Tumor-to-tumor metastasis: esophageal carcinoma metastatic to an intracranial paraganglioma

2009 ◽  
Vol 110 (4) ◽  
pp. 744-748 ◽  
Author(s):  
Jian-Qiang Lu ◽  
Moosa Khalil ◽  
William Hu ◽  
Garnette R. Sutherland ◽  
Arthur W. Clark
Keyword(s):  
Esophageal Carcinoma ◽  
Tumor Metastasis ◽  
Histopathological Examination ◽  
Unique Case ◽  
Blurred Vision ◽  
Poorly Differentiated Carcinoma ◽  
History Of ◽  
Poorly Differentiated ◽  
Tumor To Tumor Metastasis ◽  
Upper Gastrointestinal

Tumor-to-tumor metastasis (TTM) is a relatively rare but well-documented phenomenon. The authors report a unique case of esophageal carcinoma metastatic to an intracranial paraganglioma. A sellar and suprasellar tumor was found using MR imaging in an 81-year-old man who presented with a 3-week history of progressive headache and blurred vision. A subtotal excision of the tumor was achieved. Histopathological examination of the tumor disclosed a neoplasm with two distinct components: one showing the classic Zellballen pattern of a paraganglioma, the other exhibiting malignant features leading to the diagnosis of a poorly differentiated carcinoma metastatic to a sellar/suprasellar paraganglioma. The primary esophageal carcinoma was not uncovered until 2 months later, after the patient presented with upper gastrointestinal bleeding. The patient died 4 months after initial presentation. This case expands the spectrum of TTM, and emphasizes the importance of TTM in the practice of pathology.

scholarly journals Unique case of inverted papilloma of septum with nasopharyngeal carcinoma: Is it a metachronous tumour?

2020 ◽  
Vol 8 ◽  
pp. 2050313X2092203
Author(s):  
Susanne Flach ◽  
Aaron SJ Ferguson ◽  
Sharon White ◽  
Paul S White ◽  
Jaiganesh Manickavasagam
Keyword(s):  
Malignant Transformation ◽  
Inverted Papilloma ◽  
High Rate ◽  
Unique Case ◽  
Solitary Lesion ◽  
Poorly Differentiated Carcinoma ◽  
Nasopharyngeal Biopsy ◽  
Poorly Differentiated ◽  
The Right

Inverted papilloma is a rare and benign tumour. It affects the nasal cavity and paranasal sinuses, has a high rate of recurrence and is associated with malignant transformation. Only few cases of a poorly differentiated carcinoma arising from inverted papilloma have been reported, none of which in the nasopharynx. We report a case of a 37-year-old female, who presented originally in 2012 with inverted papilloma of the nasal septum which was surgically resected. Nasopharyngeal biopsy from 2014 was reported as carcinoma in situ and treated with local endoscopic resection. Three years later she presented with a solitary lesion of the right Eustachian tube opening, confirmed as invasive poorly differentiated carcinoma. Imaging revealed T4 N2b M0 malignancy with skull base and prevertebral space invasion, likely extension into right temporal lobe and malignant adenopathy. Although rare, malignant transformation of inverted papilloma in unusual places should be considered during workup and monitoring of patients.

Metastatic endometrial carcinoma of the neck

2000 ◽  
Vol 114 (3) ◽  
pp. 229-230 ◽  
Author(s):  
M. A. Siddiq ◽  
S. K. Bhudia ◽  
P. Gana ◽  
J. Patel
Keyword(s):  
Endometrial Carcinoma ◽  
Clear Cell ◽  
Needle Aspiration ◽  
Neck Mass ◽  
Aspiration Cytology ◽  
Poorly Differentiated Carcinoma ◽  
Carcinoma Of The Larynx ◽  
History Of ◽  
Poorly Differentiated ◽  
Needle Aspiration Cytology

We report a case of metastatic endometrial carcinoma of the neck. A patient with a past medical history of squamous cell carcinoma of the larynx, breast carcinoma and endometrial carcinoma presented with a neck mass. Fine needle aspiration cytology (FNAC) showed this to be a poorly differentiated carcinoma with squamoid features and thus a potentially curative neck dissection was performed. Histology of the mass showed a clear cell endometrial carcinoma. Metastatic gynacecological malignancies to the head and neck are rare and this is the first reported case of metastatic endometrial carcinoma in the neck.

