Long-term ongoing cortical remodeling after contralateral C-7 nerve transfer

2013 ◽  
Vol 118 (4) ◽  
pp. 725-729 ◽  
Author(s):  
Xu-Yun Hua ◽  
Bin Liu ◽  
Yan-Qun Qiu ◽  
Wei-Jun Tang ◽  
Wen-Dong Xu ◽  
...  
Keyword(s):  
Nerve Transfer ◽  
Cortical Reorganization ◽  
Long Term Results ◽  
Adaptive Plasticity ◽  
Healthy Male ◽  
Long Period ◽  
Network Activation ◽  
Nerve Transfers ◽  
Male Patients

Object Contralateral C-7 nerve transfer was developed for the treatment of patients with brachial plexus avulsion injury (BPAI). In the surgical procedure the affected recipient nerve is connected to the ipsilateral motor cortex, and the dramatic peripheral alteration may trigger extensive cortical reorganization. However, little is known about the long-term results after such specific nerve transfers. The purpose of this study was to investigate the long-term cortical adaptive plasticity after BPAI and contralateral C-7 nerve transfer. Methods In this study, 9 healthy male volunteers and 5 male patients who suffered from right-sided BPAI and had undergone contralateral C-7-transfer more than 5 years earlier were included. Functional MRI studies were used for the investigation of long-term cerebral plasticity. Results The neuroimaging results suggested that the ongoing cortical remodeling process after contralateral C-7 nerve transfer could last for a long period; at least for 5 years. The motor control of the reinnervated limb may finally transfer from the ipsilateral to the contralateral hemisphere exclusively, instead of the bilateral neural network activation. Conclusions The authors believe that the cortical remodeling may last for a long period after peripheral rearrangement and that the successful cortical transfer is the foundation of the independent motor recovery.

scholarly journals Long-Term Results of a Standard Algorithm for Intravenous Port Implantation

2021 ◽  
Vol 11 (5) ◽  
pp. 344
Author(s):  
Ching-Feng Wu ◽  
Jui-Ying Fu ◽  
Chi-Tsung Wen ◽  
Chien-Hung Chiu ◽  
Ming-Ju Hsieh ◽  
...  
Keyword(s):  
Operative Time ◽  
Functional Results ◽  
Long Term Results ◽  
Related Complication ◽  
Standard Algorithm ◽  
Port Implantation ◽  
Male Patients ◽  
Catheter Fracture ◽  
Guided Puncture

Intravenous ports serve as vascular access and are indispensable in cancer treatment. Most studies are not based on a systematic and standardized approach. Hence, the aim of this study was to demonstrate long-term results of port implantation following a standard algorithm. A total of 2950 patients who underwent intravenous port implantation between March 2012 and December 2018 were included. Data of patients managed following a standard algorithm were analyzed for safety and long-term outcomes. The cephalic vein was the predominant choice of entry vessel. In female patients, wire assistance without use of puncture sheath was less likely and echo-guided puncture via internal jugular vein (IJV) with use of puncture sheath was more likely to be performed, compared to male patients (p < 0.0001). The procedure-related complication rate was 0.07%, and no pneumothorax, hematoma, catheter kinking, catheter fracture, or pocket erosion was reported. Catheter implantations by echo-guided puncture via IJV notably declined from 4.67% to 0.99% (p = 0.027). Mean operative time gradually declined from 37.88 min in 2012 to 23.20 min in 2018. The proposed standard algorithm for port implantation reduced the need for IJV echo-guided approach and eliminated procedure-related catastrophic complications. In addition, it shortened operative time and demonstrated good functional results.

scholarly journals Early experience with the Penumbra SMART coil in the endovascular treatment of intracranial aneurysms: Safety and efficacy

2016 ◽  
Vol 22 (6) ◽  
pp. 654-658 ◽  
Author(s):  
Christopher J Stapleton ◽  
Collin M Torok ◽  
Aman B Patel
Keyword(s):  
Endovascular Treatment ◽  
Intracranial Aneurysms ◽  
Thromboembolic Complication ◽  
Flow Diversion ◽  
Long Term Results ◽  
Conformational Structure ◽  
Safety And Efficacy ◽  
Endovascular Coil Embolization ◽  
Male Patients

