scholarly journals Arterial Stiffness and Age Moderate the Association Between Physical Activity and Cognition in Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 54-55
Author(s):  
Adrian Noriega de la Colina ◽  
Atef Badji ◽  
Maxime Lamarre-Cliche ◽  
Louis Bherer ◽  
Hélène Girouard ◽  
...  

Abstract Background Evidence supports that time spent on physical activity has beneficial effects on cognition in older adults. Nevertheless, this beneficial effect is likely to change in function of individual modifying factors like age and level of arterial stiffness. This study aims to reveal whether arterial stiffness and age modulate the positive impact of physical activity on cognition by developing a double moderation model. Methods 110 healthy older adults aged 60 to 75 years old were examined for arterial stiffness (carotid-femoral Pulse Wave Velocity [cf-PWV]), global cognition (composite score of Montreal Cognitive Assessment, and Mini-Mental State Examination), and self-reported physical activity (PACED diary). Using PROCESS macro for SPSS, we evaluated if cf-PWV (moderator 1), and age (moderator 2) moderate the relationship between physical activity (X) and global cognition (Y). The threshold for high stiffness was set at 8.5 m/s based on previous studies that reported this cut-off more appropriate for classifying cerebrovascular risk groups. Results The interaction of arterial stiffness x age moderated the effect of physical activity on global cognition (β=-.89, SE=.42, p=.037) (Model: R2=.15, p=.018). Physical activity had a positive effect on cognition in younger-older adults (aged 60 to 68.5 years) with cf-PWV>8.5 m/s (β=.57, SE=.222, p=.011, 95% CI.133 to 1.014) and on older-older adults (aged 68.6 to 75 years) with cf-PWV<8.5 m/s (β=.49, SE=.190, p=.010, 95% CI=.116 to .869). Conclusions Identifying the right age groups and arterial stiffness levels at which physical activity can have beneficial effects on cognition is a key step in providing tailored behavioral interventions.

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Adrián Noriega de la Colina ◽  
Atef Badji ◽  
Maxime Lamarre-Cliche ◽  
Louis Bherer ◽  
Hélène Girouard ◽  
...  

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
A Noriega De La Colina ◽  
A Badji ◽  
M Lamarre-Cliche ◽  
L Bherer ◽  
H Girouard ◽  
...  

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Merck Sharp & Dohme Corp Program of the Faculty of Medicine of the Université de Montréal The Canadian Institutes of Health Research (CIHR) Background The growing concern on the impact of higher arterial stiffness on cognitive decline in older adults, leads to the question of whether non-pharmacological interventions like physical activity should be introduced to correct or diminish the progression of arterial stiffness. Purpose The goal of this study is to elaborate a model for arterial stiffness as a moderator for the physical activity and global cognition relationship in function of age.  Methods One hundred ten healthy older adults aged 60 to 75 years old (46 men and 64 women) were examined for arterial stiffness (carotid-femoral Pulse Wave Velocity (cf-PWV)), global cognition (Montreal Cognitive Assessment and Mini Mental State Examination) and self-reported physical activity (PACED diary). The double moderation analysis used PROCESS macro for SPSS, where physical activity was included as the independent variable (X), global cognition as the dependent variable (Y), arterial stiffness as moderator 1 (W), and age moderator 2 (Z). This study used a cf-PWV cutoff of 8.5 m/s to identify micro-structural damage in the brain related to arterial stiffness. Results Results found that the arterial stiffness x age interaction moderated the effect of physical activity on global cognition (β = -.89, SE = .42, p = .037) (Model: R2 = .15, p = .018). Physical activity had a positive effect on cognition in younger-older adults (aged 60 to 68.5 years) with high arterial stiffness i.e. cf-PWV > 8.5 m/s (β = .57, SE = .222, p = .011, 95% CI .133 to 1.014), and in older-older adults (aged 68.6 to 75 years) with low arterial stiffness i.e. cf-PWV < 8.5 m/s (β = .49, SE = .190, p = .010, 95% CI = .116 to .869).  Conclusions These results support targeted physical activity interventions based on age and degree of arterial stiffness, furthering the notion that even daily life physical activity could play an important role in older adults’ cognitive performances. Physical activity on global cognition Conditional effects of physical activity on global cognition Moderators cf-PWV Age Effect SE p CI < 8.5 m/s < 68.5 years .171 .245 .487 -.315 to .657 < 8.5 m/s > = 68.5 years .574 .222 .011* .133 to 1.014 > = 8.5 m/s < 68.5 years .492 .190 .010* .116 to .868 > = 8.5 m/s > = 68.5 years .002 .180 .990 -.355 to .359 Physical activity conditional effects on global cognition at determined values of arterial stiffness and age. SE: Standard Error, CI: Confidence Interval, cf-PWV: carotid-femoral Pulse Wave Velocity, *p-value<.05.


