Diffuse Skin Tightness in Familial Mediterranean Fever: A Case Report and Review of Literature

Introduction: Familial Mediterranean Fever (FMF) is an autosomal recessive inherited disorder that has skin presentations like vasculitis and paniculitis. There has not been shown any association between systemic sclerosis and FMF in studies. Hence, we report a case of FMF with diffuse skin tightness. Case Presentation: An 18-year-old girl known as a case of FMF for 3 years presents to our department with tight skin since childhood. The stiffness of skin appeared when she was about 7 years old. In physical examination, tight skin with general induration in all surfaces of skin, sclerodactyly and beaked nose microstomia are noticed. The findings of all hematological, biochemical and pathological studies were normal. Conclusion: Finally, it may be concluded that FMF should be considered as a differential diagnosis in patients attending with skin tightness and the possible etiology is cytokines. [GMJ.2015;4(4):169-72]

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Familial Mediterranean fever with chronic ascites: a case report and a review of literature

Rheumatology International ◽

10.1007/s00296-009-0842-6 ◽

2009 ◽

Vol 29 (12) ◽

pp. 1477-1480 ◽

Cited By ~ 6

Author(s):

Kemal Üreten ◽

Ahmet Bostancı ◽

Erdem Akbal ◽

Gülsüm Gönülalan ◽

Mustafa Özbek ◽

...

Keyword(s):

Case Report ◽

Familial Mediterranean Fever ◽

Review Of Literature ◽

Mediterranean Fever

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Systemic Lupus Erythematosus with Familial Mediterranean Fever: Case Report and Review of Literature

Acta Dermato Venereologica ◽

10.2340/00015555-3197 ◽

2019 ◽

Vol 99 (9) ◽

pp. 822-823 ◽

Cited By ~ 1

Author(s):

H Kokubu ◽

H Ida ◽

T Tanaka ◽

N Fujimoto

Keyword(s):

Systemic Lupus Erythematosus ◽

Case Report ◽

Familial Mediterranean Fever ◽

Lupus Erythematosus ◽

Review Of Literature ◽

Systemic Lupus ◽

Fever Case ◽

Mediterranean Fever

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A Case of Eosinophilic Esophagitis Accompanying Familial Mediterranean Fever

Case Reports in Gastrointestinal Medicine ◽

10.1155/2017/6863921 ◽

2017 ◽

Vol 2017 ◽

pp. 1-3

Author(s):

Pejman Rohani ◽

Mehri Najafi Sani ◽

Mitra Ahmadi ◽

Vahid Ziaee

Keyword(s):

Abdominal Pain ◽

Familial Mediterranean Fever ◽

Eosinophilic Esophagitis ◽

Autosomal Recessive ◽

Autosomal Recessive Disorder ◽

High Power Field ◽

Case Presentation ◽

History Of ◽

Mediterranean Fever ◽

Poor Weight Gain

Background. Eosinophilic esophagitis is an inflammatory condition where there is a dense infiltration of eosinophils typically exceeding fifteen cells per high power field. Familial Mediterranean fever is an autosomal recessive disorder characterized by brief, acute, and self-limited episodes of fever and polyserositis that recur at irregular intervals. Case Presentation. A three-year-and-nine-month-old Iranian girl was admitted to our center. The patient’s parents complained of a history of abdominal pain, poor appetite, and poor weight gain from 1.5 years ago and episodes of food impaction after starting solid foods. Eosinophilic esophagitis was diagnosed based on histology. Because of continuing abdominal pain after treatment of eosinophilic esophagitis, the episodic nature of disease, and the presence of fever with pain, screening for familial Mediterranean fever mutation was performed and the patient was found to be heterozygote for Mediterranean fever. Conclusion. We have reported a case of eosinophilic esophagitis coexisting with familial Mediterranean fever which has not been described previously.

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Is orchiectomy avoidable in testicular tuberculosis mimicking malignancy? A case report

African Journal of Urology ◽

10.1186/s12301-021-00244-9 ◽

2021 ◽

Vol 27 (1) ◽

Author(s):

Youssef Kharbach ◽

Youssef Retal ◽

Abdelhak Khallouk

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Family History ◽

Physical Examination ◽

Testicular Cancer ◽

Testicular Tumor ◽

Pathologic Examination ◽

Case Presentation ◽

Scrotal Swelling ◽

Firm Mass

Abstract Background Isolated testicular tuberculosis (TB) is extremely uncommon. It has non-specific presentation; thus, diagnosis is challenging and is often discovered on pathology examination after orchiectomy. Case presentation We report herein the case of a 73-year-old male, with no significant medical or family history, who presented with left scrotal swelling, physical examination revealed a left testicular firm mass measuring 3 cm and ultrasound was suggestive of testicular tumor. Left inguinal orchiectomy was performed and the pathologic examination revealed testicular TB. The presentation was typically mimicking a testicular cancer with no evocative evidence of TB; this can lead to a dilemma and highlights the need to consider TB in differential diagnosis of testicular tumor, especially in areas endemic for the disease. Conclusions The aim of our presentation is to argue if orchiectomy was avoidable. It also illustrates the probable hematogenous or lymphatic spread of Mtb to the testicle.