Background Penumbra SMART coils differ from traditional microcoils used for endovascular coil embolization of intracranial aneurysms (IAs) in that they (1) become progressively softer from their distal to proximal end, rather than being of uniform stiffness, (2) have a tight conformational structure, and (3) have a more robust stretch-resistance platform. These properties aid in preventing microcatheter prolapse and coil herniation during coil deployment and in filling small pockets of the aneurysm sac. Objective/Methods To determine the safety and efficacy of this device, the records of 17 consecutive patients with IAs treated with SMART coils were retrospectively analyzed. Results Thirteen female and four male patients were identified. Eleven patients presented with subarachnoid hemorrhage, four had recurrent aneurysms, and two had incidentally discovered aneurysms. Twelve aneurysms (two of which were recurrent) were treated with stand-alone coiling, three were treated with stent-assisted coiling, and two with flow diversion with adjuvant coiling. Microcatheter prolapse occurred in one case of a recurrent aneurysm, due to mechanical limitations imposed by a stent placed during prior coiling. Raymond-Roy Occlusion Classification (RROC) I or II occlusion was achieved in 12 aneurysms, including all 10 undergoing primary stand-alone coiling. Of the five RROC III occlusions, two were expected given treatment with flow diversion, while the other three occurred in complex, recurrent aneurysms. One patient suffered a thromboembolic complication of unclear clinical significance. Conclusions The Penumbra SMART coil is a safe and effective device for the endovascular treatment of IAs. Follow-up studies are required to establish long-term results.

SINGLE CENTRE LONG TERM RESULTS OF INTERNAL URETHROTOMY IN 924 MALE PATIENTS

2008 ◽  
Vol 179 (4S) ◽  
pp. 179-179
Author(s):  
Florian Imkamp ◽  
Thomas R Herrmann ◽  
Udo Jonas ◽  
Martin Buchardt
Keyword(s):  
Long Term Results ◽  
Internal Urethrotomy ◽  
Single Centre ◽  
Male Patients

scholarly journals Verteporfin Photodynamic Therapy Combined with Intravitreal Ranibizumab for Polypoidal Choroidal Vasculopathy Controversy Concerning Long-Term Followup

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Maribel Fernández ◽  
María Gil ◽  
Francisco Gomez-Ulla ◽  
Pablo Charlón
Keyword(s):  
Photodynamic Therapy ◽  
Polypoidal Choroidal Vasculopathy ◽  
Hot Spot ◽  
Spot Size ◽  
Long Term Results ◽  
Controlled Clinical Trials ◽  
Intravitreal Ranibizumab ◽  
Long Period ◽  
Choroidal Vasculopathy

Purpose. To show the long-term results of intravitreal ranibizumab combined with photodynamic therapy (PDT) for the treatment of polypoidal choroidal vasculopathy (PCV).Methods. We analyzed the progress of two patients for 36 and 58 months, respectively. We only used PDT for the treatment in the area of the active PCV or “hot spot” evident on the indocyanine green angiography (ICGA). The spot size was chosen so as to cover only the active neovascular lesion. We combined intravitreal ranibizumab with PDT when PCV remained active without visible polyps in ICGA or without a response to PDT.Conclusion. Administration, as required, of verteporfin photodynamic therapy combined with intravitreal ranibizumab is an effective treatment for symptomatic polypoidal choroidal vasculopathy. These data need to be confirmed in large, prospective, and controlled clinical trials which are randomized and carried out over a long period.

