Clinical characteristics of relapsing idiopathic nephrotic syndrome associated with influenza virus infection or influenza virus vaccine in six pediatric patients

Immunization of mice by infection or intraperitoneal injection with homotypic A2, heterotypic A0, or recombinant A0A2 virus have differing effects on transmission of influenza A2 virus infection. Immunization by infection with A2 virus resulted in refractoriness to reinfection either by artificial aerosols or by exposure to infected cage-mates. Immunization by inoculation with inactivated A2 virus vaccine resulted in a decreased susceptibility to transmitted infection in immunized contacts, but following A2 virus challenge, transmission of infection by immunized infectors was not altered. Immunization by infection with influenza A0 virus or recombinant A0A2 virus resulted in a decreased susceptibility to transmitted A2 virus infection in immunized contacts, and to decreased transmission after A2 virus infection in immunized infector mice. These differing effects on transmission of infection are attributed to differences in specific local immunologic responses following the various immunization procedures.

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Interferon mediated prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine lacking non-structural protein 1

Scientific Reports ◽

10.1038/s41598-021-01780-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Raveen Rathnasinghe ◽

Mirella Salvatore ◽

Hongyong Zheng ◽

Sonia Jangra ◽

Thomas Kehrer ◽

...

Keyword(s):

Influenza Virus ◽

Virus Vaccine ◽

Influenza A ◽

Influenza Virus Infection ◽

Influenza Virus Vaccine ◽

Influenza Viruses ◽

Type I ◽

Respiratory Pathogens ◽

Structural Protein ◽

Human Influenza Virus

AbstractThe influenza A non-structural protein 1 (NS1) is known for its ability to hinder the synthesis of type I interferon (IFN) during viral infection. Influenza viruses lacking NS1 (ΔNS1) are under clinical development as live attenuated human influenza virus vaccines and induce potent influenza virus-specific humoral and cellular adaptive immune responses. Attenuation of ΔNS1 influenza viruses is due to their high IFN inducing properties, that limit their replication in vivo. This study demonstrates that pre-treatment with a ΔNS1 virus results in an antiviral state which prevents subsequent replication of homologous and heterologous viruses, preventing disease from virus respiratory pathogens, including SARS-CoV-2. Our studies suggest that ΔNS1 influenza viruses could be used for the prophylaxis of influenza, SARS-CoV-2 and other human respiratory viral infections, and that an influenza virus vaccine based on ΔNS1 live attenuated viruses would confer broad protection against influenza virus infection from the moment of administration, first by non-specific innate immune induction, followed by specific adaptive immunity.

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Radiological and Clinical Characteristics of a Military Outbreak of Pandemic H1N1 2009 Influenza Virus Infection

Korean Journal of Radiology ◽

10.3348/kjr.2010.11.4.417 ◽

2010 ◽

Vol 11 (4) ◽

pp. 417 ◽

Cited By ~ 8

Author(s):

Tae Jin Yun ◽

Gu Jin Kwon ◽

Mi Kyeong Oh ◽

Sung Koo Woo ◽

Seung Hoon Park ◽

...

Keyword(s):

Influenza Virus ◽

Virus Infection ◽

Clinical Characteristics ◽

Influenza Virus Infection ◽

Pandemic H1n1 ◽

Pandemic H1n1 2009

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Editorial Response: Influenza, Influenza Virus Vaccine, and Human Immunodeficiency Virus Infection

Clinical Infectious Diseases ◽

10.1086/515171 ◽

1999 ◽

Vol 28 (3) ◽

pp. 548-551 ◽

Cited By ~ 31

Author(s):

Robert B. Couch

Keyword(s):

Human Immunodeficiency Virus ◽

Influenza Virus ◽

Virus Infection ◽

Human Immunodeficiency Virus Infection ◽

Virus Vaccine ◽

Influenza Virus Vaccine ◽

Immunodeficiency Virus

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Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza virus infection in mice

International Congress Series ◽

10.1016/j.ics.2004.02.101 ◽

2004 ◽

Vol 1263 ◽

pp. 618-621

Author(s):

Ayato Takada ◽

Sachiko Matsushita ◽

Ai Ninomiya ◽

Yoshihiro Kawaoka ◽

Hiroshi Kida

Keyword(s):

