scholarly journals Role of Cav3.2 Low-Threshold Calcium Channel in Mechanosensitivity and Neuropathic Pain

2019 ◽  
Vol 32 (4) ◽  
pp. 214-216
Author(s):  
T. Chauveau ◽  
N. Kobakhidze ◽  
R. Weill Rossi ◽  
L. Winckler
Keyword(s):  
Neuropathic Pain ◽  
Calcium Channel ◽  
Douleurs Neuropathiques ◽  
Low Threshold

Les fibres nerveuses peuvent être divisées en trois catégories, jouant chacune leur rôle dans différents types de sensations. Ces fibres ainsi que les récepteurs qu’elles expriment jouent un rôle crucial dans les pathologies liées aux perceptions thermiques, chimiques, nociceptives et mécaniques. Dans cette étude, les auteurs ont porté leur intérêt sur les fibres nerveuses Aδ et C, connues pour leurs rôles dans la mécanoception, et une sous-famille de ces fibres plus particulièrement, les fibres exprimant des récepteurs mécaniques à faible seuil d’activation (low-threshold mechanoreceptor or LTMRs). Sachant que les canaux calciques Cav 3.2, de type T, sont connus pour leur rôle dans la transmission d’informations sensorielles, leur prévalence ainsi que leur activité dans les LTMRs ont été évaluées via l’utilisation de souris génétiquement modifiées. Cette étude montre que les canaux Cav3.2 sont impliqués dans la transmission d’informations mécanique et thermique au froid, et donc potentiellement dans les douleurs neuropathiques. En outre, les canaux Cav3.2 ont été détectés le long des axones des fibres LTMRs, suggérant un rôle important de ces canaux dans la vitesse de conduction.

Role of spinal voltage-dependent calcium channel α2δ-1 subunit in the expression of a neuropathic pain-like state in mice

Life Sciences ◽  
2007 ◽  
Vol 80 (22) ◽  
pp. 2015-2024 ◽  
Author(s):  
Minoru Narita ◽  
Mayumi Nakajima ◽  
Kan Miyoshi ◽  
Michiko Narita ◽  
Yasuyuki Nagumo ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Calcium Channel ◽  
Voltage Dependent Calcium Channel ◽  
Voltage Dependent

Emerging Role of microRNA in Neuropathic Pain

2016 ◽  
Vol 17 (4) ◽  
pp. 336-344 ◽  
Author(s):  
Pu Jiangpan ◽  
Meng Qingsheng ◽  
Yang Zhiwen ◽  
Zhu Tao
Keyword(s):  
Neuropathic Pain

scholarly journals Pre-motor versus motor cerebral cortex neuromodulation for chronic neuropathic pain

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Igor Lavrov ◽  
Timur Latypov ◽  
Elvira Mukhametova ◽  
Brian Lundstrom ◽  
Paola Sandroni ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Cerebral Cortex ◽  
Motor Cortex ◽  
Initial Assessment ◽  
Motor Cortex Stimulation ◽  
Chronic Neuropathic Pain ◽  
Long Term Effect ◽  
Stimulation Of

AbstractElectrical stimulation of the cerebral cortex (ESCC) has been used to treat intractable neuropathic pain for nearly two decades, however, no standardized approach for this technique has been developed. In order to optimize targeting and validate the effect of ESCC before placing the permanent grid, we introduced initial assessment with trial stimulation, using a temporary grid of subdural electrodes. In this retrospective study we evaluate the role of electrode location on cerebral cortex in control of neuropathic pain and the role of trial stimulation in target-optimization for ESCC. Location of the temporary grid electrodes and location of permanent electrodes were evaluated in correlation with the long-term efficacy of ESCC. The results of this study demonstrate that the long-term effect of subdural pre-motor cortex stimulation is at least the same or higher compare to effect of subdural motor or combined pre-motor and motor cortex stimulation. These results also demonstrate that the initial trial stimulation helps to optimize permanent electrode positions in relation to the optimal functional target that is critical in cases when brain shift is expected. Proposed methodology and novel results open a new direction for development of neuromodulation techniques to control chronic neuropathic pain.

Role of TRPV4-P2X7 Pathway in Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion

2021 ◽  
Author(s):  
Xiaohua Fan ◽  
Chuanwei Wang ◽  
Junting Han ◽  
Xinli Ding ◽  
Shaocan Tang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Dorsal Root Ganglion ◽  
Dorsal Root

scholarly journals IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation

2021 ◽  
Vol 22 (11) ◽  
pp. 5657
Author(s):  
Seounghun Lee ◽  
Hyo-Jung Shin ◽  
Chan Noh ◽  
Song-I Kim ◽  
Young-Kwon Ko ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Microglial Activation ◽  
Glycolic Acid ◽  
Nuclear Factor Kappa B ◽  
Decisive Role ◽  
Plga Nanoparticles ◽  
Spinal Nerve ◽  
Nuclear Factor ◽  
Interfering Rna

Activation of nuclear factor-kappa B (NF-κB) in microglia plays a decisive role in the progress of neuropathic pain, and the inhibitor of kappa B (IκB) is a protein that blocks the activation of NF-κB and is degraded by the inhibitor of NF-κB kinase subunit beta (IKBKB). The role of IKBKB is to break down IκB, which blocks the activity of NF-kB. Therefore, it prevents the activity of NK-kB. This study investigated whether neuropathic pain can be reduced in spinal nerve ligation (SNL) rats by reducing the activity of microglia by delivering IKBKB small interfering RNA (siRNA)-encapsulated poly (lactic-co-glycolic acid) (PLGA) nanoparticles. PLGA nanoparticles, as a carrier for the delivery of IKBKB genes silencer, were used because they have shown potential to enhance microglial targeting. SNL rats were injected with IKBKB siRNA-encapsulated PLGA nanoparticles intrathecally for behavioral tests on pain response. IKBKB siRNA was delivered for suppressing the expression of IKBKB. In rats injected with IKBKB siRNA-encapsulated PLGA nanoparticles, allodynia caused by mechanical stimulation was reduced, and the secretion of pro-inflammatory mediators due to NF-κB was reduced. Delivering IKBKB siRNA through PLGA nanoparticles can effectively control the inflammatory response and is worth studying as a treatment for neuropathic pain.

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