2021 ◽  
Author(s):  
Adrián Noriega de la Colina ◽  
Atef Badji ◽  
Maxime Lamarre-Cliche ◽  
Louis Bherer ◽  
Hélène Girouard ◽  
...  

2021 ◽  
Vol 3 ◽  
Author(s):  
Claire Jenkin ◽  
Jannique G. Z. van Uffelen ◽  
Grant O'Sullivan ◽  
Jack Harvey ◽  
Rochelle M. Eime ◽  
...  

Community sport is seen as a suitable setting for physical activity for different population groups. Older adults (aged 50+ years) are a rapidly growing population group. Physical activity is critical for healthy ageing, however sport participation rates for older adults are very low. The aim of this study was to investigate how sporting organisations perceive sport for older adults. This cross-sectional study surveyed 171 representatives from Australian National and State Sporting Organisations. Descriptive statistics were used to summarise the results and the three sporting organisation categories' (high, medium, and low participation) responses were compared using non-parametric statistics. Contextualised in the perspective of organisational change, a framework for marketing to the ageing consumer was used to interpret the results. Older adults are not a high priority group for most sporting organisations, however the benefits of engaging older adults were recognised, particularly in context of increasing participation numbers. A lack of age-appropriate programmes was perceived to be a major barrier of engaging older adults. This lack of programmes stems from older adults being deemed as a less attractive segment than other age groups for sporting organisations. Modifications that sports felt they could make to attract and/or retain older adults included specific marketing and age appropriate opportunities. There was widespread consensus across sporting organisations, suggesting that perceptions of older adult sport participation were comparable across the sector, such as increasing participation numbers and engaging their older fan base. In the context of attracting, and retaining, older adults in sport clubs, it was concluded that most sporting organisations are not (yet) ready to build “age friendly” sporting environments. There is very limited literature on the organisational perspective of older adults and sport, meaning this study is unique in the field. Although sport policy encourages organisations to grow their participation, most organisations do not actively and strategically engage older adults. This research provides an understanding of why this untapped market is not a priority target and provides comprehensive insights for policy makers to better engage with this population group.


2019 ◽  
Vol 27 (6) ◽  
pp. 929-944 ◽  
Author(s):  
Karl Spiteri ◽  
David Broom ◽  
Amira Hassan Bekhet ◽  
John Xerri de Caro ◽  
Bob Laventure ◽  
...  

Identifying the difference in the barriers and motivators between middle-aged and older adults could contribute toward the development of age-specific health promotion interventions. The aim of this review was to synthesize the literature on the barriers and motivators for physical activity in middle-aged (50–64 years) and older (65–70 years) adults. This review examined qualitative and quantitative studies using the theoretical domain framework as the guiding theory. The search generated 9,400 results from seven databases, and 55 articles meeting the inclusion criteria were included. The results indicate that the barriers are comparable across the two age groups, with environmental factors and resources being the most commonly identified barriers. In older adults, social influences, reinforcement, and assistance in managing change were the most identified motivators. In middle-aged adults, goal-setting, the belief that an activity will be beneficial, and social influences were identified as the most important motivators. These findings can be used by professionals to encourage engagement with and adherence to physical activity.