Rotational acetabular osteotomy for symptomatic hip dysplasia in patients younger than 21 years of age

2019 ◽  
Vol 101-B (4) ◽  
pp. 390-395
Author(s):  
Y. Yasunaga ◽  
R. Tanaka ◽  
K. Mifuji ◽  
T. Shoji ◽  
T. Yamasaki ◽  
...  
Keyword(s):  
Hip Dysplasia ◽  
Clinical Score ◽  
Adolescent And Young Adult ◽  
Long Term Results ◽  
Rotational Acetabular Osteotomy ◽  
Time Of Surgery ◽  
Effective Form ◽  
Male Patients ◽  
The Mean

Aims The aim of this study was to report the long-term results of rotational acetabular osteotomy (RAO) for symptomatic hip dysplasia in patients aged younger than 21 years at the time of surgery. Patients and Methods We evaluated 31 patients (37 hips) aged younger than 21 years at the time of surgery retrospectively. There were 29 female and two male patients. Their mean age at the time of surgery was 17.4 years (12 to 21). The mean follow-up was 17.9 years (7 to 30). The RAO was combined with a varus or valgus femoral osteotomy or a greater trochanteric displacement in eight hips, as instability or congruence of the hip could not be corrected adequately using RAO alone. Results The mean Merle d’Aubigné clinical score improved significantly from 15.4 to 17.2 (p < 0.0001). The mean centre-edge (CE) angle improved from -2.6° to 26°, the mean acetabular roof angle improved from 3.0° to 5.2°, and the mean head lateralization index improved from 0.68 to 0.62. Progression of radiological osteoarthritis (OA) was seen in seven hips, but no patient underwent total hip arthroplasty. Conclusion RAO is an effective form of correction for a severely dysplastic hip in adolescent and young adult patients. Cite this article: Bone Joint J 2019;101-B:390–395.

New urethroplasty for treating anterior urethral stenosis

1997 ◽  
Vol 64 (4) ◽  
pp. 443-446
Author(s):  
E. Palminteri ◽  
G. Lombardi ◽  
F. Travaglini ◽  
G. Barbagli
Keyword(s):  
Free Flap ◽  
Ventral Surface ◽  
Long Term Results ◽  
Urethral Stenosis ◽  
Bulbar Urethra ◽  
Corpora Cavernosa ◽  
Urethral Strictures ◽  
Male Patients

– Urethroplasties with free or pedicle preputial flaps are widely used in strictures of the spongy urethra. These techniques involve application of the preputial flap on the ventral surface of the urethra, with collapse of the spongy body and the frequent development of pseudodiverticula or urethroceles which are responsible for post-micturitional dribbling. The authors suggest a new urethroplasty for treating anterior urethral strictures, in which the free flap is applied dorsally and not ventrally, mechanically supported by the overlying spongy body and the underlying corpora cavernosa, and thus avoiding collapse of the flap. Thirty male patients with stenosis of the penile or bulbar urethra were treated with 2 different techniques using a free dorsal flap. Long-term results, with a mean follow-up of 34.5 months, were satisfying.

scholarly journals Vliyanie na prognoz estrogenovykh retseptorov a v opukholevykh kletkakh u patsientov, radikal'no operirovannykh po povodu nemelkokletochnogo raka legkogo

2018 ◽  
Vol 20 (3) ◽  
pp. 43-50
Author(s):  
D V Novikov ◽  
B E Polotskiy ◽  
T A Bogush ◽  
M M Davidov ◽  
B B Ahmedov ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Expression Level ◽  
Long Term Results ◽  
Relapse Free Survival ◽  
Free Survival ◽  
Disease Prognosis ◽  
Male Patients ◽  
The Impact

Aim. Evaluation of prognostic role of estrogen receptors a (ERa) expression level at patients with non-small cell lung cancer (NSLC) after surgical treatment. Methods and materials. 115 clinical cases of patients who underwent treatment in N.N.Blokhin Russian Cancer Research Center fr om 2009 to 2016 were studied. There were 95 males and 20 females. All patients had NSLC confirmed by histological analysis and followed-up for long term results. Results. There was no statistical evidence that the level of estrogen a expression in tumor cells has an impact on relapse free survival among men with both adenocarcinoma and squamous cell carcinoma of the lung. Similar results were obtained for women group. Also, no correlations between overall survival and the level of estrogen a expression were noticed among men and women. Thus ERa can’t be used as a predictor marker for patients with NSLC. Conclusion. The level of ERa expression in tumor cells among male patients does not influence on disease prognosis regardless stage of the disease and tumor morphology and can’t be used as a prognostic factor. The impact of the ERa expression level in tumor cells among female patients on disease prognosis is questionable.

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