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Cerebral fat embolization with paroxysmal sympathetic hyperactivity syndrome and septic shock at high altitude: a case report and literature review

Chinese Neurosurgical Journal ◽

10.1186/s41016-021-00232-6 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Min Li ◽

Gang Zhu ◽

Hao Guo ◽

Shun Nan Ge ◽

Guo Dong Gao ◽

...

Keyword(s):

Septic Shock ◽

Differential Diagnosis ◽

Case Report ◽

Literature Review ◽

High Altitude ◽

Fat Embolism ◽

Neurological Rehabilitation ◽

Case Presentation ◽

Sympathetic Hyperactivity ◽

Paroxysmal Sympathetic Hyperactivity

AbstractBackgroundCerebral fat embolism (CFE) syndrome at high altitude was rare complicated with paroxysmal sympathetic hyperactivity (PSH) syndrome and septic shock. It is a challenge to differential diagnosis and treatment at high altitude.Case presentationThis case presents a CFE with PSH and septic shock of a 23-year-old man occurred at high altitude of 3800 m above sea level, transferred by airplane successfully and cured in the department of neurosurgery, Xi’an Tangdu Hospital.ConclusionsIt is key that CFE with PSH can be rapid diagnosed and treatment bundles of septic shock should be initiated as soon as possible. Early neurological rehabilitation played an important role for good outcome.

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Uptake of exogenous estrogen as a differential diagnosis of ovarian-remnant-syndrome in a bitch: a case report

BMC Veterinary Research ◽

10.1186/s12917-021-02923-9 ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Sebastian Ganz ◽

Axel Wehrend

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Luteinizing Hormone ◽

Clinical Signs ◽

Menopausal Symptoms ◽

Case Presentation ◽

Estrogen Exposure ◽

Exogenous Estrogen ◽

Endocrine Parameters

Abstract Background Clinical signs of heat in bitches that have been previously spayed are often associated with the presence of ovarian remnant syndrome. The inclusion of exogenous estrogens as a differential diagnosis in this regard is often ignored and may lead to misinterpretation of the case. Case presentation Herein, we report a case of exogenous estrogen exposure over several months to a 6.5-year-old spayed crossbred bitch, weighing 8.4 kg. The bitch presented in the clinic because of suspected ovarian remnant syndrome. Castration was performed within the first 6 months after birth. Important endocrine parameters measured at the first appointment were Anti-Müllerian hormone (< 0.01 ng/mL), progesterone (0.36 ng/mL), estradiol-17ß (20.7 pg/mL), and luteinizing hormone (< 0.1 ng/mL). After an extensive conversation with the owner, it was revealed that she was using an estrogen spray because of severe menopausal symptoms. After the owner stopped using this spray, the symptoms of the bitch disappeared. Conclusion Therefore, the uptake of estrogens should be a differential diagnosis for symptoms of the ovarian remnant syndrome. A detailed anamnesis is crucial to identify the source of estrogen in the environment of the affected bitch.

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Neonate born with ischemic limb to a COVID-19 positive mother: management and review of literature

Case Reports in Perinatal Medicine ◽

10.1515/crpm-2020-0086 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Shahana Perveen ◽

Karmaine A. Millington ◽

Suchitra Acharya ◽

Amit Grag ◽

Vita Boyar

Keyword(s):

Differential Diagnosis ◽

Compartment Syndrome ◽

Upper Extremity ◽

Preterm Neonate ◽

Review Of Literature ◽

Case Presentation ◽

Ischemic Limb ◽

History Of ◽

Hand Amputation ◽

Work Up

AbstractObjectivesTo describe challenges in diagnosis and treatment of congenital neonatal gangrene lesions associated with history of maternal coronavirus disease 2019 (COVID-19) infection.Case presentationA preterm neonate was born with upper extremity necrotic lesions and a history of active maternal COVID-19 infection. The etiology of his injury was challenging to deduce, despite extensive hypercoagulability work-up and biopsy of the lesion. Management, including partial forearm salvage and hand amputation is described.ConclusionsNeonatal gangrene has various etiologies, including compartment syndrome and intrauterine thromboembolic phenomena. Maternal COVID-19 can cause intrauterine thrombotic events and need to be considered in a differential diagnosis.

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