Malignant Solitary Fibrous Tumor Metastatic to Widely Invasive Hurthle Cell Thyroid Carcinoma: A Distinct Tumor-to-Tumor Metastasis

2018 ◽  
Vol 26 (6) ◽  
pp. 521-524 ◽  
Author(s):  
Eva Kolson Kokohaare ◽  
Francesco M. G. Riva ◽  
Jonathan M. Bernstein ◽  
Aisha B. Miah ◽  
Khin Thway
Keyword(s):  
Cell Carcinoma ◽  
Solitary Fibrous Tumor ◽  
Tumor Metastasis ◽  
Unique Case ◽  
Hürthle Cell ◽  
Hürthle Cell Carcinoma ◽  
Hurthle Cell Carcinoma ◽  
Tumor To Tumor Metastasis ◽  
Widely Invasive ◽  
Fibrous Tumor

We illustrate a case of synchronous malignant solitary fibrous tumor of the thoracic cavity, and widely invasive thyroid Hurthle cell carcinoma. The Hurthle cell carcinoma was found to harbor distinct areas of malignant solitary fibrous tumor. This is a unique case of tumor-to-tumor metastasis that, to the best of our knowledge, has not been previously reported.

scholarly journals Unusual case of a midline neck swelling in a fifty year old female

2016 ◽  
Vol 2 (3) ◽  
pp. 157
Author(s):  
Akshay Agarwal ◽  
Shilpi Sahu ◽  
Reeta Dhar
Keyword(s):  
Case Report ◽  
Unusual Case ◽  
Histopathological Examination ◽  
Differentiated Thyroid Carcinoma ◽  
Neck Swelling ◽  
Review Of Literature ◽  
Poorly Differentiated Carcinoma ◽  
Underlying Malignancy ◽  
Architectural Patterns ◽  
Poorly Differentiated

<p class="abstract">Goitrous enlargement of the thyroid can present as a massive enlargement of the neck. It can be so huge as to obscure detection of an underlying malignancy. Poorly differentiated carcinoma of the thyroid gland is very rare. A 50 year old female patient who was diagnosed preoperatively as having colloid goiter underwent near total thyroidectomy was diagnosed with poorly differentiated thyroid carcinoma on histopathological examination. This case report highlights the various architectural patterns, azzopardi phenomenon with emphasis on immunohistochemical stains and an aberrant rhabdoid phenotype of tumor cells along with review of literature.</p>

Riga-Fede disease: a mimicker of malignancy

2021 ◽  
Vol 14 (3) ◽  
pp. e235976
Author(s):  
Somu Lakshmanan ◽  
Srinivasan Venkataraman ◽  
Urvashi Singh
Keyword(s):  
Histopathological Examination ◽  
Eosinophilic Granuloma ◽  
Rare Condition ◽  
Malignant Tumour ◽  
Clinical Suspicion ◽  
Inflammatory Condition ◽  
Unique Case ◽  
Body Sensation ◽  
History Of

Riga-Fede disease (RFD), also known as traumatic eosinophilic granuloma, is a benign inflammatory condition of the oral cavity that may mimic a malignant tumour. It’s a rare condition mainly reported in infants. We present a unique case report of a 57-year-old man who presented to our outpatient department with foreign body sensation in the throat and swelling over the dorsum of the tongue for a period of 1 month. He gave no history of trauma, especially due to sharp teeth. Video laryngoscopy done revealed an ulceroproliferative growth on the midline of the dorsum of the tongue. With clinical suspicion of malignancy, the patient underwent wide local excision of the tongue lesion. Histopathological examination was suggestive of RFD. The postoperative follow-up was uneventful with good wound healing. The patient was followed up with no evidence of recurrence.

scholarly journals Unique position of a pancreatic head insulinoma during laparoscopic enucleation: case report

2020 ◽  
Vol 7 (9) ◽  
pp. 3095
Author(s):  
Abdullah M. Alshamrani ◽  
Hisham M. Ghabbani ◽  
Omar M. Alobaid ◽  
Abdullah J. AlShehri ◽  
Khalid M. Alzaraa ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Serum Insulin ◽  
Delayed Diagnosis ◽  
Young Patients ◽  
Pancreatic Head ◽  
Serum Glucose ◽  
High Serum ◽  
Blurred Vision ◽  
History Of ◽  
Laparoscopic Enucleation

Insulinomas are benign pancreatic neuroendocrine tumors that require surgical intervention as a therapeutic measure. We describe an 18-year-old male patient who presented to the emergency department with a history of syncope, blurred vision, and diaphoresis. His blood sugar level was low upon admission, and a 72-hour fasting plasma glucose test showed low serum glucose, high serum insulin, and high C-peptide. An abdominal computed tomography scan and magnetic resonant imaging revealed a solitary tumor in the pancreatic head with no sign of ductal dilatation. Laparoscopic enucleation was performed, and a histopathological examination revealed findings consistent with insulinoma. The patient’s postoperative course was uneventful, and his follow-up examination was unremarkable. In conclusion, physicians should have a high clinical suspicion index for insulinomas, especially in young patients with a history of syncope, blurred vision, and diaphoresis, in order to avoid delayed diagnosis.

scholarly journals Mixed adenoneuroendocrine carcinoma of proximal stomach; a rare but sinister pathology

