. SE: Standard Error, CI: Confidence Interval, cf-PWV: carotid-femoral Pulse Wave Velocity, *p-value<.05.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 54-55
Author(s):  
Adrian Noriega de la Colina ◽  
Atef Badji ◽  
Maxime Lamarre-Cliche ◽  
Louis Bherer ◽  
Hélène Girouard ◽  
...  

Abstract Background Evidence supports that time spent on physical activity has beneficial effects on cognition in older adults. Nevertheless, this beneficial effect is likely to change in function of individual modifying factors like age and level of arterial stiffness. This study aims to reveal whether arterial stiffness and age modulate the positive impact of physical activity on cognition by developing a double moderation model. Methods 110 healthy older adults aged 60 to 75 years old were examined for arterial stiffness (carotid-femoral Pulse Wave Velocity [cf-PWV]), global cognition (composite score of Montreal Cognitive Assessment, and Mini-Mental State Examination), and self-reported physical activity (PACED diary). Using PROCESS macro for SPSS, we evaluated if cf-PWV (moderator 1), and age (moderator 2) moderate the relationship between physical activity (X) and global cognition (Y). The threshold for high stiffness was set at 8.5 m/s based on previous studies that reported this cut-off more appropriate for classifying cerebrovascular risk groups. Results The interaction of arterial stiffness x age moderated the effect of physical activity on global cognition (β=-.89, SE=.42, p=.037) (Model: R2=.15, p=.018). Physical activity had a positive effect on cognition in younger-older adults (aged 60 to 68.5 years) with cf-PWV>8.5 m/s (β=.57, SE=.222, p=.011, 95% CI.133 to 1.014) and on older-older adults (aged 68.6 to 75 years) with cf-PWV<8.5 m/s (β=.49, SE=.190, p=.010, 95% CI=.116 to .869). Conclusions Identifying the right age groups and arterial stiffness levels at which physical activity can have beneficial effects on cognition is a key step in providing tailored behavioral interventions.


2021 ◽  
Author(s):  
Adrián Noriega de la Colina ◽  
Atef Badji ◽  
Maxime Lamarre-Cliche ◽  
Louis Bherer ◽  
Hélène Girouard ◽  
...  

2015 ◽  
Vol 12 (C) ◽  
pp. 15
Author(s):  
Simon Endes* ◽  
Emmanuel Schaffner ◽  
Seraina Caviezel ◽  
Julia Dratva ◽  
Christine S. Autenrieth ◽  
...  

2021 ◽  
pp. 089826432098736
Author(s):  
Hae Sagong ◽  
Ah Ram Jang ◽  
Da Eun Kim ◽  
Chang Won Won ◽  
Ju Young Yoon

Objectives: This study was to investigate the reciprocal relationship between frailty and physical activity among older adults by age group (middle-old: 70–79 years; oldest-old: 80–84 years) within 2 years using cross-lagged panel analysis. Methods: The study data were derived from the Korean Frailty and Aging Cohort Study, and a total of 1092 participants were included. Results: Frailty and high physical activity had significant reciprocal relationships in the middle-old group, which indicates that frailty was associated with less high physical activity, and high physical activity predicts less frailty after 2 years. In the oldest-old group, there was no statistically significant reciprocal relationship between frailty and any level of physical activity reference to low physical activity and vice versa after 2 years. Discussion: Further studies on the relationship between frailty and physical activity of the oldest-old population and specific physical activity guidelines for older adults are needed.


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