2019 ◽  
pp. 155982761987688
Author(s):  
Kristina Zawaly ◽  
Richard Fortier ◽  
Stephen Buetow ◽  
Lynette Tippett ◽  
Ngaire Kerse

Objective. A systematic review with a meta-analysis explored effects of cognitively loaded physical activity interventions on global cognition in community-dwelling older adults (≥65 years of age) experiencing mild cognitive impairment (MCI), compared to any control. Methods. A literature search was conducted in 4 databases (MEDLINE [OvidSP], PubMed, CINAHL, and the Cochrane Central Register of Controlled Trials [Wiley]) from inception until January 30, 2018. The meta-analysis was conducted with Review Manager 5.3. Results. Six randomized controlled trials (RCTs) with 547 participants were identified. The interventions ranged from 4 to 52 weeks. Baseline and initial follow-up assessments were used. The primary pooled analysis of all RCTs demonstrated a nonsignificant trivial effect (standardized mean difference [SMD] 0.07, 95% confidence interval [CI] −0.44 to 0.58) favoring the intervention. In pooled subanalysis of 4 RCTs (n = 405) using the same global cognition measure (Mini-Mental State Examination) and duration of intervention >12 weeks, the intervention group achieved a small but significant improvement for global cognition (SMD 0.45, 95% CI 0.14 to 0.75). Conclusion. When all the RCTs were pooled, the effect of cognitively loaded physical activity intervention on global cognitive function in older adults with MCI remained unclear. The subgroup analysis provides translation evidence for future RCT study designs.


Author(s):  
Jennifer L. Etnier

There is substantial interest in identifying the behavioral means by which to improve cognitive performance. Recent research and commercial ventures have focused on cognitive training interventions, but evidence suggests that the effects of these programs are small and task-specific. Researchers have also shown interest in exploring the potential benefits of physical activity for cognitive performance. Because the effects of physical activity have been found to be small to moderate and to be more global in nature, interest in physical activity has been growing over the past several decades. Evidence regarding the efficacy of physical activity is provided through cross-sectional studies, longitudinal prospective studies, and randomized controlled trials. When reviewed meta-analytically, small-to-moderate beneficial effects are reported for children, adults, older adults, and cognitively impaired older adults, and these effects are evident for a wide range of cognitive domains, including executive function, memory, and information processing. Researchers are currently focused on identifying the mechanisms of these effects. Most of this research has been conducted using animal models, but there is a growing body of literature with humans. From this evidence, there is support for the role of changes in cerebral structure, hippocampal perfusion, and growth factors in explaining the observed benefits. Thus far, however, the literature is quite sparse, and future research is needed to clarify our understanding of the mechanisms that provide the causal link between physical activity and cognitive performance. Research is also focused on understanding how to increase the benefits by potentially combining cognitive training with physical activity and by identifying the genetic moderators of the effects. These lines of work are designed to elucidate ways of increasing the magnitude of the benefits that can be obtained. At this point in time, the evidence with respect to the potential of physical activity for benefiting cognitive performance is quite promising, but it is critical that funding agencies commit their support to the continued exploration necessary to allow us to ultimately be able to prescribe physical activity to specific individuals with the express purpose of improving cognition.


2019 ◽  
Vol 65 (2) ◽  
pp. 146-152 ◽  
Author(s):  
Ryota Kobayashi ◽  
Kaori Sato ◽  
Toshihiko Takahashi ◽  
Kenji Asaki ◽  
Soichiro Iwanuma ◽  
...  

2016 ◽  
Vol 5 (1) ◽  
pp. 39-49 ◽  
Author(s):  
L.R. Brawley ◽  
P.K. Flora ◽  
S.R. Locke ◽  
M.S.H. Gierc

In this paper, we argue that the social influence of the group is a supportive medium for older adult thriving. To promote the physical well-being aspect of thriving, we discuss groups as one means of offering social support. We present a specific model of physical activity intervention (i.e., group-mediated cognitive behavioral intervention) that uses deliberately-formed interactive groups to help motivate older adults to engage in and sustain physical activity. Our article includes four sections that concern the GMCB intervention model. The first serves as background as to why groups can be powerful behavior change agents and describes the basic model of group motivated intervention. The second section provides a generic description of the intervention structure and how the GMCB intervention is conducted. The third section presents a meta-analytic summary of results of older adult GMCB physical activity interventions across three levels of outcomes: adherence to physical activity, functional and physiological, and social cognitive. The fourth section concludes with commentary about the translational perspective for the GMCB in the future.


Sign in / Sign up

Export Citation Format

Share Document