Influenza Virus ◽

Virus Infection ◽

Virus Vaccine ◽

Broad Spectrum ◽

Influenza Virus Infection ◽

Intranasal Immunization ◽

Heterosubtypic Immunity

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ANTIBODY RESPONSE TO INFLUENZA-VIRUS VACCINE IN CHILDREN WITH NEPHROSIS: EFFECT OF CORTISONE

PEDIATRICS ◽

10.1542/peds.23.1.54 ◽

1959 ◽

Vol 23 (1) ◽

pp. 54-62

Author(s):

Calvin M. Kunin ◽

Robert Schwartz ◽

Sumner Yaffe ◽

John Knapp ◽

Francis X. Fellers ◽

...

Keyword(s):

Influenza Virus ◽

Nephrotic Syndrome ◽

Antibody Response ◽

Virus Vaccine ◽

Influenza A ◽

Serum Levels ◽

Influenza Virus Vaccine ◽

Inactive Disease ◽

Strain Component ◽

Adrenogenital Syndrome

Polyvalent influenza-virus vaccine was administered to 55 children; 44 of these children were in various stages of nephrotic syndrome, including 17 under treatment with adrenocortical hormones; 5 were children with the adrenogenital syndrome receiving replacement cortisone therapy, and 6 were normal controls. Antibody response, as measured by the hemagglutination-inhibition test 2 weeks following a single subcutaneous dose of vaccine, was not significantly different in children with active or inactive disease, and appeared to be similar in those receiving hormone therapy and in those who were not. The serum levels of gamma-globulin were lower in children with active nephrotic syndrome, but this did not affect either the prevaccination levels of influenza A prime antibody or the response to the vaccine. No change in the status of activity of nephrosis occurred during the period of immunization or immediately thereafter, even in patients who had moderate febrile reactions to the vaccine. The failure of any of the groups to respond serologically to the Asian strain component of the vaccine is discussed.

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Clinical characteristics of influenza virus infection in juvenile idiopathic arthritis patients treated with tocilizumab

Modern Rheumatology ◽

10.3109/s10165-012-0780-0 ◽

2013 ◽

Vol 23 (5) ◽

pp. 972-976 ◽

Cited By ~ 6

Author(s):

Jun-ichi Kawada ◽

Yoshiro Kitagawa ◽

Naomi Iwata ◽

Yoshinori Ito

Keyword(s):

Influenza Virus ◽

Juvenile Idiopathic Arthritis ◽

Virus Infection ◽

Clinical Characteristics ◽

Influenza Virus Infection

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Prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine

10.1101/2021.04.28.441797 ◽

2021 ◽

Author(s):

Raveen Rathnasinghe ◽

Mirella Salvatore ◽

Hongyong Zheng ◽

Sonia Jangra ◽

Thomas Kehrer ◽

...

Keyword(s):

Influenza Virus ◽

Virus Vaccine ◽

Influenza A ◽

Influenza Virus Infection ◽

Influenza Virus Vaccine ◽

Influenza Viruses ◽

Type I ◽

Respiratory Pathogens ◽

Structural Protein ◽

Human Influenza Virus

AbstractThe influenza A non-structural protein 1 (NS1) is known for its ability to hinder the synthesis of type I interferon (IFN) during viral infection. Influenza viruses lacking NS1 (ΔNS1) are under clinical development as live attenuated human influenza virus vaccines and induce potent influenza virus-specific humoral and cellular adaptive immune responses. Attenuation of ΔNS1 influenza viruses is due to their high IFN inducing properties, that limit their replication in vivo. This study demonstrates that pre-treatment with a ΔNS1 virus results in an immediate antiviral state which prevents subsequent replication of homologous and heterologous viruses, preventing disease from virus respiratory pathogens, including SARS-CoV-2. Our studies suggest that ΔNS1 influenza viruses could be used for the prophylaxis of influenza, SARS-CoV-2 and other human respiratory viral infections, and that an influenza virus vaccine based on ΔNS1 live attenuated viruses would confer broad protection against influenza virus infection from the moment of administration, first by non-specific innate immune induction, followed by specific adaptive immunity.

Download Full-text