2020 ◽  
Vol 10 (2) ◽  
pp. 1772-1775
Author(s):  
Deepshikha Gaire ◽  
Daisy Maharjan ◽  
Nisha Sharma
Keyword(s):  
Gastrointestinal Endoscopy ◽  
Histopathological Examination ◽  
Gastroesophageal Junction ◽  
Upper Gastrointestinal Endoscopy ◽  
Radiological Findings ◽  
Proximal Stomach ◽  
History Of ◽  
Adenocarcinoma Component ◽  
Physical Findings ◽  
Upper Gastrointestinal

Mixed adeno-neuroendocrine carcinoma is a rare tumor of the gastrointestinal tract comprising of both epithelial and neuroendocrine components, each representing at least 30% of the tumor. Diagnosis is based on clinical evaluation, radiological findings, histopathological features in conjunction with immunostaining with specific neuroendocrine markers such as chromogranin, synaptophysin, CD56, and markers of epithelial differentiation such as cytokeratin, CDX2, and carcinoembryonic antigen. A 50-year-old female presented with a history of dysphagia, chest pain, anorexia, and significant weight loss with normal physical findings and baseline investigations. Upper Gastrointestinal endoscopy showed growth at the gastroesophageal junction involving cardia of the stomach. Histopathological examination of the resected mass showed both adenocarcinoma and neuroendocrine carcinomatous components each involving more than 30% of total mass examined. Identifying adenocarcinoma component admixed with a high-grade neuroendocrine component is significant as the prognosis and survival of patients differ from pure adenocarcinoma.

scholarly journals A unique case of an alpha-fetoprotein-producing lung cancer with testicular metastasis

2012 ◽  
Vol 6 (5) ◽  
Author(s):  
Jennifer M Willder ◽  
Andrew M Thomson ◽  
Kenneth M Grigor ◽  
Grahame Howard ◽  
Grant D Stewart
Keyword(s):  
Lower Lobe ◽  
Lung Lesion ◽  
Alpha Fetoprotein ◽  
Lung Tumour ◽  
Unique Case ◽  
First Case ◽  
Overwhelming Evidence ◽  
Metastatic Lung ◽  
History Of ◽  
Poorly Differentiated

Alpha-fetoprotein (AFP)-producing primary lung tumours are rare; we present the first case of an AFP-producing lung tumour with metastasis to testes. The patient, a 72-year-old man, presented with a history of flu-like symptoms and abdominal pain. On examination he had a hard, tender left scrotal mass. Imaging showed a 4.4-cm right lower lobe lung mass and the serum-AFP was raised (1189 ng/mL). Left orchidectomy excised a necrotic tumour. Microscopy showed complete hemorrhagic infarction and immunohistochemistry showed a lack of staining for AFP. Serum-AFP rose 3 days post-orchidectomy to 1466 ng/mL. The patient subsequently developed melaena and died. Autopsy revealed a 9 × 5-cm necrotic right lower lobe lung tumour. Immunohistochemistry showed the tumour cells reacted with a pan-cytokeratin antibody and less than 5% expressed AFP. Bilateral adrenal tumour deposits were also identified in addition to those in the bowel and spleen. The expression of AFP solely in the lung lesion and lack of expression in both testes, together with a rise in serum-AFP post-orchidectomy and the bilateral adrenal metastases, is overwhelming evidence for the reversal of the usual situation: a poorly differentiated AFP-secreting metastatic lung adenocarcinoma

scholarly journals Autopolypectomy of a Vocal Cord Polyp

2018 ◽  
Vol 26 (2) ◽  
pp. 134-136
Author(s):  
Saud Ahmed ◽  
Altaf Hussain ◽  
Basharat Nadeem ◽  
Faroq Ali
Keyword(s):  
Case Report ◽  
Vocal Cord ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Acute Cough ◽  
Unique Case ◽  
Vocal Cord Polyp ◽  
History Of ◽  
Microlaryngeal Surgery ◽  
The Right

Introduction Vocal cord polyps commonly occur in those with a history of vocal abuse. Patients with large lesions generally undergo microlaryngeal surgery under general anaesthesia. This unique case report highlights a strange scenario where the patient coughed out a fleshy mass during his morning walk and which was later confirmed as a vocal cord polyp.  Case Report A 62 year old male with a history of hoarseness of voice for 3 months presented to the ENT OPD holding a chunk of tissue which was apparently coughed out by him during his morning walk. After the incident, his symptoms had immediately improved. A videolaryngoscopy showed a congested spot on the right vocal cord being the probable site of origin of the lesion. On Histopathological examination, the tissue was reported as a vocal cord polyp.  The patient was managed conservatively but the lesion recurred at the same site after a month for which a microlaryngeal excision was performed. Discussion Vocal cord polyps are fairly common in ENT practice and usually present to the clinic with hoarseness of voice. Polyps that are small are usually managed conservatively by voice therapy alone whereas large polyps require surgical excision. This unique case report highlights a strange clinical scenario where the patient coughed out a large vocal cord polyp (Auto-polypectomy) during a bout of acute cough. This event saved him a surgery at the first instance, but eventually had a recurrence and had to undergo an excision under GA. 

Sign in / Sign up

Export Citation Format

Share Document